Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study
|ClinicalTrials.gov Identifier: NCT00282802|
Recruitment Status : Unknown
Verified July 2009 by The Parkinson's Institute.
Recruitment status was: Active, not recruiting
First Posted : January 27, 2006
Last Update Posted : July 2, 2009
|Condition or disease|
Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous studies in this group indicated that genetic factors were involved only in early-onset PD, however there was no follow-up to these studies.
The purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins—at least one of whom has PD.
The overall goal of this research is determine the contributions of genetic and environmental factors in the cause of PD.
The study will involve traditional clinical research methods, such as a clinical examination, as well as innovative imaging techniques, such as single photon emission computed tomography (SPECT). SPECT—a nuclear imaging test involving blood flow to tissue—is used to evaluate certain brain functions.
Findings from this study may help to set research priorities in PD, and to develop tools for early detection of the disorder.
|Study Type :||Observational|
|Estimated Enrollment :||250 participants|
|Official Title:||Twins and the Risk of PD: A Clinical and Imaging Study|
|Study Start Date :||April 2001|
|Estimated Study Completion Date :||July 2010|
National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort
- Onset of Parkinson's disease [ Time Frame: duration of the project ]
- Age of Parkinson's disease onset [ Time Frame: duration of the project ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00282802
|United States, California|
|The Parkinson's Institute, 675 Almanor Avene|
|Sunnyvale, California, United States, 94085|
|Principal Investigator:||Caroline M. Tanner, MD||The Parkinson's Institute|