Surgery With or Without Docetaxel and Leuprolide or Goserelin in Treating Patients With High-Risk Localized Prostate Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2015 by Alliance for Clinical Trials in Oncology
Sponsor:
Collaborators:
Eastern Cooperative Oncology Group
NCIC Clinical Trials Group
Southwest Oncology Group
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT00430183
First received: January 30, 2007
Last updated: March 13, 2015
Last verified: March 2015
  Purpose

RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as goserelin and leuprolide, may stop the adrenal glands from making androgens. Giving docetaxel and leuprolide or goserelin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known whether giving docetaxel and leuprolide or goserelin before surgery is more effective than surgery alone in treating patients with prostate cancer.

PURPOSE: This randomized phase III trial is studying docetaxel and leuprolide or goserelin to see how well they work when given before surgery compared with surgery alone in treating patients with high-risk localized prostate cancer.


Condition Intervention Phase
Prostate Cancer
Drug: docetaxel
Drug: LHRH agonist
Procedure: surgery
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy Versus Immediate Radical Prostatectomy in Patients With High-Risk, Clinically Localized Prostate Cancer

Resource links provided by NLM:


Further study details as provided by Alliance for Clinical Trials in Oncology:

Primary Outcome Measures:
  • 3-year biochemical progression-free survival (bPFS) rate [ Time Frame: 3 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • 5-year bPFS rate and bPFS [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  • Time to clinical local recurrence (The time from randomization to the first biopsy-proven recurrence in the prostatic bed or new mass.) [ Time Frame: Up to 15 years post-randomization ] [ Designated as safety issue: No ]
  • Time to metastatic disease progression (The date of randomization to date of evidence of systemic disease on bone scan or cross sectional imaging.) [ Time Frame: Up to 15 years post-randomization ] [ Designated as safety issue: No ]
  • Unacceptable toxicity (grade 3 or higher toxicity) [ Time Frame: Up to 15 years post-randomization ] [ Designated as safety issue: Yes ]
  • Prostate cancer-specific-free survival (The time from randomization to the time of death due to prostate cancer.) [ Time Frame: Up to 15 years post-randomization ] [ Designated as safety issue: No ]
  • Disease progression [ Time Frame: Up to 15 years post-randomization ] [ Designated as safety issue: No ]
  • Overall survival (The date of randomization to the time of death due to prostate cancer.) [ Time Frame: Up to 15 years post-randomization ] [ Designated as safety issue: No ]

Estimated Enrollment: 750
Study Start Date: December 2006
Estimated Primary Completion Date: June 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm A: docetaxel + LHRH agonist + surgical intervention

Patients receive six cycles of docetaxel administered every 3 weeks combined with 18-24 weeks of androgen deprivation therapy. During each cycle of chemotherapy, all patients should undergo premedication with dexamethasone 8 mg orally prior to docetaxel. Dexamethasone may also be given intravenously according to institutional guidelines.

Patients will also receive androgen deprivation for 18-24 weeks of an LHRH agonist (eg, leuprolide acetate, goserelin acetate). Additional premedication and antiemetics may be given at the physician's discretion and as defined by the protocol.

Patients will undergo standard surgical intervention. The surgical procedures will be performed within 60 days of the completion of neoadjuvant therapy. Patients are allowed to receive adjuvant external beam radiation at the discretion of the treating physician and as defined per the protocol. It must be initiated within 6 months of the date of surgery.

Drug: docetaxel
75 mg/m^2 will be administered intravenously over one hour on Day 1 of each cycle, every 21 days
Drug: LHRH agonist
Given intramuscularly
Other Names:
  • leuprolide acetate OR
  • goserelin acetate
Procedure: surgery
Patients undergo radical prostatectomy with staging pelvic lymphadenectomy.
Active Comparator: Arm B: surgical intervention
All patients undergo standard surgical intervention. The surgical procedures will be performed within 60 days of randomization. Patients are allowed to receive adjuvant external beam radiation at the discretion of the treating physician and as defined per the protocol. Adjuvant radiation must be initiated within 6 months of the date of surgery.
Procedure: surgery
Patients undergo radical prostatectomy with staging pelvic lymphadenectomy.

Detailed Description:

This randomized trial tests whether the addition of chemohormonal therapy improves PSA-progression free survival in patients with high risk, clinically-localized prostate cancer. The neoadjuvant approach is taken since there appears to be a higher acceptance rate in the prostate population for this type of therapy and several phase II trials have demonstrated its safety. Multiple chemotherapeutic therapies have shown efficacy in advanced prostate cancer and docetaxel has become the community standard. Many high risk patients are initiated on LHRH agonists at or near the time of diagnosis of their prostate cancer. In order to allow the inclusion of these patients in the protocol, enhanced enrollment and maintain compliance with therapy, up to 3 months of androgen deprivation therapy prior to enrollment will be permitted. This study will therefore be able to test the hypothesis that targeting both androgen-sensitive and chemotherapy- sensitive prostate cancer cells will improve outcomes in these high-risk patients.

OUTLINE: This is a multicenter, randomized study. Patients are stratified according to nomogram-predicted biochemical progression-free survival at 5 years (0-20.9% vs 21-39.9% vs 40-59.9% vs ≥ 60%) and androgen-deprivation therapy prior to randomization ≤ 4 months (no vs yes). Patients are randomized to 1 of 2 treatment arms. Please see the Arms sections for more details.

The primary and secondary objectives are described below.

Primary:

- To determine whether treatment with neoadjuvant docetaxel and androgen deprivation therapy prior to radical prostatectomy will increase the rate of 3-year biochemical progression-free survival (bPFS) compared to treatment with immediate radical prostatectomy alone for high-risk prostate cancer patients.

Secondary:

  • To compare the 5-year bPFS rate, bPFS, disease progression, disease-free survival, and overall survival of patients randomized to the two arms of this trial
  • To determine the safety and tolerability of neoadjuvant docetaxel and androgen deprivation therapy prior to surgery for high-risk patients undergoing radical prostatectomy
  • To compare the impact of neoadjuvant docetaxel and androgen deprivation therapy on time to clinically apparent local disease recurrence and metastatic disease in high-risk patients undergoing radical prostatectomy for clinically localized prostate cancer
  • To compare the impact of neoadjuvant docetaxel and androgen deprivation therapy relative to RP on pathologic tumor stage, frequency of lymph node metastases and positive margin rates for high-risk patients undergoing radical prostatectomy for clinically localized prostate cancer
  • To determine if changes in serum testosterone levels will predict bPFS
  • To determine prospectively whether PSA doubling time (PSADT) is a surrogate endpoint for time to clinical metastases and overall survival

Patients are followed up to 15 years post-randomization.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria
  1. Histologic documentation - Histologic documentation of prostatic adenocarcinoma.

    Patients with small cell, neuroendocrine, or transitional cell carcinomas are not eligible.

    All eligible patients must have a known Gleason sum based on biopsy or TURP at the time of registration.

  2. Clinically localized disease - Patients must have clinical stage T1-T3a and no radiographic evidence of metastatic disease as demonstrated by:

    • EITHER CT or MRI of the abdomen and pelvis, OR endorectal MRI of the pelvis that demonstrate no nodes > 1.5 cm. If one or more pelvic lymph node(s) measures > 1.5 cm, a negative biopsy is required. If more than one lymph node is > 1.5 cm, the largest or most accessible node should be biopsied.

    AND

    • Negative bone scan (with plain films and/or MRI and/or CT scan confirmation, if necessary). Positive PET and Prostascint scans are not considered proof of metastatic disease.
  3. Determination of high-risk status: Patients must have either:

    • A Kattan nomogram predicted probability of being free from biochemical progression at 5 years after surgery of < 60%.

    OR

    • Prostate biopsy Gleason sum ≥ 8 (NOTE: The Kattan nomogram probability must be calculated for all patients, including those eligible based on Gleason sum ≥ 8 only.)
  4. Prior treatment - No prior treatment for prostate cancer including prior surgery (excluding TURP), pelvic lymph node dissection, radiation therapy, or chemotherapy.

    Patients may have received up to 4 months of androgen deprivation therapy (LHRH agonists, antiandrogens, or both) prior to being enrolled on the study.

  5. Appropriate surgical candidates - Patients must be appropriate candidates for radical prostatectomy with an estimated life expectancy > 10 years as determined by a urologist. Evidence of underlying cardiac disease should be evaluated prior to enrollment to ensure that patients are not at high risk of cardiac complications.
  6. Clotting history - Patients with a history of deep venous thrombosis, pulmonary embolism, and/or cerebrovascular accident or currently requiring systemic anticoagulation are eligible provided they are determined to be candidates for radical prostatectomy.
  7. ECOG performance status: 0-2
  8. Age: ≥ 18 years of age
  9. Required Initial Laboratory Values:

    • ANC ≥ 1500/μL
    • Platelet count ≥ 150,000/μL
    • Creatinine ≤ 2.0 mg/dL
    • Pre-registration serum PSA level ≤ 100 ng/mL
    • Bilirubin ≤ 1.5XULN (2.5XULN in patients with Gilbert's disease)
    • AST/ALT ≤1.5XULN
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00430183

Contacts
Contact: James Eastham, MD 646 422-4390

  Hide Study Locations
Locations
United States, Alaska
Providence Cancer Center Recruiting
Anchorage, Alaska, United States, 99508
Contact: Clinical Trials Office - Providence Cancer Center    907-261-3109      
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Recruiting
Fairbanks, Alaska, United States, 99701
Contact: Craig R. Nichols, MD    503-494-6346      
United States, California
Alta Bates Summit Comprehensive Cancer Center Recruiting
Berkeley, California, United States, 94704
Contact: Ari David Baron, MD    415-923-3012      
Peninsula Medical Center Recruiting
Burlingame, California, United States, 94010
Contact: Ari D. Baron    415-696-5400      
USC/Norris Comprehensive Cancer Center and Hospital Recruiting
Los Angeles, California, United States, 90089-9181
Contact: Clinical Trials Office - USC/Norris Comprehensive Cancer Cente    323-865-0451      
Sutter Health - Western Division Cancer Research Group Recruiting
Novato, California, United States, 94945
Contact: Ari D. Baron    415-600-6548      
University of California Davis Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: Clinical Trials Office - University of California Davis Cancer    916-734-3089      
Naval Medical Center - San Diego Recruiting
San Diego, California, United States, 92134
Contact: Preston S. Gable, MD, FACP    619-532-7319      
California Pacific Medical Center - Pacific Campus Recruiting
San Francisco, California, United States, 94118
Contact: Ari David Baron, MD    415-923-3012      
Sutter Pacific Medical Foundation Recruiting
Santa Rosa, California, United States, 95403
Contact: Ari D. Baron    415-209-1835      
Tahoe Forest Cancer Center Recruiting
Truckee, California, United States, 96161
Contact: Primo N. Lara, MD    916-734-3771      
Sutter Solano Medical Center Recruiting
Vallejo, California, United States, 94589
Contact: Ari D. Baron    707-554-4444      
United States, Colorado
University of Colorado Cancer Center at UC Health Sciences Center Recruiting
Aurora, Colorado, United States, 80045
Contact: Clinical Trials Office - University of Colorado Cancer Center    720-848-0650      
Denver Health Medical Center Recruiting
Denver, Colorado, United States, 80204
Contact: Paul D. Maroni    303-436-6000      
Veterans Affairs Medical Center - Denver Recruiting
Denver, Colorado, United States, 80220
Contact: Paul D. Maroni    303-399-8020      
Shaw Regional Cancer Center Recruiting
Edwards, Colorado, United States, 81632
Contact: Paul D. Maroni    970-569-7429      
Valley View Hospital Cancer Center Recruiting
Glenwood Springs, Colorado, United States, 81601
Contact: Paul D. Maroni    970-945-6535      
Montrose Memorial Hospital Cancer Center Recruiting
Montrose, Colorado, United States, 81401
Contact: Clinical Trials Office - Montrose Memorial Hospital Cancer Cen    670-240-7267      
United States, Connecticut
Helen and Harry Gray Cancer Center at Hartford Hospital Recruiting
Hartford, Connecticut, United States, 06102-5037
Contact: Clinical Trials Office - Helen and Harry Gray Cancer Center    860-545-5363      
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Philip J. Stella, MD    734-712-1000      
Yale Cancer Center Recruiting
New Haven, Connecticut, United States, 06520-8028
Contact: Clinical Trials Office - Yale Cancer Center    203-785-5702      
Eastern Connecticut Hematology and Oncology Associates Recruiting
Norwich, Connecticut, United States, 06360
Contact: Dennis E. Slater, MD    860-886-8362      
Veterans Affairs Medical Center - West Haven Recruiting
West Haven, Connecticut, United States, 06516
Contact: Charles N. Walker    203-937-3421      
United States, Delaware
Tunnell Cancer Center at Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Clinical Trials Office - Tunnell Cancer Center    302-645-3171      
CCOP - Christiana Care Health Services Recruiting
Newark, Delaware, United States, 19713
Contact: Clinical Trial Office - CCOP - Christiana Care Health Services    302-623-4450      
United States, Florida
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Recruiting
Fort Lauderdale, Florida, United States, 33308
Contact: Clinical Trials Office - Michael and Dianne Bienes Comprehensi    954-776-3239      
Ella Milbank Foshay Cancer Center at Jupiter Medical Center Recruiting
Jupiter, Florida, United States, 33458
Contact: Clinical Trials Office - Ella Milbank Foshay Cancer Center    561-745-5768      
CCOP - Mount Sinai Medical Center Recruiting
Miami Beach, Florida, United States, 33140
Contact: Michael Schwartz, MD    305-535-3310      
Florida Hospital Cancer Institute at Florida Hospital Orlando Recruiting
Orlando, Florida, United States, 32803-1273
Contact: Clinical Trials Office - Florida Hospital Cancer Institute    407-303-5623      
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida Recruiting
Tampa, Florida, United States, 33612-9497
Contact: Clinical Trials Office - H. Lee Moffitt Cancer Center and Rese    800-456-7121    canceranswers@moffitt.org   
Cleveland Clinic Florida - Weston Recruiting
Weston, Florida, United States, 33331
Contact: Clinical Trials Office - Cleveland Clinic Florida - Weston    954-659-5705      
United States, Hawaii
Kapiolani Medical Center at Pali Momi Recruiting
Aiea, Hawaii, United States, 96701
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
Hawaii Medical Center - East Recruiting
Honolulu, Hawaii, United States, 96817
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
Kapiolani Medical Center for Women and Children Recruiting
Honolulu, Hawaii, United States, 96826
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
OnCare Hawaii, Incorporated - Kuakini Recruiting
Honolulu, Hawaii, United States, 96817
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
OnCare Hawaii, Incorporated - Lusitana Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
Queen's Cancer Institute at Queen's Medical Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
Straub Clinic and Hospital, Incorporated Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
Castle Medical Center Recruiting
Kailua, Hawaii, United States, 96734
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
Kauai Medical Clinic Recruiting
Lihue, Hawaii, United States, 96766
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
Maui Memorial Medical Center Recruiting
Wailuku, Hawaii, United States, 96793
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
Pacific Cancer Institute - Maui Recruiting
Wailuku, Hawaii, United States, 96793
Contact: Jeffrey L. Berenberg, MD    808-433-4089      
United States, Idaho
Idaho Urologic Institute, PA Recruiting
Meridian, Idaho, United States, 83642
Contact: Philip J. Stella, MD    734-712-1000      
United States, Illinois
Louis A. Weiss Memorial Hospital Recruiting
Chicago, Illinois, United States, 60640
Contact: Clinical Trials Office - Louis A. Weiss Memorial Hospital    773-564-5044      
University of Chicago Cancer Research Center Recruiting
Chicago, Illinois, United States, 60637-1470
Contact: Clinical Trials Office - University of Chicago Cancer Research    773-834-7424      
Decatur Memorial Hospital Cancer Care Institute Recruiting
Decatur, Illinois, United States, 62526
Contact: Clinical Trials Office - Decatur Memorial Hospital Cancer Care    217-876-4750      
Delnor Hospital - Geneva Recruiting
Geneva, Illinois, United States, 60134
Contact: Christopher M. George, MD    630-232-0610      
Veterans Affairs Medical Center - Hines Recruiting
Hines, Illinois, United States, 60141
Contact: Nirmala Bhoopalam, MD    708-202-2782      
Cardinal Bernardin Cancer Center at Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Clinical Trials Office - Cardinal Bernardin Cancer Center    708-226-4357      
Regional Cancer Center at Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: Clinical Trials Office - Regional Cancer Center at Memorial Me    217-788-4233      
Central Dupage Cancer Center Recruiting
Warrenville, Illinois, United States, 60555
Contact: Michael Kahn    630-933-1600      
United States, Indiana
Michiana Hematology-Oncology, PC - Elkhart Recruiting
Elkhart, Indiana, United States, 46514
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Elkhart General Hospital Recruiting
Elkhart, Indiana, United States, 46515
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Elkhart Clinic, LLC Recruiting
Elkhart, Indiana, United States, 46514-2098
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Howard Community Hospital Recruiting
Kokomo, Indiana, United States, 46904
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Center for Cancer Therapy at LaPorte Hospital and Health Services Recruiting
La Porte, Indiana, United States, 46350
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Michiana Hematology-Oncology, PC - South Bend Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Saint Joseph Regional Medical Center Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Michiana Hematology Oncology PC - Plymouth Recruiting
Plymouth, Indiana, United States, 46563
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Clinical Trials Office - Memorial Hospital of South Bend    800-284-7370      
CCOP - Northern Indiana CR Consortium Recruiting
South Bend, Indiana, United States, 46601
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Michiana Hematology Oncology PC - La Porte Recruiting
Westville, Indiana, United States, 46391
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
United States, Iowa
Hematology Oncology Associates of the Quad Cities Recruiting
Bettendorf, Iowa, United States, 52722
Contact: Shobha R. Chitneni, MD, MBBS    563-355-7733      
Genesis Regional Cancer Center at Genesis Medical Center Recruiting
Davenport, Iowa, United States, 52803
Contact: George Kovach, MD    563-421-1960      
Holden Comprehensive Cancer Center at University of Iowa Recruiting
Iowa City, Iowa, United States, 52242-1002
Contact: Cancer Information Service    800-237-1225      
United States, Kansas
St. Rose Ambulatory and Surgery Center Recruiting
Great Bend, Kansas, United States, 67530
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Hays Medical Center Recruiting
Hays, Kansas, United States, 67601
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Hutchinson Hospital Corporation Recruiting
Hutchinson, Kansas, United States, 67502
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Kansas City Cancer Centers - West Recruiting
Kansas City, Kansas, United States, 66112
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160-7357
Contact: Clinical Trials Office - Kansas Masonic Cancer Research Instit    913-588-4709      
Kansas City Cancer Centers - Southwest Recruiting
Overland Park, Kansas, United States, 66210
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Mount Carmel Regional Cancer Center Recruiting
Pittsburg, Kansas, United States, 66762
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Tammy Walker Cancer Center at Salina Regional Health Center Recruiting
Salina, Kansas, United States, 67401
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Kansas City Cancer Center - Shawnee Mission Recruiting
Shawnee Mission, Kansas, United States, 66204
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
St. Francis Comprehensive Cancer Center Recruiting
Topeka, Kansas, United States, 66606
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
United States, Louisiana
Mary Bird Perkins Cancer Center - Baton Rouge Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert W. Veith    225-767-0847      
Pennington Cancer Center at Baton Rouge General Recruiting
Baton Rouge, Louisiana, United States, 70806
Contact: Clinical Trials Office - Pennington Cancer Center at Baton Rou    225-381-6451      
