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Reproducibility of Magnetic Resonance Myocardial Salvage Index

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ClinicalTrials.gov Identifier: NCT00794300
Recruitment Status : Completed
First Posted : November 20, 2008
Last Update Posted : June 25, 2018
Sponsor:
Information provided by (Responsible Party):
Holger Thiele, University of Leipzig

Brief Summary:
The myocardial salvage assessed by using multimodal cardiac magnetic resonance imaging is a rather new technique which can be used as a surrogate endpoint to reduce the sample size in studies comparing different reperfusion strategies in myocardial infarction. As reproducibility of myocardial salvage has not been evaluated appropriately, we aim to scan 20 patients on 2 subsequent days to evaluate reproducibility of myocardial salvage index.

Condition or disease Intervention/treatment
Myocardial Infarction Device: second magnetic resonance imaging scan

Study Type : Observational
Actual Enrollment : 250 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Reproducibility of Myocardial Salvage Index in Acute Myocardial Infarction by Cardiac Magnetic Resonance Imaging
Actual Study Start Date : November 1, 2008
Actual Primary Completion Date : November 1, 2009
Actual Study Completion Date : May 1, 2010

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Acute myocardial infarction patients Device: second magnetic resonance imaging scan



Primary Outcome Measures :
  1. Myocardial salvage index reproducibility [ Time Frame: 2 days ]

Secondary Outcome Measures :
  1. infarct size reproducibility [ Time Frame: 2 days ]
  2. area at risk reproducibility [ Time Frame: 2 days ]
  3. microvascular obstruction reproducibility [ Time Frame: 2 days ]


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Ages Eligible for Study:   18 Years to 99 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
ST-elevation myocardial infarction
Criteria

Inclusion Criteria:

  • ST-elevation myocardial infarction
  • Primary percutaneous coronary intervention

Exclusion Criteria:

  • Contraindications for magnetic resonance imaging

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00794300


Locations
Germany
University of Leipzig - Heart Center
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
Investigators
Principal Investigator: Holger Thiele, MD Heartcenter Leipzig GmbH

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Holger Thiele, Director, University of Leipzig
ClinicalTrials.gov Identifier: NCT00794300     History of Changes
Other Study ID Numbers: Repro100
First Posted: November 20, 2008    Key Record Dates
Last Update Posted: June 25, 2018
Last Verified: June 2018

Keywords provided by Holger Thiele, University of Leipzig:
reproducibility
contrast agent
magnetic resonance imaging
infarct size
myocardial salvage index
myocardial salvage assessment

Additional relevant MeSH terms:
Infarction
Myocardial Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases