Honolulu Heart Program

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
First received: May 25, 2000
Last updated: April 13, 2016
Last verified: September 2004
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.

Cardiovascular Diseases
Coronary Disease
Cerebrovascular Accident
Heart Diseases
Heart Failure, Congestive
Myocardial Infarction
Lung Diseases, Obstructive
Aortic Aneurysm, Abdominal
Chronic Obstructive Pulmonary Disease
Heart Failure

Study Type: Observational

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: July 1965
Estimated Study Completion Date: September 2002
  Show Detailed Description


Ages Eligible for Study:   up to 100 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00005123

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: J. Curb Kuakini Medical Center
OverallOfficial: Jess Curb Kuakini Medical Center
  More Information

McGee D, Rhoads G, Feinleib M: The Logistic Function. A Model for Assessing Risk of Heart Disease. In Proceedings of the Fourteenth Hawaii International Conference on System Sciences. Edited by B. Shriver et al. Honolulu, Hawaii, University of Hawaii Press pp 722-740, 1981
Kagan A, Yano K, McGee D, Rhoads GG: Epidemiology of Glucose Intolerance in Hawaii Japanese Men. Excerpta Medica. In: Genetic-Enviornmental Interaction in Diabetes Mellitus, Proceedings of the Third Symposium on Diabetes Mellitus in Asia and Oceania; Honolulu Feb 6-7, 1981; ISBN Elsevier North Holland, (International Congress Series No. 549, pp 51-56, 1982
Reed D: Social Stress, Social Support and Hypertension Among Japanese Men in Hawaii. In Proceedings of the Second Intercontinental Symposium on Hypertension and the Japanese. Molokai, Hawaii. Japan, Medical Tribune, pp 21-30, 1983
Yano K, Reed DM, MacLean CJ: Coffee Consumption and Coronary Heart Disease. N Engl J Med (letter) 316(15):946, 1987
Reed DM: Predictors of a Long Healthy Life Among Japanese Men in Hawaii. In: Prevention of Cardiovascular Diseases: an Approach to Active Long Life. Yamori Y, Lenfant C (Eds). Elsevier Science Publishers, pp 225-234, 1987
Belsky JL, Kagan A, Syme SL: Epidemiologic Studies of Coronary Heart Disease and Stroke in Japanese Men Living in Japan, Hawaii and California: Research Plan. ABCC TR 12-71, 1971
Rhoads GG, Zeegen PD, Glober GA, Boelling GM: The Epidemiology of Pterygium a High Risk Population. Transactions of Pacific Coast Oto-Ophthalmological Society pp 163-173, 1972
Kagan A: The World Wide Investigation of the Epidemiology of Coronary Heart Disease. J Hiroshima Med Assoc 26:10:1145-1157, 1973
Winkelstein W Jr: Cooperative Studies of Blood Pressure in Japanese in Japan, Hawaii and the United States. In Epidemiology and Control of Hypertension Paul O (Ed.) Miami: Symposia Specialists, pp 101-114, 1975
Kagan A: Epidemiology of Hypertension and Stroke in Oceania. In Hypertension and Stroke Control in the Community Hatano S, Shigematsu I, Strasser T (Eds.) Geneva: World Health Organization, pp 97-105, 1976
Kagan A, Popper J, Rhoads GG, Takeya Y, Kato H, Brown-Goode G, Marmot MG: Epidemiologic Studies of Coronary Heart Disease and Stroke in Japanese Men Living in Japan, Hawaii, and California: Prevalence of Stroke. In Cerebrovascular Diseases, Tenth Princeton Conference Scheinberg P (Ed.) New York: Raven Press, pp 267-277, 1976
Takeya Y, Kato H, Kagan A, Popper J, Rhoads GG, Browne Goode G, Marmot M: Epidemiologic Study of Stroke in Japanese Men Living in Japan, Hawaii and California: Prevalence of Stroke. In Gene-Environment Interaction in Common Diseases Inouye E, Nishimura H (Eds.) University of Tokyo Press, pp 15-18, 1977
Kagan A, Marmot MG, Kato H: The Ni-Hon-San Study of Cardiovascular Disease Epidemiology: Population Characteristics and Epidemiology of Stroke. In Epidemiology of Arterial Blood Pressure. Kesteloot H, Joossens JV (Eds.). The Hague/Boston/London: Martinus Nijhoff, pp 423-436, 1980, 0000
Marmot MG, Kagan A, Kato H: Hypertension and Heart Disease in the Ni-Hon-San Study. In Epidemiology of Arterial Blood Pressure. Kesteloot H, Joossens JV (Eds.). The Hague/Boston/London: Martinus Nijhoff, pp 437-452, 1980

ClinicalTrials.gov Identifier: NCT00005123     History of Changes
Other Study ID Numbers: 902 
Study First Received: May 25, 2000
Last Updated: April 13, 2016
Health Authority: Unspecified

Additional relevant MeSH terms:
Aortic Aneurysm
Aortic Aneurysm, Abdominal
Cardiovascular Diseases
Coronary Artery Disease
Coronary Disease
Heart Failure
Lung Diseases
Lung Diseases, Obstructive
Myocardial Infarction
Pulmonary Disease, Chronic Obstructive
Aortic Diseases
Arterial Occlusive Diseases
Brain Diseases
Bronchial Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Heart Diseases
Myocardial Ischemia
Nervous System Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Vascular Diseases

ClinicalTrials.gov processed this record on May 26, 2016