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Immunotherapy Using Cyclosporine, Interferon Gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin's Lymphoma

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ClinicalTrials.gov Identifier: NCT00070187
Recruitment Status : Completed
First Posted : October 7, 2003
Last Update Posted : October 17, 2013
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group

Brief Summary:

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Giving immunotherapy using cyclosporine, interferon gamma, and interleukin-2 after stem cell transplantation may help the transplanted cells make an immune response and kill any remaining cancer cells. It is not yet known whether high-dose chemotherapy followed by autologous stem cell transplantation is more effective with or without immunotherapy.

PURPOSE: This randomized phase II/III trial is studying how well high-dose chemotherapy followed by autologous stem cell transplantation, cyclosporine, interferon gamma, and interleukin-2 works and compares it to high-dose chemotherapy followed by autologous stem cell transplantation only in treating patients with refractory or relapsed Hodgkin's lymphoma.


Condition or disease Intervention/treatment Phase
Lymphoma Biological: aldesleukin Biological: filgrastim Biological: recombinant interferon gamma Drug: carmustine Drug: cyclosporine Drug: cytarabine Drug: etoposide Drug: melphalan Procedure: autologous bone marrow transplantation Procedure: bone marrow ablation with stem cell support Procedure: peripheral blood stem cell transplantation Phase 2 Phase 3

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Detailed Description:

OBJECTIVES:

Primary

  • Phase II

    • Determine the feasibility and toxicity of immunotherapy comprising cyclosporine, interferon gamma, and interleukin-2 after high-dose myeloablative chemotherapy with autologous stem cell transplantation (ASCT) in patients with refractory or relapsed Hodgkin's lymphoma.

      • Phase II part of the study was completed and should have proceeded to Phase III; however long delay occurred due to some proposed protocol changes to Phase III , so long that the study got permanently closed ***********
  • Phase III

    • Compare the event-free and overall survival of patients treated with vs without this immunotherapy regimen.

Secondary

  • Determine the event-free and overall survival rates, toxic effects, and response rates to reinduction chemotherapy followed by hyperfractionated involved-field radiotherapy, high-dose chemotherapy comprising carmustine, etoposide, cytarabine, and melphalan, and ASCT in these patients.
  • Correlate tumor biologic characteristics with response in patients treated with these regimens.
  • Determine the effectiveness of this immunotherapy regimen in producing autologous graft-vs-host disease (GVHD) and auto-reactive cytotoxic T-lymphocyte activity in these patients.
  • Correlate greater levels of autologous GVHD and in vitro cytolytic activity with improved event-free and overall survival in patients treated with these regimens.
  • Determine whether treatment with immunotherapy can overcome the negative prognostic significance of p53 mutation and high serum levels of interleukin-10 and interleukin-2 receptor in these patients.
  • Determine the genotoxicity of retrieval therapy and the incidence of hypermutability by longitudinal genotoxic biomonitoring in these patients.
  • Correlate HLA class II invariant peptide (CLIP) expression in tumor cells with improved event-free and overall survival in patients treated with immunotherapy regimen.

OUTLINE: This is a nonrandomized, multicenter phase II study followed by a randomized, multicenter phase III study. Patients are stratified according to study phase (II vs III).

Patients receive 2 courses of salvage induction therapy on COG-AHOD00P1 or equivalent. Within 2-5 weeks after completion of salvage induction therapy, patients receive protocol therapy.

  • Phase II: All patients receive the following treatment:

    • Hyperfractionated involved-field radiotherapy: Patients who have completed prior salvage induction therapy and have not received full tissue tolerance from prior radiotherapy may receive hyperfractionated involved-field radiotherapy twice daily for 7 days.
    • High-dose preparative regimen: Beginning within 7 days after radiotherapy, patients receive carmustine IV over 3 hours on day -6; etoposide IV over 1 hour and cytarabine IV over 1 hour on days -5 to -2; and melphalan IV over 30 minutes on day -1.
    • Autologous stem cell transplantation: Patients undergo autologous bone marrow or peripheral blood stem cell transplantation on day 0. Patients then receive filgrastim (G-CSF) subcutaneously (SC) or IV beginning on day 1 and continuing until blood counts recover.
    • Immunotherapy: Patients receive cyclosporine IV twice daily beginning on day 0 and continuing until the completion of the course of interferon gamma and interleukin-2. When sufficiently recovered, patients also receive interferon gamma SC every other day for 10 doses. Beginning 2 days after the start of interferon gamma, patients also receive interleukin-2 SC once daily for 18 days.
  • Phase III: Patients who respond to prior salvage induction therapy are randomized to 1 of 2 treatment arms. Patients who have progressive disease after 2 courses of prior salvage induction therapy are assigned to arm I.

