Social Media Based Peer-Led Intervention for HIV Prevention

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ClinicalTrials.gov Identifier: NCT03213366

Recruitment Status : Completed

First Posted : July 11, 2017

Results First Posted : September 6, 2019

Last Update Posted : November 6, 2019

View this study on Beta.ClinicalTrials.gov

Sponsor:

Collaborators:

National Institutes of Health (NIH)

Albert Einstein College of Medicine

National Institute of Mental Health (NIMH)

Information provided by (Responsible Party):

Viraj V. Patel, Montefiore Medical Center

Study Type	Interventional
Study Design	Allocation: Randomized; Intervention Model: Parallel Assignment; Masking: Double (Participant, Outcomes Assessor); Primary Purpose: Prevention
Conditions	HIV Prevention PrEP Uptake
Interventions	Behavioral: E-PrEP- Peer-Led Intervention about PrEP Behavioral: BxNow - General Health Campaign
Enrollment	152

Participant Flow

Recruitment Details
Pre-assignment Details


Arm/Group Title	E-PrEP- Peer-Led Intervention About PrEP		BxNow-General Health Control Arm:
Arm/Group Description	We recruited Peer Leaders over a 5-...		We recruited Peer Leaders over a 5-...
Arm/Group Description	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.		We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Period Title: Overall Study
	Number of participants	Number of units (Peers)	Number of participants	Number of units (Peers)
Started	81	7	71	5
Completed	72	5	67	5
Not Completed	9	2	4	0
Reason Not Completed
Lost to Follow-up	9		4

Baseline Characteristics

Arm/Group Title		E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm	Total
Arm/Group Description		We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...	Total of all reporting groups
Arm/Group Description		We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.	Total of all reporting groups
Overall Number of Baseline Participants		81	71	152
Baseline Analysis Population Description		[Not Specified]
Baseline Analysis Population Description		[Not Specified]
Age, Continuous Mean (Standard Deviation) Unit of measure: Years
	Number Analyzed	81 participants	71 participants	152 participants
		24.28 (2.83)	23.32 (3.39)	23.84 (2.83)
Sex/Gender, Customized Measure Type: Count of Participants Unit of measure: Participants
Gender Identity	Number Analyzed	81 participants	71 participants	152 participants
	Male	68 84.0%	64 90.1%	132 86.8%
	Female/Transfemale	7 8.6%	3 4.2%	10 6.6%
	Transmale	1 1.2%	0 0.0%	1 0.7%
	Gender Non-conforming/Gender Non-Binary	2 2.5%	0 0.0%	2 1.3%
	Queer	3 3.7%	4 5.6%	7 4.6%
Race/Ethnicity, Customized Measure Type: Count of Participants Unit of measure: Participants
Race/Ethnicity	Number Analyzed	81 participants	71 participants	152 participants
	Latinx/Hispanic	26 32.1%	47 66.2%	73 48.0%
	Non-Hispanic Black	55 67.9%	24 33.8%	79 52.0%
Residence Measure Type: Count of Participants Unit of measure: Participants
	Number Analyzed	81 participants	71 participants	152 participants
	Bronx	44 54.3%	35 49.3%	79 52.0%
	Brooklyn	18 22.2%	14 19.7%	32 21.1%
	Manhattan	16 19.8%	13 18.3%	29 19.1%
	Queens	2 2.5%	8 11.3%	10 6.6%
	Staten Island	1 1.2%	1 1.4%	2 1.3%
Sexual Identity Measure Type: Count of Participants Unit of measure: Participants
	Number Analyzed	81 participants	71 participants	152 participants
	Gay/Homosexual	60 74.1%	56 78.9%	116 76.3%
	Queer	12 14.8%	3 4.2%	15 9.9%
	Bisexual	7 8.6%	10 14.1%	17 11.2%
	Heterosexual/Straight	1 1.2%	1 1.4%	2 1.3%
	Other	1 1.2%	1 1.4%	2 1.3%
Education Level Measure Type: Count of Participants Unit of measure: Participants
	Number Analyzed	81 participants	71 participants	152 participants
	High School or Less	36 44.4%	27 38.0%	63 41.4%
	Some College	28 34.6%	35 49.3%	63 41.4%
	College and Beyond	17 21.0%	9 12.7%	26 17.1%
Employment ^[1] Measure Type: Count of Participants Unit of measure: Participants	Number Analyzed	81 participants	71 participants	152 participants
Full Time		24 29.6%	29 40.8%	53 34.9%
Part Time		17 21.0%	15 21.1%	32 21.1%
Unemployed		31 38.3%	15 21.1%	46 30.3%
Disable		3 3.7%	2 2.8%	5 3.3%
Student		12 14.8%	13 18.3%	25 16.4%
		[1] Measure Description: Participants had the option to select more than one answer in order to best describe their employment status (not mutually exclusive).
Income Measure Type: Count of Participants Unit of measure: Participants
	Number Analyzed	81 participants	71 participants	152 participants
	None	12 14.8%	14 19.7%	26 17.1%
	Less than $10,000	26 32.1%	15 21.1%	41 27.0%
	$10,000-$19,999	11 13.6%	10 14.1%	21 13.8%
	$20,000-$29,999	13 16.0%	6 8.5%	19 12.5%
	$30,000-$39,999	11 13.6%	16 22.5%	27 17.8%
	$40,000-more	8 9.9%	10 14.1%	18 11.8%
Living Situation Measure Type: Count of Participants Unit of measure: Participants
	Number Analyzed	81 participants	71 participants	152 participants
	Don't have a place to live	4 4.9%	2 2.8%	6 3.9%
	Temporary Living Situation	15 18.5%	7 9.9%	22 14.5%
	Parents/Family	29 35.8%	36 50.7%	65 42.8%
	Partner/Boyfriend/Husband	2 2.5%	7 9.9%	9 5.9%
	Roomates	20 24.7%	14 19.7%	34 22.4%
	Alone	11 13.6%	4 5.6%	15 9.9%
	Wife/Females Partner/Girlfriend	0 0.0%	1 1.4%	1 0.7%
Health Insurance Measure Type: Count of Participants Unit of measure: Participants
	Number Analyzed	81 participants	71 participants	152 participants
	Yes	61 75.3%	59 83.1%	120 78.9%
	No	18 22.2%	10 14.1%	28 18.4%
	I don't kno	2 2.5%	2 2.8%	4 2.6%

Outcome Measures

1.Primary Outcome


Title	Number of Participants Intending to Start Using PrEP Over Time
Description	This primary outcome is intention to use PrEP in the next month measur...
Description	This primary outcome is intention to use PrEP in the next month measured at baseline, 6 weeks, and 12 weeks. This was assessed with a yes/no question (dichotomous variable). However, this variable does not include anyone who reported PrEP use at either 6 or 12 weeks. This outcome will inform sample size calculations for a subsequent fully powered trial.
Time Frame	baseline, 6 weeks, and 12 weeks

Outcome Measure Data

Analysis Population Description

Each of the rows indicates the number of participants who indicated intending to use PrEP at each time point (Baseline vs. 6 weeks vs. 12 weeks).


Arm/Group Title		E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:		We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:		We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed		65	63
Measure Type: Count of Participants Unit of Measure: Participants
Baseline	Yes	32 49.2%	34 54.0%
Baseline	No	33 50.8%	29 46.0%
6 Weeks	Yes	23 35.4%	27 42.9%
6 Weeks	No	42 64.6%	36 57.1%
12 Weeks	Yes	27 41.5%	32 50.8%
12 Weeks	No	38 58.5%	31 49.2%

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 6 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.5783
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	-0.0095
	Confidence Interval	(2-Sided) 95% -0.04676 to 0.02776
	Estimation Comments	[Not Specified]

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 12 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.3185
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	-0.01692
	Confidence Interval	(2-Sided) 95% -0.05318 to 0.01933
	Estimation Comments	[Not Specified]

