Examination of B Cell Responses in Human Blood

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.

ClinicalTrials.gov Identifier: NCT00806845

Recruitment Status : Completed

First Posted : December 11, 2008

Last Update Posted : May 13, 2015

Sponsor:

Collaborator:

University of Leipzig

Information provided by (Responsible Party):

Christian Jassoy, Regenerative Medicine Network

Study Description

Brief Summary:

The aim of this study is the assessment B-cell immune responses in HIV-infected individuals.

Condition or disease
HIV Infections

Detailed Description:

Groups of patients with different immune competencies will be examined. The impact of HIV infection on immune response will be assessed.

Study Design

Layout table for study information

Study Type :	Observational
Actual Enrollment :	50 participants
Observational Model:	Cohort
Time Perspective:	Cross-Sectional
Official Title:	Gewinnung Humaner antikörperproduzierender Zellen Aus Dem Blut
Study Start Date :	July 2008
Actual Primary Completion Date :	December 2009
Actual Study Completion Date :	February 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: HIV/AIDS

U.S. FDA Resources

Groups and Cohorts

Group/Cohort
HIV infected individuals, HIV controllers CD4+ T cell count > 350/µl, HIV load < 1000 copies/ml
HIV infected individuals, early progressors CD4+ T cell count > 350/µl, HIV load > 1000 copies/ml
HIV infected individuals, late progressors CD4+ T cell count < 200/µl
HIV infected individuals, late progressors with therapy CD4+ T cell count < 200/µl, under ART
Healthy individuals Uninfected

Outcome Measures

Primary Outcome Measures :

Antigen specific B-cell responses [ Time Frame: 18 months ]

Biospecimen Retention: Samples Without DNA

peripheral blood

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information

Ages Eligible for Study:	18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

HIV patients and controls attending specialised clinics, Germany

Criteria

Inclusion Criteria:

HIV-infected individuals
controls

Exclusion Criteria:

- none

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00806845

Locations

Layout table for location information

Germany
Universität Leipzig
Leipzig, Sachsen, Germany, 04103

Sponsors and Collaborators

Regenerative Medicine Network

University of Leipzig

Investigators

Layout table for investigator information

Study Director:	Christian Jassoy, MD	Universität Leipzig

More Information

Publications of Results:

Bussmann BM, Reiche S, Bieniek B, Krznaric I, Ackermann F, Jassoy C. Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV. Virology. 2010 Feb 5;397(1):7-13. doi: 10.1016/j.virol.2009.11.003. Epub 2009 Dec 4.

Kunz K, Reiche S, Dwai Y, Cordes C, Krznaric I, Bussmann BM, Jassoy C. A broad spectrum of functional HIV-specific memory B cells in the blood of infected individuals with high CD4+ T-cell counts. J Acquir Immune Defic Syndr. 2011 Jul 1;57(3):e56-8. doi: 10.1097/QAI.0b013e31821dd9d1.

Reiche S, Nestler C, Sieg M, Schulz K, Cordes C, Krznaric I, Jassoy C. Hepatitis C virus (HCV)-specific memory B-cell responses in transiently and chronically infected HIV positive individuals. J Clin Virol. 2014 Apr;59(4):218-22. doi: 10.1016/j.jcv.2014.01.023. Epub 2014 Feb 4.

Layout table for additonal information

Responsible Party:	Christian Jassoy, Professor of Virology, Regenerative Medicine Network
ClinicalTrials.gov Identifier:	NCT00806845
Other Study ID Numbers:	RegMedNet-001
First Posted:	December 11, 2008 Key Record Dates
Last Update Posted:	May 13, 2015
Last Verified:	May 2015

Keywords provided by Christian Jassoy, Regenerative Medicine Network:


HIV B-lymphocyte

Additional relevant MeSH terms:

Layout table for MeSH terms

HIV Infections Blood-Borne Infections Communicable Diseases Infections Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases	Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Immunologic Deficiency Syndromes Immune System Diseases

To Top