Use of Neurally Adjusted Ventilatory Assist in Infants Respiratory Failure (NAVA)
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|ClinicalTrials.gov Identifier: NCT00603174|
Recruitment Status : Completed
First Posted : January 28, 2008
Last Update Posted : September 19, 2012
|Condition or disease||Intervention/treatment||Phase|
|Respiratory Failure||Device: neurally adjusted ventilatory assist (NAVA)||Not Applicable|
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Research Design and Methods
Aim: To demonstrate the feasibility and efficacy of delivering NAVA in an intubated infant with the Servoi ventilator.
Measurements: All ventilatory and EAdi parameters will be stored in a laptop computer connected to the ventilator. SAO2 will be measured via pulse oximetry with a probe placed on one of the infant's extremities. End Tidal PCO2 measurements will also be made via probe placed on the Y piece of the respirator circuit.
General protocol sequence:
- All patients in the PICU at HSJ screened daily for eligibility
- Eligible cases reviewed with attending team and study team
- Informed consent obtained from parents or guardian
- Change to Servoi ventilator (conventional settings)
- Nasogastric tube replacement
- Monitor EAdi during conventional settings
- Adjust PEEP to minimize tonic activity
- NAVA level titration
- Application of NAVA for 12 hours with the titrated settings of PEEP and NAVA level.
- Return to conventional ventilator settings on servoi and monitor for 1 hour
NAVA for 12 hours Following the titration of PEEP and the NAVA level, the infant will be ventilated on NAVA with the titrated levels. The following will be monitored and recorded for 20 min at 1 hour intervals: Phasic EAdi, tonic EAdi, tidal volume, ventilator-delivered pressure, respiratory rate, oxygen saturation, end tidal PCO2, and heart rate.
The NAVA level and PEEP levels can be adjusted throughout the study period, and is based on clinical judgment (as they would routinely do for a conventional mode). Following any new setting, the 12 hour period will continue with those new settings. Following the end of this 12th hour of NAVA, the feeding tube with the sensors will remain in place for feeding the patient as per ICU protocol.
Protocol termination criteria: If the infant demonstrates a sustained change in any of the following, the protocol will be terminated:
- Sustained decrease in SaO2 < 92% requiring increase in FIO2 > 60%
- End tidal PCO2 > 60 mm Hg requiring progressive increases in the NAVA level,
- Sustained increase in heart rate>180 bpm during 15 min,
- Sustained increase in respiratory rate>60 bpm during 15 min,
- Uncontrolled agitation judged by the attending physician
Monitoring during conventional ventilation after discontinuation of NAVA (1 hour):
In order to compare NAVA to conventional ventilation, monitoring will be continued with conventional settings on the Servoi ventilator for 1 hour. The following will be monitored and recorded at 20 min intervals: Phasic EAdi, tonic EAdi, tidal volume, respiratory rate, saturation, CO2, HR. Following this, the baby will be returned to the ventilator and settings determined by the clinical team.
- Patient-ventilator synchrony (trigger delays, cycling-off delays (Beck 2007))
- Phasic EAdi
- Tonic EAdi
- tidal volume, airway pressure, respiratory rate
- SAO2, End Tidal PCO2, FIO2 Number of times back-up rate started (per hour)
- Number of PEEP or NAVA level adjustments
Analysis and statistics
NAVA level titration: A continuous analysis will be performed breath-by-breath for phasic EAdi, ventilator-delivered pressure, respiratory rate and tidal volume. These values will be plotted versus the NAVA level. The NAVA level at the inflection point will be compared to the NAVA level initially used to match the conventional ventilation settings.
NAVA for 12 hours: EAdi signals will be processed automatically by the ventilator with standardized automated algorithms that have been implemented in to the Servoi. Phasic and tonic EAdi, as well as the ventilatory parameters (Vt, rr, SAO2, CO2) will be quantified breath-by breath and the last 20 min of each hour will be analyzed.
IN order to compare patient-ventilator synchrony between NAVA vs Conventional ventilation, trigger delays and cycling-off delays will be compared for each subject between the 2 modes. Paired t-tests will be used for this comparison.
Repeated measures ANOVA will be used to verify significant changes in variables over the twelve hour intervention period. The impact of PEEP on tonic diaphragm activity and the impact of NAVA level on tidal volume, pressures, and phasic diaphragm activity will also be compared by RM ANOVA.
Sample size determination: This is a case study and we will include 5 infants.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||10 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Use of Neurally Adjusted Ventilatory Assist in Infants With Acute Respiratory Failure: a Case Study on Servo I|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||September 2009|
|Actual Study Completion Date :||September 2009|
Intubated and mechanically ventilated infants with respiratory failure (age < 1 year old). see inclusion-exclusion criteria.
Device: neurally adjusted ventilatory assist (NAVA)
Following the titration of PEEP and the NAVA level, the infant will be ventilated on NAVA with the titrated levels. The following will be monitored and recorded for 20 min at 1 hour intervals: Phasic EAdi, tonic EAdi, tidal volume, ventilator-delivered pressure, respiratory rate, oxygen saturation, end tidal PCO2, and heart rate.
- patient-ventilator synchrony [ Time Frame: up to 28 days ]Patient-ventilator synchrony (trigger delays, cycling-off delays (Beck 2007))
- Tolerance [ Time Frame: up to 28 days ]Evolution of tidal volume, airway pressure, respiratory rate, SAO2, End Tidal PCO2, FIO2
- Number of times back-up rate started (per hour) in NAVA mode [ Time Frame: up to 28 days ]
- Number of PEEP or NAVA level adjustments in NAVA mode [ Time Frame: up to 28 days ]
- Phasic EAdi • Tonic EAdi Phasic EAdi and tonic EAdi [ Time Frame: up to 28 days ]Phasic EAdi and tonic EAdi compared between pressure support, pressure control and NAVA modes
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00603174
|Research Center -CHU Sainte Justine - University of Montreal|
|Montreal, Quebec, Canada, H3T 1C5|
|Principal Investigator:||Philippe A Jouvet, MD||Université de Montréal|
|Principal Investigator:||Jennifer Beck, PhD||SunnyBrook Health Sciences Centre - Toronto|