Lamotrigine in the Treatment of Binge Eating Disorder Associated With Obesity
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ClinicalTrials.gov Identifier: NCT00277641 |
Recruitment Status
:
Completed
First Posted
: January 16, 2006
Last Update Posted
: June 22, 2011
|
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This research study is to evaluate the effectiveness, tolerability, and safety of lamotrigine therapy in the treatment of binge eating disorder associated with obesity.
Lamotrigine has been approved by the Food and Drug Administration for the treatment of bipolar disorder, but has not been approved for use in the treatment of binge eating disorder with obesity.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Binge Eating Disorder Obesity | Drug: Lamotrigine Drug: placebo | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 70 participants |
Allocation: | Randomized |
Intervention Model: | Single Group Assignment |
Masking: | Triple (Participant, Care Provider, Investigator) |
Primary Purpose: | Treatment |
Official Title: | Lamotrigine in the Treatment of Binge Eating Disorder Associated With Obesity: A Single-Center, Double-Blind, Placebo-Controlled, Flexible-Dose Study in Outpatients |
Study Start Date : | March 2006 |
Actual Primary Completion Date : | January 2009 |
Actual Study Completion Date : | January 2009 |

Arm | Intervention/treatment |
---|---|
Experimental: 1
lamotrigine
|
Drug: Lamotrigine
25 mg or 100 mg
|
Placebo Comparator: 2 |
Drug: placebo
identical tablets to study drug
|
- The specific aims of this study are to examine the efficacy and safety of lamotrigine compared with placebo in outpatients with binge eating disorder associated with obesity. [ Time Frame: 17 weeks ]

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Ages Eligible for Study: | 18 Years to 65 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
-
Patients will meet DSM-IV-TR criteria for BED for at least the last 6 months, determined by the Structured Clinical Interview for DSM-IV-TR (SCID) (61) and supported by the Eating Disorder Examination (EDE) (62). These criteria are as follows:
-
Recurrent episodes of binge eating. An episode of binge eating is characterized by both of the following:
- eating, in discrete period of time (e.g., within any two hour period), an amount of food that is definitely larger than most people would eat in a similar period of time under similar circumstances
- a sense of lack of control over eating during the episode (e.g., a feeling that one cannot stop eating or control what or how much one is eating)
-
The binge eating episodes are associated with at least three of the following:
- eating much more rapidly than normal
- eating until uncomfortably full
- eating large amounts of food when not feeling physically hungry
- eating alone because of being embarrassed by how much one is eating
- feeling disgusted with oneself, depressed, or feeling very guilty after overeating
- Marked distress regarding binge eating.
- The binge eating occurs, on average, at least two days a week for six months.
- Does not occur exclusively during the course of bulimia nervosa and anorexia nervosa.
-
- Obesity, defined by body mass index > 30 kg/m2.
- Men or women, between the ages of 18 and 65.
Exclusion Criteria:
- Have current body mass index < 30 kg/m2.
- Women who are pregnant or lactating and women of childbearing potential who are not taking adequate contraceptive measures. (All women of childbearing potential will have a negative pregnancy test before entering the study.)
- Subjects who are displaying clinically significant suicidality or homicidality.
- Subjects who are displaying a current clinically unstable depressive or bipolar disorder, defined as a Montgomery Asberg Depression Rating Scale (MADRS) (63) > 24 or a Young Mania Rating Scale (YMRS) (64) > 8.
- A current or recent (within 6 months of the start of study medication) DSM-IV-TR diagnosis of substance abuse or dependence.
- A lifetime history of a DSM-IV-TR psychotic disorder or dementia.
- History of a personality disorder (e.g., schizotypal, borderline, or antisocial) which might interfere with assessment or compliance with study procedures.
- Clinically unstable medical disease, including cardiovascular, hepatic, renal, gastrointestinal, pulmonary, metabolic, endocrine or other systemic disease which could interfere with diagnosis, assessment, or treatment of binge eating disorder. Patients should be biochemically euthyroid prior to entering the study.
- History of seizures, including febrile seizures in childhood.
- Subjects requiring treatment with any drug which might interact adversely with or obscure the action of the study medication (e.g., stimulants, sympathomimetics, antidepressants, carbonic anhydrase inhibitors, anti-obesity drugs).
- Subjects who have received psychoactive medication (other than zaleplon [Sonata] or zolpidem [Ambien] -- as needed for restlessness/insomnia) within one week prior to randomization.
- Subjects who have begun and/or are receiving formal psychotherapy (cognitive behavioral therapy, interpersonal therapy, or dietary behavioral therapy) for BED or weight loss within the past 3 months.
- Subjects previously enrolled in this study or have previously been treated with lamotrigine.
- Subjects who have received an experimental drug or used an experimental device within 30 days.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00277641
United States, Ohio | |
Lindner Center of HOPE | |
Mason, Ohio, United States, 45040 |
Principal Investigator: | Susan L. McElroy, MD | Lindner Center of HOPE |
Publications of Results:
Responsible Party: | Susan L. McElroy, MD, University of Cincinnati & Lindner Center of HOPE |
ClinicalTrials.gov Identifier: | NCT00277641 History of Changes |
Other Study ID Numbers: |
106531 |
First Posted: | January 16, 2006 Key Record Dates |
Last Update Posted: | June 22, 2011 |
Last Verified: | June 2011 |
Keywords provided by Lindner Center of HOPE:
Binge Eating Disorder Associated with Obesity |
Additional relevant MeSH terms:
Disease Obesity Feeding and Eating Disorders Binge-Eating Disorder Bulimia Pathologic Processes Overnutrition Nutrition Disorders Overweight Body Weight Signs and Symptoms Mental Disorders Hyperphagia |
Signs and Symptoms, Digestive Lamotrigine Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Excitatory Amino Acid Antagonists Excitatory Amino Acid Agents Neurotransmitter Agents Physiological Effects of Drugs Voltage-Gated Sodium Channel Blockers Sodium Channel Blockers |