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Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

This study is currently recruiting participants.
Verified September 2017 by Alliance for Clinical Trials in Oncology
Sponsor:
ClinicalTrials.gov Identifier:
NCT00887146
First Posted: April 23, 2009
Last Update Posted: October 2, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborators:
National Cancer Institute (NCI)
European Organisation for Research and Treatment Center (EORTC)
NCIC Clinical Trials Group
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology
  Purpose
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.

Condition Intervention Phase
Brain and Central Nervous System Tumors Drug: concomitant temozolomide (TMZ) Radiation: radiotherapy Drug: procarbazine Drug: adjuvant temozolomide (TMZ) Drug: CCNU Drug: vincristine Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase III Intergroup Study of Radiotherapy With Concomitant and Adjuvant Temozolomide Versus Radiotherapy With Adjuvant PCV Chemotherapy in Patients With 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma

Resource links provided by NLM:


Further study details as provided by Alliance for Clinical Trials in Oncology:

Primary Outcome Measures:
  • Progression-free survival [ Time Frame: Up to 5 years post-treatment ]

Secondary Outcome Measures:
  • Overall survival [ Time Frame: Up to 5 years post-treatment ]
  • Objective tumor response [ Time Frame: Up to 5 years post-treatment ]
  • Treatment-related adverse event as per the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [ Time Frame: Up to 5 years post-treatment ]
  • Time to progression (eg, clinical progression, radiographic progression or neurocognitive progression) [ Time Frame: Up to 5 years post-treatment ]

Estimated Enrollment: 360
Study Start Date: September 2009
Estimated Primary Completion Date: December 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Arm A - Radiotherapy followed by PCV

Patients undergo radiotherapy (RT) 5 days per week for about 6-7 weeks. (Cycle 1 is about 6 to 7 weeks)

Cycle 2 rest period is about 4 weeks.

Patients receive PCV chemotherapy for about 6-7 weeks, a total of 6 cycles.

Radiation: radiotherapy Drug: procarbazine
Days 8-21: 60 mg/m^2 orally
Drug: CCNU
Day 1: 110 mg/m^2 orally
Drug: vincristine
Days 8 and 29: 1.4 mg/m^2 IV
Active Comparator: Arm B - Radiotherapy + TMZ followed by TMZ

Patients undergo radiotherapy (RT) and temozolomide (TMZ) treatment for 5 days per week for about 6-7 weeks (Cycle 1).

Cycle 2 rest period is about 4 weeks.

Patients receive adjuvant temozolomide for about 4 weeks, a total of 6 cycles. TMZ may be extended to 12 cycles if the patient shows acceptable tolerance and no evidence of progression.

Drug: concomitant temozolomide (TMZ)
75 mg/m^2, orally daily
Radiation: radiotherapy Drug: adjuvant temozolomide (TMZ)
150 or 200 mg/m^2 orally

Detailed Description:

This study will be a randomized phase III for patients with newly diagnosed co-deleted 1p/19q anaplastic glioma or high risk low grade glioma. The trial will only enroll patients with 1p/19q co-deletion. This study includes two arms as described in the "Arms" section. A dynamic allocation procedure will be used to allocate an equal number of patients to different arms (Arms A:B = 1:1). This procedure will balance the marginal distributions of the stratification factors among arms. The stratification factors that will be used are cooperative groups (EORTC vs. all North American groups), age (≤ 50 vs. > 50), performance score (ECOG 0-1 vs. 2), and tumor grade (anaplastic glioma vs. low grade glioma).

The primary goal is to determine whether patients who receive radiotherapy with concomitant temozolomide (TMZ) followed by adjuvant temozolomide (RT + TMZ --> TMZ) (Arm B) have a marginally better progression free survival (PFS) as compared with patients who receive radiotherapy followed by PCV chemotherapy (RT --> PCV)(Arm A).

Secondary Goals:

  1. Time to Progression - To determine whether patients who receive (RT + TMZ --> TMZ) have a significantly longer time to progression (clinical or radiographic progression) as compared with patients who receive radiotherapy followed by adjuvant PCV chemotherapy (RT --> PCV).
  2. Correlation between exploratory biomarkers and survival - To determine whether there is a difference in survival based on t(1;19)(q10, p10) translocation status and MGMT promoter hypermethylation status.
  3. Descriptive Comparisons of Additional Secondary Endpoints - To perform descriptive comparisons of additional secondary outcome endpoints, including overall survival, objective tumor response, prognostic factor analysis and quality of life.
  4. Toxicity - To determine the toxicity of the treatment in each arm and perform descriptive comparisons.
  5. Neurocognitive and Quality of Life (QOL) Effects - To determine the neurocognitive and QOL effects in patients treated on this protocol and correlate these results with outcome endpoints.
  6. Banking of Biospecimens and Neuroimaging Studies - To store blood products (i.e., plasma, DNA and buffy coat), tumor tissue and MRI/CT images for future scientific investigations.

After completion of study treatment, patients are followed every 12 weeks for 1 year, then every 4 months for 2 years and then every 6 months until progressive disease or until the end of study participation.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Pre-Registration Inclusion Criteria:

Central Pathology Review Submission: This review is mandatory prior to registration to confirm eligibility. Patients must be willing to submit tissue samples for mandatory central pathology review submission and deletion status determination. It should be initiated as soon after surgery as possible.

Registration Inclusion Criteria:

  1. Age ≥ 18 years
  2. Newly diagnosed and ≤ 3 months from surgical diagnosis
  3. Histological confirmation of anaplastic glioma (oligodendroglioma, mixed, or astrocytoma [WHO grade 2 or 3] or low grade glioma [WHO grade 2], as determined by pre-registration central pathology review. Note: Mixed gliomas are eligible, regardless of the degree of astrocytic or oligodendrocytic predominance, as long as the tumor is also co-deleted for 1p and 19q.
  4. Patients with codeleted low grade gliomas must also be considered "high risk" by clinical criteria utilized in RTOG 9802 and must be either: age ≥ 40 and any surgical therapy or age < 40 and subtotal resection or biopsy.
  5. Tumor tissue must show co-deletion for the relevant portions of chromosomes 1p and 19q by FISH analysis, as defined by the testing laboratory.
  6. Surgery (partial or gross total resection or biopsy) must be performed ≥ 2 weeks prior to registration. Patient must have recovered from the effects of surgery.
  7. The following laboratory values obtained ≤ 21 days prior to registration.

    1. Absolute neutrophil count (ANC) ≥ 1500/mm^3
    2. Platelet (PLTs) count ≥ 100,000/mm^3
    3. Hemoglobin (Hgb) > 9.0g/dL
    4. Total bilirubin ≤ 1.5 x upper limit of normal (ULN)
    5. Serum glutamic oxaloacetic transaminase (SGOT) aspartate transaminase (AST) ≤ 3 x ULN
    6. Creatinine ≤ 1.5 x ULN
  8. Negative serum or urine pregnancy test done ≤ 7 days prior to registration for women of childbearing potential only.
  9. Willing and able to complete neurocognitive testing without assistance and the Quality of Life (QOL) questionnaires with or without assistance
  10. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
  11. Provide informed written consent.
  12. Willing to return to enrolling institution for follow-up during the Active Monitoring Phase (ie, active treatment and observation portion) of the study
  13. Mandatory Tissue Samples for Correlative Research -Patient willing to provide tissue samples for correlative research purposes

Registration Exclusion Criteria:

  1. Fetal/Newborn Toxicity: Any of the following because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects: Pregnant women, nursing women, men or women of childbearing potential who are unwilling to employ adequate contraception during this study and for up to 6 months following the completion of temozolomide treatments.
  2. Received any prior surgery, radiation therapy or chemotherapy for any central nervous system (CNS) neoplasm. Note: Patients who have had a prior low grade glioma with or without surgery and who now have anaplastic glioma with no prior radiation or chemotherapy are eligible for the study.
  3. Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.
  4. Concomitant serious immunocompromised status (other than that related to concomitant steroids) that would compromise the safety of the patient on the study.
  5. Patients known to be Human Immunodeficiency Virus (HIV) positive and currently receiving retroviral therapy. Note: Patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for the study.
  6. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  7. Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm.
  8. Other active malignancy within 5 years of registration. Exceptions:

    Non-melanotic skin cancer or carcinoma in situ of the cervix. Note: If there is a history of prior malignancy, the patient must not be receiving other specific treatment (other than hormonal therapy) for their cancer.

  9. History of myocardial infarction ≤ 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias.
  10. Recent history of hepatitis infection or treating physician determined that the patient would be at significant risk of reactivation of hepatitis.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00887146


Contacts
Contact: Kurt Jaeckle, MD 904-953-7102

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Cancer Center Recruiting
Birmingham, Alabama, United States, 35233
Contact: John B. Fiveash    800-828-8816      
Principal Investigator: John B. Fiveash         
Providence Hospital Suspended
Mobile, Alabama, United States, 36608
United States, Alaska
Anchorage Associates in Radiation Medicine Recruiting
Anchorage, Alaska, United States, 98508
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
Alaska Oncology and Hematology LLC Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
Alaska Women's Cancer Care Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
Anchorage Oncology Centre Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
Katmai Oncology Group Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
Providence Alaska Medical Center Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
United States, Arizona
Saint Joseph's Hospital and Medical Center Recruiting
Phoenix, Arizona, United States, 85013
Contact: David G. Brachman    800-360-6371      
Principal Investigator: David G. Brachman         
Arizona Oncology-Deer Valley Center Suspended
Phoenix, Arizona, United States, 85027
Arizona Oncology Services Foundation Suspended
Scottsdale, Arizona, United States, 85260
United States, California
Sutter Cancer Centers Radiation Oncology Services-Auburn Recruiting
Auburn, California, United States, 95603
Contact: Stacy D. D'Andre    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Stacy D. D'Andre         
Mills-Peninsula Medical Center Recruiting
Burlingame, California, United States, 94010
Contact: Stacy D. D'Andre    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Stacy D. D'Andre         
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Recruiting
Cameron Park, California, United States, 95682
Contact: Stacy D. D'Andre    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Stacy D. D'Andre         
University Oncology Associates Recruiting
Fresno, California, United States, 93701
Contact: Uzair B. Chaudhary    559-447-4050      
Principal Investigator: Uzair B. Chaudhary         
California Cancer Center - North Fresno Recruiting
Fresno, California, United States, 93720
Contact: Uzair B. Chaudhary    559-447-4050      
Principal Investigator: Uzair B. Chaudhary         
UC San Diego Moores Cancer Center Suspended
La Jolla, California, United States, 92093
Kaiser Permanente Los Angeles Medical Center Recruiting
Los Angeles, California, United States, 90027
Contact: Michael R. Girvigian    626-564-3455      
Principal Investigator: Michael R. Girvigian         
Cedars Sinai Medical Center Recruiting
Los Angeles, California, United States, 90048
Contact: Jethro L. Hu    310-423-8965      
Principal Investigator: Jethro L. Hu         
Memorial Medical Center Recruiting
Modesto, California, United States, 95355
Contact: Stacy D. D'Andre    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Stacy D. D'Andre         
Kaiser Permanente Oakland-Broadway Suspended
Oakland, California, United States, 94611
Sutter Cancer Centers Radiation Oncology Services-Roseville Recruiting
Roseville, California, United States, 95661
Contact: Stacy D. D'Andre    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Stacy D. D'Andre         
Sutter Medical Center Sacramento Recruiting
Sacramento, California, United States, 95816
Contact: Stacy D. D'Andre    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Stacy D. D'Andre         
Kaiser Permanente Medical Center - Santa Clara Suspended
Santa Clara, California, United States, 95051
Kaiser Permanente-South San Francisco Suspended
South San Francisco, California, United States, 94080
Sutter Cancer Centers Radiation Oncology Services-Vacaville Recruiting
Vacaville, California, United States, 95687
Contact: Stacy D. D'Andre    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Stacy D. D'Andre         
Sutter Solano Medical Center/Cancer Center Recruiting
Vallejo, California, United States, 94589
Contact: Stacy D. D'Andre    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Stacy D. D'Andre         
United States, Colorado
The Medical Center of Aurora Suspended
Aurora, Colorado, United States, 80012
University of Colorado Hospital Recruiting
Aurora, Colorado, United States, 80045
Contact: Brian D. Kavanagh    720-848-0650      
Principal Investigator: Brian D. Kavanagh         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Memorial Hospital Central Recruiting
Colorado Springs, Colorado, United States, 80909
Contact: Brian D. Kavanagh    720-848-0650      
Principal Investigator: Brian D. Kavanagh         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
McKee Medical Center Suspended
