Trial record 1 of 1 for:    calgb 30610
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Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and Etoposide

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2015 by Alliance for Clinical Trials in Oncology
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT00632853
First received: March 8, 2008
Last updated: August 10, 2015
Last verified: August 2015
  Purpose

Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as etoposide, carboplatin and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known which radiation therapy regimen is more effective when given together with chemotherapy in treating patients with limited-stage small cell lung cancer. This randomized phase III trial is comparing different chest radiation therapy regimens to see how well they work in treating patients with limited-stage small cell lung cancer.


Condition Intervention Phase
Lung Cancer
Radiation: Standard Radiation Dose Therapy
Drug: cisplatin
Drug: etoposide
Radiation: High Radiation Dose Therapy
Drug: carboplatin
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase III Comparison of Thoracic Radiotherapy Regimens in Patients With Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide

Resource links provided by NLM:


Further study details as provided by Alliance for Clinical Trials in Oncology:

Primary Outcome Measures:
  • Overall survival time between 3 treatment arms [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Complete and partial response rates [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]
  • Failure-free survival [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 729
Study Start Date: March 2008
Estimated Primary Completion Date: June 2023 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Arm A - Standard Radiotherapy + Chemotherapy

Radiotherapy (every day, Monday-Friday, for a total of 3 weeks) XRT: 45 Gy BID (1.5 Gy/fx) starting on day 1 of Cycle 1 or 2, every day, for 3 weeks

Chemotherapy (every 21 days for 4 cycles, for a total of 12 weeks):

  • Cisplatin 80 mg/m2 IV on day 1 OR Carboplatin AUC 5 IV day 1, every 21 days
  • Etoposide 100 mg/m2 IV Register/ on days 1, 2, and 3, every 21 days
Radiation: Standard Radiation Dose Therapy
45 Gy
Drug: cisplatin
IV
Drug: etoposide
IV
Drug: carboplatin
IV
Experimental: Arm B - High Dose Radiotherapy + Chemotherapy

Radiotherapy (every day, Monday-Friday, for a total of 7 weeks) XRT: 70 Gy QD (2.0 Gy/fx), starting on day 1 of Cycle 1 or 2, every day, for 7 weeks

Chemotherapy (every 21 days for 4 cycles, for a total of 12 weeks):

  • Cisplatin 80 mg/m2 IV on day 1 OR Carboplatin AUC 5 IV day 1, every 21 days
  • Etoposide 100 mg/m2 IV on days 1, 2, and 3, every 21 days
Drug: cisplatin
IV
Drug: etoposide
IV
Radiation: High Radiation Dose Therapy
70 Gy
Drug: carboplatin
IV

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
  1. Documentation of Disease

    1. Histologically or cytologically documented small cell lung cancer (SCLC)
    2. Limited-stage disease patients with disease restricted to one hemithorax with regional lymph node metastases, including ipsilateral hilar, ipsilateral and contralateral mediastinal, and ipsilateral supraclavicular lymph nodes

      • Patients with disease involvement of the contralateral hilar or supraclavicular lymph nodes are not eligible
      • Patients with pleural effusions that are visible on plain chest radiographs, whether cytologically positive or not are not eligible unless they have a negative thoracentesis
      • Patients with cytologically positive pleural or pericardial fluid, regardless of the appearance on plain x-ray are not eligible
  2. Measurable disease - Patients must have measurable disease, which includes lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 2 cm with conventional techniques OR ≥ 1 cm by spiral CT scan
  3. Prior Treatment

    1. Patients may have received one and only one cycle of chemotherapy prior to enrolling on CALGB 30610, which must have included carboplatin or cisplatin and etoposide.
    2. If a patient has had one cycle of cisplatin or carboplatin/etoposide prior to registration, the patient must have had all of it prior to registration tests as outlined in the protocol and prior to starting their first cycle of chemotherapy.
    3. Additionally, these patients also must have met all of the eligibility criteria in the protocol prior to receiving the first cycle of chemotherapy.
    4. Registration to CALGB 30610 must take place within 14-21 days after the start of the non-protocol therapy.
    5. Failing to do all of the above will make the patient NOT eligible for CALGB 30610.
    6. No prior radiotherapy or chemotherapy (except for the chemotherapy described in the bullet above) for SCLC
    7. No prior mediastinal or thoracic radiotherapy
    8. Patients with complete surgical resection of disease are not eligible
  4. Age Requirement ≥ 18 years of age
  5. ECOG Performance Status 0-2
  6. Non-pregnant and non-nursing - No patients that are known to be pregnant or nursing
  7. Required Initial Laboratory Values

    1. Granulocytes ≥ 1,500/µl
    2. Platelet count ≥ 100,000/µl
    3. Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
    4. AST (SGOT) ≤ 2.0 times ULN
    5. Serum creatinine ≤ 1.5 times ULN OR Calculated creatinine clearance ≥ 70 mL/min
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00632853

Contacts
Contact: Jeffrey A. Bogart, MD 315 464-5276

  Hide Study Locations
Locations
United States, Alabama
The Kirklin Clinic at Acton Road Recruiting
Birmingham, Alabama, United States, 35233
Contact: Michael Dobelbower, MD    205-934-0309      
UAB Comprehensive Cancer Center Recruiting
Birmingham, Alabama, United States, 35294
Contact: Michael Dobelbower, MD    205-934-0309      
United States, Arkansas
University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Rangaswamy Govindarajan, MD    501-686-8511      
United States, California
Providence Saint Joseph Medical Center/Disney Family Cancer Center Recruiting
Burbank, California, United States, 91505
Contact: Keith Lanier, MD    503-216-6300      
Bay Area Breast Surgeons, Incorporated Recruiting
Emeryville, California, United States, 94608
Contact: James H. Feusner, MD    510-428-3689      
Contra Costa Regional Medical Center Recruiting
Martinez, California, United States, 94553-3156
Contact: James H. Feusner, MD    510-428-3689      
Memorial Medical Center Recruiting
Modesto, California, United States, 95355
Contact: Peter Yu, MD    408-730-2817      
Palo Alto Medical Foundation-Camino Division Recruiting
Mountain View, California, United States, 94040
Contact: Peter Yu, MD    408-730-2817      
Alta Bates Summit Medical Center - Summit Campus Recruiting
Oakland, California, United States, 94609
Contact: James Feusner, MD    510-428-3689      
Bay Area Tumor Institute Recruiting
Oakland, California, United States, 94609
Contact: James H. Feusner, MD    510-428-3689      
Hematology and Oncology Associates-Oakland Recruiting
Oakland, California, United States, 94609
Contact: James Feusner    510-428-3689      
Kaiser Permanente Medical Center - Oakland Recruiting
Oakland, California, United States, 94611
Contact: Louis Fehrenbacher, MD    707-651-2577      
Stanford Cancer Institute Recruiting
Palo Alto, California, United States, 94304
Contact: Billy Loo, MD    650-736-7143      
Kaiser Permanente Medical Center - Redwood City Recruiting
Redwood City, California, United States, 94063
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - Richmond Recruiting
Richmond, California, United States, 94801
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - Roseville Recruiting
Roseville, California, United States, 95661
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - Sacramento Recruiting
Sacramento, California, United States, 95825
Contact: Louis Fehrenbacher, MD    707-651-2577      
University of California Davis Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: David Gandara, MD    916-734-3089      
Saint Helena Hospital Recruiting
Saint Helena, California, United States, 94574
Contact: Gregory B. Smith    707-963-3611      
Kaiser Permanente Medical Center - San Francisco Recruiting
San Francisco, California, United States, 94115
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - Santa Teresa Recruiting
San Jose, California, United States, 95119
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Foundation Hospital - San Rafael Recruiting
San Rafael, California, United States, 94903
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - Santa Rosa Recruiting
Santa Rosa, California, United States, 95403
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - South San Francisco Recruiting
South San Francisco, California, United States, 94080
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Facility - Stockton Recruiting
Stockton, California, United States, 95210
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - Vallejo Recruiting
Vallejo, California, United States, 94589
Contact: Louis Fehrenbacher, MD    707-651-2577      
Kaiser Permanente Medical Center - Walnut Creek Recruiting
Walnut Creek, California, United States, 94596
Contact: Louis Fehrenbacher, MD    707-651-2577      
United States, Colorado
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz, MD    303-777-2663      
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz, MD    303-777-2663      
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz, MD    303-777-2663      
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz, MD    303-777-2663      
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz, MD    303-777-2663      
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz, MD    303-777-2663      
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz, MD    303-777-2663      
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz, MD    303-777-2663      
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz, MD    303-777-2663      
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz, MD    303-777-2663      
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz, MD    303-777-2663      
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz, MD    303-777-2663      
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz, MD    303-777-2663      
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz, MD    303-777-2663      
United States, Delaware
Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Stephen Grubbs, MD    302-366-1200      
Christiana Gynecologic Oncology LLC Recruiting
Newark, Delaware, United States, 19713
Contact: Stephen Grubbs, MD    302-366-1200      
United States, Florida
Baptist Cancer Institute - Jacksonville Recruiting
Jacksonville, Florida, United States, 32207
Contact: Mark Augspurger, MD    904-271-6890      
Mount Sinai Medical Center Recruiting
Miami Beach, Florida, United States, 33140
Contact: Michael Schwartz, MD    305-535-3310      
United States, Georgia
Emory University/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Kristin Higgins, MD    404-778-0603      
Emory University Hospital Midtown Recruiting
Atlanta, Georgia, United States, 30308
Contact: Kristin Higgins, MD    404-778-0603      
John B. Amos Cancer Center Recruiting
Columbus, Georgia, United States, 31904
Contact: Douglas Ciuba, MD    706-571-1050      
Northeast Georgia Medical Center Recruiting
Gainesville, Georgia, United States, 30501
Contact: Richard J. LoCicero, MD    770-297-5700      
Memorial University Medical Center Recruiting
Savannah, Georgia, United States, 31404
Contact: Harvey Lebos, MD    912-354-6187      
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Samir Narayan, MD    734-712-5658      
United States, Illinois
St. Joseph Medical Center Recruiting
Bloomington, Illinois, United States, 61701
Contact: James Wade, MD    217-876-6600      
Illinois CancerCare - Bloomington Recruiting
Bloomington, Illinois, United States, 61704
Contact: James Wade, MD    217-876-6600      
Illinois CancerCare - Canton Recruiting
Canton, Illinois, United States, 61520
Contact: James Wade, MD    217-876-6600      
University of Chicago Comprehensive Cancer Center Recruiting
Chicago, Illinois, United States, 60637
Contact: Ravi Salgia, MD    773-702-4399      
Advocate Illinois Masonic Medical Center Recruiting
Chicago, Illinois, United States, 60657
Contact: Deepti Singh, MD    773-296-5397      
Swedish Covenant Hospital Recruiting
Chicago, Illinois, United States, 60625
Contact: Elyse Lambiase, MD    847-869-2076      
John H. Stroger, Jr. Hospital of Cook County Recruiting
Chicago, Illinois, United States, 60612-3785
Contact: Thomas Lad, MD    312-864-7260      
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James Wade, MD    217-876-6600      
Illinois CancerCare - Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: James Wade, MD    217-876-6600      
Saint Francis Hospital Recruiting
Evanston, Illinois, United States, 60202
Contact: Elyse Lambiase, MD         
Illinois CancerCare - Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: James Wade, MD    217-876-6600      
Illinois CancerCare - Pekin Recruiting
Pekin, Illinois, United States, 61603
Contact: James Wade, MD    217-876-6600      
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: James Wade, MD    217-876-6600      
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: James Wade, MD    217-876-6600      
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61636
Contact: James Wade, MD    217-876-6600      
Illinois CancerCare - Peru Recruiting
Peru, Illinois, United States, 61354
Contact: James Wade, MD    217-876-6600      
Valley Radiation Oncology Recruiting
Peru, Illinois, United States, 61354
Contact: James Wade, MD    217-876-6600      
Swedish-American Regional Cancer Center Recruiting
Rockford, Illinois, United States, 61104
Contact: Harvey Einhorn, MD         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: James Wade, MD    217-876-6600      
United States, Indiana
Michiana Hematology-Oncology, PC - Elkhart Recruiting
Elkhart, Indiana, United States, 46514
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Saint Vincent Oncology Center Recruiting
Indianapolis, Indiana, United States, 46260
Contact: Robert Liebross    317-415-6760      
Michiana Hematology-Oncology, PC - South Bend Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Saint Joseph Regional Medical Center Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Michiana Hematology Oncology PC - Plymouth Recruiting
Plymouth, Indiana, United States, 46563
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Thomas Reid, MD         
Michiana Hematology Oncology PC-South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Rafat Ansari, MD    574-234-5123      
Michiana Hematology Oncology PC - La Porte Recruiting
Westville, Indiana, United States, 46391
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
United States, Kansas
Cancer Center of Kansas, PA - Dodge City Recruiting
Dodge City, Kansas, United States, 67801
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - El Dorado Recruiting
El Dorado, Kansas, United States, 67042
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Associates in Womens Health, PA - North Review Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Medical Arts Tower Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Via Christi Regional Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Wesley Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Winfield Recruiting
Winfield, Kansas, United States, 67156
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
United States, Kentucky
University of Kentucky/Markey Cancer Center Recruiting
Lexington, Kentucky, United States, 40536
Contact: Ronald McGarry, MD         
James Graham Brown Cancer Center at University of Louisville Recruiting
Louisville, Kentucky, United States, 40202
Contact: Neal E. Dunlap    502-562-4158      
United States, Louisiana
Mary Bird Perkins Cancer Center - Baton Rouge Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Augusto Ochoa, MD         
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Suma P. Satti, MD    504-842-3910      
Louisiana State University Health Science Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Augusto Ochoa, MD         
Tulane University Health Sciences Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: William Robinson, MD         
University Medical Center New Orleans Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Augusto Ochoa, MD         
United States, Maryland
Saint Agnes Hospital Recruiting
Baltimore, Maryland, United States, 21229
Contact: Richard S. Hudes, MD    410-368-2965      
Sinai Hospital of Baltimore Recruiting
Baltimore, Maryland, United States, 21215
Contact: Roberto F. Martinez, MD    410-601-4734      
University of Maryland/Greenebaum Cancer Center Recruiting
Baltimore, Maryland, United States, 21201
Contact: Josephine Feliciano, MD         
Greater Baltimore Medical Center Recruiting
Baltimore, Maryland, United States, 21204
Contact: Robert Brookland, MD         
Peninsula Regional Medical Center Recruiting
Salisbury, Maryland, United States, 21801
Contact: Paul Zorsky, MD         
United States, Massachusetts
Massachusetts General Hospital Cancer Center Recruiting
Boston, Massachusetts, United States, 02114
Contact: David E. Kozono, MD    617-632-3474      
Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02115
Contact: David E. Kozono, MD    617-632-3474      
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02115
Contact: David E. Kozono    617-632-3474      
Brigham and Women's Hospital Recruiting
Boston, Massachusetts, United States, 02115
Contact: David E. Kozono, MD    617-632-3474      
University of Massachusetts Medical School Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Vijay K. Kasturi, MD    508-856-0011      
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48075
Contact: Samir Narayan, MD    734-712-5658      
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Samir Narayan, MD         
Green Bay Oncology - Escanaba Recruiting
Escanaba, Michigan, United States, 49431
Contact: Anthony J. Jaslowski, MD, FACP    920-884-3135      
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Samir Narayan, MD         
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48503
Contact: Samir Narayan, MD         
Green Bay Oncology - Iron Mountain Recruiting
Iron Mountain, Michigan, United States, 49801
Contact: Anthony J. Jaslowski, MD    920-884-3135      
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007-3731
Contact: Sunil Nagpal, MD         
Sparrow Hospital Recruiting
Lansing, Michigan, United States, 48912
Contact: Samir Narayan, MD    734-712-5658      
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Samir Narayan, MD    734-464-4800      
Lakeland Community Hospital Recruiting
Niles, Michigan, United States, 49120
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341
Contact: Samir Narayan, MD    734-712-5658      
William Beaumont Hospital - Royal Oak Recruiting
Royal Oak, Michigan, United States, 48073
Contact: John Robertson, MD         
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Samir Narayan, MD         
Lakeland Hospital Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Providence Hospital-Southfield Cancer Center Recruiting
Southfield, Michigan, United States, 48075
Contact: Anibal Drelichman, MD, MPH, FACP    313-552-0620      
