Effect of Heredity and Environment on Asthma Development and Severity in Puerto Rican Children
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00461227|
Recruitment Status : Completed
First Posted : April 17, 2007
Last Update Posted : December 19, 2012
|Condition or disease|
Asthma is a chronic disease that causes constriction of the airways. People with asthma may experience wheezing, coughing, chest tightness, and trouble breathing. Although asthma is a major public health problem among Puerto Ricans, little research has been done to determine the influence of heredity and environment on the disease in this population. To learn more about these relationships, this study will examine the effects of certain genes and allergens on the development and severity of asthma in Puerto Rican children.
This observational study will recruit both children with asthma and children without asthma. Participants will meet with study staff twice during the study. The first visit will take place at participants' homes. Participants will complete questionnaires about demographics, respiratory and general health, and household characteristics. Lung function testing, collection of blood samples, and collection of household dust samples will also take place at the home-based visit. The second visit will take place at the study site. At this visit, participants will undergo allergy tests on the skin and a methacholine challenge test to assess their airway responsiveness and asthma severity. The methacholine challenge test will involve inhaling mist through a mouthpiece and blowing forcefully into a special apparatus called a spirometer. Parents will be asked to provide information about their children's exposure to pets in early life. Each visit will last approximately 1.5 hours and will be scheduled close to the date on which a participant enters the study.
|Study Type :||Observational|
|Actual Enrollment :||1127 participants|
|Observational Model:||Case Control|
|Official Title:||Genes, Home Allergens, and Asthma in Puerto Rican Children|
|Study Start Date :||August 2006|
|Primary Completion Date :||June 2010|
|Study Completion Date :||June 2010|
- Effect of certain genes and allergens on the development and severity of asthma in Puerto Rican children [ Time Frame: Measured at participants' two study visits ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00461227
|University of Puerto Rico|
|San Juan, Puerto Rico|
|Principal Investigator:||Juan C. Celedon, MD, DrPH||Brigham and Women's Hospital|