Trial record 1 of 1 for:    NCT00499330
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Comparison of Different Types of Surgery in Treating Patients With Stage IA Non-Small Cell Lung Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2016 by Alliance for Clinical Trials in Oncology
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT00499330
First received: July 10, 2007
Last updated: June 21, 2016
Last verified: June 2016
  Purpose

RATIONALE: Wedge resection or segmentectomy may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy are more effective than lobectomy in treating stage IA non-small cell lung cancer.

PURPOSE: This randomized phase III trial is studying different types of surgery to compare how well they work in treating patients with stage IA non-small cell lung cancer.


Condition Intervention Phase
Lung Cancer
Procedure: lobectomy
Procedure: segmentectomy or wedge resection
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Randomized Trial of Lobectomy Versus Sublobar Resection for Small (≤ 2 cm) Peripheral Non-Small Cell Lung Cancer

Resource links provided by NLM:


Further study details as provided by Alliance for Clinical Trials in Oncology:

Primary Outcome Measures:
  • disease-free survival [ Time Frame: Up to 7 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • overall survival [ Time Frame: Up to 7 years ] [ Designated as safety issue: No ]
  • rate of loco-regional and systemic recurrence [ Time Frame: Up to 7 years ] [ Designated as safety issue: No ]
  • pulmonary function as measured by expiratory flow rate 6 months postoperatively [ Time Frame: at 6 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 1258
Study Start Date: June 2007
Estimated Primary Completion Date: March 2021 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Arm A
Patients undergo a standard operation for lung cancer called a lobectomy.
Procedure: lobectomy
Experimental: Arm B
Patents undergo a limited resection (segentectomy or wedge resection), which a smaller portion of the lung is removed.
Procedure: segmentectomy or wedge resection

Detailed Description:

OUTLINE: This is a multicenter, randomized study. Patients are stratified according to tumor size (< 1 cm vs 1-1.5 cm vs > 1.5-2.0 cm) (based on the maximum dimension determined from the preoperative CT scan), histology (squamous cell carcinoma vs adenocarcinoma vs other), and smoking status (never smoked [smoked < 100 cigarettes over lifetime] vs former smoker [smoked > 100 cigarettes AND quit ≥ 1 year ago] vs current smoker [quit < 1 year ago or currently smokes]). Patients are randomized to 1 of 2 treatment arms. For more information, please see the Arms section.

Primary Objective:

To determine whether DFS after sublobar resection (segmentectomy or wedge) is non-inferior to that after lobectomy in patients with small peripheral (≤ 2 cm) NSCLC.

Secondary Objectives:

  1. To determine whether overall survival (OS) (after sublobar resection) is non-inferior to that after lobectomy.
  2. To determine the rates of loco-regional and systemic recurrence (exclusive of second primaries) after lobar and sublobar resection.
  3. To determine the difference between the two arms of the study in pulmonary function as determined by expiratory flow rates measured at 6 months post-operatively.
  4. Imaging Substudy: To explore the relationship between characteristics of the primary lung cancer, as revealed by pre-operative CT and PET imaging, and outcomes; a determination of the false-negative rate of the pre-operative PET scan for identification of involved hilarand mediastinal lymph nodes; and an assessment of the utility of annual follow-up CT imaging after surgical resection of small stage IA NSCLC.

After completion of study treatment, patients are followed up every 6 months for 2 years and then annually for 5 years.

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Pre-registration Eligibility Criteria:

  1. Peripheral lung nodule ≤ 2 cm on preoperative CT scan and presumed to be lung cancer. The center of the tumor, as seen on CT, must be located in the outer third of the lung in either the transverse, coronal or sagittal plane. Patients with pure ground glass opacities or pathologically confirmed N1 or N2 disease are not eligible.
  2. The tumor location must be suitable for either lobar or sublobar resection (wedge or segment).
  3. ECOG performance status of 0-2.
  4. No prior malignancy within 3 years other than non-melanoma skin cancer, superficial bladder cancer, or CIS of the cervix.
  5. No prior chemotherapy or radiation therapy for this malignancy.
  6. No evidence of locally advanced or metastatic disease.
  7. Age ≥ 18 years

Intra-operative Randomization Eligibility Criteria:

  1. Histologic confirmation of NSCLC (if not already obtained)
  2. Confirmation of N0 status by frozen section examination. Right sided tumors require that node levels 4, 7, and 10 be sampled and diagnosed as negative on frozen section. Left sided tumors require that node levels 5 or 6, 7 and 10 be sampled and diagnosed as negative on frozen section. Levels 4 and 7 nodes may be sampled by mediastinoscopy, endobronchial ultrasound (EBUS) and/or endoscopic ultrasound (EUS), or at the time of thoracotomy or VATS exploration. Nodes previously sampled by mediastinoscopy (or EBUS and/or EUS) either immediately prior to or within 6 weeks of the definitive surgical procedure (thoracotomy or VATS) do not need to be resampled.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00499330

