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Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00003594
Recruitment Status : Completed
First Posted : September 25, 2003
Last Update Posted : July 6, 2016
Sponsor:
Collaborators:
National Cancer Institute (NCI)
NCIC Clinical Trials Group
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology

Brief Summary:

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy is most effective in treating advanced colorectal cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of various combination chemotherapy regimens in treating patients who have advanced, recurrent, or metastatic colorectal cancer that cannot be treated with surgery or radiation therapy.


Condition or disease Intervention/treatment Phase
Colorectal Cancer Drug: irinotecan Drug: fluorouracil Drug: leucovorin calcium Drug: oxaliplatin Phase 3

Detailed Description:

OBJECTIVES:

  • Compare the time to progression in patients with locally advanced, locally recurrent, or metastatic colorectal adenocarcinoma treated with combinations of oxaliplatin, fluorouracil, leucovorin calcium, and irinotecan.
  • Compare the quality of life, response rate, time to treatment failure, and overall survival in patients treated with these regimens.
  • Compare the toxicity of these regimens in these patients.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to ECOG performance status (0-1 vs 2), prior adjuvant chemotherapy (yes vs no), prior immunotherapy (yes vs no), and age (under 65 vs 65 and over). Patients are randomized to one of three treatment arms.

Only arm II remains open to accrual.

  • Arm I (Saltz regimen): Patients receive irinotecan IV over 90 minutes followed by leucovorin calcium IV over 15 minutes and fluorouracil IV once a week for 4 weeks followed by 2 weeks of rest. Courses repeat every 6 weeks. (Arm I closed to accrual as of March 15, 2002.)
  • Arm II (FOLFOX4 regimen): Patients receive oxaliplatin IV over 2 hours on day 1 and leucovorin calcium IV over 2 hours plus fluorouracil IV over 22 hours on days 1 and 2. Courses repeat every 2 weeks.
  • Arm III (oxaliplatin plus irinotecan): Patients receive oxaliplatin IV over 2 hours and irinotecan IV over 30 minutes on day 1. Courses repeat every 3 weeks. (Arm III closed to accrual as of March 15, 2002.) Treatment continues in the absence of disease progression or unacceptable toxicity.

Quality of life is assessed before treatment, during treatment (arm specific), and after completion of treatment.

Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 825 patients (275 per arm) have been accrued for this study thus far. Additional patients are being accrued on arm II. (Arms I and III closed to accrual as of March 15, 2002.)


Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 1691 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Randomized Phase III Trial of Three Different Regimens of CPT-11 Plus 5-Fluorouracil and Leucovorin Compared to 5-Fluorouracil and Leucovorin in Patients With Advanced Adenocarcinoma of the Colon and Rectum
Study Start Date : October 1998
Actual Primary Completion Date : October 2004
Actual Study Completion Date : October 2004

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: irinotecan + leucovorin + fluorouracil

Patients receive irinotecan IV over 90 minutes followed by leucovorin calcium IV over 15 minutes and fluorouracil IV once a week for 4 weeks followed by 2 weeks of rest. Courses repeat every 6 weeks.

Treatment continues in the absence of disease progression or unacceptable toxicity.

Quality of life is assessed before treatment, during treatment (arm specific), and after completion of treatment.

Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.

Drug: irinotecan
Drug: fluorouracil
Drug: leucovorin calcium
Experimental: oxaliplatin + leucovorin + fluorouracil

Patients receive oxaliplatin IV over 2 hours on day 1 and leucovorin calcium IV over 2 hours plus fluorouracil IV over 22 hours on days 1 and 2. Courses repeat every 2 weeks.

Treatment continues in the absence of disease progression or unacceptable toxicity.

Quality of life is assessed before treatment, during treatment (arm specific), and after completion of treatment.

Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.

Drug: fluorouracil
Drug: leucovorin calcium
Drug: oxaliplatin
Experimental: oxaliplatin + irinotecan

Patients receive oxaliplatin IV over 2 hours and irinotecan IV over 30 minutes on day 1. Courses repeat every 3 weeks.

Treatment continues in the absence of disease progression or unacceptable toxicity.

Quality of life is assessed before treatment, during treatment (arm specific), and after completion of treatment.

Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.

Drug: irinotecan
Drug: oxaliplatin



Primary Outcome Measures :
  1. time to progression [ Time Frame: Up to 5 years ]

Secondary Outcome Measures :
  1. overall survival [ Time Frame: Up to 5 years ]
  2. time to treatment failure [ Time Frame: Up to 5 years ]
  3. response rate [ Time Frame: Up to 5 years ]
  4. quality of life [ Time Frame: Up to 5 years ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed locally advanced, locally recurrent, or metastatic colorectal adenocarcinoma not curable by surgery or radiotherapy

    • Histological or cytological requirement waived in patients who developed radiological or clinical evidence of metastatic cancer after a prior surgical resection unless:

      • More than 5 years has elapsed since primary surgery OR
      • Primary cancer was stage I or II
  • Site of primary lesion must be or have been confirmed endoscopically, radiologically, or surgically to be or have been in the large bowel
  • Measurable or evaluable disease
  • No CNS metastases or carcinomatous meningitis

PATIENT CHARACTERISTICS:

Age:

  • 18 and over

Performance status:

  • ECOG 0-2

Life expectancy:

  • At least 12 weeks

Hematopoietic:

  • Absolute granulocyte count at least 1,500/mm^3
  • Platelet count at least 100,000/mm^3
  • Hemoglobin at least 9.0 g/dL (transfusion allowed)

Hepatic:

  • Bilirubin no greater than 1.5 mg/dL
  • AST no greater than 5 times upper limit of normal (ULN)
  • Alkaline phosphatase no greater than 5 times ULN

Renal:

  • Creatinine no greater than 1.5 times ULN

Cardiovascular:

  • No uncontrolled hypertension
  • No unstable angina
  • No symptomatic congestive heart failure
  • No myocardial infarction within the past 6 months
  • No serious uncontrolled arrhythmia
  • No New York Heart Association class III or IV cardiac disease

Pulmonary:

  • No interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung
  • No pleural effusion or ascites that cause respiratory compromise (grade 2 or worse dyspnea)

Other:

  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No active or uncontrolled infection
  • No symptomatic sensory peripheral neuropathy
  • No known allergy to platinum compounds
  • No history of gastrointestinal bleeding unless it is determined to be acceptable by the enrolling physician
  • No other prior or concurrent malignancy within the past 3 years except nonmelanoma skin cancer, carcinoma in situ of the uterine cervix, or other resected malignant tumor with less than a 10% probability of tumor relapse within 3 years of diagnosis
  • No medical or psychiatric conditions that would preclude study
  • No colonic or small bowel disorders with uncontrolled symptoms of more than 3 loose stools per day
  • Colostomy or ileostomy allowed at investigator's discretion

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Prior adjuvant immunotherapy for resected stage II-IV disease allowed if adjuvant therapy concluded at least 1 year before documentation of recurrent disease
  • No concurrent sargramostim (GM-CSF)

Chemotherapy:

  • No prior chemotherapy for advanced colorectal cancer
  • No prior standard adjuvant chemotherapy for rectal cancer
  • Prior adjuvant fluorouracil for resected stage II-IV disease allowed if adjuvant therapy concluded at least 1 year before documentation of recurrent disease

Radiotherapy:

  • See Disease Characteristics
  • At least 4 weeks since prior major radiotherapy (e.g., chest or bone palliative radiotherapy)
  • No prior radiotherapy to more than 15% of bone marrow
  • No prior standard adjuvant radiotherapy for rectal cancer

Surgery:

  • See Disease Characteristics
  • At least 4 weeks since prior major surgery (e.g., laparotomy) (2 weeks for minor surgery) and recovered
  • Insertion of a vascular access device not considered major or minor surgery

Other:

  • No other concurrent investigational agents

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00003594


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Locations
United States, Alabama
Veterans Affairs Medical Center - Birmingham
Birmingham, Alabama, United States, 35233-1996
MBCCOP - Gulf Coast
Mobile, Alabama, United States, 36688
United States, Arizona
CCOP - Greater Phoenix
Phoenix, Arizona, United States, 85006-2726
Veterans Affairs Medical Center - Phoenix (Hayden)
Phoenix, Arizona, United States, 85012
Mayo Clinic Hospital
Phoenix, Arizona, United States, 85054-4502
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States, 85259
Veterans Affairs Medical Center - Tucson
Tucson, Arizona, United States, 85723
Arizona Cancer Center
Tucson, Arizona, United States, 85724
United States, Arkansas
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
Veterans Affairs Medical Center - Little Rock (McClellan)
Little Rock, Arkansas, United States, 72205
United States, California
Cancer Center and Beckman Research Institute, City of Hope
Duarte, California, United States, 91010-3000
University of California San Diego Cancer Center
La Jolla, California, United States, 92093-0658
Veterans Affairs Medical Center - Long Beach
Long Beach, California, United States, 90822
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States, 90033-0804
Veterans Affairs Medical Center - West Los Angeles
Los Angeles, California, United States, 90073
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, United States, 90095-1781
Veterans Affairs Outpatient Clinic - Martinez
Martinez, California, United States, 94553
Community Hospital of the Monterey Peninsula
Monterey, California, United States, 93940
CCOP - Bay Area Tumor Institute
Oakland, California, United States, 94609-3305
Chao Family Comprehensive Cancer Center
Orange, California, United States, 92868
Veterans Affairs Medical Center - Palo Alto
Palo Alto, California, United States, 94304
University of California Davis Medical Center
Sacramento, California, United States, 95817
Veterans Affairs Medical Center - San Francisco
San Francisco, California, United States, 94121
UCSF Cancer Center and Cancer Research Institute
San Francisco, California, United States, 94143-0128
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, United States, 95403
Stanford University Medical Center
Stanford, California, United States, 94305-5408
David Grant Medical Center
Travis Air Force Base, California, United States, 94535
United States, Colorado
Columbia Medical Center of Aurora North Campus
Aurora, Colorado, United States, 80011
Penrose Cancer Center
Colorado Springs, Colorado, United States, 80933
University of Colorado Cancer Center
Denver, Colorado, United States, 80010
CCOP - Colorado Cancer Research Program, Inc.
Denver, Colorado, United States, 80209-5031
Porter Adventist Hospital
Denver, Colorado, United States, 80210
Presbyterian-St Luke's Medical Center
Denver, Colorado, United States, 80218
St. Joseph Hospital
Denver, Colorado, United States, 80218
HealthOne Rose Medical Center
Denver, Colorado, United States, 80220
Veterans Affairs Medical Center - Denver
Denver, Colorado, United States, 80220
Swedish Medical Center
Englewood, Colorado, United States, 80110
Rocky Mountain Cancer Centers - Northern Colorado
Fort Collins, Colorado, United States, 80524-4038
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
Poudre Valley Radiation Oncology
Fort Collins, Colorado, United States, 80528
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, United States, 81004
United States, Connecticut
Bristol Hospital
Bristol, Connecticut, United States, 06011-0977
University of Connecticut Health Center
Farmington, Connecticut, United States, 06360-7106
St. Francis Hospital and Medical Center
Hartford, Connecticut, United States, 06105
New Britain General Hospital
New Britain, Connecticut, United States, 06050
Lawrence and Memorial Hospital
New London, Connecticut, United States, 06320
William W. Backus Hospital
Norwich, Connecticut, United States, 06360
Northwestern Connecticut Oncology-Hematology Associates
Torrington, Connecticut, United States, 06790
United States, Delaware
CCOP - Christiana Care Health Services
Wilmington, Delaware, United States, 19899
United States, District of Columbia
Walter Reed Army Medical Center
Washington, District of Columbia, United States, 20307-5000
United States, Florida
University of Florida - Gainesville
Gainesville, Florida, United States, 32610-0277
Baptist Regional Cancer Institute - Jacksonville
Jacksonville, Florida, United States, 32207
University of Florida Health Science Center - Jacksonville
Jacksonville, Florida, United States, 32209
Mayo Clinic
Jacksonville, Florida, United States, 32224
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612-9497
United States, Georgia
Emory University Hospital - Atlanta
Atlanta, Georgia, United States, 30322
Grady Memorial Hospital
Atlanta, Georgia, United States, 30335
CCOP - Atlanta Regional
Atlanta, Georgia, United States, 30342-1701
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, United States, 30033
Dwight David Eisenhower Army Medical Center
Fort Gordon, Georgia, United States, 30905-5650
United States, Hawaii
Cancer Research Center of Hawaii
Honolulu, Hawaii, United States, 96813
United States, Illinois
BroMenn Lifecare Center
Bloomington, Illinois, United States, 61701-3081
St. Joseph's Hospital Medical Center
Bloomington, Illinois, United States, 61701
Graham Hospital Association
Canton, Illinois, United States, 61520
Memorial Hospital
Carthage, Illinois, United States, 62321
Hematology-Oncology Associates of Illinois
Chicago, Illinois, United States, 60611-2998
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, United States, 60611-3013
Hematology Oncology Associates of Illinois - Lake Shore Dr
Chicago, Illinois, United States, 60611
Veterans Affairs Medical Center - Lakeside Chicago
Chicago, Illinois, United States, 60611
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, United States, 60612
Mercy Hospital and Medical Center
Chicago, Illinois, United States, 60616
University of Chicago Cancer Research Center
Chicago, Illinois, United States, 60637-1470
CCOP - Central Illinois
Decatur, Illinois, United States, 62526
Holy Family Medical Center
Des Plaines, Illinois, United States, 60016
St. Anthony's Memorial Hospital
Effingham, Illinois, United States, 62401
Northwest Oncology and Hematology, S.C.
Elk Grove Village, Illinois, United States, 60007
Eureka Hospital
Eureka, Illinois, United States, 61530
CCOP - Evanston
Evanston, Illinois, United States, 60201
Galesburg Clinic
Galesburg, Illinois, United States, 61401
InterCommunity Cancer Center of Western Illinois
Galesburg, Illinois, United States, 61401
Galesburg Cottage Hospital
Galesburg, Illinois, United States, 61402
Glenbrook Hospital
Glenview, Illinois, United States, 60025
Ingalls Memorial Hospital
Harvey, Illinois, United States, 60426
Mason District Hospital
Havana, Illinois, United States, 62644
Hematology Oncology Associates of Illinois-Highland Park
Highland Park, Illinois, United States, 60035
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
Hines, Illinois, United States, 60141
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, United States, 60521
Hopedale Medical Complex Hospital
Hopedale, Illinois, United States, 61747
Silver Cross Hospital
Joliet, Illinois, United States, 60432
Joliet Oncology/Hematology Associates, Ltd.
Joliet, Illinois, United States, 60435
Saint Joseph Medical Center
Joliet, Illinois, United States, 60435
Kewanee Hospital
Kewanee, Illinois, United States, 61443
Deerpath Medical Associates
Lake Forest, Illinois, United States, 60045
North Shore Oncology Hematology Associates
Libertyville, Illinois, United States, 60048
McDonough District Hospital
Macomb, Illinois, United States, 61455
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Hematology/Oncology Associates of Illinois, LLC
Melrose Park, Illinois, United States, 60160
Mendota Community Hospital
Mendota, Illinois, United States, 61342
Trinity Medical Center
Moline, Illinois, United States, 61265-1291
Morris Hospital
Morris, Illinois, United States, 60450
BroMenn Regional Medical Center
Normal, Illinois, United States, 61761
Community Cancer Center
Normal, Illinois, United States, 61761
Hematology Oncology Associates of Illinois, LLC
Oak Park, Illinois, United States, 60304
Community Hospital of Ottawa
Ottawa, Illinois, United States, 61350
Pekin Hospital
Pekin, Illinois, United States, 61554
Illinois Oncology Research Association
Peoria, Illinois, United States, 61602
Oncology/Hematology Associates of Central Illinois, P.C.
Peoria, Illinois, United States, 61602
Affiliated Urology Specialists
Peoria, Illinois, United States, 61603
Midwest Urological Group
Peoria, Illinois, United States, 61603
Peoria Urological Associates
Peoria, Illinois, United States, 61614
Proctor Hospital
Peoria, Illinois, United States, 61614
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61636
Midwest Radiation Oncology Physicians
Peoria, Illinois, United States, 61636
St. Francis Medical Center
Peoria, Illinois, United States, 61637
Illinois Valley Community Hospital
Peru, Illinois, United States, 61354
St. James Hospital
Pontiac, Illinois, United States, 61764
Perry Memorial Hospital
Princeton, Illinois, United States, 61356
Trinity Medical Center
Rock Island, Illinois, United States, 61201
Swedish-American Health System
Rockford, Illinois, United States, 61104-2315
Sarah D. Culbertson Memorial Hospital
Rushville, Illinois, United States, 62681
Edward H. Kaplan MD and Associates
Skokie, Illinois, United States, 60076
Hematology Oncology Associates - Skokie
Skokie, Illinois, United States, 60076
Midwest Cancer Research Group, Inc.
Skokie, Illinois, United States, 60077
St. Margaret's Hospital
Spring Valley, Illinois, United States, 61362
Valley Cancer Center
Spring Valley, Illinois, United States, 61362
Carle Cancer Center
Urbana, Illinois, United States, 61801
Carle Foundation Hospital
Urbana, Illinois, United States, 61801
United States, Indiana
Therapy Associates Hematology/Oncology
Evansville, Indiana, United States, 47715
Oncology Institute of Greater Lafayette
Lafayette, Indiana, United States, 47904
United States, Iowa
McFarland Clinic, P.C.
Ames, Iowa, United States, 50010
William R. Bliss Cancer Center
Ames, Iowa, United States, 50010
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, United States, 52722
Saint Anthony Regional Hospital
Carroll, Iowa, United States, 51401
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, United States, 52403
Mercy Medical Center
Cedar Rapids, Iowa, United States, 52403
St. Luke's Hospital
Cedar Rapids, Iowa, United States, 52406
Alegent Health Southwest Iowa Medical Center
Council Bluffs, Iowa, United States, 51503
Des Moines General Hospital
Des Moines, Iowa, United States, 50309
Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates
Des Moines, Iowa, United States, 50314
Mercy Hospital Medical Center
Des Moines, Iowa, United States, 50314
Iowa Lutheran Hospital
Des Moines, Iowa, United States, 50316-2392
Holden Comprehensive Cancer Center at The University of Iowa
Iowa City, Iowa, United States, 52242-1009
Mercy Cancer Center
Mason City, Iowa, United States, 50401
Community Memorial Hospital
Missouri Valley, Iowa, United States, 51555-1199
Burgess Health Center
Onawa, Iowa, United States, 51040
Oncology & Hematology of Ottumwa, PC
Ottumwa, Iowa, United States, 52501
Ottumwa Regional Health Center
Ottumwa, Iowa, United States, 52501
Siouxland Hematology-Oncology
Sioux City, Iowa, United States, 51101-1733
Mercy Medical Center - Sioux City
Sioux City, Iowa, United States, 51101
St. Luke's Regional Medical Center
Sioux City, Iowa, United States, 51104
United States, Kansas
Cancer Center of Kansas - Arkansas City
Arkansas City, Kansas, United States, 67005
Cancer Center of Kansas - Chanute
Chanute, Kansas, United States, 66720
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, United States, 67801
Radiation Oncology Center
Dodge City, Kansas, United States, 67801
Halstead Cancer Center of Kansas
Halstead, Kansas, United States, 67056
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160-7357
Cancer Center of Kansas - Kingman
Kingman, Kansas, United States, 67068
Liberal Cancer Center of Kansas
Liberal, Kansas, United States, 67901
Cancer Center of Kansas - Newton
Newton, Kansas, United States, 67114
Pratt Cancer Center of Kansas
Pratt, Kansas, United States, 67124
Cancer Center of Kansas - Salina
Salina, Kansas, United States, 67401
Cancer Center of Kansas - Wellington
Wellington, Kansas, United States, 67152
Associates in Women's Health - Wichita
Wichita, Kansas, United States, 67208
Wichita Clinic Cancer Medicine Associates, P.A.
Wichita, Kansas, United States, 67208
CCOP - Wichita
Wichita, Kansas, United States, 67214-3882
Cancer Center of Kansas - Wichita
Wichita, Kansas, United States, 67214
Via Christi Regional Medical Center
Wichita, Kansas, United States, 67214
Veterans Affairs Medical Center - Wichita
Wichita, Kansas, United States, 67218
Cancer Center of Kansas - Winfield
Winfield, Kansas, United States, 67156
United States, Kentucky
Veterans Affairs Medical Center - Lexington
Lexington, Kentucky, United States, 40511-1093
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, United States, 40536-0084
United States, Louisiana
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, United States, 70112
Tulane University School of Medicine
New Orleans, Louisiana, United States, 70112
Louisiana State University Health Sciences Center - Shreveport
Shreveport, Louisiana, United States, 71130-3932
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, United States, 71130
United States, Maine
Veterans Affairs Medical Center - Togus
Togus, Maine, United States, 04330
United States, Maryland
Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
United States, Massachusetts
New England Medical Center Hospital
Boston, Massachusetts, United States, 02111
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Boston Medical Center
Boston, Massachusetts, United States, 02118
Faulkner Hospital
Jamaica Plain, Massachusetts, United States, 02130
Veterans Affairs Medical Center - Boston (Jamaica Plain)
Jamaica Plain, Massachusetts, United States, 02130
Lawrence Memorial Hospital of Medford/Hallmark Health Systems
Medford, Massachusetts, United States, 02155
Morton Hospital & Medical Center
Taunton, Massachusetts, United States, 02780
University of Massachusetts Memorial Medical Center
Worcester, Massachusetts, United States, 01655
United States, Michigan
Bixby Medical Center
Adrian, Michigan, United States, 49221
Veterans Affairs Medical Center - Ann Arbor
Ann Arbor, Michigan, United States, 48105
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, United States, 48106
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109-0752
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States, 48201-1379
Veterans Affairs Medical Center - Detroit
Detroit, Michigan, United States, 48201-1932
Henry Ford Hospital
Detroit, Michigan, United States, 48202
St. John Hospital and Medical Center
Detroit, Michigan, United States, 48236
Genesee Regional Medical Center
Flint, Michigan, United States, 48503
CCOP - Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, United States, 49503
Bronson Methodist Hospital
Kalamazoo, Michigan, United States, 49007
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Borgess Medical Center
Kalamazoo, Michigan, United States, 49048-1666
Sparrow Regional Cancer Center
Lansing, Michigan, United States, 48909
Office of E. Michael Lodish
Madison Heights, Michigan, United States, 48071-3457
Community Cancer Center of Monroe
Monroe, Michigan, United States, 48162
St. Mary's Medical Center
Saginaw, Michigan, United States, 48601
Balcueva Clinic
Saginaw, Michigan, United States, 48602
Providence Hospital - Southfield
Southfield, Michigan, United States, 48075-9975
St. John Macomb Hospital
Warren, Michigan, United States, 48093-3494
United States, Minnesota
Alexandria Clinic
Alexandria, Minnesota, United States, 56308
Alexandria Radiation Oncology
Alexandria, Minnesota, United States, 56308
Brainerd Medical Center
Brainerd, Minnesota, United States, 56401
St. Joseph's Medical Center
Brainerd, Minnesota, United States, 56401
Fairview Ridges Hospital
Burnsville, Minnesota, United States, 55337
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Duluth Clinic
Duluth, Minnesota, United States, 55805
Miller-Dwan Medical Center
Duluth, Minnesota, United States, 55805
St. Mary's/Duluth Clinic Health System
Duluth, Minnesota, United States, 55805
Fairview-Southdale Hospital
Edina, Minnesota, United States, 55435
Fergus Falls Medical Group
Fergus Falls, Minnesota, United States, 56537
Mercy/Unity Hospitals
Fridley, Minnesota, United States, 55432
Central Mesabi Medical Center
Hibbing, Minnesota, United States, 55746
Duluth Clinic - Hibbing
Hibbing, Minnesota, United States, 55746
Radiation Therapy Center
Hibbing, Minnesota, United States, 55746
Hutchinson Area Health Care
Hutchinson, Minnesota, United States, 55350
Meeker County Memorial Hospital
Lichfield, Minnesota, United States, 55355
St. John's Hospital
Maplewood, Minnesota, United States, 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Virginia Piper Cancer Institute
Minneapolis, Minnesota, United States, 55407
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, United States, 55415
Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota, United States, 55417
North Memorial Research Center
Minneapolis, Minnesota, United States, 55442-2900
Fairview University Medical Center - Riverside Campus
Minneapolis, Minnesota, United States, 55454-1395
University of Minnesota Cancer Center
Minneapolis, Minnesota, United States, 55455
Mayo Clinic Cancer Center
Rochester, Minnesota, United States, 55905
CentraCare Health Plaza
Saint Cloud, Minnesota, United States, 56303
St. Cloud Hospital
Saint Cloud, Minnesota, United States, 56303
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, United States, 55416
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Healtheast Cancer Care
Saint Paul, Minnesota, United States, 55102
United Hospital
Saint Paul, Minnesota, United States, 55102
Saint Francis Regional Medical Center
Shakopee, Minnesota, United States, 55379
Park Nicollet Clinic
St. Louis Park, Minnesota, United States, 55416
Ridgeview Medical Center
Waconia, Minnesota, United States, 55387
Rice Memorial Hospital
Willmar, Minnesota, United States, 56201
United States, Mississippi
Veterans Affairs Medical Center - Biloxi
Biloxi, Mississippi, United States, 39531-2410
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216-4505
Veterans Affairs Medical Center - Jackson
Jackson, Mississippi, United States, 39216
Keesler Medical Center - Keesler AFB
Keesler AFB, Mississippi, United States, 39534-2576
United States, Missouri
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, United States, 65201
Ellis Fischel Cancer Center - Columbia
Columbia, Missouri, United States, 65203
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, United States, 64128
CCOP - Kansas City
Kansas City, Missouri, United States, 64131
St. Louis University Health Sciences Center
Saint Louis, Missouri, United States, 63110-0250
Barnes-Jewish Hospital
Saint Louis, Missouri, United States, 63110
CCOP - St. Louis-Cape Girardeau
Saint Louis, Missouri, United States, 63141
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, United States, 65807
United States, Montana
CCOP - Montana Cancer Consortium
Billings, Montana, United States, 59101
United States, Nebraska
Fremont Area Medical Center
Fremont, Nebraska, United States, 68025-2387
Bryan LGH Medical Center
Lincoln, Nebraska, United States, 68502-3780
Prairie View Clinic
Lincoln, Nebraska, United States, 68506-5247
Bryan LGH Medical Center East
Lincoln, Nebraska, United States, 68506
Office of Susan Hansen, M.D.
Lincoln, Nebraska, United States, 68506
St. Elizabeth Regional Medical Center
Lincoln, Nebraska, United States, 68510
Wedgewood Medical Center
Lincoln, Nebraska, United States, 68510
Southeast Nebraska Hematology
Lincoln, Nebraska, United States, 68516
Southeast Nebreska Hematology-Oncology Consultants, PC
Lincoln, Nebraska, United States, 68516
Williamsburg Radiation Oncology Center
Lincoln, Nebraska, United States, 68516
Veterans Affairs Medical Center - Omaha
Omaha, Nebraska, United States, 68105
Oncology Hematology West, P.C.
Omaha, Nebraska, United States, 68114
Alegent Health - Immanuel Medical Center
Omaha, Nebraska, United States, 68122
Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Creighton University Cancer Center
Omaha, Nebraska, United States, 68131-2197
St. Joseph Hospital
Omaha, Nebraska, United States, 68131-2197
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198-3330
Alegent Health-Midlands Community Hospital
Papillion, Nebraska, United States, 68046-4194
United States, Nevada
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, United States, 89106
United States, New Hampshire
Norris Cotton Cancer Center
Lebanon, New Hampshire, United States, 03756-0002
United States, New Jersey
Center for Cancer And Hematologic Disease
Cherry Hill, New Jersey, United States, 08046
Trinitas Hospital - Jersey Street Campus
Elizabeth, New Jersey, United States, 07201
Hunterdon Regional Cancer Center
Flemington, New Jersey, United States, 08822
South Jersey Regional Cancer Center
Millville, New Jersey, United States, 08332
Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
Mount Holly, New Jersey, United States, 08060
Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08903
Riverview Medical Center - Booker Cancer Center
Red Bank, New Jersey, United States, 07701
St. Francis Medical Center
Trenton, New Jersey, United States, 08629
Southern Oncology-Hematology Associates, P.A.
Vineland, New Jersey, United States, 08360
Comprehensive Cancer and Hematology Associates
Voorhees, New Jersey, United States, 08043
Burlington County Hematology Oncology Association, P.A.
Willingboro, New Jersey, United States, 08046
United States, New Mexico
Veterans Affairs Medical Center - Albuquerque
Albuquerque, New Mexico, United States, 87108-5138
MBCCOP - University of New Mexico HSC
Albuquerque, New Mexico, United States, 87131
United States, New York
Albert Einstein Comprehensive Cancer Center
Bronx, New York, United States, 10461
Veterans Affairs Medical Center - Buffalo
Buffalo, New York, United States, 14215
Mary Imogene Bassett Hospital
Cooperstown, New York, United States, 13326
CCOP - North Shore University Hospital
Manhasset, New York, United States, 11030
Schneider Children's Hospital at North Shore
Manhasset, New York, United States, 11030
Veterans Affairs Medical Center - New York
New York, New York, United States, 10010
NYU School of Medicine's Kaplan Comprehensive Cancer Center
New York, New York, United States, 10016
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10021
New York Presbyterian Hospital - Cornell Campus
New York, New York, United States, 10021
Mount Sinai Medical Center, NY
New York, New York, United States, 10029
Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
Rochester General Hospital
Rochester, New York, United States, 14621
State University of New York - Upstate Medical University
Syracuse, New York, United States, 13210
Veterans Affairs Medical Center - Syracuse
Syracuse, New York, United States, 13210
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, United States, 13217
United States, North Carolina
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, United States, 27599-7295
Veterans Affairs Medical Center - Durham
Durham, North Carolina, United States, 27705
Duke Comprehensive Cancer Center
Durham, North Carolina, United States, 27710
CCOP - Southeast Cancer Control Consortium
Winston-Salem, North Carolina, United States, 27104-4241
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, United States, 27157-1082
United States, North Dakota
Bismarck Cancer Center
Bismarck, North Dakota, United States, 58501-4445
Medcenter One Health System
Bismarck, North Dakota, United States, 58501
Mid Dakota Clinic, P.C.
Bismarck, North Dakota, United States, 58501
St. Alexius Medical Center
Bismarck, North Dakota, United States, 58502
CCOP - Merit Care Hospital
Fargo, North Dakota, United States, 58122
Meritcare Roger Maris Cancer Center
Fargo, North Dakota, United States, 58122
Altru Health Systems
Grand Forks, North Dakota, United States, 58201
Altru Cancer Center
Grand Forks, North Dakota, United States, 58206
United States, Ohio
Akron City Hospital
Akron, Ohio, United States, 44309
Wood County Oncology Center
Bowling Green, Ohio, United States, 43402
Mercy Ireland Cancer Center
Canton, Ohio, United States, 44708
Aultman Cancer Center
Canton, Ohio, United States, 44710
Veterans Affairs Medical Center - Cincinnati
Cincinnati, Ohio, United States, 45220-2288
Barrett Cancer Center, The University Hospital
Cincinnati, Ohio, United States, 45267-0502
Ireland Cancer Center
Cleveland, Ohio, United States, 44106-5065
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States, 44195
CCOP - Columbus
Columbus, Ohio, United States, 43206
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, United States, 43210-1240
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, United States, 45428
Woman Wise Blanchard Valley Regional Health Center
Findlay, Ohio, United States, 45840
Fremont Memorial Hospital
Fremont, Ohio, United States, 43420
Office of Sharon Cole, M.D.
Kenton, Ohio, United States, 43326
CCOP - Dayton
Kettering, Ohio, United States, 45429
St. Rita's Medical Center
Lima, Ohio, United States, 45801
Lima Memorial Hospital
Lima, Ohio, United States, 45804
North West Ohio Oncology Center
Maumee, Ohio, United States, 43537
Saint Luke's Hospital
Maumee, Ohio, United States, 43537
St. Charles Hospital
Oregon, Ohio, United States, 43616
Firelands Regional Medical Center
Sandusky, Ohio, United States, 44870
North Coast Cancer Care, Inc.
Sandusky, Ohio, United States, 44870
Flower Hospital - Pro Medica Health System
Sylvania, Ohio, United States, 43560
Riverside Hospital
Toledo, Ohio, United States, 43604
Toledo Hospital
Toledo, Ohio, United States, 43606
St. Vincent Mercy Medical Center
Toledo, Ohio, United States, 43608
Medical College of Ohio Hospital
Toledo, Ohio, United States, 43614-0008
MCO Cancer Institute
Toledo, Ohio, United States, 43614
Haematology-Oncology Associates, Inc.
Toledo, Ohio, United States, 43623-4474
Toledo Clinic, Inc.
Toledo, Ohio, United States, 43623
Fulton County Health Center
Wauseon, Ohio, United States, 43567
United States, Oklahoma
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, United States, 73104
Veterans Affairs Medical Center - Oklahoma City
Oklahoma City, Oklahoma, United States, 73104
CCOP - Oklahoma
Tulsa, Oklahoma, United States, 74136
United States, Oregon
Oregon Cancer Center
Portland, Oregon, United States, 97201-3098
Veterans Affairs Medical Center - Portland
Portland, Oregon, United States, 97207
CCOP - Columbia River Program
Portland, Oregon, United States, 97213
United States, Pennsylvania
Lehigh Valley Hospital
Allentown, Pennsylvania, United States, 18103
Muhlenberg Hospital Center
Bethlehem, Pennsylvania, United States, 18017
Marion Community Hospital
Carbondale, Pennsylvania, United States, 18407
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822-2001
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, United States, 19026
DuBois Regional Medical Center
DuBois, Pennsylvania, United States, 15801-0447
UPMC Horizon
Greenville, Pennsylvania, United States, 16125
Pinnacle Health Hospitals
Harrisburg, Pennsylvania, United States, 17105-8700
Wayne Memorial Hospital
Honesdale, Pennsylvania, United States, 18431-1498
UPCI @ UPMC Lee Hospital
Johnstown, Pennsylvania, United States, 15901
Conemaugh Memorial Hospital
Johnstown, Pennsylvania, United States, 15905
Armstrong County Memorial Hospital
Kittanning, Pennsylvania, United States, 16201-8808
Lancaster General Hospital
Lancaster, Pennsylvania, United States, 17604-3555
Saint Mary Regional Center
Langhorne, Pennsylvania, United States, 19047
Latrobe Area Hospital
Latrobe, Pennsylvania, United States, 15650
Central Pennsylvania Hematology and Medical Oncology Associates
Lemoyne, Pennsylvania, United States, 17043
Hahnemann University Hospital
Philadelphia, Pennsylvania, United States, 19102-1192
University of Pennsylvania Cancer Center
Philadelphia, Pennsylvania, United States, 19104-4283
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, United States, 19141
Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States, 15213-3180
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
UPMC/Passavant Hospital
Pittsburgh, Pennsylvania, United States, 15237
Pottstown Memorial Regional Cancer Center
Pottstown, Pennsylvania, United States, 19464
Reading Hospital and Medical Center
Reading, Pennsylvania, United States, 19612-6052
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, United States, 18501
Moses Taylor Hospital
Scranton, Pennsylvania, United States, 18510
Scranton Hematology-Oncology
Scranton, Pennsylvania, United States, 18510
Geisinger Medical Group
State College, Pennsylvania, United States, 16801
Chester County Hospital
West Chester, Pennsylvania, United States, 19380
Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, United States, 18711
United States, Rhode Island
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
United States, South Carolina
CCOP - Greenville
Greenville, South Carolina, United States, 29615
CCOP - Upstate Carolina
Spartanburg, South Carolina, United States, 29303
United States, South Dakota
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57709
Sioux Valley Clinic
Sioux Falls, South Dakota, United States, 57104
Avera McKennan Hospital and University Health Center
Sioux Falls, South Dakota, United States, 57105-1080
Avera Cancer Institute
Sioux Falls, South Dakota, United States, 57105
Sioux Valley Hospital
Sioux Falls, South Dakota, United States, 57117
United States, Tennessee
University of Tennessee, Memphis Cancer Center
Memphis, Tennessee, United States, 38103
Veterans Affairs Medical Center - Memphis
Memphis, Tennessee, United States, 38104
United States, Texas
Brooke Army Medical Center
Fort Sam Houston, Texas, United States, 78234
University of Texas Medical Branch
Galveston, Texas, United States, 77555-0209
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78284-7811
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, United States, 78284
Veterans Affairs Medical Center - Temple
Temple, Texas, United States, 76504
CCOP - Scott and White Hospital
Temple, Texas, United States, 76508
United States, Utah
Huntsman Cancer Institute
Salt Lake City, Utah, United States, 84112
Veterans Affairs Medical Center - Salt Lake City
Salt Lake City, Utah, United States, 84148
United States, Vermont
Vermont Cancer Center
Burlington, Vermont, United States, 05401-3498
Veterans Affairs Medical Center - White River Junction
White River Junction, Vermont, United States, 05009
United States, Virginia
Veterans Affairs Medical Center - Richmond
Richmond, Virginia, United States, 23249
MBCCOP - Massey Cancer Center
Richmond, Virginia, United States, 23298-0037
United States, Washington
CCOP - Virginia Mason Research Center
Seattle, Washington, United States, 98101
Swedish Cancer Institute
Seattle, Washington, United States, 98104
Veterans Affairs Medical Center - Seattle
Seattle, Washington, United States, 98108
CCOP - Northwest
Tacoma, Washington, United States, 98405-0986
Madigan Army Medical Center
Tacoma, Washington, United States, 98431-5000
United States, Wisconsin
Fox Valley Hematology and Oncology
Appleton, Wisconsin, United States, 54911
Memorial Medical Center
Ashland, Wisconsin, United States, 54806
Luther Hospital
Eau Claire, Wisconsin, United States, 54703
Midelfort Clinic
Eau Claire, Wisconsin, United States, 54703
St. Vincent Hospital
Green Bay, Wisconsin, United States, 54307-3508
Franciscan Skemp Healthcare
La Crosse, Wisconsin, United States, 54601-4796
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States, 54601
Veterans Affairs Medical Center - Madison
Madison, Wisconsin, United States, 53705
Dean Medical Center
Madison, Wisconsin, United States, 53715
Meriter Hospital
Madison, Wisconsin, United States, 53715
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States, 53792-6164
CCOP - Marshfield Medical Research and Education Foundation
Marshfield, Wisconsin, United States, 54449
Aurora Sinai Samaritan Medical Center
Milwaukee, Wisconsin, United States, 53201-0342
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Veterans Affairs Medical Center - Milwaukee (Zablocki)
Milwaukee, Wisconsin, United States, 53295
Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, United States, 53066
Waukesha Memorial Hospital
Waukesha, Wisconsin, United States, 53188
UW Cancer Center Wausau Hospital
Wausau, Wisconsin, United States, 54401
Canada, Alberta
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Canada, British Columbia
British Columbia Cancer Agency - Centre for the Southern Interior
Kelowna, British Columbia, Canada, V1Y 5L3
Nanaimo Cancer Clinic
Nanaimo, British Columbia, Canada, V9S 2B7
British Columbia Cancer Agency - Fraser Valley Cancer Centre
Surrey, British Columbia, Canada, V3V 1Z2
British Columbia Cancer Agency
Vancouver, British Columbia, Canada, V5Z 4E6
British Columbia Cancer Agency - Vancouver Island Cancer Centre
Victoria, British Columbia, Canada, V8R 6V5
Canada, Manitoba
St. Boniface General Hospital
Winnipeg, Manitoba, Canada, R2H 2A6
Canada, Nova Scotia
Nova Scotia Cancer Centre
Halifax, Nova Scotia, Canada, B3H 1V7
Canada, Ontario
William Osler Health Centre
Brampton, Ontario, Canada, L6W 2Z8
Cancer Care Ontario-London Regional Cancer Centre
London, Ontario, Canada, N6A 4L6
Trillium Health Centre
Mississauga, Ontario, Canada, L5B 1B8
Credit Valley Hospital
Mississauga, Ontario, Canada, L5M 2N1
Southlake Regional Health Centre
Newmarket, Ontario, Canada, L3Y 2P9
Peterborough Oncology Clinic
Peterborough, Ontario, Canada, K9H 7B6
Algoma District Medical Group
Sault Sainte Marie, Ontario, Canada, P6B 1Y5
Hotel Dieu Health Sciences Hospital - Niagara
St. Catharines, Ontario, Canada, L2R 5K3
Northeastern Ontario Regional Cancer Centre, Sudbury
Sudbury, Ontario, Canada, P3E 5J1
Northwestern Ontario Regional Cancer Centre, Thunder Bay
Thunder Bay, Ontario, Canada, P7A 7T1
Mount Sinai Hospital - Toronto
Toronto, Ontario, Canada, M5G 1X5
Saint Joseph's Health Centre - Toronto
Toronto, Ontario, Canada, M6R 1B5
Humber River Regional Hospital
Weston, Ontario, Canada, M9N 1N8
Canada, Prince Edward Island
Queen Elizabeth Hospital, PEI
Charlottetown, Prince Edward Island, Canada, C1A 8T5
Canada, Quebec
Hopital Charles Lemoyne
Greenfield Park, Quebec, Canada, J4V 2H1
Maisonneuve-Rosemont Hospital
Montreal, Quebec, Canada, H1T 2M4
Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada, H2L-4M1
CHUM Hopital Saint-Luc
Montreal, Quebec, Canada, H2X 3J4
L'Hopital Laval
Ste-Foy, Quebec, Canada, G1V 4G5
Canada, Saskatchewan
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada, S4T 7T1
Pasqua Hospital
Regina, Saskatchewan, Canada, S4T 7T1
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada, S7N 4H4
Canada
Lions Gate Hospital
North Vancouver, Canada, V7L 2P9
Puerto Rico
Centro Mamografia Hospital Oncologico
Hato Rey, Puerto Rico, 00919-1811
Veterans Affairs Medical Center - San Juan
San Juan, Puerto Rico, 00927-5800
San Juan City Hospital
San Juan, Puerto Rico, 00936-7344
South Africa
Medical Oncology Centre of Rosebank
Johannesburg, South Africa, 2193
Pretoria Academic Hospitals
Pretoria, South Africa, 0001
Sponsors and Collaborators
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)
NCIC Clinical Trials Group
Investigators
Study Chair: Henry C. Pitot, MD Mayo Clinic

