Effect of Garlic on Inflammatory Mediators
This research will investigate the effect of garlic oil extract when added to daily diet on inflammatory mediators and blood clotting activation.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Effect of Garlic Oil Macerate on Inflammatory Mediators in Healthy Normal Weight and Obese Subjects.|
- 1. To examine the pharmacokinetics of the garlic oil macerate.
- 2. To examine the effect of garlic oil macerate on inflammatory mechanisms at the cellular and molecular level.
|Study Start Date:||April 2006|
|Estimated Study Completion Date:||March 2007|
To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00275405
|United States, New York|
|Albany Medical Center|
|Albany, New York, United States, 12208|
|Principal Investigator:||Howard S Smith, MD||Albany Medical College|
|Principal Investigator:||Shaker A Mousa, PhD||Albany College of Pharmacy|
|Principal Investigator:||Ahmad Aljada, PhD||Albany College of Pharmacy|