Loveland, Colorado, United States, 80539
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
United States, Connecticut
Yale University Recruiting
New Haven, Connecticut, United States, 06520
Contact: Kevin P. Becker    203-785-5702      
Principal Investigator: Kevin P. Becker         
United States, District of Columbia
Sibley Memorial Hospital Recruiting
Washington, D.C., District of Columbia, United States, 20016
Contact: Matthias Holdhoff    410-955-8804    jhcccro@jhmi.edu   
Principal Investigator: Matthias Holdhoff         
United States, Florida
Boca Raton Regional Hospital Recruiting
Boca Raton, Florida, United States, 33486
Contact: Sajeel A. Chowdhary    561-955-4800      
Principal Investigator: Sajeel A. Chowdhary         
University of Florida Health Science Center ?? Gainesville Recruiting
Gainesville, Florida, United States, 32610
Contact: David D. Tran    352-273-8675    trials@cancer.ufl.edu   
Principal Investigator: David D. Tran         
Baptist MD Anderson Cancer Center Recruiting
Jacksonville, Florida, United States, 32207
Contact: Alton V. Hallum    520-544-2919      
Principal Investigator: Alton V. Hallum         
Mayo Clinic in Florida Recruiting
Jacksonville, Florida, United States, 32224-9980
Contact: Paul D. Brown    855-776-0015      
Principal Investigator: Paul D. Brown         
Florida Hospital Orlando Withdrawn
Orlando, Florida, United States, 32803
United States, Georgia
Emory University Hospital Midtown Suspended
Atlanta, Georgia, United States, 30308
Piedmont Hospital Recruiting
Atlanta, Georgia, United States, 30309
Contact: Adam W. Nowlan    404-425-7943    ORS@piedmont.org   
Principal Investigator: Adam W. Nowlan         
Emory University/Winship Cancer Institute Suspended
Atlanta, Georgia, United States, 30322
United States, Idaho
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Northwestern University Suspended
Chicago, Illinois, United States, 60611
University of Chicago Comprehensive Cancer Center Suspended
Chicago, Illinois, United States, 60637
Cancer Care Center of Decatur Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Crossroads Cancer Center Recruiting
Effingham, Illinois, United States, 62401
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
AMITA Health Adventist Medical Center Suspended
La Grange, Illinois, United States, 60525
Loyola University Medical Center Suspended
Maywood, Illinois, United States, 60153
Advocate Lutheran General Hospital Suspended
Park Ridge, Illinois, United States, 60068
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Recruiting
Pekin, Illinois, United States, 61554
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Recruiting
Peoria, Illinois, United States, 61615
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Cancer Care Specialists of Illinois-Swansea Recruiting
Swansea, Illinois, United States, 62226
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
United States, Indiana
Parkview Hospital Randallia Recruiting
Fort Wayne, Indiana, United States, 46805
Contact: Brian K. Chang    260-373-8888    parkviewresearch@parkview.com   
Principal Investigator: Brian K. Chang         
Memorial Regional Cancer Center Day Road Recruiting
Mishawaka, Indiana, United States, 46545
Contact: Thomas J. Reid    800-284-7370      
Principal Investigator: Thomas J. Reid         
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Thomas J. Reid    800-284-7370      
Principal Investigator: Thomas J. Reid         
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Suspended
Ames, Iowa, United States, 50010
Medical Oncology and Hematology Associates-West Des Moines Recruiting
Clive, Iowa, United States, 50325
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Mercy Cancer Center-West Lakes Recruiting
Clive, Iowa, United States, 50325
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Iowa-Wide Oncology Research Coalition NCORP Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-282-2921      
Principal Investigator: Robert J. Behrens         
Medical Oncology and Hematology Associates-Des Moines Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Broadlawns Medical Center Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Medical Oncology and Hematology Associates-Laurel Recruiting
Des Moines, Iowa, United States, 50314
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Iowa Lutheran Hospital Recruiting
Des Moines, Iowa, United States, 50316
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Methodist West Hospital Recruiting
West Des Moines, Iowa, United States, 50266-7700
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Mercy Medical Center-West Lakes Recruiting
West Des Moines, Iowa, United States, 50266
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
United States, Kansas
Kansas City NCI Community Oncology Research Program Terminated
Prairie Village, Kansas, United States, 66208
United States, Kentucky
University of Kentucky/Markey Cancer Center Recruiting
Lexington, Kentucky, United States, 40536
Contact: John L. Villano    859-257-3379      
