Is Carotid Intima-media Thickness Affected by A1C Variability?
This study has been completed.
First Posted: February 12, 2009
Last Update Posted: September 15, 2009
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This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness in type 2 diabetic patients.
Type 2 Diabetes
||Observational Model: Cohort
Time Perspective: Prospective
Information from the National Library of Medicine
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|Ages Eligible for Study:
||34 Years to 79 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
typeII, Fluroscopy in carotid once a year during 2 years.
- type II
- fluoroscopy in carotid once a year during 2 years
- type 1 diabetes
- history or clinical evidence of coronary artery disease or cerebral or peripheral vascular disease
- the presence of albuminuria (defined as 24 hour urine albumin excretion ≥ 30 mg)
- renal dysfunction (defined as creatinine blood level ≥ 2.0 mg/dL)
- hepatic dysfunction (defined as alanine aminotransferase and/or aspartate aminotransferase blood level ≥ 3 × upper normal limit)
- smoking within the past 3 months prior to commencement of the study
- use of any medication likely to alter IMT such as calcium channel blocker, thiazolidinedione, antiplatelet agent (clopidogrel, cilostazol)
- use of glucocorticoid
- severe concomitant disease such as cancer
- Cushing's syndrome
- acromegaly, or any other disorder likely to alter glycemia
- primary hypercholesterolemia
- hypothyroidism or hyperthyroidism
- use of any hormonal drugs
- alcoholism or drug abuse
No Contacts or Locations Provided
||Ahn, Chul Woo, Gangnam Severance Hospital
History of Changes
|Other Study ID Numbers:
||February 11, 2009
||February 12, 2009
|Last Update Posted:
||September 15, 2009