Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2016 by Pfizer
Sponsor:
Information provided by (Responsible Party):
Pfizer
ClinicalTrials.gov Identifier:
NCT00413699
First received: December 18, 2006
Last updated: August 9, 2016
Last verified: August 2016
  Purpose

The purpose of this study is to determine the long-term effectiveness and safety of CP-690,550 for the treatment of rheumatoid arthritis. Subjects are eligible for this study only after participating in another "qualifying" study of CP-690,550

A sub-study will be conducted within the A3921024 study, this study will evaluate the immune response to pneumococcal and influenza vaccines in patients receiving CP-690,550


Condition Intervention Phase
Arthritis, Rheumatoid
Drug: CP-690,550
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Long-Term, Open-Label Follow-Up Study Of Tofacitinib (CP-690,550) For Treatment Of Rheumatoid Arthritis

Resource links provided by NLM:


Further study details as provided by Pfizer:

Primary Outcome Measures:
  • Primary endpoints will be standard laboratory safety data (chemistry, hematology, etc.) and adverse event (AE) reports [ Time Frame: Every visit until last observation ] [ Designated as safety issue: Yes ]
  • The long-term safety and tolerability of CP-690,550 5 mg BID and 10 mg BID for the treatment of rheumatoid arthritis [ Time Frame: Every visit until last observation ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Percent of patients with ACR 20, 50, and 70 responses [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • Area under ACR n curve [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • DAS 28 (CRP) and DAS 28 (ESR)as well as incidence of Disease Activity Score <2.6 and <3.2 [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • HAQ DI score [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • SF 36 score [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • FACIT Fatigue Scale, EuroQol EQ 5D, Work Limitations Questionnaire, and RA Healthcare Resource Utilization Questionnaire [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • Preservation of joint structure in patients who had baseline radiographs obtained in their qualifying index study [ Time Frame: Every 6 months until last observation. ] [ Designated as safety issue: No ]
  • Vaccine sub-study endpoints: 1. % achieving a satisfactory humoral response to the pneumococcal vaccine as defined by ≥ 2-fold increase in antibody concentrations [ Time Frame: at vaccine substudy visit 2 and 4 ] [ Designated as safety issue: No ]
  • Vaccine sub-study 2. % achieving a satisfactory humoral response to the seasonal influenza vaccine as defined by ≥ 4-fold increase in antibody titers [ Time Frame: at vaccine substudy visit 2 and 4 ] [ Designated as safety issue: No ]
  • 1. Percentage of subjects achieving protective antibody titers to the seasonal influenza vaccine as measured by a hemagglutination inhibition (HI) assay titer of ≥ 1:40 in ≥ 2 of 3 influenza antigens measured at vaccine sub-study [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 2. Percentage of subjects who respond to each of the 12 pneumococcal antigens as defined by ≥ 2-fold increase in antibody concentrations from vaccine sub-study visit 2 (vaccination baseline) measured at vaccine sub-study visit 4 [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 3. Percentage of subjects who respond to each of the 3 influenza antigens as defined by ≥ 4-fold increase in antibody titers from vaccine sub-study visit 2 (vaccination baseline) measured at vaccine sub-study visit 4 [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 4. Fold increase of anti-pneumococcal antibody levels to each of the 12 pneumococcal antigens above vaccination baseline values (vaccine sub-study visit 2) at vaccine sub-study visit 4 [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 5. Fold increase of anti-influenza antibody levels to each of the 3 influenza antigens above vaccination baseline values (vaccine sub-study visit 2) at vaccine sub-study visit 4 [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 6. Concentrations of anti-pneumococcal antibodies at vaccine sub-study visit 3 and 4 [ Time Frame: at visit 3 and 4 ] [ Designated as safety issue: No ]
  • 7. Titers of anti-influenza antibodies at vaccine sub-study visit 3 and 4 [ Time Frame: at visit 3 and 4 ] [ Designated as safety issue: No ]

Estimated Enrollment: 4500
Study Start Date: February 2007
Estimated Study Completion Date: November 2016
Estimated Primary Completion Date: November 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Open-Label Active Treatment Enrolled from Phase 2
Patients enrolling from Phase 2 studies
Drug: CP-690,550
5 mg PO BID open label; may increase to 10 mg PO BID to provide greater control of RA if no related AEs are present. May be off study drug temporarily for up to 28 days for mild to moderate AEs.
Experimental: Open-Label Active Treatment Enrolled from Phase 3
Patients enrolling from Phase 3 studies
Drug: CP-690,550
10 mg PO BID open label; may decrease to 5 mg PO BID for mild to moderate AEs. May be off study drug temporarily for up to 28 days for mild to moderate AEs.

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Subjects who have participated in a randomized "qualifying" study of CP-690,550 for the treatment of rheumatoid arthritis

Vaccine sub-study visit

  • Subjects actively participating in Study A3921024 must have completed at least 3 months of continuous 10 mg BID CP-690,550 treatment in A3921024 as defined by >80% compliance with prescribed dose consumption of CP-690,550 over the previous 3 months.

Exclusion Criteria:

  • Serious medical conditions that would make treatment with CP-690,550 potentially unsafe

Vaccine sub-study visit

  1. Any documented influenza or pneumococcal infection within the last 3 months prior to randomization in this study
  2. Received any vaccine within 1 month prior to randomization in this study
  3. Received an influenza vaccine within 6 months or a pneumococcal vaccine within 5 years of randomization in this study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00413699

Contacts
Contact: Pfizer CT.gov Call Center 1-800-718-1021

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Active, not recruiting
Birmingham, Alabama, United States, 35294
Rheumatology Associates of North Alabama, PC Recruiting
Huntsville, Alabama, United States, 35801
United States, Arizona
ArthroCare, Arthritis Care & Research P.C. Active, not recruiting
Gilbert, Arizona, United States, 85234
Arizona Arthritis & Rheumatology Associates, P.C. Recruiting
Phoenix, Arizona, United States, 85032
Radiant Research, Inc Active, not recruiting
Scottsdale, Arizona, United States, 85251
Catalina Pointe Clinical Research Active, not recruiting
Tucson, Arizona, United States, 85704
United States, Arkansas
CHI St. Vincent Medical Group Hot Springs Active, not recruiting
Hot Springs, Arkansas, United States, 71913
NEA Baptist Clinic Recruiting
Jonesboro, Arkansas, United States, 72401
Osborne Research Center, LLC Terminated
Little Rock, Arkansas, United States, 72201
Little Rock Diagnostic Clinic, PA Active, not recruiting
Little Rock, Arkansas, United States, 72205
United States, California
Talbert Medical Group Recruiting
Huntington Beach, California, United States, 92646
University of California San Diego Center for Innovative Therapy Active, not recruiting
La Jolla, California, United States, 92093
Keck Medicine of USC Active, not recruiting
Los Angeles, California, United States, 90033
University of Southern California (USC) Norris Comprehensive Cancer Center- Active, not recruiting
Los Angeles, California, United States, 90033
USC Norris Comprehensive Cancer Center Active, not recruiting
Los Angeles, California, United States, 90033
Ronald Reagan UCLA Medical Center, Drug Information Center (Drug Shipment Address, IRB#11-000056) Active, not recruiting
Los Angeles, California, United States, 90095-6984
University of California Los Angeles Active, not recruiting
Los Angeles, California, United States, 90095
Stanford University School of Medicine Active, not recruiting
Palo Alto, California, United States, 94304
Sierra Rheumatology Recruiting
Roseville, California, United States, 95661
San Diego Arthritis Medical Clinic Active, not recruiting
San Diego, California, United States, 92108
Pacific Arthritis Center Medical Group Recruiting
Santa Maria, California, United States, 93454
Stanford Health Services - Medical Specialty Clinics Active, not recruiting
Stanford, California, United States, 94305
Boling Clinical Trails (BCT) Active, not recruiting
Upland, California, United States, 91786
Inland Rheumatology Clinical Trials, Inc. Active, not recruiting
Upland, California, United States, 91786
United States, Colorado
Boulder Medical Center, PC Active, not recruiting
Boulder, Colorado, United States, 80304
Arthritis Associates and Osteoporosis Center of Colorado Springs Active, not recruiting
Colorado Springs, Colorado, United States, 80910
United States, Connecticut
University of Connecticut Health Center Active, not recruiting
Farmington, Connecticut, United States, 06030-5353
Arthritis & Osteoporosis Center, PC Active, not recruiting
Hamden, Connecticut, United States, 06518
New England Research Associates, LLC Recruiting
Trumbull, Connecticut, United States, 06611
United States, Delaware
Delaware Arthritis and Osteoporosis Center Active, not recruiting
Newark, Delaware, United States, 19713
United States, Florida
Arthritis and Rheumatic Disease Specialties Recruiting
Aventura, Florida, United States, 33180
Allergy, Asthma, Arthritis, & Lung Active, not recruiting
Daytona Beach,, Florida, United States, 32114
Physicians Research Alliance LLC Terminated
Debary, Florida, United States, 32713
Southeastern Arthritis Center Active, not recruiting
Gainesville, Florida, United States, 32607
Southeastern Imaging and Diagnostics Active, not recruiting
Gainesville, Florida, United States, 32607
Southeastern Integrated Medical PL d/b/a Florida Medical Research Institute Active, not recruiting
Gainesville, Florida, United States, 32607
Southeastern Integrated Medical, PL, d/b/a Florida Medical Research Institute Active, not recruiting
Gainesville, Florida, United States, 32607
Jacksonville Center for Clinical Research Recruiting
Jacksonville, Florida, United States, 32216
Florida Arthritis Center, P.L. Terminated
Lake Mary, Florida, United States, 32746
BayCare Outpatient Imaging at Bardmoor Recruiting
Largo, Florida, United States, 33777
Center for Arthritis and Rheumatic Diseases Recruiting
Miami, Florida, United States, 33173
Jeffrey Alper MD Research Recruiting
Naples, Florida, United States, 34102
Suncoast Clinical Research, Inc. Recruiting
New Port Richey, Florida, United States, 34652
Ocala Rheumatology Research Center Active, not recruiting
Ocala, Florida, United States, 34474
The Office of Jeffrey E. Poiley, MD Active, not recruiting
Orlando, Florida, United States, 32804
Millennium Research Active, not recruiting
Ormond Beach, Florida, United States, 32174
DMI Research, Inc. Recruiting
Pinellas Park, Florida, United States, 33782
Florida Arthritis & Osteoporosis Center Recruiting
Port Richey, Florida, United States, 34668
Gulf Coast Medical Center Recruiting
Port Richey, Florida, United States, 34668
Miami Research Associates Active, not recruiting
South Miami, Florida, United States, 33143
Suncoast Medical Clinic Recruiting
St. Petersburg, Florida, United States, 33782
West Broward Rheumatology Associates, Inc. Recruiting
Tamarac, Florida, United States, 33321
Burnette & Silverfield, MDS, PLC Active, not recruiting
Tampa, Florida, United States, 33614
Lovelace Scientific Resources Active, not recruiting
Venice, Florida, United States, 34292
Venice Arthritis Center Active, not recruiting
Venice, Florida, United States, 34292
Florida Medical Clinic, P.A. Recruiting
Zephyrhills, Florida, United States, 33542
United States, Georgia
Arthritis and Rheumatology of Georgia Active, not recruiting
Atlanta, Georgia, United States, 30342
Jeffrey D. Lieberman, MD, PC Recruiting
Decatur, Georgia, United States, 30333
Marietta Rheumatology Associates Active, not recruiting
Marietta, Georgia, United States, 30060
United States, Idaho
St. Luke's Clinic - Rhematology Active, not recruiting
Boise, Idaho, United States, 83702
St. Luke's Clinic Active, not recruiting
Boise, Idaho, United States, 83702
Institute of Arthritis Research Recruiting
Idaho Falls, Idaho, United States, 83404
St. Luke's Clinic - Rhematology Active, not recruiting
Meridian, Idaho, United States, 83642
United States, Illinois
Loyola University Medical Center Active, not recruiting
Maywood, Illinois, United States, 60153
Illinois Bone and Joint Institute, LLC Active, not recruiting
Morton Grove, Illinois, United States, 60053
Rockford Health Physicians Active, not recruiting
Rockford, Illinois, United States, 61103-3692
Rockford Orthopedic Associates Active, not recruiting
Rockford, Illinois, United States, 61114
Springfield Clinic Active, not recruiting
Springfield, Illinois, United States, 62702
Springfield Clinic - Clinical Research Active, not recruiting