Principal Investigator: John L. Villano         
Norton Hospital Pavilion and Medical Campus Recruiting
Louisville, Kentucky, United States, 40202
Contact: Aaron C. Spalding    866-530-5516      
Principal Investigator: Aaron C. Spalding         
United States, Maine
Maine Medical Center-Bramhall Campus Suspended
Portland, Maine, United States, 04102
Maine Medical Center- Scarborough Campus Suspended
Scarborough, Maine, United States, 04074
United States, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center Recruiting
Baltimore, Maryland, United States, 21287
Contact: Matthias Holdhoff    410-955-8804    jhcccro@jhmi.edu   
Principal Investigator: Matthias Holdhoff         
Cancer Trials Support Unit Recruiting
Rockville, Maryland, United States, 20850-2062
Contact: Kurt A. Jaeckle         
Principal Investigator: Kurt A. Jaeckle         
United States, Massachusetts
Massachusetts General Hospital Cancer Center Suspended
Boston, Massachusetts, United States, 02114
United States, Michigan
Bixby Medical Center Suspended
Adrian, Michigan, United States, 49221
University of Michigan Comprehensive Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Michelle M. Kim    800-865-1125      
Principal Investigator: Michelle M. Kim         
Henry Ford Hospital Suspended
Detroit, Michigan, United States, 48202
Mercy Health Saint Mary's Suspended
Grand Rapids, Michigan, United States, 49503
Spectrum Health at Butterworth Campus Suspended
Grand Rapids, Michigan, United States, 49503
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Sunil Nagpal    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Sunil Nagpal         
William Beaumont Hospital-Royal Oak Suspended
Royal Oak, Michigan, United States, 48073
Munson Medical Center Suspended
Traverse City, Michigan, United States, 49684
William Beaumont Hospital - Troy Suspended
Troy, Michigan, United States, 48098
United States, Minnesota
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Essentia Health Cancer Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Miller-Dwan Hospital Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Paul D. Brown    855-776-0015      
Principal Investigator: Paul D. Brown         
Metro Minnesota Community Oncology Research Consortium Terminated
Saint Louis Park, Minnesota, United States, 55416
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
Minnesota Oncology Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Daniel M. Anderson    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Daniel M. Anderson         
United States, Missouri
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Jian L. Campian    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Jian L. Campian         
United States, Montana
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
CHI Health Saint Francis Recruiting
Grand Island, Nebraska, United States, 68803
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
CHI Health Good Samaritan Recruiting
Kearney, Nebraska, United States, 68847
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Missouri Valley Cancer Consortium Recruiting
Omaha, Nebraska, United States, 68106
Contact: Gamini S. Soori    402-991-8070 ext 202    mwilwerding@mvcc.cc   
Principal Investigator: Gamini S. Soori         
Alegent Health Immanuel Medical Center Recruiting
Omaha, Nebraska, United States, 68122
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Alegent Health Bergan Mercy Medical Center Recruiting
Omaha, Nebraska, United States, 68124
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
Oncology Hematology West Recruiting
Omaha, Nebraska, United States, 68124
Contact: Gamini S. Soori    402-991-8070    mwilwerding@mvcc.cc   
Principal Investigator: Gamini S. Soori         
Alegent Health Lakeside Hospital Recruiting
Omaha, Nebraska, United States, 68130
Contact: Mehmet S. Copur    501-622-2100      
Principal Investigator: Mehmet S. Copur         
University of Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Nicole A. Shonka    402-559-6941    unmcrsa@unmc.edu   
Principal Investigator: Nicole A. Shonka         
Midlands Community Hospital Suspended
Papillion, Nebraska, United States, 68046
United States, Nevada
Radiation Oncology Centers of Nevada Central Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    805-474-9143      
Principal Investigator: John A. Ellerton         
21st Century Oncology Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John A. Ellerton    805-474-9143      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John A. Ellerton    805-474-9143      
Principal Investigator: John A. Ellerton         
Renown Regional Medical Center Recruiting
Reno, Nevada, United States, 89502
Contact: John A. Ellerton    805-474-9143      
Principal Investigator: John A. Ellerton         
Saint Mary's Regional Medical Center Recruiting
Reno, Nevada, United States, 89503
Contact: John A. Ellerton    805-474-9143      
Principal Investigator: John A. Ellerton         
United States, New Hampshire
Dartmouth Hitchcock Medical Center Suspended
Lebanon, New Hampshire, United States, 03756