United States, Minnesota
Sanford Clinic North-Bemidji Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Preston D. Steen, MD    610-402-2273      
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Patrick J. Flynn, MD    612-884-6300      
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Patrick J. Flynn, MD    612-884-6300      
Fairview Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Patrick Flynn, MD    612-884-6300      
Minnesota Oncology - Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn, MD    612-884-6300      
Hennepin County Medical Center - Minneapolis Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Patrick Flynn, MD    612-884-6300      
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn, MD    612-884-6300      
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Patrick Flynn, MD    612-884-6300      
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Patrick J. Flynn, MD    612-884-6300      
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Patrick J. Flynn, MD    612-884-6300      
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Patrick J. Flynn, MD    612-884-6300      
Minnesota Oncology Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Patrick J. Flynn, MD    612-884-6300      
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: Louis V. Puneky, MD    601-984-5590      
Singing River Hospital Recruiting
Pascagoula, Mississippi, United States, 39581
Contact: James E. Clarkson, MD    228-374-6296      
United States, Montana
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59107
Contact: Benjamin Marchello, MD    406-238-6290      
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello, MD    406-238-6290      
United States, Nebraska
Alegent Health Lakeside Hospital Recruiting
Omaha, Nebraska, United States, 68130
Contact: Mehmet Copur, MD         
Creighton University Medical Center Recruiting
Omaha, Nebraska, United States, 68131
Contact: Mehmet Copur, MD         
Nebraska Methodist Hospital Recruiting
Omaha, Nebraska, United States, 68114
Contact: Tien-Shew William Huang, MD    402-354-4104      
United States, Nevada
University Medical Center of Southern Nevada Recruiting
Las Vegas, Nevada, United States, 89102
Contact: John A. Ellerton, MD, CM    702-384-0013      
United States, New Jersey
Memorial Sloan Kettering Cancer Center at Basking Ridge Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: Andreas Rimner    212-639-6025      
Cooper Hospital University Medical Center Recruiting
Camden, New Jersey, United States, 08103
Contact: Robert Somer, MD         
Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County Recruiting
Mount Holly, New Jersey, United States, 08060
Contact: Lemuel S. Ariaratnam    609-261-7074      
Fox Chase Virtua Health Cancer Program at Virtua West Jersey Recruiting
Voorhees, New Jersey, United States, 08043
Contact: Lemuel S. Ariaratnam, MD    609-261-7074      
Virtua West Jersey Hospital Voorhees Recruiting
Voorhees, New Jersey, United States, 08043
Contact: Lemuel Ariaratnam, MD    609-261-7074      
United States, New York
Veterans Affairs Western New York Health Care System-Buffalo Recruiting
Buffalo, New York, United States, 14215
Contact: Lynn M. Steinbrenner, MD    716-862-3191      
Memorial Sloan-Kettering Cancer Center at Suffolk Recruiting
Commack, New York, United States, 11725
Contact: Andreas Rimner, MD    212-639-6025      
Glens Falls Hospital Recruiting
Glens Falls, New York, United States, 12801
Contact: Aqeel Gillani, MD         
Memorial Sloan Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Andreas Rimner, MD    212-639-6025      
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen, MD    585-275-5345      
University Radiation Oncology Recruiting
Rochester, New York, United States, 14626
Contact: Yuhchyau Chen, MD    585-225-3989      
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Yuhchyau Chen, MD    585-473-2200      
Memorial Sloan-Kettering Cancer Center Rockville Centre Recruiting
Rockville Centre, New York, United States, 11570
Contact: Andreas Rimner, MD    212-639-6025      
Memorial Sloan-Kettering Cancer Center at Phelps Recruiting
Sleepy Hollow, New York, United States, 10591
Contact: Andreas Rimner, MD    212-639-6025      
State University of New York Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Jeffrey Bogart, MD         
United States, North Dakota
Sanford Bismarck Medical Center Recruiting
Bismarck, North Dakota, United States, 58501
Contact: Preston Steen, MD    610-402-2273      
Sanford Clinic North-Fargo Recruiting
Fargo, North Dakota, United States, 58102
Contact: Preston D. Steen, MD    610-402-2273      
Sanford Medical Center-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen, MD    610-402-2273      
Sanford Roger Maris Cancer Center Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston Steen, MD    610-402-2273      
Altru Cancer Center Recruiting
Grand Forks, North Dakota, United States, 58201
Contact: Grant Seeger, MD         
Trinity CancerCare Center Recruiting
Minot, North Dakota, United States, 58701
Contact: Kevin B. Collins, MD    701-857-3535      
United States, Ohio
Akron General Medical Center Recruiting
Akron, Ohio, United States, 44307
Contact: Esther H. Rehmus, MD    330-344-6505      
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Charles Kunos, MD    330-745-1611      
Barberton Citizens Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Charles A. Kunos    330-745-1611      
Summa Barberton Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Charles Kunos    330-375-4485      
UHHS Chagrin Highlands Medical Center Recruiting
Beachwood, Ohio, United States, 44122
Contact: Gregory Videtic, MD    216-444-9797      
Aultman Health Foundation Recruiting
Canton, Ohio, United States, 44710
Contact: Laird Olson, MD         
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: John Kuebler, MD    614-442-3130      
University of Cincinnati Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Kevin Redmond, MD    513-584-9089      
Cleveland Clinic Cancer Center at Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Gregory Videtic, MD    216-444-9797      
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Gregory Videtic, MD    216-444-9797      
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Gregory Videtic    216-444-9797      
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John Kuebler, MD    614-442-3130      
Doctors Hospital Recruiting
Columbus, Ohio, United States, 43228
Contact: John Kuebler, MD    614-442-3130      
Grant Medical Center Recruiting
Columbus, Ohio, United States, 43215
Contact: John Kuebler, MD    614-442-3130      
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: John Kuebler, MD    614-442-3130      
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John Kuebler, MD    614-442-3130      
Ohio State University Comprehensive Cancer Center Recruiting
Columbus, Ohio, United States, 43210
Contact: John Grecula, MD         
Grady Memorial Hospital Recruiting
Delaware, Ohio, United States, 43015
Contact: John Kuebler, MD    614-442-3130      
Cleveland Clinic Cancer Center Independence Recruiting
Independence, Ohio, United States, 44131
Contact: Gregory Videtic, MD    216-444-9797      
Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: John Kuebler, MD    614-442-3130      
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Gregory Videtic, MD    216-444-9797      
Lake/University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Gregory Videtic, MD    216-444-9797      
Southwest General Health Center Ireland Cancer Center Recruiting
Middleburg Heights, Ohio, United States, 44130
Contact: Gregory Videtic, MD    216-444-9797      
Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: John Kuebler, MD    614-442-3130      
Southern Ohio Medical Center Recruiting
Portsmouth, Ohio, United States, 45662
Contact: John Kuebler, MD    614-442-3130      
North Coast Cancer Care Recruiting
Sandusky, Ohio, United States, 44870
Contact: Gregory Videtic, MD    216-444-9797      
Springfield Regional Medical Center Recruiting
Springfield, Ohio, United States, 45505
Contact: John Kuebler    614-442-3130      
UHHS Westlake Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Gregory Videtic, MD    216-444-9797      
Cleveland Clinic Wooster Specialty Center Recruiting
Wooster, Ohio, United States, 44691
Contact: Gregory Videtic, MD    216-444-9797      
Genesis Healthcare System Cancer Care Center Recruiting
Zanesville, Ohio, United States, 43701
Contact: John Kuebler, MD    614-442-3130      
United States, Oklahoma
Oklahoma University Cancer Institute Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Mohammad Razaq, MD         
United States, Pennsylvania
UPMC-Heritage Valley Health System Beaver Recruiting
Beaver, Pennsylvania, United States, 15009
Contact: Mark Socinski, MD    412-623-4083      
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Albert DeNittis, MD         
Mercy Fitzgerald Hospital Recruiting
Darby, Pennsylvania, United States, 19023
Contact: Maria Werner-Wasik, MD         
Delaware County Memorial Hospital Recruiting
Drexel Hill, Pennsylvania, United States, 19026
Contact: Rachelle M. Lanciano, MD    610-284-8240      
Pocono Medical Center Recruiting
East Stroudsburg, Pennsylvania, United States, 18301
Contact: Maria Werner-Wasik, MD    215-955-7679      
Adams Cancer Center Recruiting
Gettysburg, Pennsylvania, United States, 17325
Contact: Amit B. Shah    717-741-8180      
Cherry Tree Cancer Center Recruiting
Hanover, Pennsylvania, United States, 17331
