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Computer-Based Training for Mild Alzheimer's Disease

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00319891
First Posted: April 27, 2006
Last Update Posted: May 15, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
University of California, San Francisco
Information provided by:
Posit Science Corporation
  Purpose
The primary objective of this study is to evaluate the effects of computer-based training program ("HiFi-AD") on the memory and cognitive abilities of individuals diagnosed with mild Alzheimer's Disease (AD).

Condition Intervention Phase
Alzheimer's Disease Procedure: Computer-based Cognitive Training Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Computer-Based Training for Mild Cognitive Impairment and Mild Alzheimer's Disease

Resource links provided by NLM:


Further study details as provided by Posit Science Corporation:

Primary Outcome Measures:
  • The primary objective of this trial will be to assess the feasibility of using computer-based
  • cognitive training in an a population with early Alzheimer's Disease.

Secondary Outcome Measures:
  • A standardized set of neuropsychological assessments will be conducted pre- and post-
  • compuer-based training.

Estimated Enrollment: 6
Study Start Date: September 2004
Estimated Study Completion Date: October 2006
Primary Completion Date: October 2006 (Final data collection date for primary outcome measure)
Detailed Description:
The purpose of this study is to determine the extent to which computer-based cognitive remediation improves cognitive functions using standardized neuropsychological assessments relevant to AD; 2) the acceptability and feasibility of using computer-based cognitive remediation in an AD population.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   60 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Fluent in English.
  • Mini-Mental Status Examination (MMSE) score of 22 or higher.
  • Adequate visual capacity.
  • Adequate hearing capacity.
  • Has a caregiver with some computer experience.
  • Willing and able to commit to the time requirement of the entire study.

Exclusion Criteria:

  • Clinically significant cerebrovascular disease.
  • Participant is planning to begin acetylcholinesterase inhibitor (AChEI) therapy.
  • Participants with severe tremor.
  • Axis 1 or 2 psychiatric disorders.
  • History of substance abuse.
  • History of head trauma.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00319891


Locations
United States, California
University of California, San Francisco
San Francisco, California, United States, 94143
Sponsors and Collaborators
Posit Science Corporation
University of California, San Francisco
Investigators
Principal Investigator: Joel Kramer, PsyD University of California, San Francisco
Principal Investigator: Kristine Yaffe, MD University of California, San Francisco
  More Information

ClinicalTrials.gov Identifier: NCT00319891     History of Changes
Other Study ID Numbers: OUT-109-2005
First Submitted: April 27, 2006
First Posted: April 27, 2006
Last Update Posted: May 15, 2013
Last Verified: May 2013

Keywords provided by Posit Science Corporation:
Alzheimer's
AD
Mild Cognitive Impairment
Dementia
Cognitive remediation
computer-based training

Additional relevant MeSH terms:
Alzheimer Disease
Cognitive Dysfunction
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Cognition Disorders