2.Primary Outcome


Title	Number of Participants Using PrEP Over Time
Description	This outcome is the number of participants who self-report using PrEP ...
Description	This outcome is the number of participants who self-report using PrEP at baseline, 6 weeks, or 12 weeks. This was measure by a yes/no question asking if the participant currently uses PrEP (dichotomous variable).
Time Frame	at baseline, 6 weeks, and 12 weeks

Outcome Measure Data

Analysis Population Description

[Not Specified]


Arm/Group Title		E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:		We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:		We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed		65	63
Measure Type: Count of Participants Unit of Measure: Participants
Baseline	Yes	13 20.0%	11 17.5%
Baseline	No	52 80.0%	52 82.5%
6 weeks	Yes	17 26.2%	11 17.5%
6 weeks	No	48 73.8%	52 82.5%
12 weeks	Yes	14 21.5%	13 20.6%
12 weeks	No	51 78.5%	50 79.4%

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 6 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.07863
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.03674
	Confidence Interval	(2-Sided) 95% -0.00516 to 0.07863
	Estimation Comments	[Not Specified]

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 12 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.1999
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.02594
	Confidence Interval	(2-Sided) 95% -0.01648 to 0.06836
	Estimation Comments	[Not Specified]

3.Secondary Outcome


Title	Change in PrEP Knowledge
Description	Self-reported PrEP related knowledge. ...
Description	Self-reported PrEP related knowledge. Participants were asked two questions about PrEP knowledge. For each question, they got one point if the answer was correct. Scale range from 0-2. The score were added and the average of the sum was reported. The higher the score, the higher the knowledge of PrEP.
Time Frame	at baseline, 6 weeks, and 12 weeks

Outcome Measure Data

Analysis Population Description

[Not Specified]


Arm/Group Title	E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:	We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed	65	63
Mean (Standard Deviation) Unit of Measure: score on a scale
Baseline	1.86 (0.43)	1.7 (0.59)
6 Weeks	1.86 (0.39)	1.83 (0.46)
12 Weeks	1.83 (0.49)	1.73 (0.55)

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 6 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.8963
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.000443
	Estimation Comments	[Not Specified]

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 12 weeks
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.3229
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.004308
	Estimation Comments	[Not Specified]

4.Secondary Outcome


Title	PrEP Awareness
Description	Awareness about PrEP. ...
Description	Awareness about PrEP. PrEP awareness was measured with one question, scored 1 to 5. The mean for each arm was calculated at each time point. The higher the score, the higher the level of awareness about PrEP.
Time Frame	baseline, 6 weeks, 12 weeks

Outcome Measure Data

Analysis Population Description


Arm/Group Title	E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:	We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed	65	63
Mean (Standard Deviation) Unit of Measure: score on a scale
Baseline	4.14 (0.95)	4.02 (0.88)
6 Weeks	4.29 (0.96)	4.13 (0.91)
12 Weeks	4.52 (0.69)	4.19 (0.91)

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	[Not Specified]
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.2433
	Comments	This t-test was for the random effects model not for comparing the difference between the arms.
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.008705
	Estimation Comments	[Not Specified]

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 12 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.0839
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.01358
	Estimation Comments	[Not Specified]

5.Secondary Outcome


Title	PrEP Stigma
Description	Any stigma the participant might have about PrEP or those who use PrEP...
Description	Any stigma the participant might have about PrEP or those who use PrEP To measure PrEP Stigma we asked 3 questions, using a Likert scale (from 1-4; 1= Strongly Disagree, 4=Strongly Agree). The scores were summed for each participant. The scores range from 1-12, with higher scores indicating higher levels of PrEP Stigma. The higher the score, the higher the level of PrEP stigma.
Time Frame	baseline, 6 weeks, 12 weeks

Outcome Measure Data

Analysis Population Description

[Not Specified]


Arm/Group Title	E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:	We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed	69	63
Mean (Standard Deviation) Unit of Measure: score on a scale
Baseline	6.25 (2.21)	6.78 (2.39)
6 Weeks	5.40 (2.55)	6.24 (2.87)
12 Weeks	5.12 (2.34)	6.0 (2.53)

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 6 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.2114
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	-0.302
	Estimation Comments	[Not Specified]

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 12 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.2141
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	-0.03149
	Estimation Comments	[Not Specified]