Springfield, Illinois, United States, 62703
Deerbrook Medical Associates Recruiting
Vernon Hills, Illinois, United States, 60061
United States, Indiana
Diagnostic Rheumatology And Research PC Recruiting
Indianapolis, Indiana, United States, 46227
United States, Iowa
Physician's Clinic of Iowa, P.C. Active, not recruiting
Cedar Rapids, Iowa, United States, 52403
Medical Associates Clinic, PC Active, not recruiting
Dubuque, Iowa, United States, 52002
United States, Kansas
Kansas City Internal Medicine Active, not recruiting
Overland Park, Kansas, United States, 66209
Professional Research Network of Kansas, LLC Active, not recruiting
Wichita, Kansas, United States, 67203
Via Christi Clinic, P.A. Active, not recruiting
Wichita, Kansas, United States, 67208
United States, Kentucky
Bluegrass Community Research, Inc. Active, not recruiting
Lexington, Kentucky, United States, 40504
United States, Louisiana
Ochsner Clinic Foundation - Baton Rouge Active, not recruiting
Baton Rouge, Louisiana, United States, 70809
Louisiana State University Health Sciences Center Active, not recruiting
New Orleans, Louisiana, United States, 70115
United States, Maine
Rheumatology Associates Active, not recruiting
Portland, Maine, United States, 04102
United States, Maryland
Klein and Associates, MD, PA Recruiting
Cumberland, Maryland, United States, 21502
Arthritis & Osteoporosis Center of Maryland Active, not recruiting
Frederick, Maryland, United States, 21702
The Center for Rheumatology and Bone Research Active, not recruiting
West Wheaton, Maryland, United States, 20902
Center for Rheumatology & Bone Research Active, not recruiting
Wheaton, Maryland, United States, 20902-1905
Center for Rheumatology and Bone Research Active, not recruiting
Wheaton, Maryland, United States, 20902
The Center for Rheumatology and Bone Research Active, not recruiting
Wheaton, Maryland, United States, 20902
United States, Massachusetts
Clinical Research Center of Cape Cod, Inc. Active, not recruiting
Hyannis, Massachusetts, United States, 02601
Reliant Medical Group, Inc. Recruiting
Worcester, Massachusetts, United States, 01605
Reliant Medical Group at Worcester Medical Center Recruiting
Worcester, Massachusetts, United States, 01608
Reliant Medical Group, Inc. at Worcester Medical Center Recruiting
Worcester, Massachusetts, United States, 01608
Clinical Pharmacology Study Group Active, not recruiting
Worchester, Massachusetts, United States, 01605
United States, Michigan
Bronson Internal Medicine and Rheumatology Recruiting
Battle Creek, Michigan, United States, 49015
QUEST Research Institiute Active, not recruiting
Bingham Farms, Michigan, United States, 48025
Borgess Research Institute Active, not recruiting
Kalamazoo, Michigan, United States, 49048
Farrnbrook Radiology Associates Active, not recruiting
Southfield, Michigan, United States, 48034
United States, Minnesota
Arthritis and Rheumatology Consultants, P.A. Recruiting
Edina, Minnesota, United States, 55435
United States, Mississippi
North Mississippi Medical Clinics, Inc. Recruiting
Tupelo, Mississippi, United States, 38801
United States, Missouri
University Physicians - Woodrail Clinic Recruiting
Columbia, Missouri, United States, 65203
University Of Missouri-Columbia Recruiting
Columbia, Missouri, United States, 65212
United States, Nebraska
Physician Research Collaboration, LLC Recruiting
Lincoln, Nebraska, United States, 68516
Westroads Clinical Research, Inc. Recruiting
Omaha, Nebraska, United States, 68114
Heartland Clinic Research, Inc. Active, not recruiting
Omaha, Nebraska, United States, 68134
United States, New Hampshire
Dartmouth-Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
United States, New Jersey
Rheumatology Associates of North Jersey Recruiting
Teaneck, New Jersey, United States, 07666
Arthritis, Rheumatic & Back Disease Associates Active, not recruiting
Voorhees, New Jersey, United States, 08043
United States, New York
The Center for Rheumatology, LLP Active, not recruiting
Albany, New York, United States, 12203
Regional Rheumatology Associates Active, not recruiting
Binghamton, New York, United States, 13905
Southern Tier Arthritis and Rheumatism Recruiting
Olean, New York, United States, 14760
Buffalo Rheumatology and Medicine, PLLC Active, not recruiting
Orchard Park, New York, United States, 14127
AAIR Research Center Recruiting
Rochester, New York, United States, 14618
United States, North Carolina
Asheville Rheumatology & Osteoporosis Research Associates, P.A. Active, not recruiting
Asheville, North Carolina, United States, 28801
Asheville Rheumatology & Osteoporosis Research Associates, PA Active, not recruiting
Asheville, North Carolina, United States, 28803
DJL Clinical Research, PLLC Active, not recruiting
Charlotte, North Carolina, United States, 28210
PMG Research of Hickory Active, not recruiting
Hickory,, North Carolina, United States, USA 28602
PMG Research Hickory, LLC Active, not recruiting
Hickory, North Carolina, United States, 28602
Boice-Willis Clinic Active, not recruiting
Rocky Mount, North Carolina, United States, 27804
United States, North Dakota
Trinity Health Center - Medical Arts Active, not recruiting
Minot, North Dakota, United States, 58701
United States, Ohio
Cincinnati Rheumatic Disease Study Group, Inc. Recruiting
Cincinnati, Ohio, United States, 45219
STAT Research, Inc. Active, not recruiting
Dayton, Ohio, United States, 45417
Office of David R. Mandel, MD, Inc. Active, not recruiting
Mayfield Village, Ohio, United States, 44143
United States, Oklahoma
Oklahoma Medical Research Foundation (OMRF) Recruiting
Oklahoma City, Oklahoma, United States, 73104
Lynn Health Science Institute Recruiting
Oklahoma City, Oklahoma, United States, 73112
United States, Pennsylvania
East Penn Rheumatology Associates, PC Recruiting
Bethlehem, Pennsylvania, United States, 18015
Altoona Center for Clinical Research Active, not recruiting
Duncansville, Pennsylvania, United States, 16635
Rheumatic Disease Associates, Ltd. Active, not recruiting
Willow Grove, Pennsylvania, United States, 19090
Clinical Research Center of Reading LLP Active, not recruiting
Wyomissing, Pennsylvania, United States, 19610
United States, South Carolina
Piedmont Arthritis Clinic, PA Active, not recruiting
Greenville, South Carolina, United States, 29601
United States, Tennessee
Arthritis Associates, PLLC Recruiting
Hixson, Tennessee, United States, 37343
Arthritis Clinic Recruiting
Jackson, Tennessee, United States, 38305
West Tennessee Research Institute Recruiting
Jackson, Tennessee, United States, 38305
Rheumatology Consultants, PLLC Active, not recruiting
Knoxville, Tennessee, United States, 37909-1907
Vanderbilt University Medical Center Active, not recruiting
Nashville, Tennessee, United States, 37203
United States, Texas
Office of John P. Lavery, MD, PA Active, not recruiting
Allen, Texas, United States, 75013
Austin Rheumatology Research Active, not recruiting
Austin, Texas, United States, 78705
Arthritis Care and Diagnostic Center, P.A. Recruiting
Dallas, Texas, United States, 75231
Baylor Research Institute Active, not recruiting
Dallas, Texas, United States, 75231
Metroplex Clinical Research Center Active, not recruiting
Dallas, Texas, United States, 75231
University of North Texas Health Science Center at Fort Worth Active, not recruiting
Fort Worth, Texas, United States, 76107
Accurate Clinical Research, Inc. Recruiting
Houston, Texas, United States, 77034
Houston Institute for Clinical Research Active, not recruiting
Houston, Texas, United States, 77074
Arthritis and Osteoporosis Associates, LLP Recruiting
Lubbock, Texas, United States, 79424
Southwest Rheumatology Research LLC Active, not recruiting
Mesquite, Texas, United States, 75150
Southwest Rheumatology Research, LLC Active, not recruiting
Mesquite, Texas, United States, 75150
United States, Washington
Virginia Mason Medical Center Terminated
Seattle,, Washington, United States, 98101
Swedish Medical Center Investigational Drug Service Active, not recruiting
Seattle,, Washington, United States, 98122
Virginia Mason Medical Center Terminated
Seattle, Washington, United States, 98101
Seattle Rheumatology Associates Active, not recruiting
Seattle, Washington, United States, 98122
Swedish Medical Center Active, not recruiting
Seattle, Washington, United States, 98122
The Seattle Arthritis Clinic Recruiting
Seattle, Washington, United States, 98133
Tacoma Center of Arthritis Research, PS Active, not recruiting
Tacoma, Washington, United States, 98405
The Vancouver Clinic, Inc. PS Recruiting
Vancouver, Washington, United States, 98664
United States, West Virginia
Mountain State Clinical Research Active, not recruiting
Clarksburg, West Virginia, United States, 26301
United States, Wisconsin
Gundersen Clinic, Ltd Active, not recruiting
Onalaska, Wisconsin, United States, 54601
Gundersen Clinic, Ltd Active, not recruiting
Onalaska, Wisconsin, United States, 54650
Argentina
OMI - Organización Médica de Investigación Active, not recruiting
Buenos Aires, Caba, Argentina, C1015ABO
Centro de Investigaciones Reumatologicas y Osteologicas -CIRO Active, not recruiting
Buenos Aires, Caba, Argentina, C1114AAH
Hospital Sirio Libanes Active, not recruiting
Buenos Aires, Argentina, 1419AHN
Saint Dennis Medical Group S.A. Active, not recruiting
Buenos Aires, Argentina, C1034ACO
Hospital Sirio Libanes Active, not recruiting
Buenos Aires, Argentina, C1419AHN
Consultorios Reumatologicos Pampa Active, not recruiting
Buenos Aires, Argentina, C1428DZF
Australia, New South Wales
Optimus Clinical Research Pty. Ltd. Active, not recruiting
Kogarah, New South Wales, Australia, 2217
Australia, Queensland
Rheumatology Research Active, not recruiting
Cairns, Queensland, Australia, 4870
Rheumatology Research Unit Sunshine Coast Active, not recruiting
Maroochydore, Queensland, Australia, 4558
Australia, South Australia
Queen Elizabeth Hospital, Department of Rheumatology Active, not recruiting
Woodville, South Australia, Australia, 5011
Australia, Victoria
Emeritus Research Active, not recruiting
Malvern East, Victoria, Australia, 3145
Australia, Western Australia
Goatcher Clinical Research Unit Active, not recruiting
Perth, Western Australia, Australia, WA 6000
Australia
Royal North Shore Hospital Active, not recruiting
St Leonards, Australia, NSW2065
Austria
Medizinische Universitaet Wien / AKH Active, not recruiting
Wien, Austria, A-1090
Rheuma-Ordination Favoriten Active, not recruiting
Wien, Austria, A-1100
Sozialmedizinisches Zentrum Sued - Kaiser Franz Josef Spital Active, not recruiting
Wien, Austria, A-1100
Belgium
Universitair Ziekenhuis Gent - Reumatologie Active, not recruiting
Gent, Belgium, 9000
AZ Groeninge Active, not recruiting
Kortrijk, Belgium, 8500
Centre Hospitalier Universitaire de Liège Active, not recruiting
Liège, Belgium, 4020
Bosnia and Herzegovina
University Clinical Center Sarajevo Active, not recruiting
Sarajevo, Bosnia and Herzegovina, 71000
Brazil
CIP - Centro Internacional de Pesquisa Active, not recruiting
Goiania, GO, Brazil, 74110-120
Centro de Estudos em Terapias Inovadoras Active, not recruiting
Curitiba, Paraná, Brazil, 80030-110
Hospital Sao Lucas da PUCRS Active, not recruiting
Porto Alegre, Rio Grande Do Sul, Brazil, 91330-190
CCBR Brasil Centro de Pesquisas e Analises Clinicas Ltda Active, not recruiting
Rio de Janeiro, RJ, Brazil, 22271-100
CCBR Brasil Active, not recruiting
Rio de Janeiro, RJ, Brazil, 22271-100
Hospital de Clinicas de Porto Alegre Active, not recruiting
Porto Alegre, RS, Brazil, 90035-903
Centro de Pesquisa em Oncologia - Hospital Sao Lucas da PUC Rio Grande do Sul Active, not recruiting
Porto Alegre, RS, Brazil, 90610-000
Hospital Sao Lucas da PUCRS Active, not recruiting
Porto Alegre, RS, Brazil, 90610-000
Hospital Alemao Oswaldo Cruz Active, not recruiting
Sao Paulo, SP, Brazil, 01323-903
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP) Active, not recruiting
Sao Paulo, SP, Brazil, 05403-010
IMA Brazil -Instituto de Pesquisa Clinica e Medicina Avancada Active, not recruiting
Sao Paulo, SP, Brazil, 05437-010
CCBR Brasil - Centro de Pesquisas e Analises Clinicas LTDA Active, not recruiting
Rio de Janeiro, Brazil, 22271-100
CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda Active, not recruiting
Sao Paulo, Brazil, 04266-010
Bulgaria
Military Medical Academy (MMA) - Sofia Active, not recruiting
Sofia, Sofiya-grad, Bulgaria, 1606
Revmatologichen kabinet, DKTs Sveti Pantaleimon OOD Active, not recruiting
Pleven, Bulgaria, 5800
Revmatologichno Otdelenie, MBAL - Plovdiv Active, not recruiting
Plovdiv, Bulgaria, 4000
UMHAT Kaspela Plovdiv Active, not recruiting
Plovdiv, Bulgaria, 4002
MBAL Akta Medika OOD Active, not recruiting
Sevlievo, Bulgaria, 5400
Clinic of Rheumatology Multiprofile Hospital for Active treatment Sveti Ivan Rilski Active, not recruiting
Sofia, Bulgaria, 1612
MBAL Sveti Ivan Rilski Sofia, Klinika po Revmatologia Active, not recruiting
Sofia, Bulgaria, 1612
MBAL Sveti Ivan Rilski Sofia Active, not recruiting
Sofia, Bulgaria, 1612
DKTs "Sveta Anna" Sofia, Konsultativen kabinet po Revmatologia Active, not recruiting
Sofia, Bulgaria, 1709
DKTs "Sveta Anna", Sofia / Diagnostic Consultative Center "Sveta Anna" Active, not recruiting
Sofia, Bulgaria, 1709
MOBAL "D-r Stefan Cherkezov" AD, Vtoro otdelenie po vatreshni bolesti-MHAT "Dr. Stefan Cherkezov" AD Active, not recruiting
Veliko Tarnovo, Bulgaria, 5000
MOBAL "D-r Stefan Cherkezov" AD, Active, not recruiting
Veliko Tarnovo, Bulgaria, 5000
Canada, Alberta
Rheumatology Research Associates Ltd. Active, not recruiting
Edmonton, Alberta, Canada, T5M 0H4
Canada, British Columbia
Dr. Alice Klinkhoff, Inc. Active, not recruiting
Vancouver, British Columbia, Canada, V5Z 1L7
Percuro Clinical Research Limited Active, not recruiting
Victoria, British Columbia, Canada, V8V 3P9
Canada, Manitoba
Manitoba Clinic Active, not recruiting
Winnipeg, Manitoba, Canada, R3A 1M3
Canada, Newfoundland and Labrador
Nexus Clinical Research Active, not recruiting
St. John's, Newfoundland and Labrador, Canada, A1A 5E8
Canada, Ontario
Dr. William G. Bensen Medicine Professional Corporation Active, not recruiting