United States, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital Suspended
New Brunswick, New Jersey, United States, 08903
Rutgers Cancer Institute of New Jersey Suspended
New Brunswick, New Jersey, United States, 08903
Overlook Hospital Recruiting
Summit, New Jersey, United States, 07902
Contact: Kurt A. Jaeckle    855-776-0015      
Principal Investigator: Kurt A. Jaeckle         
United States, New Mexico
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87102
Contact: Olivier Rixe    706-721-1663    cancer@augusta.edu   
Principal Investigator: Olivier Rixe         
United States, New York
New York-Presbyterian/Brooklyn Methodist Hospital Recruiting
Brooklyn, New York, United States, 11215
Contact: Sameer Rafla-Demetrious    718-780-3677    Adg9003@nyp.org   
Principal Investigator: Sameer Rafla-Demetrious         
Columbia University/Herbert Irving Cancer Center Recruiting
New York, New York, United States, 10032
Contact: Andrew B. Lassman    212-639-7202      
Principal Investigator: Andrew B. Lassman         
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Yuhchyau Chen    585-341-8113      
Principal Investigator: Yuhchyau Chen         
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen    585-341-8113      
Principal Investigator: Yuhchyau Chen         
State University of New York Upstate Medical University Suspended
Syracuse, New York, United States, 13210
United States, North Carolina
Wake Forest University Health Sciences Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Glenn J. Lesser    336-713-6771      
Principal Investigator: Glenn J. Lesser         
United States, North Dakota
Altru Cancer Center Recruiting
Grand Forks, North Dakota, United States, 58201
Contact: Grant R. Seeger    855-776-0015      
Principal Investigator: Grant R. Seeger         
United States, Ohio
Case Western Reserve University Suspended
Cleveland, Ohio, United States, 44106
MetroHealth Medical Center Suspended
Cleveland, Ohio, United States, 44109
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Samuel T. Chao    866-223-8100      
Principal Investigator: Samuel T. Chao         
Ohio State University Comprehensive Cancer Center Suspended
Columbus, Ohio, United States, 43210
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: Timothy D. Moore    614-488-2745    sheree@columbusccop.org   
Principal Investigator: Timothy D. Moore         
Columbus NCI Community Oncology Research Program Terminated
Columbus, Ohio, United States, 43215
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: Timothy D. Moore    614-488-2745    sheree@columbusccop.org   
Principal Investigator: Timothy D. Moore         
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: Timothy D. Moore    614-488-2745    sheree@columbusccop.org   
Principal Investigator: Timothy D. Moore         
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Samuel T. Chao    866-223-8100      
Principal Investigator: Samuel T. Chao         
Saint Ann's Hospital Recruiting
Westerville, Ohio, United States, 43081
Contact: Timothy D. Moore    614-488-2745    sheree@columbusccop.org   
Principal Investigator: Timothy D. Moore         
Cleveland Clinic Wooster Family Health and Surgery Center Recruiting
Wooster, Ohio, United States, 44691
Contact: Samuel T. Chao    866-223-8100      
Principal Investigator: Samuel T. Chao         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Terence S. Herman    405-271-8777    ou-clinical-trials@ouhsc.edu   
Principal Investigator: Terence S. Herman         
Oklahoma Cancer Specialists and Research Institute-Tulsa Recruiting
Tulsa, Oklahoma, United States, 74146
Contact: Terence S. Herman    405-271-8777    ou-clinical-trials@ouhsc.edu   
Principal Investigator: Terence S. Herman         
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
Legacy Mount Hood Medical Center Withdrawn
Gresham, Oregon, United States, 97030
Legacy Good Samaritan Hospital and Medical Center Withdrawn
Portland, Oregon, United States, 97210
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
United States, Pennsylvania
Abington Memorial Hospital Recruiting
Abington, Pennsylvania, United States, 19001
Contact: Willard G. Andrews    215-481-2402      
Principal Investigator: Willard G. Andrews         
Lehigh Valley Hospital-Cedar Crest Suspended
Allentown, Pennsylvania, United States, 18103
Saint Luke's University Hospital-Bethlehem Campus Recruiting
Bethlehem, Pennsylvania, United States, 18015
Contact: Hugh D. Moulding    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Hugh D. Moulding         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Scott G. Turner    570-271-5251      
Principal Investigator: Scott G. Turner         
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Jon Glass    215-955-6084      
Principal Investigator: Jon Glass         
Temple University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19140
Contact: Aruna Padmanabhan    215-728-2983      
Principal Investigator: Aruna Padmanabhan         
University of Pittsburgh Cancer Institute (UPCI) Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: David A. Clump    412-647-8073      
Principal Investigator: David A. Clump         
Geisinger Wyoming Valley/Henry Cancer Center Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Scott G. Turner    570-271-5251      
Principal Investigator: Scott G. Turner         
United States, South Carolina
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Scott M. Lindhorst    843-792-9321      
Principal Investigator: Scott M. Lindhorst         
Greenville Health System Cancer Institute-Andrews Suspended
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Butternut Suspended
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Eastside Recruiting
Greenville, South Carolina, United States, 29615
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Greer Recruiting
Greer, South Carolina, United States, 29650
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Spartanburg Medical Center Withdrawn
Spartanburg, South Carolina, United States, 29303
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
United States, South Dakota
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Michael O. Robinson    605-716-3982    research@rcrh.org   
Principal Investigator: Michael O. Robinson         
United States, Tennessee
Vanderbilt University/Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Paul L. Moots    800-811-8480      
Principal Investigator: Paul L. Moots         
United States, Texas
UT Southwestern/Simmons Cancer Center-Dallas Recruiting
Dallas, Texas, United States, 75390
Contact: Edward Pan    214-590-5582      
Principal Investigator: Edward Pan         
University of Texas Medical Branch Recruiting
Galveston, Texas, United States, 77555-0565
Contact: Martin Colman    409-772-1950    clinical.research@utmb.edu   
Principal Investigator: Martin Colman         
UTMB Cancer Center at Victory Lakes Recruiting
League City, Texas, United States, 77573
Contact: Martin Colman    409-772-1950    clinical.research@utmb.edu   
Principal Investigator: Martin Colman         
United States, Utah
Sandra L Maxwell Cancer Center Recruiting
Cedar City, Utah, United States, 84720
Contact: Gordon A. Watson    800-248-1199      
Principal Investigator: Gordon A. Watson         
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84107
Contact: Gordon A. Watson    800-248-1199      
Principal Investigator: Gordon A. Watson         
Utah Valley Regional Medical Center Recruiting
Provo, Utah, United States, 84604
Contact: Gordon A. Watson    800-248-1199      
Principal Investigator: Gordon A. Watson         
Dixie Medical Center Regional Cancer Center Recruiting
Saint George, Utah, United States, 84770
Contact: Gordon A. Watson    800-248-1199      
Principal Investigator: Gordon A. Watson         
Utah Cancer Specialists-Salt Lake City Recruiting
Salt Lake City, Utah, United States, 84106
Contact: Gordon A. Watson    800-248-1199      
Principal Investigator: Gordon A. Watson         
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Adam L. Cohen    801-581-4477    clinical.trials@hci.utah.edu   
Principal Investigator: Adam L. Cohen         
LDS Hospital Recruiting
Salt Lake City, Utah, United States, 84143
Contact: Gordon A. Watson    800-248-1199      
Principal Investigator: Gordon A. Watson         
United States, Virginia
Virginia Commonwealth University/Massey Cancer Center Recruiting
Richmond, Virginia, United States, 23298
Contact: Mark G. Malkin    414-805-4380      
Principal Investigator: Mark G. Malkin         
United States, Washington
PeaceHealth Saint Joseph Medical Center Recruiting
Bellingham, Washington, United States, 98225
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
Kadlec Clinic Hematology and Oncology Recruiting
Kennewick, Washington, United States, 99336
Contact: George E. Laramore    800-422-6237      
Principal Investigator: George E. Laramore         
Tri-Cities Cancer Center Suspended
Kennewick, Washington, United States, 99336
Skagit Valley Hospital Regional Cancer Care Center Recruiting
Mount Vernon, Washington, United States, 98273
Contact: George E. Laramore    800-422-6237      
Principal Investigator: George E. Laramore         
Skagit Valley Hospital Recruiting
Mount Vernon, Washington, United States, 98274
Contact: George E. Laramore    800-422-6237      
Principal Investigator: George E. Laramore         
Virginia Mason Medical Center Recruiting
Seattle, Washington, United States, 98101
Contact: Craig R. Nichols    253-403-2394      
Principal Investigator: Craig R. Nichols         
Fred Hutchinson Cancer Research Center Recruiting
Seattle, Washington, United States, 98109
Contact: George E. Laramore    800-422-6237      
Principal Investigator: George E. Laramore         
Seattle Cancer Care Alliance Recruiting
Seattle, Washington, United States, 98109
Contact: George E. Laramore    800-422-6237      
Principal Investigator: George E. Laramore         
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: George E. Laramore    800-422-6237      