Contacts
Contact: Nasser Altorki, MD 212 746-5156

  Hide Study Locations
Locations
United States, Alaska
Anchorage Associates in Radiation Medicine Recruiting
Anchorage, Alaska, United States, 98508
Contact: Keith Lanier, MD    503-216-6300      
Anchorage Radiation Therapy Center Recruiting
Anchorage, Alaska, United States, 99504
Contact: Keith Lanier, MD    503-216-6300      
Alaska Breast Care and Surgery LLC Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Alaska Oncology and Hematology LLC Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Alaska Women's Cancer Care Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Anchorage Oncology Centre Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Katmai Oncology Group Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Providence Alaska Medical Center Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
United States, Arizona
The University of Arizona Medical Center-University Campus Recruiting
Tucson, Arizona, United States, 85724
Contact: Samuel Kim, MD    520-626-5340      
United States, Arkansas
CHI Saint Vincent Cancer Center-Hot Springs Recruiting
Hot Springs, Arkansas, United States, 71913
Contact: Joseph Verdirame, MD    402-572-3535      
University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Matthew Steliga, MD    501-686-7884      
Highlands Oncology Group Recruiting
Rogers, Arkansas, United States, 72758
Contact: Joseph Beck, MD    479-587-1700      
United States, California
Providence Saint Joseph Medical Center-Disney Family Cancer Center Recruiting
Burbank, California, United States, 91505
Contact: Keith Lanier, MD    503-216-6300      
Veterans Administration Long Beach Medical Center Recruiting
Long Beach, California, United States, 90822
Contact: Amir Abolhoda, MD    562-826-5957      
Kaiser Permanente-Riverside Recruiting
Riverside, California, United States, 92505
Contact: Gregory Marrujo, MD    951-353-4728      
University of California Davis Comprehensive Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: David Cooke, MD    916-734-3861      
United States, Colorado
University of Colorado Cancer Center-Anschutz Cancer Pavilion Recruiting
Aurora, Colorado, United States, 80045
Contact: John Mitchell, MD    303-724-2800      
United States, Connecticut
Saint Vincent's Medical Center Recruiting
Bridgeport, Connecticut, United States, 06606
Contact: Albert DiMeo, MD    203-576-6000      
Stamford Hospital/Bennett Cancer Center Recruiting
Stamford, Connecticut, United States, 06904
Contact: Michael Ebright, MD    203-276-4404      
United States, Delaware
Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Christiana Gynecologic Oncology LLC Recruiting
Newark, Delaware, United States, 19713
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Delaware Clinical and Laboratory Physicians PA Recruiting
Newark, Delaware, United States, 19713
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Medical Oncology Hematology Consultants PA Recruiting
Newark, Delaware, United States, 19713
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Regional Hematology and Oncology PA Recruiting
Newark, Delaware, United States, 19713
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Beebe Health Campus Recruiting
Rehoboth Beach, Delaware, United States, 19971
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Nanticoke Memorial Hospital Recruiting
Seaford, Delaware, United States, 19973
Contact: Brian Taikwoo Nam, MD    302-623-4530      
Christiana Care Health System-Wilmington Hospital Recruiting
Wilmington, Delaware, United States, 19801
Contact: Brian Taikwoo Nam, MD    302-623-4530      
United States, Georgia
Emory University Hospital-Midtown Recruiting
Atlanta, Georgia, United States, 30308
Contact: Felix Fernandez, MD    404-728-7680      
Atlanta VA Medical Center Recruiting
Decatur, Georgia, United States, 30033
Contact: Felix Fernandez, MD    404-728-7680      
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Phillip Stella, MD    734-712-1000      
Saint Luke's Mountain States Tumor Institute Recruiting
Boise, Idaho, United States, 83712
Contact: Keith Lanier, MD    503-216-6300      
Kootenai Medical Center Recruiting
Coeur D'Alene, Idaho, United States, 83814
Contact: Benjamin Marchello, MD    406-237-5460      
Saint Luke's Mountain States Tumor Institute-Fruitland Recruiting
Fruitland, Idaho, United States, 83619
