Ritonavir and Agenerase Treatment for Patients Who Have Failed Previous Anti-HIV Treatment
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ClinicalTrials.gov Identifier: NCT00006591
Verified December 2004 by NIH AIDS Clinical Trials Information Service. Recruitment status was: Active, not recruiting
The purpose of this study is to determine if treatment with an anti-HIV drug containing ritonavir and Agenerase is safe and can lower the level of HIV in the blood in patients who have failed an anti-HIV drug treatment containing nelfinavir.
Condition or disease
Drug: RitonavirDrug: Amprenavir
HIV-infected patients will be treated with a ritonavir-enhanced Agenerase regimen.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients may be eligible for this study if they:
Are 18 years of age or older.
Have a viral load (level of HIV in the body) of more than 1,000 copies/ml.
Have had more than 12 weeks of prior anti-HIV drug treatment.
Have failed a previous anti-HIV treatment containing nelfinavir as the only protease inhibitor.
Are responsive to Agenerase.
Are able to follow study requirements.
Patients will not be eligible for this study if they:
Are intolerant to ritonavir (an anti-HIV drug).
Have or have had problems with absorption.
Have liver disease or damage.
Have pancreatic disease or damage.
Have taken any protease inhibitor other than nelfinavir.
Are receiving investigational drugs or devices from another study.
Are pregnant or breast-feeding.
Currently use triazolam, astemizole, ergot medications, cisapride, midazolam, bepridil, rifampin, terfenadine, or pimozide.