6.Secondary Outcome


Title	Communication About PrEP
Description	Discussion of PrEP with friends, partners, or family. Communication ab...
Description	Discussion of PrEP with friends, partners, or family. Communication about PrEP was measured with 2 questions, using a Likert scale ( from 1-5;1=Not at all, 5= Extremely). The scores of the 2 questions were summed for each participant. The scores range from 1-10, with higher the score indicating higher the level of communication about PrEP (i.e. higher scores indicates participants communicating more about PrEP).
Time Frame	baseline, 6 weeks, 12 weeks

Outcome Measure Data

Analysis Population Description

[Not Specified]


Arm/Group Title	E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:	We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed	65	63
Mean (Standard Deviation) Unit of Measure: score on a scale
Baseline	8.42 (2.38)	8.24 (2.29)
6 Weeks	9.14 (1.47)	8.60 (1.85)
12 Weeks	8.94 (1.81)	8.32 (2.14)

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 6 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.0124
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.0278
	Estimation Comments	[Not Specified]

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 12 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.0022
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.03052
	Estimation Comments	[Not Specified]

7.Secondary Outcome


Title	PrEP Barriers
Description	Any Barriers to PrEP uptake. ...
Description	Any Barriers to PrEP uptake. To measure barriers to PrEP uptake, 7 items were used. Each item was measured using a likert scale ( from 1-4; 1=Strongly Disagree, 4= Strongly Agree). The scores of each question were summed for each participant (scale scores ranged 1-28, with higher scores indicating higher levels of PrEP Barriers). The higher the score, the higher the number of PrEP Barriers.
Time Frame	baseline, 6 weeks, 12 weeks

Outcome Measure Data

Analysis Population Description

[Not Specified]


Arm/Group Title	E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:	We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed	65	63
Mean (Standard Deviation) Unit of Measure: score on a scale
Baseline	17.80 (4.28)	18.73 (4.6)
6 Weeks	17.11 (5.17)	18.76 (5.22)
12 Weeks	16.55 (4.92)	17.84 (5.20)

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 6 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.1021
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	-0.05747
	Estimation Comments	[Not Specified]

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 12 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.133
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	-0.05101
	Estimation Comments	[Not Specified]

8.Secondary Outcome


Title	Self-efficacy About Using PrEP
Description	Self-reported answer to questions about self-efficacy of using PrEP. T...
Description	Self-reported answer to questions about self-efficacy of using PrEP. There were two questions to measure self-efficacy of PrEP using a Likert scale (ranging from 1-5; 1=Not at all, 5=Extremely). The scores from both questions were summed for each participant. The scale range from 1-10 with higher scores indicating higher the levels of PrEP self-efficacy.
Time Frame	at baseline, 6 weeks, and 12 weeks

Outcome Measure Data

Analysis Population Description

[Not Specified]


Arm/Group Title	E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:	We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed	65	63
Mean (Standard Deviation) Unit of Measure: score on a scale
Baseline	8.26 (2.39)	8.19 (2.35)
6 Weeks	8.88 (1.72)	8.49 (1.86)
12 Weeks	8.75 (1.97)	8.13 (2.35)

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 6 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.0818
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	-0.0209
	Estimation Comments	[Not Specified]

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	E-PrEP- Peer-Led Intervention About PrEP, BxNow- General Health Control Arm
	Comments	At 12 weeks.
	Type of Statistical Test	Superiority
	Comments	[Not Specified]

Statistical Test of Hypothesis	P-Value	0.0334
	Comments	[Not Specified]
	Method	Mixed Models Analysis
	Comments	[Not Specified]

Method of Estimation	Estimation Parameter	Slope
	Estimated Value	0.03103
	Estimation Comments	[Not Specified]

9.Other Pre-specified Outcome


Title	Number of Participants With Self-reported HIV Testing
Description	Self-reported HIV testing at baseline, 6 weeks, and 12 weeks.
Description	Self-reported HIV testing at baseline, 6 weeks, and 12 weeks.
Time Frame	at baseline, 6 weeks, and 12 weeks

Outcome Measure Data

Analysis Population Description

Each row indicates when the participant who responded to the survey at baseline, 6 weeks, and 12 weeks.


Arm/Group Title		E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:		We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:		We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed		81	71
Measure Type: Count of Participants Unit of Measure: Participants
Baseline	Number Analyzed	81 participants	71 participants
	1 month	33 40.7%	22 31.0%
	3 months or less	29 35.8%	20 28.2%
	4 to 6 months	10 12.3%	16 22.5%
	7 to 12 months	6 7.4%	7 9.9%
	More than 12 months	1 1.2%	2 2.8%
	I have never been tested for STI	2 2.5%	4 5.6%
6 Weeks	Number Analyzed	69 participants	66 participants
	1 month	24 34.8%	20 30.3%
	3 months or less	26 37.7%	23 34.8%
	4 to 6 months	11 15.9%	13 19.7%
	7 to 12 months	1 1.4%	6 9.1%
	More than 12 months	5 7.2%	3 4.5%
	I have never been tested for STI	2 2.9%	1 1.5%
12 Weeks	Number Analyzed	71 participants	65 participants
	1 month	26 36.6%	18 27.7%
	3 months or less	31 43.7%	19 29.2%
	4 to 6 months	9 12.7%	15 23.1%
	7 to 12 months	0 0.0%	7 10.8%
	More than 12 months	4 5.6%	3 4.6%
	I have never been tested for STI	1 1.4%	3 4.6%

10.Other Pre-specified Outcome


Title	Number of Participants With Self-reported Linkage-to-Care
Description	Self-reported information about health care access (i.e. going to a me...
Description	Self-reported information about health care access (i.e. going to a medical appointment).
Time Frame	at baseline, 6 weeks, and 12 weeks

Outcome Measure Data

Analysis Population Description

Each row has the number of participants who access healthcare at each time point in the "yes" category, and the number of people who did not access healthcare in the "no" category. (Baseline vs. 6 weeks vs. 12 weeks).


Arm/Group Title		E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:		We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:		We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed		81	71
Measure Type: Count of Participants Unit of Measure: Participants
Baseline- Visit in the past 12 months	Number Analyzed	81 participants	71 participants
	Yes	61 75.3%	64 90.1%
	No	20 24.7%	7 9.9%
6 Weeks- Visit in the past 6 weeks	Number Analyzed	69 participants	66 participants
	Yes	40 58.0%	41 62.1%
	No	29 42.0%	25 37.9%
12 Weeks- Visit in the past 12 weeks	Number Analyzed	71 participants	65 participants
	Yes	45 63.4%	33 50.8%
	No	26 36.6%	32 49.2%

11.Other Pre-specified Outcome


Title	Trust in the Peer by Participant
Description	The scale measure the level of trust the Participant had on the Peer's...
Description	The scale measure the level of trust the Participant had on the Peer's online post. Trust in the Peer Leader was measured using 4 questions, each scored from 1-7 (1=Strongly Disagree, 7=Strongly Agree). The score for the 4 questions was summed for each participant. The score ranged from 1-28 with higher scores indicating a higher level of trust the participant had in their Peer Leader.
Time Frame	at baseline and 6 weeks

Outcome Measure Data

Analysis Population Description

The total number of participants who completed baseline study was 81 for e-prep and 71 for control. The analysis for 6 weeks included only the people who completed the survey at each that time period.


Arm/Group Title		E-PrEP- Peer-Led Intervention About PrEP	BxNow- General Health Control Arm
Arm/Group Description:		We recruited Peer Leaders over a 5-...	We recruited Peer Leaders over a 5-...
Arm/Group Description:		We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.	We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them. Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
Overall Number of Participants Analyzed		81	71
Mean (Standard Deviation) Unit of Measure: score on a scale
Baseline	Number Analyzed	81 participants	71 participants
Baseline		16.4 (4.15)	14.32 (4.27)
6 Weeks	Number Analyzed	69 participants	66 participants
6 Weeks		16.06 (4.48)	15.71 (4.28)

Adverse Events

Time Frame	Adverse events were tracked for a period of 12 weeks.
Adverse Event Reporting Description	There was no risk for serious or adverse events. All of the the risk were minimal. None of the participants were at risk of mortality.

Arm/Group Title	E-PrEP- Peer-Led Intervention About PrEP	BxNow - General Health Campaign
Arm/Group Description	8 Peer Leaders (PLs) will be random...	BxNow is an attention-matched contr...
Arm/Group Description	8 Peer Leaders (PLs) will be randomly assigned to the E-PrEP arm. Each of the PLs will recruit at least 15 participants into a private social media group on one of several social media platforms. PLs will then deliver a behavioral intervention over a 6 week period, posting information and engaging participants in a discussion about PrEP, PrEP access, and other related health issues. All contents will be formatted to be both mobile device accessible. Intervention contents and targets were informed by a systematic review of PrEP barriers and facilitators, a locally conducted qualitative study, and key informant and peer leader inputs. The contents were developed or adapted by study staff and peer leaders. Components and associated text have been designed to engage participants in online discussions about PrEP and related health and social topics. Posts will also include information about linkage-to-care, and insurance access. New contents will be posted almost daily.	BxNow is an attention-matched control. Eight of the 16 PLs will be randomly assigned to the BxNow arm. The BxNow campaign will be a 6-week long social media intervention about general health wellness topics chosen and administered by the PLs assigned into this arm. Similarly to the intervention group, PLs in the BxNow arm will create private social media groups and recruit participants into these private groups. General health information in the BxNow arm will be posted with the same frequency as in the intervention arm. BxNow - General Health Campaign: BxNow will focus on general health topics unrelated to HIV or sexual health (i.e. fitness, nutrition, smoking), as chosen by PLs. Contents will be developed or adapted by PLs and posted almost daily. Posts will also include information about linkage-to-care and insurance access. At the end of the intervention, BxNow participants will be exposed to E-PrEP components at the end of the trial.
All-Cause Mortality
	E-PrEP- Peer-Led Intervention About PrEP	BxNow - General Health Campaign
	Affected / at Risk (%)	Affected / at Risk (%)
Total	0/81 (0.00%)	0/71 (0.00%)
Serious Adverse Events Serious Adverse Events
	E-PrEP- Peer-Led Intervention About PrEP	BxNow - General Health Campaign
	Affected / at Risk (%)	Affected / at Risk (%)
Total	0/81 (0.00%)	0/71 (0.00%)
Other (Not Including Serious) Adverse Events
Frequency Threshold for Reporting Other Adverse Events	0%
	E-PrEP- Peer-Led Intervention About PrEP	BxNow - General Health Campaign
	Affected / at Risk (%)	Affected / at Risk (%)
Total	0/81 (0.00%)	0/71 (0.00%)

Limitations and Caveats

[Not Specified]

More Information

Certain Agreements

Principal Investigators are NOT employed by the organization sponsoring the study.

There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.

Results Point of Contact

Layout table for Results Point of Contact information

Name/Title:	Dr. Viraj V Patel
Organization:	Albert Einstein College of Medicine
Phone:	718.920-7102
EMail:	vpatel@montefiore.org

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Patel VV, Ginsburg Z, Golub SA, Horvath KJ, Rios N, Mayer KH, Kim RS, Arnsten JH. Empowering With PrEP (E-PrEP), a Peer-Led Social Media-Based Intervention to Facilitate HIV Preexposure Prophylaxis Adoption Among Young Black and Latinx Gay and Bisexual Men: Protocol for a Cluster Randomized Controlled Trial. JMIR Res Protoc. 2018 Aug 28;7(8):e11375. doi: 10.2196/11375.

Layout table for additonal information

Responsible Party:	Viraj V. Patel, Montefiore Medical Center
ClinicalTrials.gov Identifier:	NCT03213366
Other Study ID Numbers:	2016-7263 5K23MH102118-04 ( U.S. NIH Grant/Contract )
First Submitted:	March 28, 2017
First Posted:	July 11, 2017
Results First Submitted:	April 25, 2019
Results First Posted:	September 6, 2019
Last Update Posted:	November 6, 2019

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