Hamilton, Ontario, Canada, L8N 1Y2
Office of Dr. Fernando Bianchi Active, not recruiting
Hamilton, Ontario, Canada, L8N 1Y2
Cividino Medicine Professional Corporation Active, not recruiting
Hamilton, Ontario, Canada, L8N 2B6
MAC Research Inc. Active, not recruiting
Hamilton, Ontario, Canada, L8N 2B6
KW Musculoskeletal Research Inc. Active, not recruiting
Kitchener, Ontario, Canada, N2M 5N6
St Joseph's Health Centre Active, not recruiting
London, Ontario, Canada, N6A 4V2
Credit Valley Rheumatology Terminated
Missisauga, Ontario, Canada, L5M 2V8
The Arthritis Program Research Group Inc. Active, not recruiting
Newmarket, Ontario, Canada, L3Y 3R7
Rheumatology and Osteoporosis Clinic Active, not recruiting
Oakville, Ontario, Canada, L6M 4J2
Rheumatology Research Associates Active, not recruiting
Ottawa, Ontario, Canada, K1H 1A2
Niagara Peninsula Arthritis Centre Active, not recruiting
St. Catharines, Ontario, Canada, L2N 7E4
Clinical Research and Arthritis Centre Active, not recruiting
Windsor, Ontario, Canada, N8X 5A6
Canada, Quebec
Institut de Rhumatologie de Montreal Active, not recruiting
Montreal, Quebec, Canada, H2L 1S6
West Island Rheumatology Research Associates Active, not recruiting
Pointe Claire, Quebec, Canada, H9R 3J1
Centre de Recherche Musculo-Squelettique Active, not recruiting
Trois-Rivieres, Quebec, Canada, G8Z 1Y2
Canada, Saskatchewan
Arthritis Research Center, Royal University Hospital Active, not recruiting
Saskatoon, Saskatchewan, Canada, S7N 0W8
Canada
Groupe De Recherche En Rhumatologie Et Maladies Osseuses Inc. Active, not recruiting
Quebec, Canada, G1V 3M7
Centre de Recherche Saint-Louis Active, not recruiting
Quebec, Canada, G1W4R4
Chile
Consulta Privada Dra. Lucia Ponce Active, not recruiting
Vina del Mar Temuco, Ix Region, Chile, 4790928
Hospital Base Valdivia, Policlinico de Reumatologia Active, not recruiting
Valdivia, Region Xiv, Chile, 5090145
Centro de Estudios Reumatologicos Active, not recruiting
Santiago, RM, Chile, 7501126
Consulta Privada Dra. Marta Aliste Active, not recruiting
Santiago, RM, Chile, 7510186
Centro de Diagnostico y Tratamiento San Borja Arriaran Active, not recruiting
Santiago, RM, Chile, 8360156
Clinica Santa Maria, Seccion Reumatologia Terminated
Providencia, Santiago, Rm, Chile, 7530206
Hospital Regional de Rancagua Active, not recruiting
Rancagua, Chile, 2841959
Clinica Santa Maria Terminated
Santiago, Chile, 7530206
Estudios Clinicos V Region Active, not recruiting
Vina del Mar, V Region, Chile, 2520997
China, Beijing
Beijing Chaoyang Hospital, Capital University of Medical Science Active, not recruiting
Beijing, Beijing, China, 100020
China, Guangdong
The Second Affiliated Hospital of Guangzhou Medical University Active, not recruiting
Guangzhou, Guangdong, China, 510260
China, Hubei
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Active, not recruiting
Wuhan, Hubei, China, 430030
China, Hunan
Xiangya Hospital of Centre-south University Active, not recruiting
Changsha, Hunan, China, 410008
China, Shaanxi
Xijing Hospital, The Fourth Military Medical University Active, not recruiting
Xi'an, Shaanxi, China, 710032
China, Shandong
QiLu Hospital of Shandong University Active, not recruiting
Jinan, Shandong, China, 250012
Qingdao Municipal Hospital Active, not recruiting
Qingdao, Shandong, China, 266011
China, Shanghai
Shanghai Changzheng Hospital Active, not recruiting
Shanghai, Shanghai, China, 200003
China
Peking University People's Hospital/Rheumatology and Immunology Department Terminated
Beijing, China, 100044
PLA General Hospital Terminated
Beijing, China, 100853
Si Chuan Huaxi Hospital Active, not recruiting
Chengdu, China, 610041
The Third Affiliated Hospital Of Sun Yat-sen University Active, not recruiting
Guangzhou, China, 510630
The Second Affiliated Hospital of Zhejiang University School of Medicine Active, not recruiting
Hangzhou, China, 310009
Anhui Province Hospital Active, not recruiting
Hefei, China, 230001
An Hui Medical University 1st Hospital Active, not recruiting
Hefei, China, 230022
Jiangsu Province Hospital Terminated
Nanjing, China, 210029
Rheumatology and Immunology Dept., Renji Hospital Shanghai Jiao Tong University School of Medicine Active, not recruiting
Shanghai, China, 200001
Shanghai Changhai Hospital Terminated
Shanghai, China, 200433
The First Affiliated Hospital of Soochow University Active, not recruiting
Suzhou, China, 215006
"Department of Infectious Diseases & Immunology Terminated
Tianjin, China, 300052
Colombia
Centro de Reumatologia y Ortopedia S.A.S. Active, not recruiting
Barranquilla, Atlantico, Colombia
Riesgo de Fractura S.A. Active, not recruiting
Bogota, Cundinamarca, Colombia
Servimed S.A.S. Active, not recruiting
Bucaramanga, Santander, Colombia, 680003
Centro Integral de Reumatologia e Inmunologia SAS, CIREI SAS Active, not recruiting
Bogota, Colombia
Costa Rica
Centro de Reumatologia y Osteoporosis, Cartago Active, not recruiting
Cartago, Costa Rica
Hospital Cima San Jose Terminated
San Jose, Costa Rica, 00000
Hospital Cima San Jose Terminated
San Jose, Costa Rica
Oficina Privada Del Colegio deMedicos Terminated
San Jose, Costa Rica
Croatia
University Hospital Center Osijek Active, not recruiting
Osijek, Croatia, 31000
University Hospital Split, Department for Internal Medicine, Division of Clinical Rheumatology Active, not recruiting
Split, Croatia, 21000
Clinical Hospital "Sveti Duh" Active, not recruiting
Zagreb, Croatia, 10 000
University Hospital Center "Zagreb" Active, not recruiting
Zagreb, Croatia, 10000
University Hospital Center Zagreb Active, not recruiting
Zagreb, Croatia, 10000
Czech Republic
X-MEDICA s.r.o. Active, not recruiting
Brno, Czech Republic, 61300
Revmacentrum MUDr. Mostera, s.r.o. Active, not recruiting
Brno, Czech Republic, 615 00
Fakultni Nemocnice Brno, Interni hematoonkologicka klinika Active, not recruiting
Brno, Czech Republic, 625 00
Fakultni nemocnice u sv. Anny v Brne Active, not recruiting
Brno, Czech Republic, 656 91
HESTE s.r.o. Revmatologie Active, not recruiting
Ceska Lipa, Czech Republic, 470 01
MEDIPONT Plus sro Active, not recruiting
Ceske Budejovice, Czech Republic, 370 01
L.K.N. Arthrocentrum, s.r.o. Active, not recruiting
Hlucin, Czech Republic, 748 01
ARTMEDI UPD s r.o Active, not recruiting
Hostivice, Czech Republic, 253 01
Fakultni nemocnice Hradec Kralove Active, not recruiting
Hradec Kralove, Czech Republic, 50005
MephaCentrum, a.s (X-Ray only) Active, not recruiting
Ostrava-Poruba, Czech Republic, 70868
Revmatologicka ambulance Active, not recruiting
Ostrava, Czech Republic, 70800
ARTHROMED, s. r. o. Revmatologicka ambulance Active, not recruiting
Pardubice, Czech Republic, 530 02
Affidea Praha, s.r.o. Active, not recruiting
Praha 11 - Chodov, Czech Republic, 148 00
Revmatologicky ustav Active, not recruiting
Praha 2, Czech Republic, 12850
Revmatologicka ambulance Active, not recruiting
Praha 4, Czech Republic, 140 00
Fakultni Thomayerova nemocnice s poliklinikou Active, not recruiting
Praha 4, Czech Republic, 140 59
Nuselska poliklinika RTG Active, not recruiting
Praha 4, Czech Republic, 14000
Revmatologicka ambulance Active, not recruiting
Praha 4, Czech Republic, 14000
PV-Medical s.r.o. Active, not recruiting
Zlin, Czech Republic, 760 01
Denmark
Frederiksberg Hospital Active, not recruiting
Frederiksberg, Denmark, 2000
Dominican Republic
Patricia Alvarez Site Active, not recruiting
Santo Domingo, Dominican Republic
Finland
Helsingin Reumakeskus Oy Active, not recruiting
Helsinki, Finland, 00120
Kiljavan Laaketutkimus Oy Active, not recruiting
Hyvinkaa, Finland, 05800
TAYS/Reumakeskus/Finn-Medi 1 Terminated
Tampere, Finland, 33520
France
Hopital Nord Active, not recruiting
Amiens, France, 80000
Hôpital Nord Active, not recruiting
Amiens, France, 80000
*CHR Hopital Porte Madeleine IPROS Active, not recruiting
Orleans, France, 45000
CHR ORLEANS - Service IPROS Active, not recruiting
Orleans, France, 45032
Hôpital Saint-Antoine Active, not recruiting
Paris, France, 75012
Hopital Cochin Active, not recruiting
Paris, France, 75014
Germany
Privat-Praxis Active, not recruiting
Aachen, Germany, 52064
Charite Campus Mitte, Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie Active, not recruiting
Berlin, Germany, 10117
Schlosspark-Klinik Innere Medizin II, Rheumatologie Active, not recruiting
Berlin, Germany, 14059
Ambulantes Rheumazentrum Dr Soerensen Active, not recruiting
Berlin, Germany, 14163
Krankenhaus Friedrichstadt, I. Medizinische Klinik Active, not recruiting
Dresden, Germany, 01067
Studienambulanz Universitaetsklinikum Erlangen Medizinische Klinik 3 Active, not recruiting
Erlangen, Germany, 91054
J.W.-Goethe-Universitaetsklinik, Medizinische Klinik II, Abteilung fuer Rheumatologie Active, not recruiting
Frankfurt am Main, Germany, 60590
Fä Innere Medizin/Rheumatologie Active, not recruiting
Halle, Germany, 06108
Schoen Klinik Hamburg-Eilbek Active, not recruiting
Hamburg, Germany, 22081
Rheumazentrum Ruhrgebiet Active, not recruiting
Herne, Germany, 44649
Universitaetsklinikum Koeln Klinik I fuer Innere Medizin, Haus 16, 1. OG, Raum 1.008 Active, not recruiting
Koeln, Germany, 50937
Universitaetsklinik Leipzig, Klinik fur Gastroenterologie und Rheumatologie, Sektion Rheumatologie Active, not recruiting
Leipzig, Germany, 04103
Universitaetsklinikum Leipzig, AoeR Department fuer Innere Medizin, Sektion Rheumatologie / Gerontol Active, not recruiting
Leipzig, Germany, 04103
Klinikum der Universitaet Muenchen, Campus Innenstadt, Rheuma-Einheit Active, not recruiting
Muenchen, Germany, 80336
Arztpraxis, Internist - Rheumatologie Active, not recruiting
Nuernberg, Germany, 90429
Rheumaforschung- Studienambulanz Active, not recruiting
Ratingen, Germany, 40882
Schwerpunktpraxis fuer Rheumatologie Active, not recruiting
Rheine, Germany, 48431
Universitaetsklinikum Wuerzburg Active, not recruiting
Wuerzburg, Germany, 97080
Greece
General Hospital Euromedica "KYANOUS STAVROS" Terminated
Thessaloniki, Greece, 54636
424 General Army Hospital Active, not recruiting
Thessaloniki, Greece, 56429
Hungary
Drug Research Center Kft Active, not recruiting
Balatonfured, Hungary, 8230
Orszagos Reumatologiai es Fizioterapias Intezet Active, not recruiting
Budapest, Hungary, 1023
Revita Reumatologiai Rendelo Active, not recruiting
Budapest, Hungary, 1027
Synexus Magyarorszag Kft. Active, not recruiting
Budapest, Hungary, H-1036
MAV Korhaz es Rendelointezet, Reumatologiai szakrendeles Active, not recruiting
Szolnok, Hungary, 5000
India
Mahavir Hospital & Research Center Active, not recruiting
Hyderabad, Andhra Pradesh, India, 500 004
Rheumatic Diseases Clinic Active, not recruiting
Ahmedabad, Gujarat, India, 380009
Shalby Hospitals Active, not recruiting
Ahmedabad, Gujarat, India, 380015
Chanre Rheumatology and Immunology Center and Research Terminated
Bangalore, Karnataka, India, 560 003
St. John's Medical College Hospital Active, not recruiting
Bangalore, Karnataka, India, 560 034
Shirdi Sai Hospital Active, not recruiting
Bangalore, Karnataka, India, 560 054
Chanre Rheumatology & Immunology Center & Research Terminated
Bangalore, Karnataka, India, 560 079
Arthritis Research and Care Foundation Centre for Rheumatic Diseases Active, not recruiting
Pune, Maharashtra, India, 411 001
Jehangir Clinical Development Centre Pvt. Ltd. Active, not recruiting
Pune, Maharashtra, India, 411001
Krishna Institute of Medical Sciences Ltd Active, not recruiting
Secunderabad, Telangana, India, 500 003
Ireland
St. Vincent's University Hospital Active, not recruiting
Elm Park, Dublin, Ireland
St Vincent's University Hospital Bone And Joint Unit Active, not recruiting
Dublin 4, Ireland
Italy
A.O.U. Careggi - SOD Medicina Interna 1 e Reumatologia Active, not recruiting
Firenze, FI, Italy, 50139
U.O. Clinica Reumatologica Active, not recruiting
Genova, Italy, 16132
Korea, Republic of
Inha University Hospital Active, not recruiting
Jung-gu, Incheon, Korea, Republic of, 22332
Seoul National University Hospital Active, not recruiting
Jongno, Seoul, Korea, Republic of, 03080
Dong-A University Hospital Active, not recruiting
Busan, Korea, Republic of, 602-715
Daegu Catholic University Medical Center Active, not recruiting
Daegu, Korea, Republic of, 42472
Eulji University Hospital Active, not recruiting
Daejeon, Korea, Republic of, 35233
Chonnam National University Hospital Active, not recruiting
Gwangju, Korea, Republic of, 61469
Hanyang University Seoul Hospital Active, not recruiting
Seoul, Korea, Republic of, 04763
Asan Medical Center-University of Ulsan College of Medicine Active, not recruiting
Seoul, Korea, Republic of, 05505
Gangnam Severance Hospital Active, not recruiting
Seoul, Korea, Republic of, 06273
Seoul St. Mary's Hospital-The Catholic University of Korea Active, not recruiting
Seoul, Korea, Republic of, 06591
Yonsei University College of Medicine, Severance Hospital Active, not recruiting
Seoul, Korea, Republic of, 120-752
Konkuk University Medical Center, Department of Rheumatology Active, not recruiting
Seoul, Korea, Republic of, 143-729
Malaysia
Hospital Tuanku Ja'afar Active, not recruiting
Seremban, Negeri Sembilan, Malaysia, 70300
Sunway Medical Centre Active, not recruiting
Bandar Sunway, Petaling Jaya, Selangor, Malaysia, 46150
Queen Elizabeth Hospital Active, not recruiting
Kota Kinabalu, Sabah, Malaysia, 88586
Sarawak General Hospital Active, not recruiting
Kuching, Sarawak, Malaysia, 93586
Hospital Selayang Active, not recruiting
Batu Caves, Selangor, Malaysia, 68100
Subang Jaya Medical Centre Active, not recruiting
Subang Jaya, Selangor, Malaysia, 47500
Hospital Putrajaya Active, not recruiting
Putrajaya, Wilayah Persekutuan, Malaysia, 62250
Mexico
Centro de Investigacion del Noroeste SC Active, not recruiting
Tijuana, Baja California Norte, Mexico, 22010
Unidad de Enfermedades Reumaticas y Cronico Degenerativas SC Active, not recruiting
Torreon, Coahuila, Mexico, 27000
Hospital Angeles del Pedregal Active, not recruiting
Mexico, DF, Mexico, 10700
Centro Medico Toluca Active, not recruiting
Metepec, Estado de Mexico, Mexico, 52140
Centro Integral en Reumatologia, SA de CV Active, not recruiting
Guadalajara, Jalisco, Mexico, 44160
Unidad de Investigacion en Enfermedades Cronico Degenerativas Active, not recruiting
Guadalajara, Jalisco, Mexico, 44620
Centro de Investigacion Clinica Especializada, SC Active, not recruiting
Coyoacan, Mexico D.f., Mexico, 04030
Centro de Investigacion Clinica de Morelia Active, not recruiting
Morelia, Michoacan, Mexico, 58070
Star Medica Centro de Investigacion Clinica de Morelia Active, not recruiting
Morelia, Michoacan, Mexico, 58070
Clinica de Enfermedades Cronicas y de Procedimientos Especiales (CECYPE) Active, not recruiting
Morelia, Michoacan, Mexico, 58249
Clinica de Enfermedades Cronicas y Procedimientos Especiales SC Active, not recruiting
Morelia, Michoacan, Mexico, 58249
Hospital Universitario Doctor Jose Eleuterio Gonzalez Active, not recruiting
Monterrey, Nuevo Leon, Mexico, 64020
Centro Medico de las Americas Active, not recruiting
Merida, Yucatan, Mexico, 97000
Investigacion y Biomedicina de Chihuahua S.C. Active, not recruiting
Chihuahua, Mexico, 31000
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Active, not recruiting
Mexico City, Mexico, 14080
Hospital Angeles Mocel Active, not recruiting
Mexico, D.F., Mexico, 11850
Fundacion El Hospitalito Active, not recruiting
Morelos, Mexico, 62170
Hospital Angeles de Queretaro Active, not recruiting
Queretaro, Mexico, 76178
Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi, S.C. Active, not recruiting
San Luis Potosi, Mexico, 78213
Hospital Central Dr Ignacio Morones Prieto Unidad Regional de Reumatologia y Osteoporosis Active, not recruiting
San Luis Potosi, Mexico, 78240
New Zealand
The Canterbury Geriatric Medical Research Trust, c/- The Princess Margaret Hospital Active, not recruiting
Christchurch, New Zealand, 8022
Waikato Hospital, Rheumatology Active, not recruiting
Hamilton, New Zealand, 3240
Clinical Trials Unit, Timaru Hospital Active, not recruiting
Timaru, New Zealand, 7910
Timaru Rheumatology Studies Active, not recruiting
Timaru, New Zealand, 7910
Peru
Hospital Nacional IV Alberto Sabogal Sologuren Active, not recruiting
Callao, Peru, C-02
Centro Medico Corpac/Investigaciones en Reumatologia Active, not recruiting
Lima, Peru, L-27
Instituto Peruano del Hueso y la Articulacion SAC-Privado-Lima/Centro de Investigacion IPHAR Active, not recruiting
Lima, Peru, L-27
Philippines
Mary Mediatrix Medical Center Active, not recruiting
Lipa City, Batangas, Philippines, 4217
De La Salle University Health Sciences Campus Clinical Epidemiology Unit Active, not recruiting
Dasmarinas, Cavite, Philippines, 4114
Angeles University Foundation Medical Center Active, not recruiting
Angeles City, Pampanga, Philippines, 2009
Chong Hua Hospital Terminated
Cebu City, Philippines, 6000
Southern Philippine Medical Center Active, not recruiting
Davao City, Philippines, 8000
University of Perpetual Help Rizal Dalta Medical Center Active, not recruiting
Las Piñas City, Philippines, 1742
University of Santo Tomas Hospital Active, not recruiting
Manila, Philippines, 1008
Poland
"ZDROWIE OSTEO-MEDIC" s.c. Lidia I Artur Racewicz, Agnieszka I Jerzy Supronik Active, not recruiting
Bialystok, Poland, 15-351
NZOZ "OSTEO-MEDIC" s.c. Artur Racewicz, Jerzy Supronik Active, not recruiting
Bialystok, Poland, 15-354
ClinicMed Badurski i wspolnicy Spolka Jawna Active, not recruiting
Bialystok, Poland, 15-879
SP ZOZ Wojewodzki Szpital Zespolony im.Jedrzeja Sniadeckiego Active, not recruiting
Bialystok, Poland, 15-950
NSZOZ Medicus II Active, not recruiting
Cieszyn, Poland, 43400
Szpital im. Teodora Dunina Active, not recruiting
Koscian, Poland, 64-000
Krakowskie Centrum Medyczne NZOZ Active, not recruiting
Krakow, Poland, 31-501
Centrum Badan Klinicznych s.c. Wieslawa Porawska, Lukasz Porawski Active, not recruiting
Poznan, Poland, 60-773
Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko Active, not recruiting
Sopot, Poland, 81-759
Nzoz "Nasz Lekarz" Active, not recruiting
Torun, Poland, 87-100
Synexus Polska Sp. z o.o. Oddzial w Warszawie Active, not recruiting
Warszawa, Poland, 01-192
Rheuma-Medicus - Specjalistyczne Centrum Reumatologii i Osteoporozy Active, not recruiting
Warszawa, Poland, 02-118
SYNEXUS Polska Sp. z.o.o. Active, not recruiting
Wroclaw, Poland, 50-088
Puerto Rico
Ponce School of Medicine Active, not recruiting
Ponce, Puerto Rico, 00716
Mindful Medical Research Active, not recruiting
San Juan, Puerto Rico, 00918
Romania
Spitalul Clinic "Sf. Maria" Active, not recruiting
Bucuresti, Romania, 011172
Spitalul de Recuperare Iasi Active, not recruiting
Iasi, Romania, 700661
Russian Federation
City Clinical Hospital # 1 Active, not recruiting
Novosibirsk city, Novosibirsk Region, Russian Federation, 630047
State Healthcare Institution Regional Clinical Hospital Active, not recruiting
Barnaul, Russian Federation, 656024
State Healthcare Institution Active, not recruiting
Ekaterinburg, Russian Federation, 620102
State Educational Institution of Higher Professional Education Active, not recruiting
Ekaterinburg, Russian Federation, 620149
Ltd. Medical Association Novaya Bolnitsa Active, not recruiting
Ekaterinburg, Russian Federation, 620219
State Healthcare Institution Regional Clinical Hospital for War Veterans Active, not recruiting
Kemerovo, Russian Federation, 650099
Russian State Medical University Moscow Faculty City Clinical Hospital #4 Active, not recruiting
Moscow, Russian Federation, 115093
Federal State Budgetary Scientific Institution "Scientific Research Institute of Rheumatology Active, not recruiting
Moscow, Russian Federation, 115522
CDRC "Healthy Joints" Active, not recruiting
Novosibirsk, Russian Federation, 630091
Consultative Diagnostic Rheumatology Center "Healthy Joints" Active, not recruiting
Novosibirsk, Russian Federation, 630091
Limited Liability Company Consultative Diagnostic Rheumatology Center "Healthy Joints" Active, not recruiting
Novosibirsk, Russian Federation, 630099
Republican Hospital n. a. V.A.Baranov Active, not recruiting
Petrozavodsk, Russian Federation, 185019
Federal North-West Medical Research Centre Active, not recruiting
Saint-Petersburg, Russian Federation, 197341
Smolensk State Medical Academy Active, not recruiting
Smolensk, Russian Federation, 214019
Saint-Petersburg State Budgetary Healthcare Institution ¿Clinical Rheumathology Hospital #25¿ Active, not recruiting
St. Petersburg,, Russian Federation, 190068
Clinical Hospital #122 named after L.G. Sokolov of the Federal Medical-Biological Agency Active, not recruiting
St. Petersburg, Russian Federation, 194291
St. Petersburg State Institution of Healthcare Consultative-diagnostic Center #85 Active, not recruiting
St. Petersburg, Russian Federation, 198260
State Healthcare Institution City Hospital # 40 of Administrative Health Active, not recruiting
St.Petersburg, Russian Federation, 197706
Siberian State Medical University Active, not recruiting
Tomsk, Russian Federation, 634050
Slovakia
Reumatologicka ambulancia, Poliklinika Ruzinov Active, not recruiting
Bratislava, Slovakia, 82606
NOVAPHARM s.r.o -Zeleznicna NaP, Reumatologicka ambulancia Active, not recruiting
Bratislava, Slovakia, 832 99
AAGS, s.r.o. , nestatne zdravotnicke zariadenie Active, not recruiting
Dunajska Streda, Slovakia, 92901
Interna a reumatologicka ambulancia Active, not recruiting
Kosice, Slovakia, 040 01
Ecclesia, s.r.o Reumatologicka ambulancia Active, not recruiting
Nove Zamky, Slovakia, 94001
Narodny ustav reumatickych chorob Active, not recruiting
Piestany, Slovakia, 921 01
Reumatologicka ambulancia, MUDr. Zuzana Cizmarikova, s.r.o. Active, not recruiting
Poprad, Slovakia, 058 01
Reumatologicka ambulancia, REUMEX, s.r.o. Active, not recruiting
Rimavska Sobota, Slovakia, 979 01
Reumatologicka ambulancia, Nestatne zdravotnicke zariadenie Active, not recruiting
Senica, Slovakia, 905 01
Nestatna reumatologicka ambulancia Active, not recruiting
Zilina, Slovakia, 01001
Spain
Hospital Nuestra Senora de la Esperanza Active, not recruiting
Santiago De Compostela, A Coruna, Spain, 15705
Hospital Clinico Universitario de Santiago Active, not recruiting
Santiago de Compostela, A Coruna, Spain, 15706
Hospital de Merida Active, not recruiting
Merida, Badajoz, Spain, 06800
Hospital de Cruces Active, not recruiting
Barakaldo, Vizcaya, Spain, 48903
Hospital de Basurto Active, not recruiting
Bilbao, Vizcaya, Spain, 48013
Hospital Del Mar Active, not recruiting
Barcelona, Spain, 08003
Complejo Hospitalario Universitario A Coruna Active, not recruiting
Coruna, Spain, 15006
Hospital Universitario 12 de Octubre Active, not recruiting
Madrid, Spain, 28041
Hospital Universitario La Paz Active, not recruiting
Madrid, Spain, 28046
Hospital Civil. Hospital Regional Universitario Carlos Haya Active, not recruiting
Malaga, Spain, 29009
Hospital Universitario Marques de Valdecilla (HUMV) Active, not recruiting
Santander, Spain, 39008
Hospital Universitario Virgen Macarena Active, not recruiting
Sevilla, Spain, 41009
Hospital Nuestra Señora de Valme Terminated
Sevilla, Spain, 41014
Hospital El Tomillar Terminated
Sevilla, Spain, 41700
Hospital Universitari i Politecnic La Fe de Valencia Terminated
Valencia, Spain, 46026
Sweden
Falu lasarett Active, not recruiting
Falun, Sweden, 791 82
Lanssjukhuset Ryhov Active, not recruiting
Jonkoping, Sweden, 551 85
Skanes Universitetssjukhus - Hematologi och koagulationskliniken Active, not recruiting
Malmoe, Sweden, 205 02
Sundsvalls Sjukhus Active, not recruiting
Sundsvall, Sweden, 851 86
Norrlands Universitetssjukhus Active, not recruiting
Umea, Sweden, 901 85
Akademiska University Hospital Active, not recruiting
Uppsala, Sweden, 75185
Taiwan
Chang Gung Medical Foundation- Active, not recruiting
Niao Sung Hsiang, Kaohsiung County, Taiwan, 833
Chang Gung Medical Foundation-Linkou Branch Active, not recruiting
Kwei-Shan, Taoyuan County, Taiwan, 333
Changhua Christian Hospital Active, not recruiting
Changhua, Taiwan, 500
Kaohsiung Medical University Chung-Ho Memorial Hospital Active, not recruiting
Kaohsiung, Taiwan, 807
Kaohsiung Veterans General Hospital Active, not recruiting
Kaohsiung, Taiwan, 813
Taichung Veterans General Hospital Active, not recruiting
Taichung, Taiwan, 40705
Taichung Veterans General Hospital Active, not recruiting
Taichung, Taiwan, 407
National Cheng Kung University Hospital Active, not recruiting
Tainan, Taiwan, 704
National Taiwan University Hospital Active, not recruiting
Taipei, Taiwan, 100
Taipei Veterans General Hospital Active, not recruiting
Taipei, Taiwan, 112
Thailand
Rheumatology Unit, Department of Internal Medicine, Phramongkutklao Hospital Active, not recruiting
Rajathevee, Bangkok, Thailand, 10400
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Active, not recruiting
Amphoe Mueang, Chiang Mai, Thailand, 50200
Division of Allergy-Immunology-Rheumatology, Department of Medicine, Faculty of Medicine Active, not recruiting
Muang District, Khonkaen, Thailand, 40002
Rheumatology Unit, Department of Internal Medicine, Rajavithi Hospital Active, not recruiting
Bangkok, Thailand, 10400
Siriraj Hospital, Mahidol University Active, not recruiting
Bangkok, Thailand, 10700
Turkey
Ege University Medical Faculty Active, not recruiting
Bornova, Izmir, Turkey, 35100
Hacettepe University Medical Faculty Terminated
Ankara, Turkey, 06100
Ege University Medical Faculty Active, not recruiting
Izmir, Turkey, 35100
Dokuz Eylul University Medical Faculty Active, not recruiting
Izmir, Turkey, 35340
Ukraine
Crimean Republican Institution "Clinical Territorial Medical Association "University Clinic", Active, not recruiting
Simferopol, Crimea, Ukraine, 95017
Municipal Establishment of Health Care "Kharkiv City Clinical Hospital #8", Dept. of Rheumatology Active, not recruiting
Kharkiv, Ukraine, 61178
State Institution Republican Clinical Hospital of the Ministry of Health of Ukraine Active, not recruiting
Kyiv, Ukraine, 04053
Institute of Gerontology Active, not recruiting
Kyiv, Ukraine, 04114
Municipal City Clinical Hospital #4, Policlinic Care Active, not recruiting
Lviv, Ukraine, 79011
Municipal Establishment City Clinical Hospital #9 n.a. O.I. Minakov, Department of Rheumatology Active, not recruiting
Odesa, Ukraine, 65026
CRIMEAN Republican Institution, "Clinical Hospital n.a. M.O. Semashko" Active, not recruiting
Simferopol Crimea, Ukraine, 95017
Vinnitsa Regional Clinical Hospital n.a. Pirogov Active, not recruiting
Vinnitsa, Ukraine, 21018
City Hospital #7, Department of Internal Diseases #2 of Zaporizhzhia State Medical University Active, not recruiting
Zaporizhzhia, Ukraine, 69118
United Kingdom
University Hospital Aintree Not yet recruiting
Liverpool, Merseyside, United Kingdom, L9 7AL
Arrowe Park Hospital Active, not recruiting
Wirral, Merseyside, United Kingdom, CH49 5PE
Dudley Group of Hospitals NHS Trust - Department of Rheumatology Active, not recruiting
Dudley, West Midlands, United Kingdom, DY1 2HQ
Dudley Group of Hospitals NHS Trust Active, not recruiting
Dudley, West Midlands, United Kingdom, DY1 2HQ
Cannock Chase Hospital Active, not recruiting
Cannock, United Kingdom, WS11 2XY
Royal Victoria Infirmary Active, not recruiting
Newcastle Upon Tyne, United Kingdom, NE1 4LP
Arrowe Park Hospital - Wirral University Teaching Hospital Nhs Foundation Trust Active, not recruiting
Upton Wirral, United Kingdom, CH49 5PE
Wirral University Teaching Hospital NHS Foundation Trust-Arrowe Park Hospital Active, not recruiting
Wirral, United Kingdom, CH49 5PE
Sponsors and Collaborators
Pfizer
Investigators
Study Director: Pfizer CT.gov Call Center Pfizer
  More Information

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Pfizer
ClinicalTrials.gov Identifier: NCT00413699     History of Changes
Other Study ID Numbers: A3921024  2006-005035-19 
Study First Received: December 18, 2006
Last Updated: August 9, 2016
Health Authority: United States: Food and Drug Administration

Keywords provided by Pfizer:
long-term
open-label
safety

Additional relevant MeSH terms:
Arthritis
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Tofacitinib
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on August 25, 2016