Contact: Amit B. Shah    717-741-8180      
Penn State Milton S Hershey Medical Center Recruiting
Hershey, Pennsylvania, United States, 17033-0850
Contact: Henry Wagner, MD         
Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301
Contact: Albert DeNittis, MD         
University of Pennsylvania/Abramson Cancer Center Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Corey Langer, MD         
UPMC-Shadyside Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Mark Socinski, MD    412-623-4083      
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Vladimir Valakh, MD         
Lankenau Medical Center Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Albert DeNittis, MD         
United States, South Carolina
AnMed Health Cancer Center Recruiting
Anderson, South Carolina, United States, 29621
Contact: Charles Bowers, MD         
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Anand Sharma, MD         
Saint Francis Hospital Recruiting
Greenville, South Carolina, United States, 29601
Contact: Robert Siegel, MD         
Gibbs Cancer Center-Pelham Recruiting
Greer, South Carolina, United States, 29651
Contact: Charles Bowers, MD         
United States, South Dakota
Sanford Cancer Center Oncology Clinic Recruiting
Sioux Falls, South Dakota, United States, 57104
Contact: Preston Steen, MD    610-402-2273      
Sanford USD Medical Center - Sioux Falls Recruiting
Sioux Falls, South Dakota, United States, 57117-5134
Contact: Preston Steen, MD    610-402-2273      
United States, Tennessee
Blue Ridge Medical Specialists, PC Recruiting
Bristol, Tennessee, United States, 37620
Contact: Asheesh Shipstone    423-968-2311      
Wellmont Bristol Regional Medical Center Recruiting
Bristol, Tennessee, United States, 37620
Contact: Asheesh Shipstone, MD    423-578-8538      
United States, Texas
UT Southwestern/Simmons Cancer Center-Dallas Recruiting
Dallas, Texas, United States, 75390
Contact: Hak Choy, MD    214-645-8525      
University of Texas Medical Branch Recruiting
Galveston, Texas, United States, 77555-0565
Contact: Todd Swanson, MD    409-772-7186      
M. D. Anderson Cancer Center Recruiting
Houston, Texas, United States, 77030
Contact: Ritsuko Komaki, MD    713-563-2300      
University of Texas Health Science Center at San Antonio Recruiting
San Antonio, Texas, United States, 78229
Contact: Ying Li, MD    210-567-4777      
United States, Virginia
Southwest VA Regional Cancer Center Recruiting
Norton, Virginia, United States, 24273
Contact: Asheesh Shipstone, MD    423-578-8538      
United States, Wisconsin
Saint Agnes Hospital/Agnesian Cancer Center Recruiting
Fond Du Lac, Wisconsin, United States, 54935
Contact: Micheal Vander Kooy, MD    920-926-4101      
Green Bay Oncology Limited at Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Anthony Jaslowski, MD    920-884-3135      
Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Anthony Jaslowski, MD    920-884-3135      
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Anthony Jaslowski, MD    920-884-3135      
Green Bay Oncology at Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Anthony Jaslowski, MD    920-884-3135      
Bay Area Medical Center Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Anthony Jaslowski, MD    920-884-3135      
Green Bay Oncology - Oconto Falls Recruiting
Oconto Falls, Wisconsin, United States, 54154
Contact: Anthony Jaslowski, MD    920-884-3135      
Green Bay Oncology - Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Contact: Anthony Jaslowski, MD    920-884-3135      
Sponsors and Collaborators
Alliance for Clinical Trials in Oncology
Investigators
Study Chair: Jeffrey A. Bogart, MD State University of New York - Upstate Medical University
  More Information

Additional Information:
No publications provided

Responsible Party: Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier: NCT00632853     History of Changes
Other Study ID Numbers: CALGB-30610, CALGB-30610, RTOG 0538, U10CA031946, CDR0000588879
Study First Received: March 8, 2008
Last Updated: August 10, 2015
Health Authority: United States: Food and Drug Administration
United States: NCI Central Institutional Review Board

Keywords provided by Alliance for Clinical Trials in Oncology:
limited stage small cell lung cancer

Additional relevant MeSH terms:
Lung Neoplasms
Small Cell Lung Carcinoma
Bronchial Neoplasms
Carcinoma, Bronchogenic
Lung Diseases
Neoplasms
Neoplasms by Site
Respiratory Tract Diseases
Respiratory Tract Neoplasms
Thoracic Neoplasms
Carboplatin
Cisplatin
Etoposide
Etoposide phosphate
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Radiation-Sensitizing Agents
Therapeutic Uses
Topoisomerase II Inhibitors
Topoisomerase Inhibitors

ClinicalTrials.gov processed this record on September 01, 2015