Contact: Keith Lanier, MD    503-216-6300      
Saint Luke's Mountain States Tumor Institute-Meridian Recruiting
Meridian, Idaho, United States, 83642
Contact: Keith Lanier, MD    503-216-6300      
Saint Luke's Mountain States Tumor Institute-Nampa Recruiting
Nampa, Idaho, United States, 83686
Contact: Keith Lanier, MD    503-216-6300      
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin Marchello, MD    406-237-5460      
Kootenai Cancer Clinic Recruiting
Sandpoint, Idaho, United States, 83864
Contact: Benjamin Marchello, MD    406-237-5460      
Saint Luke's Mountain States Tumor Institute-Twin Falls Recruiting
Twin Falls, Idaho, United States, 83301
Contact: Keith Lanier, MD    503-216-6300      
United States, Illinois
University of Chicago Cancer Research Center Recruiting
Chicago, Illinois, United States, 60637
Contact: Wickii Vigneswaran, MD    773-702-3551      
United States, Indiana
Indiana University-Melvin and Bren Simon Cancer Center Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Thomas Birdas, MD    317-274-7728      
Richard L. Roudebush Veterans Affairs Medical Center Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Thomas Birdas, MD    317-274-7728      
Sidney and Lois Eskenazi Hospital Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Thomas Birdas, MD    317-274-7728      
United States, Iowa
Medical Oncology and Hematology Associates-West Des Moines Recruiting
Clive, Iowa, United States, 50325
Contact: Joseph Verdirame, MD    402-572-3535      
Mercy Cancer Center-West Lakes Recruiting
Clive, Iowa, United States, 50325
Contact: Joseph Verdirame, MD    402-572-3535      
Alegent Health-Mercy Hospital Recruiting
Council Bluffs, Iowa, United States, 51503
Contact: Joseph Verdirame, MD    402-572-3535      
Medical Oncology and Hematology Associates-Laurel Recruiting
Des Moines, Iowa, United States, 50314
Contact: Joseph Verdirame, MD    402-572-3535      
Mercy Medical Center-Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Joseph Verdirame, MD    402-572-3535      
Mercy Medical Center-West Lakes Recruiting
West Des Moines, Iowa, United States, 50266
Contact: Joseph Verdirame, MD    402-572-3535      
United States, Kentucky
Flaget Memorial Hospital Recruiting
Bardstown, Kentucky, United States, 40004
Contact: Joseph Verdirame, MD    402-572-3535      
Commonwealth Cancer Center-Corbin Recruiting
Corbin, Kentucky, United States, 40701
Contact: Joseph Verdirame, MD    402-572-3535      
Saint Joseph Radiation Oncology Resource Center Recruiting
Lexington, Kentucky, United States, 40504
Contact: Joseph Verdirame, MD    402-572-3535      
Saint Joseph Hospital East Recruiting
Lexington, Kentucky, United States, 40509
Contact: Joseph Verdirame, MD    402-572-3535      
Jewish Hospital Recruiting
Louisville, Kentucky, United States, 40202
Contact: Joseph Verdirame, MD    402-572-3535      
Saints Mary and Elizabeth Hospital Recruiting
Louisville, Kentucky, United States, 40215
Contact: Mehmet Copur, MD    308-398-5450      
Jewish Hospital Medical Center-Northeast Recruiting
Louisville, Kentucky, United States, 40245
Contact: Joseph Verdirame, MD    402-572-3535      
Jewish Hospital Medical Center-South Recruiting
Shepherdsville, Kentucky, United States, 40165
Contact: Joseph Verdirame, MD    402-572-3535      
United States, Louisiana
Ochsner Medical Center-Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Brian Pettiford, MD    504-842-3966      
United States, Maryland
Anne Arundel Medical Center Recruiting
Annapolis, Maryland, United States, 21401
Contact: Stephen Cattaneo, MD    443-481-3366      
Holy Cross Hospital Recruiting
Silver Spring, Maryland, United States, 20910
Contact: Bryan Steinberg, MD    301-270-2844      
United States, Massachusetts
Boston Medical Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Virginia Litle, MD    617-638-5600      
Berkshire Hematology Oncology, PC Recruiting
Pittsfield, Massachusetts, United States, 01201
Contact: Harvey Zimbler, MD    413-496-8205      
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Philip Stella, MD    734-712-1000      
University of Michigan Comprehensive Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Andrew Chang, MD    734-763-7418      
Beaumont Hospital-Dearborn Recruiting
Dearborn, Michigan, United States, 48124
Contact: Philip Stella, MD    734-712-4931      
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Philip Stella, MD    734-712-1000      
