Computer-Based Training for Mild Alzheimer's Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00319891
Recruitment Status : Completed
First Posted : April 27, 2006
Last Update Posted : May 15, 2013
University of California, San Francisco
Information provided by:
Posit Science Corporation

Brief Summary:
The primary objective of this study is to evaluate the effects of computer-based training program ("HiFi-AD") on the memory and cognitive abilities of individuals diagnosed with mild Alzheimer's Disease (AD).

Condition or disease Intervention/treatment Phase
Alzheimer's Disease Procedure: Computer-based Cognitive Training Phase 1

Detailed Description:
The purpose of this study is to determine the extent to which computer-based cognitive remediation improves cognitive functions using standardized neuropsychological assessments relevant to AD; 2) the acceptability and feasibility of using computer-based cognitive remediation in an AD population.

Study Type : Interventional  (Clinical Trial)
Enrollment : 6 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Computer-Based Training for Mild Cognitive Impairment and Mild Alzheimer's Disease
Study Start Date : September 2004
Actual Primary Completion Date : October 2006
Study Completion Date : October 2006

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. The primary objective of this trial will be to assess the feasibility of using computer-based
  2. cognitive training in an a population with early Alzheimer's Disease.

Secondary Outcome Measures :
  1. A standardized set of neuropsychological assessments will be conducted pre- and post-
  2. compuer-based training.

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Fluent in English.
  • Mini-Mental Status Examination (MMSE) score of 22 or higher.
  • Adequate visual capacity.
  • Adequate hearing capacity.
  • Has a caregiver with some computer experience.
  • Willing and able to commit to the time requirement of the entire study.

Exclusion Criteria:

  • Clinically significant cerebrovascular disease.
  • Participant is planning to begin acetylcholinesterase inhibitor (AChEI) therapy.
  • Participants with severe tremor.
  • Axis 1 or 2 psychiatric disorders.
  • History of substance abuse.
  • History of head trauma.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00319891

United States, California
University of California, San Francisco
San Francisco, California, United States, 94143
Sponsors and Collaborators
Posit Science Corporation
University of California, San Francisco
Principal Investigator: Joel Kramer, PsyD University of California, San Francisco
Principal Investigator: Kristine Yaffe, MD University of California, San Francisco Identifier: NCT00319891     History of Changes
Other Study ID Numbers: OUT-109-2005
First Posted: April 27, 2006    Key Record Dates
Last Update Posted: May 15, 2013
Last Verified: May 2013

Keywords provided by Posit Science Corporation:
Mild Cognitive Impairment
Cognitive remediation
computer-based training

Additional relevant MeSH terms:
Alzheimer Disease
Cognitive Dysfunction
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Cognition Disorders