Exercise Changes to Peripheral Blood Mononuclear Cells in Children
|ClinicalTrials.gov Identifier: NCT00585403|
Recruitment Status : Unknown
Verified November 2010 by University of California, Irvine.
Recruitment status was: Recruiting
First Posted : January 3, 2008
Last Update Posted : November 8, 2010
|Condition or disease|
|Physical Fitness Obesity Child Development Growth|
To systematically measure for the first time in healthy children and adolescents the effects of brief bouts of exercise on:
- Numbers of circulating PMBCs, their subsets and key intercellular adhesion molecules (ICAMs).
- PBMC gene regulation of stress, inflammatory, and growth/repair mediators [including: interleukin-4 (IL-4), IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma), growth hormone (GH), insulin-like growth factor-I (IGF-I), heat shock proteins (Hsp)].
- Circulating (serum) and intracellular PBMC levels of key mediators by flow cytometry and cell culture techniques.
- Circulating endogenous triggers of PBMC mediator responses—soluble Hsp, IL-6, and F2-isoprostanes.
- To determine how the acute PBMC responses are altered by gender, pubertal status, body composition (measured by whole-body and regional DEXA), and fitness (measured by progressive cycle ergometry and gas exchange).
- To determine the relationship in healthy children and adolescents among acute PBMC responses to exercise, biochemical precursors of the metabolic syndrome (insulin, glucose, lipids), and the balance of the TH1/TH2 immune response.
|Study Type :||Observational|
|Estimated Enrollment :||160 participants|
|Official Title:||PBMC, Exercise and Children: Initial Mechanisms|
|Study Start Date :||September 2004|
|Estimated Primary Completion Date :||January 2015|
|Estimated Study Completion Date :||February 2015|
Early and late pubertal girls and boys
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00585403
|Contact: Lori D. Wilson, PhDfirstname.lastname@example.org|
|United States, California|
|General Clinical Research Center||Recruiting|
|Orange, California, United States, 92868|
|Contact: Ruth Bundy, PhD 714-456-2317 email@example.com|
|Principal Investigator:||Dan M Cooper, M.D.||Univ. California, Irvine, CA|