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Philip Stella, MD    734-712-1000      
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48503
Contact: Philip Stella, MD    734-712-1000      
Allegiance Health Recruiting
Jackson, Michigan, United States, 49201
Contact: Philip Stella, MD    734-712-4931      
Sparrow Hospital Recruiting
Lansing, Michigan, United States, 48912
Contact: Philip Stella, MD    734-712-1000      
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Philip Stella, MD    734-712-1000      
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Philip Stella, MD    734-712-1000      
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Philip Stella, MD    734-712-1000      
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Philip Stella, MD    734-712-1000      
United States, Minnesota
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Dennis Wigle, MD    507-284-8462      
United States, Missouri
Christian Hospital Recruiting
Saint Louis, Missouri, United States, 63136
Contact: Timothy Rearden, MD    314-653-5779      
United States, Montana
Community Hospital of Anaconda Recruiting
Anaconda, Montana, United States, 59711
Contact: Benjamin Marchello, MD    406-238-6290      
Montana Cancer Consortium NCORP Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin Marchello, MD    406-237-5460      
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin Marchello, MD    406-237-5460      
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59107
Contact: Benjamin Marchello, MD    406-237-5460      
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin Marchello, MD    406-237-5460      
Saint James Community Hospital and Cancer Treatment Center Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin Marchello, MD    406-237-5460      
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin Marchello, MD    406-237-5460      
Great Falls Clinic Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin Marchello, MD    406-454-2171      
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin Marchello, MD    406-237-5460      
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin Marchello, MD    406-237-5460      
Community Medical Hospital Recruiting
Missoula, Montana, United States, 59801
Contact: Benjamin Marchello, MD    406-237-5460      
Saint Patrick Hospital-Community Hospital Recruiting
Missoula, Montana, United States, 59802
Contact: Benjamin Marchello, MD    406-237-5460      
United States, Nebraska
CHI Health Saint Francis Recruiting
Grand Island, Nebraska, United States, 68803
Contact: Joseph Verdirame, MD    402-572-3535      
Heartland Hematology and Oncology Recruiting
Kearney, Nebraska, United States, 68845
Contact: Joseph Verdirame, MD    402-572-3535      
CHI Health Good Samaritan Recruiting
Kearney, Nebraska, United States, 68847
Contact: Joseph Verdirame, MD    402-572-3535      
Saint Elizabeth Regional Medical Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Joseph Verdirame, MD    402-572-3535      
Alegent Health-Immanuel Medical Center Recruiting
Omaha, Nebraska, United States, 68122
Contact: Joseph Verdirame, MD    402-572-3535      
Hematology and Oncology Consultants PC Recruiting
Omaha, Nebraska, United States, 68122
Contact: Joseph Verdirame, MD    402-572-3535      
Alegent Health-Bergan Mercy Medical Center Recruiting
Omaha, Nebraska, United States, 68124
Contact: Joseph Verdirame, MD    402-572-3535      
Alegent Health-Lakeside Hospital Recruiting
Omaha, Nebraska, United States, 68130
Contact: Joseph Verdirame, MD    402-572-3535      
Creighton University School of Medicine Recruiting
Omaha, Nebraska, United States, 68131
Contact: Joseph Verdirame, MD    402-572-3535      
Midlands Community Hospital Recruiting
Papillion, Nebraska, United States, 68046
Contact: Joseph Verdirame, MD    402-572-3535      
United States, New Jersey
Memorial Sloan Kettering Cancer Center-Basking Ridge Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: James Huang, MD    212-639-2530      
Ocean Medical Center Recruiting
Brick, New Jersey, United States, 08724
Contact: Thomas Bauer, MD    732-776-4770      
Southern Ocean County Medical Center Recruiting
Manahawkin, New Jersey, United States, 08050
Contact: Thomas Bauer, MD    732-776-4770      
Jersey Shore University Medical Center Recruiting
Neptune, New Jersey, United States, 07753
