Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomas

• ClinicalTrials.gov Identifier: NCT00782626
• Recruitment Status: Completed
• First Posted: October 31, 2008
• Results First Posted: February 2, 2016
• Last Update Posted: August 15, 2018
• Sponsor: Dana-Farber Cancer Institute
• Collaborators: Novartis; Pediatric Oncology Experimental Therapeutics Investigators' Consortium
• Information provided by (Responsible Party): Karen D. Wright MD, Dana-Farber Cancer Institute

Study Description

Brief Summary:

The purpose of this research study is to learn if the study drug RAD001 can shrink or slow the growth of low-grade gliomas. Additionally, the safety of RAD001 will be studied. RAD001 is a drug that may act directly on tumor cells by inhibiting tumor cell growth and proliferation.

Condition or disease	Intervention/treatment	Phase
Glioma; Low-grade Glioma; Astrocytoma	Drug: everolimus	Phase 2

Detailed Description:

OBJECTIVES:

Primary

• To determine the response of children with chemotherapy-refractory or progressive low-grade gliomas to everolimus. Secondary
• To evaluate pharmacogenetic polymorphisms of cytochrome P450 3A4 & 3A5 alleles and P-glycoprotein/MDR for their influence on the metabolism of everolimus in this patient population.
• To evaluate the role of Apolipoprotein E genotypes as predictors for development of hyperlipidemia during therapy with everolimus.
• To assess preliminary correlations of response with changes in pharmacodynamic parameters including p70s6 kinase activity in peripheral blood mononuclear cells.
• To describe the toxicity of everolimus when administered to this patient population.
• To characterize the pharmacokinetic profile of everolimus when administered to this patient population.

STATISTICAL DESIGN:

This study used a one-stage design to evaluate response to everolimus. If at least 3 responders are observed in 20 evaluable patients, then everolimus will be considered promising. If the true response rate is 5% (null hypothesis), the chance of concluding the treatment is active is 0.08 (Type I error). If the true response rate is 25% (alternative hypothesis), the chance of concluding the treatment is active is 0.91 (power).

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 23 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Phase II Study of Everolimus (RAD001) for Children With Chemotherapy and/or Radiation-Refractory Progressive or Recurrent Low-Grade Gliomas
• Study Start Date: June 2009
• Actual Primary Completion Date: August 2012
• Actual Study Completion Date: August 2012

Arms and Interventions

Arm	Intervention/treatment
Experimental: everolimus; Patients rcvd oral everolimus 5.0 mg/m2/day for a 28-day treatment course up to a total of 12 courses (48 weeks) if a patient had stable disease except if toxicity was unacceptable. Two dose reductions were permitted (3.0 5.0 mg/m2/day and 2.0 mg/m2/day).	Drug: everolimus; Other Name: RAD001

Outcome Measures

Primary Outcome Measures :

1. Overall Response [ Time Frame: Disease evaluations (MRI brain, including volumetric analysis) occurred at baseline, at the end of course 1, every 3 courses during treatment up to 12 courses and at early treatment discontinuation. ]
   Overall response is classified as complete response (CR), partial response (PR), stable disease (SD) or Progressive Disease (PD) on therapy.Description: Overall response is classified as complete response (CR), partial response (PR), stable disease (SD) or Progressive Disease (PD) on therapy. Response for target lesions (up to5) is based on 3 dimensions with an elliptical model volume used: 0.5L*W*T; (L) tumor extent in plane perpendicular to the selected plane; (W) longest measurement of the tumor width; (T) transverse measurement perpendicular to the width. CR is disappearance all target and non-target lesions and no new lesions. PR is >/= 65% decrease in sum of the products (referent baseline). PD 40% or more increase in any target lesion (referent smallest product observed on therapy). SD is none of the above. PR and SD classification as long as absent new lesions and unequivocal progression for non-target lesions else PD.

Eligibility Criteria

• Ages Eligible for Study: 3 Years to 21 Years (Child, Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Criteria

Inclusion Criteria:

• Patients must have histologic verification of one of the eligible diagnoses listed here: Astrocytoma variants; fibrillary, protoplasmic, mixed: Pilocytic astrocytoma; including pilomyxoid variants: Pleomorphic xanthoastrocytoma: infantile desmoplastic astrocytoma: ganglioglioma: oligodendroglial tumors: mixed glioma.
• Patients must have received at least one cancer-directed therapy and patients with allergies to carboplatin must have demonstrated progressive disease after cessation of therapy.
• Must have at least one measurable site of disease that has not been previously irradiated. If the patient has previous irradiation to the marker lesion(s), there must be evidence of progression since radiation treatment.
• Patients must be between 3 years of age and 21 years of age
• Karnofsky Performance Status of 50% or greater for patients less than 10 years of age or Lansky Score of 50% or greater for patients 10 and up.
• Participants must have recovered from the acute toxic effects of all prior chemotherapy or radiotherapy prior to entering the study. Refer to protocol for specific time restrictions with prior therapy completion.
• Adequate bone marrow function as defined in protocol
• Adequate renal function as defined in protocol
• Adequate liver function as defined in protocol
• Patients must have a fasting LDL cholesterol within the normal range per institutional guidelines
• Patients taking cholesterol lowering agent must be on a single medication and on a stable dose for at least 4 weeks
• Fasting serum cholesterol as outlined in protocol
• Patients must not be taking enzyme-inducing anticonvulsants
• Patients may not be currently receiving strong inhibitors of CYP3A4

Exclusion Criteria:

• Presence of NF1 by clinical examination or by genetic testing
• Patients who have had a major surgery or significant traumatic injury within 2 weeks of start of study drug, patients who have not recovered from teh side effects of any major surgery, or patients that may require major surgery during the course of the study
• Patients receiving chronic, systemic treatment with corticosteroids or another immunosuppressive agent. Topical or inhaled are allowed
• Evidence of plexiform neurofibroma, malignant peripheral nerve sheath tumor, or other cancer requiring treatment with chemotherapy or radiation therapy
• Uncontrolled brain or leptomeningeal metastases from plexiform neurofibromas, malignant peripheral nerve sheath tumors, or other cancers (other than astrocytoma variants; fibrillary, protoplasmic, mixed: Pilocytic astrocytoma; including pilomyxoid variants: Pleomorphic xanthoastrocytoma: infantile desmoplastic astrocytoma: ganglioglioma: oligodendroglial tumors: mixed glioma), including patients who continue to require glucocorticoids for control of symptoms related to brain or leptomeningeal metastases.
• Other malignancies within the past three years except for adequately treated carcinoma of the cervix or basal or squamous cell carcinomas of the skin
• Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study (see protocol for examples)
• Known history of HIV seropositivity
• Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of RAD001
• Active, bleeding diathesis or oral anti-vitamin K medication (except low dose coumarin)
• Female patients who are pregnant or breast feeding
• Prior treatment with an mTOR inhibitor
• Known hypersensitivity to RAD001 or other rapamycins or to is excipients
• Dental braces or prosthesis that interferes with tumor imaging
• Patients with a positive history of Hepatitis B or Hepatitis C
• Patients should not receive immunization with attenuated live vaccines within one week of study entry or during study period.

Contacts and Locations

Locations

United States, Arizona

Phoenix Children's Hospital Center for Cancer and Blood Disorders

Phoenix, Arizona, United States, 85016

United States, Colorado

The Children's Hospital

Denver, Colorado, United States, 80045

United States, Florida

University of Florida College of Medicine

Gainesville, Florida, United States, 32610

United States, Georgia

Children's Healthcare of Atlanta

Atlanta, Georgia, United States, 30322

United States, Maryland

John Hopkins Medical Center

Baltimore, Maryland, United States, 21231

United States, Massachusetts

Dana-Farber Cancer Institute

Boston, Massachusetts, United States, 02115

United States, New York

New York University

New York, New York, United States, 10016

Memorial Sloan-Kettering Cancer Institute

New York, New York, United States, 10174

United States, Oregon

Doernbecher Children's Hospital Oregon Health & Science University

Portland, Oregon, United States, 97239

United States, Washington

Seattle Cancer Care Alliance

Seattle, Washington, United States, 98109

Sponsors and Collaborators

Dana-Farber Cancer Institute

Novartis

Pediatric Oncology Experimental Therapeutics Investigators' Consortium

Investigators

• Principal Investigator: Karen Wright, MD; Dana-Farber Cancer Institute

More Information

• Responsible Party: Karen D. Wright MD, Principal Investigator, Dana-Farber Cancer Institute
• ClinicalTrials.gov Identifier: NCT00782626
• Other Study ID Numbers: 09-001
• First Posted: October 31, 2008
• Results First Posted: February 2, 2016
• Last Update Posted: August 15, 2018
• Last Verified: July 2018

Keywords provided by Karen D. Wright MD, Dana-Farber Cancer Institute:

RAD001

Additional relevant MeSH terms:

Glioma; Astrocytoma; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Everolimus; Antineoplastic Agents; Immunosuppressive Agents; Immunologic Factors; Physiological Effects of Drugs