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A Long-Term Examination of Asthma From Childhood Through Adolescence

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ClinicalTrials.gov Identifier: NCT00541255
Recruitment Status : Unknown
Verified October 2015 by Professor S Hasan Arshad, Isle of Wight NHS Trust.
Recruitment status was:  Active, not recruiting
First Posted : October 10, 2007
Last Update Posted : October 7, 2015
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma symptoms disappear and treatment can be stopped; however, for some of these people, asthma symptoms return in adulthood. This study will examine data collected over the lifetime of 18-year olds to identify factors that may increase a person's chance of having recurrent asthma as an adult.

Condition or disease
Asthma Dermatitis, Atopic Rhinitis Urticaria

Detailed Description:

Asthma is a serious, long-term illness that affects around 15% of children in the United States. During adolescence, up to 50% of teenagers stop experiencing symptoms and are able to discontinue treatment. However, asthma symptoms often reoccur in adulthood for many of these people. It is not known exactly what causes this recurrence, but potential risk factors may include obesity, elevated serum leptin levels, early onset of puberty, exposure to pollutants, parental smoking habits, and lack of breastfeeding. Additionally, it is not known why childhood asthma is initially more prevalent in boys, but during adolescence it becomes more prevalent in girls. Beginning in 1989, a group of children born on the Isle of Wight in the United Kingdom has been followed by study researchers to provide long-term information on asthma. These children have been periodically evaluated over the years and are now 18 years old. The purpose of this study is to analyze participants' data collected over a span of 18 years to identify factors that may increase a person's risk of experiencing persistent or recurrent asthma in adulthood.

At previous study visits that occurred when participants were 1, 2, 4, and 10 years old, information on the following was collected: asthma and other allergic diseases, family history of asthma, and early life risk factors, including breastfeeding and tobacco smoke exposure. A blood sample was collected at participants' 10-year study visit. For this current study, all 18-year-old participants will return for a study visit. Participants will complete questionnaires on asthma and allergy symptoms and environmental exposures, including tobacco smoke and pollution. Blood collection, an allergy skin prick test, lung function testing, and a bronchial challenge test to assess airway function will occur. Select participants will also have a sputum sample collected.


Study Design

Study Type : Observational
Estimated Enrollment : 1200 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Epidemiology of Asthma and Allergic Disease: Risk and Prognosis in a Cohort From Birth to Adolescence
Study Start Date : September 2007
Primary Completion Date : May 2012
Estimated Study Completion Date : December 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma
U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Primary Outcome Measures :
  1. Identifying factors that may increase a person's chance of having recurrent asthma as an adult [ Time Frame: Measured throughout the participant's lifetime ]

Biospecimen Retention:   Samples With DNA
Whole blood, serum, saliva, urine

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years to 19 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The study population consists of around 1500 unselected subjects (now age 18) who were recruited at birth. This is a homogenous population with 99% being Caucasians.
Criteria

Inclusion Criteria:

  • Born on the Isle of Wight in the United Kingdom between January 1, 1989 and February 28, 1990

Exclusion criteria:

  • Refused consent
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00541255


Locations
United Kingdom
The David Hide Asthma and Allergy Research Centre
Newport, Isle of Wight, United Kingdom, PO305TG
Sponsors and Collaborators
Isle of Wight NHS Trust
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Principal Investigator: Syed Arshad, MD University of Southampton, United Kingdom
More Information

Additional Information:
Responsible Party: Professor S Hasan Arshad, Chair in Allergy and Clinical Immunology, University of Southampton and Hon. Consultant Physician, University Hospital Southampton Director, The David Hide Asthma and Allergy Research Centre, Isle of Wight NHS Trust
ClinicalTrials.gov Identifier: NCT00541255     History of Changes
Other Study ID Numbers: 1408
R01HL082925 ( U.S. NIH Grant/Contract )
1R01HL082925-01A2 ( U.S. NIH Grant/Contract )
First Posted: October 10, 2007    Key Record Dates
Last Update Posted: October 7, 2015
Last Verified: October 2015

Keywords provided by Professor S Hasan Arshad, Isle of Wight NHS Trust:
Bronchial Asthma
Food Allergy
Bronchial Hyperresponsiveness

Additional relevant MeSH terms:
Asthma
Rhinitis
Dermatitis
Urticaria
Dermatitis, Atopic
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases
Nose Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Skin Diseases
Skin Diseases, Vascular
Skin Diseases, Genetic
Genetic Diseases, Inborn
Skin Diseases, Eczematous