Contact: Thomas Bauer, MD    732-776-4770      
The Valley Hospital-Luckow Pavilion Recruiting
Paramus, New Jersey, United States, 07652
Contact: Benjamin Lee, MD    201-634-5722      
Riverview Medical Center-Booker Cancer Center Recruiting
Red Bank, New Jersey, United States, 07701
Contact: Thomas Bauer, MD    732-776-4770      
Valley Hospital Recruiting
Ridgewood, New Jersey, United States, 07450
Contact: Benjamin Lee, MD    201-634-5339      
United States, New York
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263-0001
Contact: Chukwumere Nwogu, MD    716-845-5873      
Memorial Sloan Kettering Cancer Center-Commack Recruiting
Commack, New York, United States, 11725
Contact: James Huang, MD    212-639-2530      
Memorial Sloan Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Mark Dickson, MD    646-888-4164      
State University of New York Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Leslie Kohman, MD    315-464-6303      
Memorial Sloan Kettering Cancer Center-West Harrison Recruiting
West Harrison, New York, United States, 10604
Contact: James Huang, MD    212-639-2530      
United States, North Carolina
Asheville VA Medical Center Recruiting
Asheville, North Carolina, United States, 28805
Contact: Robert Ferguson, MD    828-298-7911      
Southeastern Medical Oncology Center-Clinton Recruiting
Clinton, North Carolina, United States, 28328
Contact: James Atkins, MD    919-580-0000      
Duke University Medical Center Recruiting
Durham, North Carolina, United States, 27710
Contact: Jeffrey Crawford, MD    919-681-9509      
Southeastern Medical Oncology Center-Goldsboro Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James Atkins, MD    919-580-0000      
Wayne Memorial Hospital Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James Atkins, MD    919-580-0000      
Southeastern Medical Oncology Center-Jacksonville Recruiting
Jacksonville, North Carolina, United States, 28546
Contact: James Atkins, MD    919-580-0000      
Southeastern Medical Oncology Center-Wilson Recruiting
Wilson, North Carolina, United States, 27893
Contact: James Atkins, MD    919-580-0000      
United States, Ohio
Mercy Medical Center Recruiting
Canton, Ohio, United States, 44708
Contact: Mitchell Haut, MD    330-453-9993      
Good Samaritan Hospital-Cincinnati Recruiting
Cincinnati, Ohio, United States, 45220
Contact: Joseph Verdirame, MD    402-572-3535      
Bethesda North Hospital Recruiting
Cincinnati, Ohio, United States, 45242
Contact: Joseph Verdirame, MD    402-572-3535      
TriHealth Cancer Institute-Westside Recruiting
Cincinnati, Ohio, United States, 45247
Contact: Joseph Verdirame, MD    402-572-3535      
TriHealth Cancer Institute-Anderson Recruiting
Cincinnati, Ohio, United States, 45255
Contact: Joseph Verdirame, MD    402-572-3535      
Ohio State University Comprehensive Cancer Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Robert Merritt, MD    614-293-9059      
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Deb Subrato, MD    405-271-5789      
United States, Oregon
Saint Charles Health System Recruiting
Bend, Oregon, United States, 97701
Contact: Keith Lanier, MD    503-216-6300      
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Keith Lanier, MD    503-216-6300      
Providence Oncology and Hematology Care Southeast Recruiting
Clackamas, Oregon, United States, 97015
Contact: Keith Lanier, MD    503-216-6300      
Bay Area Hospital Recruiting
Coos Bay, Oregon, United States, 97420
Contact: Keith Lanier, MD    503-216-6300      
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Keith Lanier, MD    503-216-6300      
Providence Willamette Falls Medical Center Recruiting
Oregon City, Oregon, United States, 97045
Contact: Keith Lanier, MD    503-216-6300      
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Keith Lanier, MD    503-216-6300      
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Keith Lanier, MD    503-216-6300      
United States, Pennsylvania
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Matthew Facktor, MD    570-214-1991      
Armstrong Center for Medicine and Health Recruiting
Kittanning, Pennsylvania, United States, 16201
Contact: Gene Finley, MD    724-226-7105      
Forbes Hospital Recruiting
Monroeville, Pennsylvania, United States, 15146
Contact: Gene Finley, MD    724-226-7105      
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Nathaniel Evans, MD    215-955-6996      
Fox Chase Cancer Center Recruiting
Philadelphia, Pennsylvania, United States, 19111
Contact: Walter Scott, MD    215-214-1427      
Allegheny General Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15212
Contact: Gene Finley, MD    724-226-7105      
West Penn Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15224
Contact: Gene Finley, MD    724-226-7105      
University of Pittsburgh Cancer Institute (UPCI) Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Matthew Schuchert, MD    412-647-7555      
Guthrie Medical Group PC-Robert Packer Hospital Recruiting
Sayre, Pennsylvania, United States, 18840
Contact: Bradley Lash, MD    570-887-2141      
United States, South Carolina
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Chadrick Denlinger, MD    843-876-4844      
United States, Tennessee
Memorial Hospital Recruiting
Chattanooga, Tennessee, United States, 37404
Contact: Joseph Verdirame, MD    402-572-3535      
Pulmonary Medicine Center of Chattanooga-Hixson Recruiting
Hixson, Tennessee, United States, 37343
Contact: Joseph Verdirame, MD    402-572-3535      
University of Tennessee-Knoxville Recruiting
Knoxville, Tennessee, United States, 37920
Contact: Thomas Gaines, MD    865-637-6392      
Memorial GYN Plus Recruiting
Ooltewah, Tennessee, United States, 37363
Contact: Joseph Verdirame, MD    402-572-3535      
United States, Vermont
University of Vermont College of Medicine Recruiting
Burlington, Vermont, United States, 05405
Contact: Bruce Leavitt, MD    802-656-4414      
United States, Virginia
University of Virginia Cancer Center Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Benjamin Kozower, MD    434-924-9333      
Sentara Cancer Institute at Sentara CarePlex Hospital Recruiting
Hampton, Virginia, United States, 23666
Contact: Peter Moy, MD    757-262-1110      
Sentara Hospitals Recruiting
Norfolk, Virginia, United States, 23507
Contact: Peter Moy, MD    757-262-1110      
Virginia Commonwealth University-Massey Cancer Center Recruiting
Richmond, Virginia, United States, 23298
Contact: Anthony Cassano, MD    804-828-4620      
United States, Washington
Providence Regional Cancer System-Aberdeen Recruiting
Aberdeen, Washington, United States, 98520
Contact: Keith Lanier, MD    503-216-6300      
Cancer Care Center at Island Hospital Recruiting
Anacortes, Washington, United States, 98221
Contact: Keith Lanier, MD    503-216-6300      
Swedish Cancer Institute-Eastside Oncology Hematology Recruiting
Bellevue, Washington, United States, 98005
Contact: Keith Lanier, MD    503-216-6300      
Harrison HealthPartners Hematology and Oncology-Bremerton Recruiting
Bremerton, Washington, United States, 98310
Contact: Joseph Verdirame, MD    402-572-3535      
Harrison Medical Center Recruiting
Bremerton, Washington, United States, 98310
Contact: Joseph Verdirame, MD    402-572-3535      
Highline Medical Center-Main Campus Recruiting
Burien, Washington, United States, 98166
Contact: Joseph Verdirame, MD    402-572-3535      
Providence Regional Cancer System-Centralia Recruiting
Centralia, Washington, United States, 98531
Contact: Keith Lanier, MD    503-216-6300      
Swedish Medical Center-Edmonds Recruiting
Edmonds, Washington, United States, 98026
Contact: Keith Lanier, MD    503-216-6300      
Saint Elizabeth Hospital Recruiting
Enumclaw, Washington, United States, 98022
Contact: Joseph Verdirame, MD    402-572-3535      
Providence Regional Cancer Partnership Recruiting
Everett, Washington, United States, 98201
Contact: Keith Lanier, MD    503-216-6300      
Saint Francis Hospital Recruiting
Federal Way, Washington, United States, 98003
Contact: Joseph Verdirame, MD    402-572-3535      
Swedish Cancer Institute-Issaquah Recruiting
Issaquah, Washington, United States, 98029
Contact: Keith Lanier, MD    503-216-6300      
Providence Regional Cancer System-Lacey Recruiting
Lacey, Washington, United States, 98503
Contact: Keith Lanier, MD    503-216-6300      
Saint Clare Hospital Recruiting
Lakewood, Washington, United States, 98499
Contact: Joseph Verdirame, MD    402-572-3535      
Saint John Medical Center Recruiting
Longview, Washington, United States, 98632
Contact: Keith Lanier, MD    503-215-5453      
Harrison HealthPartners Hematology and Oncology-Poulsbo Recruiting
Poulsbo, Washington, United States, 98370
Contact: Joseph Verdirame, MD    402-572-3535      
Minor and James Medical PLLC Recruiting
Seattle, Washington, United States, 98104
Contact: Keith Lanier, MD    503-216-6300      
Pacific Gynecology Specialists Recruiting
Seattle, Washington, United States, 98104
Contact: Keith Lanier, MD    503-216-6300      
Swedish Medical Center-Ballard Campus Recruiting
Seattle, Washington, United States, 98107
Contact: Keith Lanier, MD    503-216-6300      
Group Health Cooperative-Seattle Recruiting
Seattle, Washington, United States, 98112
Contact: Keith Lanier, MD    503-216-6300      
Swedish Medical Center-First Hill Recruiting
Seattle, Washington, United States, 98122
Contact: Keith Lanier, MD    503-216-6300      
Providence Regional Cancer System-Shelton Recruiting
Shelton, Washington, United States, 98584
Contact: Keith Lanier, MD    503-216-6300      
Rockwood Clinic Cancer Treatment Center-Valley Recruiting
Spokane Valley, Washington, United States, 99216
Contact: Keith Lanier, MD    503-216-6300      
Rockwood Cancer Treatment Center-DHEC-Downtown Recruiting
Spokane, Washington, United States, 99204
Contact: Keith Lanier, MD    503-216-6300      
Franciscan Research Center-Northwest Medical Plaza Recruiting
Tacoma, Washington, United States, 98405
Contact: Joseph Verdirame, MD    402-572-3535      
Northwest Medical Specialties PLLC Recruiting
Tacoma, Washington, United States, 98405
Contact: Joseph Verdirame, MD    402-572-3535      
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Keith Lanier, MD    503-215-5453      
Providence Saint Mary Regional Cancer Center Recruiting
Walla Walla, Washington, United States, 99362
Contact: Keith Lanier, MD    503-216-6300      
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Recruiting
Yakima, Washington, United States, 98902
Contact: Keith Lanier, MD    503-216-6300      
Providence Regional Cancer System-Yelm Recruiting
Yelm, Washington, United States, 98597
Contact: Keith Lanier, MD    503-216-6300      
United States, Wyoming
Big Horn Basin Cancer Center Recruiting
Cody, Wyoming, United States, 82414
Contact: Benjamin Marchello, MD    406-237-5460      
Billings Clinic-Cody Recruiting
Cody, Wyoming, United States, 82414
Contact: Benjamin Marchello, MD    406-237-5460      
Welch Cancer Center Recruiting
Sheridan, Wyoming, United States, 82801
Contact: Benjamin Marchello, MD    406-237-5460      
Canada, British Columbia
Surrey Memorial Hospital Recruiting
Surrey, British Columbia, Canada, V3V 1Z2
Contact: Ahmad Ashrafi, MD    604-581-2211      
Canada, Nova Scotia
QEII Health Sciences Centre-Capital District Health Authority Recruiting
Halifax, Nova Scotia, Canada, B3H 1V8
Contact: Marc-Emile Plourde, MD    819-346-1110      
Canada, Ontario
Saint Joseph's Healthcare Charlton Campus Recruiting
Hamilton, Ontario, Canada, L8N 4A6
Contact: Yaron Shargall, MD    905-522-4941      
London Regional Cancer Program Recruiting
London, Ontario, Canada, N6A 4L6
Contact: Richard Malthaner, MD    519-685-8615      
Ottawa Hospital and Cancer Center-General Campus Recruiting
Ottawa, Ontario, Canada, K1H 1C4
Contact: Andrew Seely, MD    613-737-7700 ext 70209      
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Marc de Perrot, MD    416-340-4857      
Canada, Quebec
CHUM-Hopital Notre Dame Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Moishe Liberman, MD    514-281-6000      
Canada
University Institute of Cardiology and Pneumology of Quebec (Laval Hospital) Recruiting
Quebec, Canada, G1V 4G5
Contact: Paula Ugalde Figueroa, MD    418-656-8711      
Sponsors and Collaborators
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)
Investigators
Study Chair: Nasser Altorki, MD Weill Medical College of Cornell University
  More Information

Additional Information:
Responsible Party: Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier: NCT00499330     History of Changes
Other Study ID Numbers: CALGB-140503  CDR0000555324 
Study First Received: July 10, 2007
Last Updated: June 21, 2016
Health Authority: United States: Institutional Review Board

Keywords provided by Alliance for Clinical Trials in Oncology:
stage IA non-small cell lung cancer
adenocarcinoma of the lung
squamous cell lung cancer
large cell lung cancer
adenosquamous cell lung cancer
bronchoalveolar cell lung cancer

Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms

ClinicalTrials.gov processed this record on August 23, 2016