Publications of Results:
Sargent DJ, Campbell M, Grothey A, et al.: Overall and 12 week tumor response versus actual tumor measurements as predictors of overall survival (OS) in advanced colorectal cancer (ACRC): findings from NCCTG N9741. [Abstract] American Society of Clinical Oncology 2008 Gastrointestinal Cancers Symposium, 25-27 January 2008, Orlando, FL. A-446, 2008.
Grothey A, Sargent DJ, Campbell ME, et al.: Waterfall plots provide detailed information on magnitude of response to conventional chemotherapy in colorectal cancer: lessons learned from N9741. [Abstract] American Society of Clinical Oncology 2007 Gastrointestinal Cancers Symposium, 19 -21 January 2007, Orlando, Florida A-337, 2007.
Goldberg RM, McLeod HL, Sargent DJ, et al.: Genetic polymorphisms, toxicity, and response rate in African Americans (AA) with metastatic colorectal cancer (MCRC) compared to Caucasians (C) when treated with IFL, FOLFOX or IROX in Intergroup N9741. [Abstract] J Clin Oncol 24 (Suppl 18): A-3503, 2006.
McLeod HL, Parodi L, Sargent DJ, et al.: UGT1A1*28, toxicity and outcome in advanced colorectal cancer: results from trial N9741. [Abstract] J Clin Oncol 24 (Suppl 18): A-3520, 2006.
Dy GK, Krook J, Green E, et al.: Impact of complete response to chemotherapy on overall survival (OS) in advanced colorectal cancer (CRC): results from Intergroup N9741. [Abstract] American Society of Clinical Oncology 2005 Gastrointestinal Cancers Symposium, 27-29 January 2005, Miami, Florida. A-185, 2005.
Fuchs C, Pollak M, Sargent DJ, et al.: Insulin-like growth factor-I (IGF-1), IGF binding protein-3 (IGFBP-3), and outcome in metastatic colorectal cancer (CRC): results from intergroup trial N9741. [Abstract] J Clin Oncol 22 (Suppl 14): A-3521, 250s, 2004.
Goldberg RM, Morton RF, Sargent DJ, et al.: N9741: oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study. [Abstract] Proceedings of the American Society of Clinical Oncology 22: A-1009, 252, 2003.
Goldberg RM, Morton RF, Sargent D, et al.: N9741: oxaliplatin (oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Initial toxicity and response data from a GI Intergroup study. [Abstract] Proceedings of the American Society of Clinical Oncology 21: A-511, 2002.
Morton RF, Goldberg RM, Sargent DJ, et al.: Oxaliplatin (OXAL) or CPT-11 Combined with 5FU/Leucovorin (LV) in Advanced Colorectal Cancer (CRC): an NCCTG/CALGB Study. [Abstract] Proceedings of the American Society of Clinical Oncology 20: A-495, 2001.

Other Publications:
Franko J, Shi Q, Goldman CD, et al.: Treatment of colorectal peritoneal carcinomatosis with systemic chemotherapy: A pooled analysis of NCCTG's phase III trials N9741 and N9841. [Abstract] J Clin Oncol 29 (Suppl 15): A-3571, 2011.
Campbell ME, Mandrekar SJ, Hillman SL, et al.: What is the added value of actual tumor measurements (TM) in predicting overall survival (OS)? The North Central Cancer Treatment Group (NCCTG) findings. [Abstract] J Clin Oncol 26 (Suppl 15): A-6520, 2008.
Grothey A, Hedrick EE, Mass RD, et al.: Response rate using conventional criteria is a poor surrogate for clinical benefit on progression-free (PFS) and overall survival (OS) in metastatic colorectal cancer (mCRC): a comparative analysis of N9741 and AVF2107. [Abstract] J Clin Oncol 24 (Suppl 18): A-3516, 2006.

Responsible Party: Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier: NCT00003594     History of Changes
Other Study ID Numbers: NCCTG-N9741
CDR0000066665 ( Registry Identifier: PDQ (Physician Data Query) )
CAN-NCIC-CO13
First Posted: September 25, 2003    Key Record Dates
Last Update Posted: July 6, 2016
Last Verified: July 2016

Keywords provided by Alliance for Clinical Trials in Oncology:
stage III colon cancer
stage IV colon cancer
stage III rectal cancer
stage IV rectal cancer
recurrent colon cancer
recurrent rectal cancer
adenocarcinoma of the colon
adenocarcinoma of the rectum

Additional relevant MeSH terms:
Colorectal Neoplasms
Adenocarcinoma
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Calcium, Dietary
Oxaliplatin
Irinotecan
Camptothecin
Fluorouracil
Levoleucovorin
Leucovorin
Bone Density Conservation Agents
Physiological Effects of Drugs
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Topoisomerase I Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action