MBCCOP - LSU Health Sciences Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Robert W. Veith    504-568-5151      
Medical Center of Louisiana - New Orleans Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Robert W. Veith    504-903-2311      
United States, Maine
Maine Center for Cancer Medicine and Blood Disorders - Scarborough Recruiting
Scarborough, Maine, United States, 04074
Contact: Frederick R. Aronson, MD    207-885-7600      
United States, Maryland
Union Hospital of Cecil County Recruiting
Elkton MD, Maryland, United States, 21921
Contact: Stephen S. Grubbs, MD    302-366-1200      
Peninsula Regional Medical Center Recruiting
Salisbury, Maryland, United States, 21801
Contact: Clinical Trials Office - Peninsula Regional Medical Center    410-543-7000      
United States, Massachusetts
Tufts Medical Center Cancer Center Recruiting
Boston, Massachusetts, United States, 02111
Contact: Paul Mathew    617-636-6100      
Berkshire Hematology Oncology, PC Recruiting
Pittsfield, Massachusetts, United States, 01201
Contact: Harvey Zimbler, MD    413-496-8205      
United States, Michigan
CCOP - Michigan Cancer Research Consortium Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Philip J. Stella, MD    734-712-1000      
Saint Joseph Mercy Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Philip J. Stella, MD    734-712-1000      
Mecosta County Medical Center Recruiting
Big Rapids, Michigan, United States, 49307
Contact: Gilbert D.A. Padula    231-796-8691      
Oakwood Cancer Center at Oakwood Hospital and Medical Center Recruiting
Dearborn, Michigan, United States, 48123-2500
Contact: Clinical Trials Office - Oakwood Cancer Center at Oakwood Hosp    313-593-8090      
Josephine Ford Cancer Center at Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Robert A. Chapman, MD    313-916-1332      
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Genesys Hurley Cancer Institute    810-762-8057      
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Hurley Medical Center    810-762-8057      
CCOP - Grand Rapids Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D.A. Padula    616-391-1230      
Lacks Cancer Center at Saint Mary's Health Care Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D.A. Padula    616-752-5222      
Van Elslander Cancer Center at St. John Hospital and Medical Center Recruiting
Grosse Pointe Woods, Michigan, United States, 48236
Contact: Clincial Trials Office - Van Elslander Cancer Center at St. Jo    313-343-3166      
Foote Memorial Hospital Recruiting
Jackson, Michigan, United States, 49201
Contact: Philip J. Stella, MD    734-712-1000      
Sparrow Regional Cancer Center Recruiting
Lansing, Michigan, United States, 48912-1811
Contact: Clinical Trials Office - Sparrow Regional Cancer Center    517-364-2890      
St. Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Philip J. Stella, MD    734-712-1000      
Mercy General Health Partners Recruiting
Muskegon, Michigan, United States, 49444
Contact: Gilbert D.A. Padula    231-672-2000      
St. Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Philip J. Stella, MD    734-712-1000      
Mercy Regional Cancer Center at Mercy Hospital Recruiting
Port Huron, Michigan, United States, 48060
Contact: Philip J. Stella, MD    734-712-1000      
Spectrum Health Reed City Hospital Recruiting
Reed City, Michigan, United States, 49677
Contact: Gilbert D.A. Padula    231-832-3271      
Seton Cancer Institute at Saint Mary's - Saginaw Recruiting
Saginaw, Michigan, United States, 48601
Contact: Clinical Trials Office - Seton Cancer Institute - Saginaw    989-776-8411      
Lakeland Regional Cancer Care Center - St. Joseph Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Lakeside Cancer Specialists, PLLC Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Rafat H. Ansari, MD, FACP    574-234-5123      
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Gilbert D.A. Padula    231-935-6202      
St. John Macomb Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Philip J. Stella, MD    734-712-1000      
United States, Minnesota
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Patrick J. Flynn, MD    612-884-6300      
Mercy and Unity Cancer Center at Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Patrick J. Flynn, MD    612-884-6300      
Fairview Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Clinical Trials Office - Fairview Southdale Hospital    612-625-3650      
Mercy and Unity Cancer Center at Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Patrick J. Flynn, MD    612-884-6300      
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Patrick J. Flynn, MD    612-884-6300      
HealthEast Cancer Care at St. John's Hospital Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn, MD    612-884-6300      
Minnesota Oncology - Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn, MD    612-884-6300      
Hennepin County Medical Center - Minneapolis Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Clinical Trials Office - Hennepin County Medical Center - Minn    612-873-5911      
Masonic Cancer Center at University of Minnesota Recruiting
Minneapolis, Minnesota, United States, 55455
Contact: Clinical Trials Office - Masonic Cancer Center at University o    612-624-2620      
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Clinical Trials Office - Virginia Piper Cancer Institute    612-863-5654      
New Ulm Medical Center Recruiting
New Ulm, Minnesota, United States, 56073
Contact: Patrick J. Flynn, MD    612-884-6300      
Humphrey Cancer Center at North Memorial Outpatient Center Recruiting
Robbinsdale, Minnesota, United States, 55422-2900
Contact: Clinical Trials Office - Humphrey Cancer Center at North Memor    763-520-1893      
CentraCare Clinic - River Campus Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    320-252-5131      
Coborn Cancer Center Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    320-229-4907      
CCOP - Metro-Minnesota Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn, MD    612-884-6300      
Park Nicollet Cancer Center Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn, MD    612-884-6300      
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Patrick J. Flynn, MD    612-884-6300      
St. Francis Cancer Center at St. Francis Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Patrick J. Flynn, MD    612-884-6300      
Regions Hospital Cancer Care Center Recruiting
St. Paul, Minnesota, United States, 55101
Contact: Clinical Trials Office - Regions Hospital Cancer Care Center    651-254-1517      
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Patrick J. Flynn, MD    612-884-6300      
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Patrick J. Flynn, MD    612-884-6300      
Willmar Cancer Center at Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Patrick J. Flynn, MD    612-884-6300      
Minnesota Oncology - Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Patrick J. Flynn, MD    612-884-6300      
United States, Mississippi
University of Mississippi Cancer Clinic Recruiting
Jackson, Mississippi, United States, 39216
Contact: Robert D. Hamilton    601-984-5590      
United States, Missouri
Kansas City Cancer Centers - North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Kansas City Cancer Centers - South Recruiting
Kansas City, Missouri, United States, 64131
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Truman Medical Center - Hospital Hill Recruiting
Kansas City, Missouri, United States, 64108
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Veterans Affairs Medical Center - Kansas City Recruiting
Kansas City, Missouri, United States, 64128
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Kansas City Cancer Centers - East Recruiting
Lee's Summit, Missouri, United States, 64064
Contact: Peter J. VanVeldhuizen, MD    816-861-4700 ext 56775      
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Joel Picus, MD    314-362-5737      
United States, Montana
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin Marchello, MD    406-238-6290      
CCOP - Montana Cancer Consortium Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello, MD    406-238-6290      
Hematology-Oncology Centers of the Northern Rockies - Billings Recruiting
Billings, Montana, United States, 59102
Contact: Benjamin T. Marchello, MD    406-238-6290      
St. Vincent Healthcare Cancer Care Services Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello, MD    406-238-6290      
Bozeman Deaconess Cancer Center Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello, MD    406-238-6290      
St. James Healthcare Cancer Care Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin T. Marchello, MD    406-238-6290      
Benefis Healthcare - Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin Marchello, MD    406-238-6290      
Great Falls Clinic - Main Facility Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello, MD    406-238-6290      
St. Peter's Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello, MD    406-238-6290      
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello, MD    406-238-6290      
Montana Cancer Specialists at Montana Cancer Center Recruiting
Missoula, Montana, United States, 59807-7877
Contact: Clinical Trials Office - Montana Cancer Specialists at Montana    406-238-6962      
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center Recruiting
Missoula, Montana, United States, 59807
Contact: Clinical Trials Office - Montana Cancer Center at St. Patrick    406-329-7029      
United States, Nebraska
CCOP - Missouri Valley Cancer Consortium Recruiting
Omaha, Nebraska, United States, 68106
Contact: Gamini S. Soori, MD, FACP, FRCP, MBA    402-393-3110      
Creighton University Medical Center Recruiting
Omaha, Nebraska, United States, 68131-2197
Contact: Clinical Trials Office - Creighton University Medical Center    402-280-4100      
Immanuel Medical Center Recruiting
Omaha, Nebraska, United States, 68122
Contact: Gamini S. Soori, MD, FACP, FRCP, MBA    402-393-3110      
Lakeside Hospital Recruiting
Omaha, Nebraska, United States, 68130
Contact: Gamini S. Soori, MD, FACP, FRCP, MBA    402-393-3110      
Methodist Estabrook Cancer Center Recruiting
Omaha, Nebraska, United States, 68114
Contact: Robert M. Langdon, MD    402-399-8762      
United States, Nevada
University Medical Center of Southern Nevada Recruiting
Las Vegas, Nevada, United States, 89102
Contact: John A. Ellerton, MD, CM    702-384-0013      
CCOP - Nevada Cancer Research Foundation Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton, MD, CM    702-384-0013      
United States, New Hampshire
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care Recruiting
Concord, New Hampshire, United States, 03301
Contact: Frederick M. Briccetti, MD    603-224-2556      
New Hampshire Oncology - Hematology, PA - Hooksett Recruiting
Hooksett, New Hampshire, United States, 03106
Contact: Frederick M. Briccetti, MD    603-224-2556      
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756-0002
Contact: Clinical Trials Office - Norris Cotton Cancer Center    603-650-7609    cancerhelp@dartmouth.edu   
United States, New Jersey
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton Recruiting
Marlton, New Jersey, United States, 08053
Contact: Clinical Trials Office - Fox Chase Virtua Health Cancer Progra    888-847-8823      
Carol G. Simon Cancer Center at Morristown Memorial Hospital Recruiting
Morristown, New Jersey, United States, 07960
Contact: Steven W. Papish, MD    973-538-5210      
Somerset Medical Center Recruiting
Somerville, New Jersey, United States, 08876
Contact: Clinical Trials Office - Somerset Medical Center    908-685-2481      
Frederick R. and Betty M. Smith Cancer Treatment Center Recruiting
Sparta, New Jersey, United States, 07871
Contact: Edouard J. Trabulsi    973-726-4180      
Overlook Hospital Recruiting
Summit, New Jersey, United States, 07901
Contact: Steven W. Papish, MD    973-538-5210      
Fox Chase Virtua Health Cancer Program at Virtua West Jersey Recruiting
Voorhees, New Jersey, United States, 08043
Contact: Michael S. Entmacher, MD    609-702-1900      
United States, New Mexico
Hematology Oncology Associates, PC Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Richard C. Lauer    505-938-5858      
Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital Recruiting
Albuquerque, New Mexico, United States, 87110
Contact: Richard C. Lauer    505-291-2462      
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87131-5636
Contact: Clinical Trials Office - University of New Mexico Cancer Cente    505-272-6972      
United States, New York
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263-0001
Contact: Clinical Trials Office - Roswell Park Cancer Institute    877-275-7724      
New York Weill Cornell Cancer Center at Cornell University Recruiting
New York, New York, United States, 10021
Contact: Clinical Trials Office - New York Weill Cornell Cancer Center    212-746-1848      
James P. Wilmot Cancer Center at University of Rochester Medical Center Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5345      
SUNY Upstate Medical University Hospital Recruiting
Syracuse, New York, United States, 13210
Contact: Clinical Trials Office    315-464-5476      
Veterans Affairs Medical Center - Syracuse Recruiting
Syracuse, New York, United States, 13210
Contact: Ajeet Gajra, MD    315-425-4666      
United States, North Carolina
Presbyterian Cancer Center at Presbyterian Hospital Recruiting
Charlotte, North Carolina, United States, 28233-3549
Contact: Clinical Trials Office - Presbyterian Cancer Center at Presbyt    704-384-5369      
Duke Cancer Institute Recruiting
Durham, North Carolina, United States, 27710
Contact: Clinical Trials Office - Duke Cancer Institute    888-275-3853      
Wayne Memorial Hospital, Incorporated Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins, MD    919-580-0000      
Kinston Medical Specialists Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson, MD    252-559-2200 ext 201      
Carolinas Medical Center - Union Recruiting
Monroe, North Carolina, United States, 28112
Contact: John F. Mahoney, MD    704-446-9046      
Rutherford Hospital Recruiting
Rutherfordton, North Carolina, United States, 28139
Contact: Charles E. Bowers    828-286-5000      
Cleveland Regional Medical Center Recruiting
Shelby, North Carolina, United States, 28150
Contact: John F. Mahoney, MD    704-446-9046      
Iredell Memorial Hospital Recruiting
Statesville, North Carolina, United States, 28677
Contact: Ruby A. Grimm, MD    704-873-2219      
Forsyth Regional Cancer Center at Forsyth Medical Center Recruiting
Winston-Salem, North Carolina, United States, 27103
Contact: Clinical Trials Office - Forsyth Regional Cancer Center at For    336-277-8887      
Wake Forest University Comprehensive Cancer Center Recruiting
Winston-Salem, North Carolina, United States, 27157-1096
Contact: Clinical Trials Office - Wake Forest University Comprehensive    336-713-6771      
United States, Ohio
Ohio State University Medical Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Paul Monk, MD    614-366-1525      
St. Rita's Medical Center Recruiting
Lima, Ohio, United States, 45801
Contact: Clinical Trials Office - St. Rita's Medical Center    419-226-9617      
United States, Oklahoma
Oklahoma University Cancer Institute Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Carla Kurkjian    405-271-6822      
United States, Oregon
Bay Area Hospital Recruiting
Coos Bay, Oregon, United States, 97420
Contact: Bret A. Cook, MD    541-267-5151      
Kaiser Permanente Health Care - Portland Recruiting
Portland, Oregon, United States, 97227
Contact: Nagendra Tirumali, MD    503-331-6500      
United States, Pennsylvania
Mercy Fitzgerald Hospital Recruiting
Darby, Pennsylvania, United States, 19023
Contact: Clinical Trials Office - Mercy Fitzgerald Hospital    610-237-4982      
Fox Chase Cancer Center - Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19111-2497
Contact: Clinical Trials Office - Fox Chase Cancer Center - Philadelphi    215-728-4790      
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19107-5541
Contact: Clinical Trials Office - Kimmel Cancer Center at Thomas Jeffer    215-955-6084      
United States, South Carolina
AnMed Health Cancer Center Recruiting
Anderson, South Carolina, United States, 29621
Contact: Charles Bowers, MD    864-560-6812      
Roper St. Francis Cancer Center at Roper Hospital Recruiting
Charleston, South Carolina, United States, 29401
Contact: James M. Orcutt, MD    843-577-2276      
CCOP - Greenville Recruiting
Greenville, South Carolina, United States, 29615
Contact: Jeffrey K. Giguere, MD, FACP    864-987-7000      
CCOP - Upstate Carolina Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: Clinical Trials Office - CCOP - Upstate Carolina    800-486-5941      
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: Clinical Trials Office - Gibbs Regional Cancer Center    800-486-5941      
United States, Tennessee
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center Recruiting
Kingsport, Tennessee, United States, 37662
Contact: Clinical Trials Office - Christine LaGuardia Phillips Cancer C    423-224-5593      
MBCCOP - Meharry Medical College - Nashville Recruiting
Nashville, Tennessee, United States, 37208-3599
Contact: Steven N. Wolff, MD    615-327-6277      
United States, Vermont
Mountainview Medical Recruiting
Berlin, Vermont, United States, 05602
Contact: Steven Ades    802-223-6196      
Fletcher Allen Health Care - University Health Center Campus Recruiting
Burlington, Vermont, United States, 05401
Contact: Clinical Trials Office - Fletcher Allen Health Care    802-656-8990      
United States, Virginia
Lynchburg Hematology-Oncology Clinic Recruiting
Lynchburg, Virginia, United States, 24501
Contact: John Leach MacNeill, MD    434-947-5925      
Southwest Virginia Regional Cancer Center at Wellmonth Health Recruiting
Norton, Virginia, United States, 24273
Contact: Asheesh Shipstone    540-679-5874      
United States, Washington
Providence Centralia Hospital Recruiting
Centralia, Washington, United States, 98531-9027
Contact: Clinical Trials Office - Providence Centralia H    360-493-4300      
St. Francis Hospital Recruiting
Federal Way, Washington, United States, 98003
Contact: Yoshio Inoue    253-944-7997      
Seattle Cancer Care Alliance at EvergreenHealth Recruiting
Kirkland, Washington, United States, 98034
Contact: Craig R. Nichols, MD    503-494-6346      
Cascade Cancer Center at Evergreen Hospital Medical Center Recruiting
Kirkland, Washington, United States, 98033
Contact: Craig R. Nichols, MD    503-494-6346      
Providence St. Peter Hospital Regional Cancer Center Recruiting
Olympia, Washington, United States, 98506-5166
Contact: Yoshio Inoue    360-493-7514      
Good Samaritan Cancer Center Recruiting
Puyallup, Washington, United States, 98372
Contact: Yoshio Inoue    253-697-4000      
CCOP - Virginia Mason Research Center Recruiting
Seattle, Washington, United States, 98101
Contact: Craig R. Nichols, MD    503-494-6346      
Pacific Medical Center Recruiting
Seattle, Washington, United States, 98104
Contact: Craig R. Nichols, MD    503-494-6346      
Virginia Mason Medical Center Recruiting
Seattle, Washington, United States, 98101
Contact: Craig R. Nichols, MD    503-494-6346      
Rockwood Clinic Cancer Treatment Center Recruiting
Spokane, Washington, United States, 99204-2967
Contact: Clinical Trials Office - Rockwood Clinic Cancer Treatment Cent    509-838-2531 ext 6880      
St. Clare Hospital Recruiting
Tacoma, Washington, United States, 98499
Contact: Yoshio Inoue    253-588-1711      
Franciscan Cancer Center at St. Joseph Medical Center Recruiting
Tacoma, Washington, United States, 98405-3004
Contact: Clinical Trials Office - Franciscan Cancer Center    253-426-6914      
Madigan Army Medical Center - Tacoma Recruiting
Tacoma, Washington, United States, 98431
Contact: Anthony J. Fadell    206-968-1110      
MultiCare Regional Cancer Center at Tacoma General Hospital Recruiting
Tacoma, Washington, United States, 98405
Contact: Clinical Trials Office - MultiCare Regional Cancer Center    253-403-3229      
CCOP - Northwest Recruiting
Tacoma, Washington, United States, 98405
Contact: Yoshio Inoue    253-403-1461      
United States, West Virginia
West Virginia University Health Sciences Center - Charleston Recruiting
Charleston, West Virginia, United States, 25304
Contact: Steven J. Jubelirer, MD    304-388-8380      
Edwards Comprehensive Cancer Center at Cabell Huntington Hospital Recruiting
Huntington, West Virginia, United States, 25701
Contact: Oncology Research Supervisor    304-399-6617      
United States, Wisconsin
Gundersen Lutheran Center for Cancer and Blood Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Clinical Trials Office - Gundersen Lutheran Cancer Center    608-775-2385    cancerctr@gundluth.org   
United States, Wyoming
Rocky Mountain Oncology Recruiting
Casper, Wyoming, United States, 82609
Contact: Benjamin T. Marchello, MD    406-238-6290      
Welch Cancer Center at Sheridan Memorial Hospital Recruiting
Sheridan, Wyoming, United States, 82801
Contact: Benjamin T. Marchello, MD    406-238-6290      
Canada, Alberta
Tom Baker Cancer Centre - Calgary Recruiting
Calgary, Alberta, Canada, T2N 4N2
Contact: Joseph D. Ruether    403-521-3723      
Canada, British Columbia
University of British Columbia Recruiting
Vancouver, British Columbia, Canada, V5Z 3P1
Contact: Martin E. Gleave, MD    604-875-5003      
Canada, Ontario
London Regional Cancer Program at London Health Sciences Centre Recruiting
London, Ontario, Canada, N6A 4L6
Contact: Joseph L. Chin    519-685-8615      
Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Alexandre R. Zlotta    416-946-2811      
Canada, Quebec
Hopital Notre-Dame du CHUM Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Fred Saad, MD, FRCS    514-890-8000ext27466      
Sponsors and Collaborators
Alliance for Clinical Trials in Oncology
Eastern Cooperative Oncology Group
NCIC Clinical Trials Group
Southwest Oncology Group
Investigators
Study Chair: James Eastham, MD Memorial Sloan Kettering Cancer Center
  More Information

Additional Information:
No publications provided

Responsible Party: Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier: NCT00430183     History of Changes
Other Study ID Numbers: CALGB 90203, U10CA031946, CDR0000526353
Study First Received: January 30, 2007
Last Updated: March 13, 2015
Health Authority: United States: Central Institutional Review Board
United States: Food and Drug Administration
Canada: Health Canada

Keywords provided by Alliance for Clinical Trials in Oncology:
stage I prostate cancer
stage IIB prostate cancer
stage IIA prostate cancer
stage III prostate cancer
adenocarcinoma of the prostate

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Diseases, Male
Genital Neoplasms, Male
Neoplasms
Neoplasms by Site
Prostatic Diseases
Urogenital Neoplasms
Docetaxel
Goserelin
Leuprolide
Antimitotic Agents
Antineoplastic Agents
Antineoplastic Agents, Hormonal
Fertility Agents
Fertility Agents, Female
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Reproductive Control Agents
Therapeutic Uses
Tubulin Modulators

ClinicalTrials.gov processed this record on April 26, 2015