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Magnetic Resonance Imaging (MRI) of Brain Iron in Neurodegenerative Disease

This study has been completed.
United States Department of Defense
Information provided by:
Albany Medical College Identifier:
First received: November 3, 2005
Last updated: August 21, 2009
Last verified: August 2009
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis are recognized as a major health concern at the present time. There is information in magnetic resonance imaging (MRI) studies regarding the role of brain iron in normal brain aging that may be enhanced with the use of better scanning equipment and procedures, and by correlating this information with clinical data. This research study aims to develop and evaluate a number of techniques that can potentially improve the effectiveness of three tesla (3T) magnetic resonance imaging of neurodegenerative brain disorders.

Neurodegenerative Diseases
Mild Cognitive Impairment

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: High Field MRI of Brain Iron in Neurodegenerative Disease

Resource links provided by NLM:

Further study details as provided by Albany Medical College:

Enrollment: 182
Study Start Date: June 2005
Study Completion Date: August 2007
Detailed Description:

Eligibility: A healthy person without memory complaints or someone with neurodegenerative disease. However, the person should not have metal in the body (ie, pacemaker, implants, shrapnel, etc.), should not be pregnant, and should not have claustrophobic anxieties.

Study Procedures: During a regular office visit, a neurologist will perform a routine physical and neurological examination, including your medical and family history, to determine your eligibility for this study. You will then be scheduled for a series of neuropsychological tests, which take between 1 to 1.5 hours, and an MRI scan, which takes approximately 1 hour to complete. This is a longitudinal study and you may be asked to repeat these procedures approximately every six months for the duration of this 2 year project.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Approximately equal numbers of subjects with clinically diagnosed Alzheimer's disease, multiple sclerosis, Parkinson's disease and normal controls (age and gender matched).

Inclusion Criteria:

  • 18 years or older
  • Healthy person without memory complaints OR person diagnosed with a neurodegenerative disease (ie, Alzheimer's disease, Parkinson's disease, multiple sclerosis)

Exclusion Criteria:

  • MR contraindication such as metal in body (ie, pacemaker, implant, shrapnel, etc.)
  • Pregnant
  • Claustrophobic anxieties
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00249080

Sponsors and Collaborators
Albany Medical College
United States Department of Defense
Study Director: Earl A Zimmerman, MD Albany Medical College
Principal Investigator: John F Schenck, MD, PhD GE Global Research Center & Neurosciences Advanced Imaging Research Center
  More Information

Responsible Party: John Schenck, MD PhD; Principal Investigator, Albany Medical College Identifier: NCT00249080     History of Changes
Other Study ID Numbers: AMC-IRB-1599
Study First Received: November 3, 2005
Last Updated: August 21, 2009

Keywords provided by Albany Medical College:
neurodegenerative disease
Alzheimer's disease
Normal, healthy subject without memory complaint
Not pregnant
MR compatible

Additional relevant MeSH terms:
Cognition Disorders
Mild Cognitive Impairment
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Nervous System Diseases processed this record on April 28, 2017