Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry
|Study Design:||Observational Model: Other
Time Perspective: Retrospective
|Official Title:||Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry|
- measurement of proteomic signatures in brain tumor samples [ Time Frame: immediately upon analysis of the sample ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||May 2003|
|Study Completion Date:||December 2012|
|Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
We are collecting brain tissue specimens and blood samples from patients at Vanderbilt University Medical Center who are undergoing intracranial surgery to remove brain tissue, including brain tumors, tissue from epilepsy surgery and brain tissue removed during surgery for other non-cancerous types of brain tissus. These specimens will then be studied using a novel microscopic laser-directed protein mass spectrometric analysis. Data from different brain tissues including tumors of different histological sub-types will be analyzed for unique protein signatures. These protein signatures will then be statistically correlated with clinical data including time to tumor progression and response to therapy.
The goal of this study is to determine molecular patterns that will be more predictive of tumor behavior, thus leading to an improved understanding of the basic biology of these poorly understood cancers. This in turn, may lead to more refined therapies and improved outcomes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00592709
|United States, Tennessee|
|Vanderbilt University Medical Center, Department of Neurological Surgery|
|Nashville, Tennessee, United States, 37232|
|Principal Investigator:||Reid C. Thompson, MD||Vanderbilt University Medical Center, Department of Neurological Surgery|