A Retrospective Analysis of the Predictive Potential of Pre-operative

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00321282
Recruitment Status : Terminated (The study never started.)
First Posted : May 3, 2006
Last Update Posted : September 27, 2013
Information provided by (Responsible Party):
Samuel C. Dudley, Jr., Emory University

Brief Summary:

Roughly thirty percent of people that undergo open heart surgery get an abnormal heart beat afterwards known as atrial fibrillation (AF). While not life threatening, this abnormal heart beat increases the likelihood of stroke and delays recovery. There are strategies to prevent post-operative AF, but they are costly and sometimes have undesirable side effects. Therefore, it would be best if we use these preventive treatments only in high risk patients.

We intend to develop a risk prediction model based on demographic and electrocardiogram (ECG) findings that will predicted who is likely to get AF. We will develop this model using data already available on patients who have undergone cardiac surgery. The development of this model will use the latest mathematical algorithms similar to those used to study genetic evolution. This type of model is capable of looking at many parameters in an unbiased way, so that only the strongest, independent predictors remain in the final model. Once, the model is developed, we will validate the model by comparing our predictions to actual outcomes previously recorded in the database.

Condition or disease Intervention/treatment Phase
Coronary Artery Bypass Procedure: Atrial Fibrillation Phase 2

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 600 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Retrospective Analysis of the Predictive Potential of Pre-operative Data on Post-operative Atrial Fibrillation
Study Start Date : February 2006
Actual Primary Completion Date : July 2007
Actual Study Completion Date : July 2007

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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

To prevent post-operative atrial fibrillation

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00321282

United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Crawford Long Hospital
Atlanta, Georgia, United States, 30365
Veterans Administration Medical Center
Decatur, Georgia, United States, 30033
Sponsors and Collaborators
Emory University
Principal Investigator: Samuel C. Dudley, Jr., MD, PhD Atlanta VAMC/Emory University

Responsible Party: Samuel C. Dudley, Jr., Principal Investigator, Emory University Identifier: NCT00321282     History of Changes
Other Study ID Numbers: 076-2006
First Posted: May 3, 2006    Key Record Dates
Last Update Posted: September 27, 2013
Last Verified: September 2013

Keywords provided by Samuel C. Dudley, Jr., Emory University:
Atrial Fibrillation
Coronary Artery Bypass Graft
Risk Stratification

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes