ClinicalTrials.gov
ClinicalTrials.gov Menu

Comparison of Different Mucoactive Agents for the Care of the Intubated Patient in a Surgical Trauma Intensive Care Unit

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00131521
Recruitment Status : Completed
First Posted : August 18, 2005
Last Update Posted : June 23, 2009
Sponsor:
Information provided by:
The University of Texas Health Science Center at San Antonio

Brief Summary:
This study compares N-acetylcysteine (mucomyst) and sodium chloride to determine their efficacy in the prevention of pulmonary mucus obstruction and retention in intubated patients admitted to the surgical trauma intensive care unit (STICU).

Condition or disease Intervention/treatment Phase
Mucus Obstruction Intubation Drug: mucomyst Drug: sodium chloride (saline) Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 260 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Comparison of Different Mucoactive Agents for the Care of the Intubated Patient in a Surgical Trauma Intensive Care Unit: A Randomized, Double Blind, Controlled Trial
Study Start Date : January 2005
Actual Study Completion Date : December 2007



Primary Outcome Measures :
  1. prevention of pulmonary mucus obstruction

Secondary Outcome Measures :
  1. days of mechanical ventilation


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Intubated and admitted to the Surgical Trauma Intensive Care Unit (STICU)
  • Subjects must be eligible to start treatment within 24 hours of their initial intubation

Exclusion Criteria:

  • Patient anticipated to be extubated within 24 hours following STICU admission
  • Hypersensitivity to acetylcysteine.
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00131521


Locations
United States, Texas
Univesity Hospital
San Antonio, Texas, United States, 78229
Sponsors and Collaborators
The University of Texas Health Science Center at San Antonio
Investigators
Principal Investigator: John G. Myers, M.D. University of Texas Health Science Center San Antonio

ClinicalTrials.gov Identifier: NCT00131521     History of Changes
Other Study ID Numbers: 034-1502-320
First Posted: August 18, 2005    Key Record Dates
Last Update Posted: June 23, 2009
Last Verified: June 2009

Keywords provided by The University of Texas Health Science Center at San Antonio:
mucus obstruction, ventilator management

Additional relevant MeSH terms:
Acetylcysteine
Antiviral Agents
Anti-Infective Agents
Expectorants
Respiratory System Agents
Free Radical Scavengers
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs