Exercise Changes to Peripheral Blood Mononuclear Cells in Children
|ClinicalTrials.gov Identifier: NCT00585403|
Recruitment Status : Unknown
Verified November 2010 by University of California, Irvine.
Recruitment status was: Recruiting
First Posted : January 3, 2008
Last Update Posted : November 8, 2010
|Condition or disease|
|Physical Fitness Obesity Child Development Growth|
To systematically measure for the first time in healthy children and adolescents the effects of brief bouts of exercise on:
- Numbers of circulating PMBCs, their subsets and key intercellular adhesion molecules (ICAMs).
- PBMC gene regulation of stress, inflammatory, and growth/repair mediators [including: interleukin-4 (IL-4), IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma), growth hormone (GH), insulin-like growth factor-I (IGF-I), heat shock proteins (Hsp)].
- Circulating (serum) and intracellular PBMC levels of key mediators by flow cytometry and cell culture techniques.
- Circulating endogenous triggers of PBMC mediator responses—soluble Hsp, IL-6, and F2-isoprostanes.
- To determine how the acute PBMC responses are altered by gender, pubertal status, body composition (measured by whole-body and regional DEXA), and fitness (measured by progressive cycle ergometry and gas exchange).
- To determine the relationship in healthy children and adolescents among acute PBMC responses to exercise, biochemical precursors of the metabolic syndrome (insulin, glucose, lipids), and the balance of the TH1/TH2 immune response.
|Study Type :||Observational|
|Estimated Enrollment :||160 participants|
|Official Title:||PBMC, Exercise and Children: Initial Mechanisms|
|Study Start Date :||September 2004|
|Estimated Primary Completion Date :||January 2015|
|Estimated Study Completion Date :||February 2015|
Early and late pubertal girls and boys
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00585403
|Contact: Lori D. Wilson, PhDfirstname.lastname@example.org|
|United States, California|
|General Clinical Research Center||Recruiting|
|Orange, California, United States, 92868|
|Contact: Ruth Bundy, PhD 714-456-2317 email@example.com|
|Principal Investigator:||Dan M Cooper, M.D.||Univ. California, Irvine, CA|