Genetic Linkage Studies of Stuttering
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|ClinicalTrials.gov Identifier: NCT00001604|
Recruitment Status : Recruiting
First Posted : November 4, 1999
Last Update Posted : December 24, 2018
Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening (prolongation), or early stopping (cessation). Stuttering is characterized by repetitions or prolongation of the first syllable, or silent prolongations, sometimes known as blocks.
Researcher intend on studying the genetic basis for stuttering. The goal of the study is to find the genes that help cause stuttering and determine regions of the human genetic make-up (genome) that are linked to stuttering.. To do this researchers will study the patterns of inheritance in families who have had members who stutter.
The study has two objectives.
The first objective is to develop a large collection of DNA samples from individuals in stuttering families, that will include both members that stutter and who do not stutter.
The second objective of the study will be to find out the basic combination of genes (genotype) making up all of the participants DNA. Once this is completed researchers hope to map out and find areas or regions of DNA that are linked to stuttering.
Genetic linkage is the initial step in positional cloning, and the cloning of genes which predispose individuals to stuttering is a long term goal of this research study.<TAB>
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||4000 participants|
|Official Title:||Genetic Studies of Stuttering|
|Study Start Date :||January 8, 1997|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001604
|Contact: Dennis T Drayna, Ph.D.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 email@example.com|
|National Rehabilitation Center for Persons with Disabilities Hospital||Recruiting|
|Contact: Kotaro Ishikawa 81-4-2995-3100 Ishikawa.firstname.lastname@example.org|
|University of Punjab||Recruiting|
|Principal Investigator:||Dennis T Drayna, Ph.D.||National Institute on Deafness and Other Communication Disorders (NIDCD)|