Activation of Hepatitis B Virus (HBV) in Hepatitis B Surface Antigen (HBsAg) - Negative But Hepatitis B Core Antibody (Anti-HBc) - Positive Patients

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2012 by Kyoto University
Information provided by (Responsible Party):
Yoshihide Ueda, Kyoto University Identifier:
First received: April 13, 2009
Last updated: September 25, 2012
Last verified: September 2012

Individuals with resolved hepatitis B, characterized as hepatitis B surface antigen (HBsAg)-negative and hepatitis B core antibody-positive, have latent hepatitis B virus (HBV) infection in their liver tissue. Cytotoxic chemotherapy and hematopoietic stem cell transplantation sometimes trigger the reactivation of latently infected HBV, resulting in de novo hepatitis B. Although de novo hepatitis B could cause acute liver failure or chronic hepatitis, an effective management strategy for de novo hepatitis B has not been well established. Risk factors and effective management for de novo hepatitis B will be clarified.

Hepatitis B

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Activation of HBV Under Immunosuppression in HBsAg-negative But Anti-HBc-positive Patients With Hematological Malignancies

Resource links provided by NLM:

Further study details as provided by Kyoto University:

Estimated Enrollment: 50
Study Start Date: August 2006
Estimated Study Completion Date: July 2018
Estimated Primary Completion Date: July 2016 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

HBsAg-negative but anti-HBc-positive patients with hematological malignancies treated at Kyoto University Hospital


Inclusion Criteria:

  • HBsAg-negative but anti-HBc-positive

Exclusion Criteria:

  • Serum HBV DNA-negative
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00881036

Kyoto Univesity Recruiting
Kyoto, Japan, 606-8507
Contact: Yoshihide Ueda, M.D. and Ph.D.    81-75-751-3111   
Principal Investigator: Yoshihide Ueda, M.D. and Ph.D.         
Sponsors and Collaborators
Kyoto University
  More Information

No publications provided

Responsible Party: Yoshihide Ueda, Associate Professor, Kyoto University Identifier: NCT00881036     History of Changes
Other Study ID Numbers: HBV from anti-HBc positive
Study First Received: April 13, 2009
Last Updated: September 25, 2012
Health Authority: Japan: Ministry of Education, Culture, Sports, Science and Technology

Keywords provided by Kyoto University:
Hepatitis B

Additional relevant MeSH terms:
Hepatitis B
DNA Virus Infections
Digestive System Diseases
Hepadnaviridae Infections
Hepatitis, Viral, Human
Liver Diseases
Virus Diseases processed this record on March 30, 2015