Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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This study performs HLA matched stem cell transplantation from unrelated donors in adults who require stem cell transplantation but do not have a matched related donor available. The incidence of graft-versus-host disease in unrelated stem cell transplantation is recorded. This study also monitors the activity and toxicity of total body irradiation and cyclosphosphamide followed by stem cell transplantation from matched unrelated donors.
This protocol identifies a standard-of-care method for unrelated stem cell transplantation in adults. Performing this service in a consistent and documented fashion allows investigators to obtain informed consent from recipients. Data is tabulated locally for quality-control comparisons with nationally-reported standards. As a condition of maintaining transplant center status and to have acess to NMDP-registered donors, UCSF submits clinical and outcome data to the NMDP. As a result, UCSF is contributing to the resolution of remaining uncertainties regarding particular transplantation practices.
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Ages Eligible for Study:
16 Years to 54 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with Hematopoeietic Disorders
Age >15 and <55
Adequate renal function with serum creatinine <2.0 mg/dl
Pulmonary diffusing capacity>50% of predicted
Cardiac ejection fraction >40% as measured by radionuclide wall motion study or echocardiography
Total bilirubin must be <2.5 mg/dl.
Alkaline phosphatase and AST must be less than three times the upper limit of normal
Negative serology for the human immunodeficiency virus
Available HLA-matched donor
Signed informed consent
No fully or single-antigen-mismatched sibling donor is available to donate stem cells