Hereditary Colorectal and Associated Tumor Registry Study
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample. Participants will also be asked for their permission for study investigators to access medical records and/or recontact them for updates to their medical and family histories. Data and biospecimens will be stored for potential future research projects.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
8 Years to 100 Years (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Potential research subjects are recruited from our Hereditary GI clinic.
Identified gene mutation
Personal history of colorectal cancer diagnosed ≤ 50
Personal history of cancer with tumor studies suggestive of Lynch syndrome
Personal history of multiple primary tumors associated with a hereditary cancer syndrome (colorectal, uterus, stomach, ovary, small bowel, hepatobiliary tract, transitional cell carcinoma of the renal pelvis/ureter, brain)
Personal history of one of the above cancers and a family history of one or more of the above cancers
Personal or family history of diffuse gastric cancer
From a known genetic predisposition family
Personal history of > 10 colon adenomas (cumulative over a lifetime)
Personal history of any number of hamartomatous polyps
Personal history of multiple large (> 1cm) serrated polyps to right of sigmoid
Individuals under the age of 8
Individuals who cannot travel to Pittsburgh for in-person enrollment