Principal Investigator: George E. Laramore         
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Alison K. Conlin    907-212-6871    AKPAMC.OncologyResearchSupport@providence.org   
Principal Investigator: Alison K. Conlin         
United States, West Virginia
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Aaron P. Provenzano    304-293-7374    cancertrialsinfo@hsc.wvu.edu   
Principal Investigator: Aaron P. Provenzano         
United States, Wisconsin
Gundersen Lutheran Medical Center Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Collin D. Driscoll    608-775-2385    cancerctr@gundersenhealth.org   
Principal Investigator: Collin D. Driscoll         
Aurora Saint Luke's Medical Center Suspended
Milwaukee, Wisconsin, United States, 53215
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Joseph A. Bovi    414-805-4380      
Principal Investigator: Joseph A. Bovi         
ProHealth Waukesha Memorial Hospital Suspended
Waukesha, Wisconsin, United States, 53188
Austria
Medical University Vienna Recruiting
Vienna, Austria, A-1090
Contact: Kurt A. Jaeckle         
Principal Investigator: Kurt A. Jaeckle         
Belgium
Alegemeen Ziekenhuis Middelheim Recruiting
Antwerpen, Belgium, 2020
Contact: Kurt A. Jaeckle    904-953-7102    jaeckle.kurt@mayo.edu   
Principal Investigator: Kurt A. Jaeckle         
Canada, Alberta
Tom Baker Cancer Centre Recruiting
Calgary, Alberta, Canada, T2N 4N2
Contact: Roger Tsang    403-521-3433      
Principal Investigator: Roger Tsang         
Cross Cancer Institute Suspended
Edmonton, Alberta, Canada, T6G 1Z2
Canada, Ontario
London Regional Cancer Program Suspended
London, Ontario, Canada, N6A 4L6
Ottawa Hospital and Cancer Center-General Campus Recruiting
Ottawa, Ontario, Canada, K1H 8L6
Contact: Garth Nicholas    613-761-4395      
Principal Investigator: Garth Nicholas         
Odette Cancer Centre- Sunnybrook Health Sciences Centre Recruiting
Toronto, Ontario, Canada, M4N 3M5
Contact: James J. Perry    215-612-5296      
Principal Investigator: James J. Perry         
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Warren P. Mason    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: Warren P. Mason         
Canada, Quebec
CHUM - Hopital Notre-Dame Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Giuseppina L. Masucci    514-890-8000 ext 23611    sylvie.beaudoin.chum@ssss.gouv.qc.ca   
Principal Investigator: Giuseppina L. Masucci         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Mussawar Iqbal    306-766-2213      
Principal Investigator: Mussawar Iqbal         
France
Centre Leon Berard Recruiting
Lyon, France, 69373
Contact: Kurt A. Jaeckle         
Principal Investigator: Kurt A. Jaeckle         
Centre Antoine Lacassagne Recruiting
Nice, France, 06189
Contact: Kurt A. Jaeckle    904-953-7102    jaeckle.kurt@mayo.edu   
Principal Investigator: Kurt A. Jaeckle         
Gustave Roussy Recruiting
Villejuif, France, 94805
Contact: Kurt A. Jaeckle         
Principal Investigator: Kurt A. Jaeckle         
Netherlands
Academ Zienkenhuis Bij De University Recruiting
Amsterdam, Netherlands, 1007 MB
Contact: Kurt A. Jaeckle         
Principal Investigator: Kurt A. Jaeckle         
University Medical Center Groningen Recruiting
Groningen, Netherlands, 9700 GZ
Contact: Kurt A. Jaeckle         
Principal Investigator: Kurt A. Jaeckle         
Maastro Clinic-Maastricht Radiation Oncology Recruiting
Maastricht, Netherlands, 6229 NA
Contact: Kurt A. Jaeckle    904-953-7102    jaeckle.kurt@mayo.edu   
Principal Investigator: Kurt A. Jaeckle         
Erasmus University Medical Center Recruiting
Rotterdam, Netherlands, 3015 CE
Contact: Kurt A. Jaeckle         
Principal Investigator: Kurt A. Jaeckle         
Switzerland
University Hospital Zurich Not yet recruiting
Zurich, Ch 8091, Switzerland
Contact: Michael Weller         
Principal Investigator: Michael Weller         
Sponsors and Collaborators
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)
European Organisation for Research and Treatment Center (EORTC)
NCIC Clinical Trials Group
Investigators
Study Chair: Kurt Jaeckle, MD Mayo Clinic
  More Information

Additional Information:
Responsible Party: Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier: NCT00887146     History of Changes
Other Study ID Numbers: N0577
NCI-2011-01915 ( Registry Identifier: CTRP (Clinical Trials Reporting System) )
EORTC-26081-22086
EudraCT-2008-007295-14
CDR0000640442 ( Registry Identifier: PDQ (Physician Data Query) )
First Submitted: April 22, 2009
First Posted: April 23, 2009
Last Update Posted: October 2, 2017
Last Verified: September 2017

Keywords provided by Alliance for Clinical Trials in Oncology:
adult anaplastic astrocytoma
adult anaplastic oligodendroglioma
adult mixed glioma

Additional relevant MeSH terms:
Glioma
Nervous System Neoplasms
Central Nervous System Neoplasms
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neoplasms by Site
Nervous System Diseases
Temozolomide
Dacarbazine
Vincristine
Procarbazine
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators