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The Influence of Psychological Interventions Upon Disease Progression in HIV-infected Patients Receiving no Medication

This study has been completed.
Hammersmith Hospitals NHS Trust
Johrei Association
Information provided by:
Imperial College London Identifier:
First received: September 13, 2005
Last updated: February 11, 2016
Last verified: September 2005
This study examines the hypothesis that psychological interventions have beneficial effects on quality of life including psychological well-being and disease progression in early HIV patients recieving no medication.

Condition Intervention
HIV Infected Individuals Behavioral: Self-hypnosis Behavioral: Johrei - a Japanese stress management system

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Official Title: The Effects of Two Psychological Intervention Techniques, Self-hypnosis and Johrei Healing Method, on Quality of Life, Psychological Well-being, EEG Measures and Various Immunological Measures Including CD4+ Counts in Early HIV: a Randomly Controlled Pilot Study

Resource links provided by NLM:

Further study details as provided by Imperial College London:

Primary Outcome Measures:
  • CD4 T-cell counts

Secondary Outcome Measures:
  • Other immunological parameters (Viral load levels, NK cell counts)
  • Psychological questionnaires (Perceived Stress Scale (PSS), STAI, Beck depression Inventory (BDI))
  • Endogenous hormone levels (cortisol, DHEA-S and melatonin)

Estimated Enrollment: 100
Study Start Date: June 2003
Estimated Study Completion Date: December 2004
Detailed Description:

Hypothesis: This investigation is based upon the hypothesis that psychological intervention may counteract the detrimental effects of stress both on psychological well-being and on general health.

Background: HIV infection may be considered to be a life-long biological and psychological stressor leading to detrimental outcomes associated with disease progression. Stress reduction in these patients may have beneficial effects through delaying disease progression via the proposed interactive psycho-neuro-endocrine-immune network.

Inclusion Criteria:

HIV infected individuals CD4 T-cell counts above 200 cells/mcl Receiving no anti-retroviral drugs Individuals who signed the informed consent form

Investigative approach: Self-hypnosis and a Japanese non-touching, laying-on-of hands-like technique, called Johrei, were used to investigate the effects of psychological intervention upon immune parameters (especially in CD4 counts) associated with disease progression along with phenomenological associations between stress perception and stress hormone levels in HIV-infected patients receiving no medication.


Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • HIV infected
  • CD4 T-cell counts above 200 cells/mcl
  • Signed the informed consent form

Exclusion Criteria:

  • receiving anti-retroviral drugs
  Contacts and Locations
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Please refer to this study by its identifier: NCT00180700

United Kingdom
Imperial College London
London, England, United Kingdom, W6 8RP
Sponsors and Collaborators
Imperial College London
Hammersmith Hospitals NHS Trust
Johrei Association
Principal Investigator: John H Gruzelier, Ph.D. Imperial College London
Study Director: Don C Henderson, Ph.D. Imperial College London
  More Information Identifier: NCT00180700     History of Changes
Other Study ID Numbers: Johrei_HIV1
Study First Received: September 13, 2005
Last Updated: February 11, 2016

Keywords provided by Imperial College London:
stress management
psychological intervention processed this record on September 20, 2017