    • Arm I: Patients receive treatment as in phase II.
    • Arm II: Patients receive treatment as in phase II without immunotherapy. In both phases, treatment continues in the absence of disease progression or unacceptable toxicity.

Patients are followed at 1 year.

PROJECTED ACCRUAL: A total of 156 patients (25 for phase II and 131 for phase III) will be accrued for this study within 5.4 years.


Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase II/III Study of Immunomodulation After High Dose Myeloablative Therapy With Autologous Stem Cell Rescue for Refractory/Relapsed Hodgkin Disease
Study Start Date : November 2003
Actual Primary Completion Date : June 2005


Arm Intervention/treatment
Experimental: Hyperfractionated Involved-Field Radiotion-immunotherapy

Completed prior salvage induction therapy and have not received full tissue tolerance from prior radiotherapy may receive hyperfractionated involved-field radiotherapy twice daily for 7 days.

HIGH-DOSE PREPARATIVE REGIMEN: Beginning within 7 days after radiotherapy, carmustine IV over 3 hours on day -6; etoposide IV over 1 hour and cytarabine IV over 1 hour on days -5 to -2; and melphalan IV over 30 minutes on day -1.

ASCT: Autologous bone marrow or peripheral blood stem cell transplantation on day 0. Filgrastim (oral or IV) beginning on day 1 and continuing until blood counts recover.

IMMUNOTHERAPY: Cyclosporine IV twice daily beginning on day 0 and continuing until the completion of the course of recombinant interferon gamma and interleukin-2. When sufficiently recovered, Aldesleukin once daily for 18 days.

Biological: aldesleukin
Given IV
Other Names:
  • Proleukin
  • IL-2
  • recombinant human Interleukin 2
  • NSC # 373364

Biological: filgrastim
Given IV
Other Names:
  • GRANULOCYTE COLONY-STIMULATING FACTOR
  • r-metHuG-CSF
  • G-CSF
  • Neupogen
  • NSC #614629

Biological: recombinant interferon gamma
Given IV
Other Names:
  • INTERFERON GAMMA-1b
  • Actimmune
  • gamma interferon
  • immune interferon
  • lymphocyte interferon
  • rIFN-gamma
  • T-interferon
  • NSC #600662

Drug: carmustine
Given IV
Other Names:
  • BCNU
  • BiCNU
  • bischloronitrosourea
  • NSC #40996

Drug: cyclosporine
Given IV
Other Names:
  • cycloporine
  • Sandimmune
  • Neoral
  • Gengraf
  • NSC #290193

Drug: cytarabine
Given IV
Other Names:
  • cytosine arabinoside
  • AraC
  • Cytosar
  • NSC #063878

Drug: etoposide
Given IV
Other Names:
  • VP-16
  • VePesid
  • Etopophos
  • NSC #141540

Drug: melphalan
Given IV
Other Names:
  • L-PHENYLANINE mustard
  • L-PAM
  • L-sarcolysin
  • Alkeran
  • NSC #008806

Procedure: autologous bone marrow transplantation
Procedure: bone marrow ablation with stem cell support
Procedure: peripheral blood stem cell transplantation
Experimental: Hyperfractionated Involved-Field Radiotion-no immunotherapy

Completed prior salvage induction therapy and have not received full tissue tolerance from prior radiotherapy may receive hyperfractionated involved-field radiotherapy twice daily for 7 days.

HIGH-DOSE PREPARATIVE REGIMEN: Beginning within 7 days after radiotherapy, carmustine IV over 3 hours on day -6; etoposide IV over 1 hour and cytarabine IV over 1 hour on days -5 to -2; and melphalan IV over 30 minutes on day -1.

ASCT: Autologous bone marrow or peripheral blood stem cell transplantation on day 0. Filgrastim (oral or IV) beginning on day 1 and continuing until blood counts recover.

Biological: filgrastim
Given IV
Other Names:
  • GRANULOCYTE COLONY-STIMULATING FACTOR
  • r-metHuG-CSF
  • G-CSF
  • Neupogen
  • NSC #614629

Drug: carmustine
Given IV
Other Names:
  • BCNU
  • BiCNU
  • bischloronitrosourea
  • NSC #40996

Drug: cyclosporine
Given IV
Other Names:
  • cycloporine
  • Sandimmune
  • Neoral
  • Gengraf
  • NSC #290193

Drug: cytarabine
Given IV
Other Names:
  • cytosine arabinoside
  • AraC
  • Cytosar
  • NSC #063878

Drug: etoposide
Given IV
Other Names:
  • VP-16
  • VePesid
  • Etopophos
  • NSC #141540

Drug: melphalan
Given IV
Other Names:
  • L-PHENYLANINE mustard
  • L-PAM
  • L-sarcolysin
  • Alkeran
  • NSC #008806

Procedure: autologous bone marrow transplantation
Procedure: bone marrow ablation with stem cell support
Procedure: peripheral blood stem cell transplantation



Primary Outcome Measures :
  1. Incidence of death, excluding death due to disease, during the period of time from day 0 (transplant) through day 100 post transplant [ Time Frame: Day 0 (transplant) through Day 100 (Post transplant) ]
    Death, excluding death due to disease, during the period of time from Day 0 (transplant) through Day 100 post transplant.



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Ages Eligible for Study:   up to 30 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of Hodgkin's lymphoma

    • Histologically confirmed at original diagnosis AND at relapse or disease progression
    • Relapsed or refractory to conventional therapy
  • No recurrence without B symptoms or bulky disease at least 1 year after completion of minimal systemic therapy defined by either of the following:

    • Stage IA/IIA with nodal disease previously treated with radiotherapy only
    • Stage IA/IIA with nodal disease previously treated with less than 3 courses of standard dose chemotherapy
  • Concurrently enrolled on the COG-AHOD00P1 salvage chemotherapy study OR received other appropriate salvage therapy (e.g., ifosfamide and vinorelbine)

PATIENT CHARACTERISTICS:

Age

  • Under 30

Performance status

  • ECOG 0-2 (for adults)
  • Lansky 50-100% (for children)

Life expectancy

  • At least 2 months

Hematopoietic

  • Absolute neutrophil count at least 500/mm^3

Hepatic

  • Bilirubin no greater than 1.5 times normal
  • SGPT less than 2.5 times normal

Renal

  • Creatinine no greater than 1.5 times normal OR
  • Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min/1.73 m^2

Cardiovascular

  • Shortening fraction at least 27% by echocardiogram OR
  • Ejection fraction at least 50% by MUGA

Pulmonary

  • No evidence of dyspnea at rest
  • No exercise intolerance
  • DLCO at least 50% (patients 8 years of age and over)

Other

  • Not pregnant or nursing
  • Negative pregnancy test
  • No concurrent serious illness

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Recovered from prior immunotherapy
  • At least 1 week since prior antineoplastic biologic agents
  • More than 1 week since prior growth factors
  • No prior stem cell transplantation
  • No other concurrent immunomodulating agents

Chemotherapy

  • See Disease Characteristics
  • More than 2 weeks since prior myelosuppressive chemotherapy (4 weeks for nitrosoureas) and recovered
  • No other concurrent anticancer chemotherapy

Endocrine therapy

  • No concurrent steroids, including dexamethasone as an antiemetic

Radiotherapy

  • See Disease Characteristics
  • Recovered from prior radiotherapy

Surgery

  • Not specified

Other

  • No concurrent participation in another COG therapeutic study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00070187


  Show 63 Study Locations
Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Investigators
Study Chair: Allen R. Chen, MD, PhD, MHS Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Study Chair: Sharon L. Gardner, MD New York University School of Medicine

Publications of Results:
Chen AR, Hutchison R, Hess A, et al.: Clinical outcomes of patients with recurrent/refractory Hodgkin disease receiving cyclosporine, interferon-, and interleukin-2 immunotherapy to induce auto-reactivity after autologous stem cell transplantation with BEAM: a COG study. [Abstract] Blood 110 (11): A-1896, 2007.

Responsible Party: Children's Oncology Group
ClinicalTrials.gov Identifier: NCT00070187     History of Changes
Other Study ID Numbers: AHOD0121
CDR0000330135 ( Other Identifier: Clinical Trials.gov )
COG-AHOD0121 ( Other Identifier: Children's Oncology Group )
First Posted: October 7, 2003    Key Record Dates
Last Update Posted: October 17, 2013
Last Verified: October 2013

Keywords provided by Children's Oncology Group:
recurrent adult Hodgkin lymphoma
recurrent/refractory childhood Hodgkin lymphoma

Additional relevant MeSH terms:
Lymphoma
Hodgkin Disease
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Etoposide phosphate
Aldesleukin
Interferons
Etoposide
Cytarabine
Melphalan
Interleukin-2
Carmustine
Interferon-gamma
Cyclosporine
Cyclosporins
Lenograstim
Antineoplastic Agents
Antiviral Agents
Anti-Infective Agents
Antineoplastic Agents, Phytogenic
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antimetabolites, Antineoplastic
Antimetabolites