Sex Differences in Coronary Pathophysiology
|ClinicalTrials.gov Identifier: NCT00823563|
Recruitment Status : Unknown
Verified July 2014 by Stanford University.
Recruitment status was: Recruiting
First Posted : January 15, 2009
Last Update Posted : July 9, 2014
|Condition or disease||Intervention/treatment|
|Chest Pain Ischemia||Procedure: 30 cc blood draw Procedure: Intravascular ultrasound (IVUS) Procedure: Coronary pressure/flow wire testing Procedure: Coronary pressure/flow testing: Acetycholine challenge Procedure: Procedure: Coronary pressure/flow testing: Nitroglycerin challenge Procedure: Procedure: Procedure: Coronary pressure/flow testing: Adenosine challenge|
Women are more likely than men to have chest pain suggestive of angina but normal-appearing coronary arteries on angiography, which ultimately imparts a significant morbidity/mortality and economic burden. Recent evidence suggests that women commonly have endothelial and microcirculatory dysfunction, as well as diffusely distributed atherosclerosis--disorders that can cause chest pain, but will not be seen on angiography. This presents an intriguing basis for pathophysiologic differences between women and men, but there are no studies that actually compare the presence of such findings in women with that of men. The objective of this research project is to determine if the incidence of such pathophysiologic differences is truly higher in women than it is in men.
We hope to determine if there is a higher incidence of diffuse atherosclerotic plaque, endothelial dysfunction, and/or microcirculatory dysfunction in women compared with men. If this sex difference exists, it has significant implications for how we should be testing and treating women with chest pain but angiographically normal coronary arteries.
|Study Type :||Observational|
|Estimated Enrollment :||126 participants|
|Official Title:||Sex Differences in Symptomatic Non-Obstructive Coronary Disease: Do Women Have a Unique Coronary Pathophysiology?|
|Study Start Date :||June 2007|
|Estimated Primary Completion Date :||June 2015|
- Sex Differences in Endothelial Dysfunction, Microvascular Dysfunction, and Diffuse Plaque [ Time Frame: Immediately ]
- Cardiovascular Outcomes [ Time Frame: 3 years and 5 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00823563
|Contact: Homa Tavana||(650) email@example.com|
|United States, California|
|Stanford University School of Medicine||Recruiting|
|Stanford, California, United States, 94305|
|Contact: Homa Tavana 650-721-5540 firstname.lastname@example.org|
|Contact: Jennifer Tremmel, MD (650) 723-0180|
|Principal Investigator: Jennifer Ann Tremmel|
|Sub-Investigator: Marcia L. Stefanick Ph.D.|
|Study Chair: Alan Ching Yuen Yeung|
|Principal Investigator:||Jennifer Ann Tremmel||Stanford University|