Early Mobilisation After Severe Traumatic Brain Injury

• ClinicalTrials.gov Identifier: NCT02924649
• Recruitment Status: Active, not recruiting
• First Posted: October 5, 2016
• Last Update Posted: May 24, 2019
• Sponsor: Rigshospitalet, Denmark
• Collaborator: University Hospital Bispebjerg and Frederiksberg
• Information provided by (Responsible Party): Kirsten Moller, Rigshospitalet, Denmark

No Study Results Posted on ClinicalTrials.gov for this Study

• Recruitment Status: Active, not recruiting
• Actual Primary Completion Date: January 2019
• Estimated Study Completion Date: January 2020

Publications:

Horn SD, DeJong G, Smout RJ, Gassaway J, James R, Conroy B. Stroke rehabilitation patients, practice, and outcomes: is earlier and more aggressive therapy better? Arch Phys Med Rehabil. 2005 Dec;86(12 Suppl 2):S101-S114.

DeJong G, Hsieh CH, Putman K, Smout RJ, Horn SD, Tian W. Physical therapy activities in stroke, knee arthroplasty, and traumatic brain injury rehabilitation: their variation, similarities, and association with functional outcomes. Phys Ther. 2011 Dec;91(12):1826-37. doi: 10.2522/ptj.20100424. Epub 2011 Oct 14.

Riberholt CG, Thorlund JB, Mehlsen J, Nordenbo AM. Patients with severe acquired brain injury show increased arousal in tilt-table training. Dan Med J. 2013 Dec;60(12):A4739.

Wilson BA DS, Tunnard C, Watson P and Florschutz G. The Effect of Positioning on the Level of Arousal and Awareness in Patients in the Vegetative State or the Minimally Conscious State: A Replication and Extension of a Previous Finding. BRAIN IMPAIRMENT. 2013;14(3):475-9.

Elliott L, Coleman M, Shiel A, Wilson BA, Badwan D, Menon D, Pickard J. Effect of posture on levels of arousal and awareness in vegetative and minimally conscious state patients: a preliminary investigation. J Neurol Neurosurg Psychiatry. 2005 Feb;76(2):298-9.

Newman M, Barker K. The effect of supported standing in adults with upper motor neurone disorders: a systematic review. Clin Rehabil. 2012 Dec;26(12):1059-77. doi: 10.1177/0269215512443373. Epub 2012 May 29. Review.

Andelic N, Bautz-Holter E, Ronning P, Olafsen K, Sigurdardottir S, Schanke AK, Sveen U, Tornas S, Sandhaug M, Roe C. Does an early onset and continuous chain of rehabilitation improve the long-term functional outcome of patients with severe traumatic brain injury? J Neurotrauma. 2012 Jan 1;29(1):66-74. doi: 10.1089/neu.2011.1811. Epub 2011 Dec 5.

Frazzitta G, Valsecchi R, Zivi I, Sebastianelli L, Bonini S, Zarucchi A, Matteri D, Molatore K, Maestri R, Saltuari L. Safety and Feasibility of a Very Early Verticalization in Patients With Severe Traumatic Brain Injury. J Head Trauma Rehabil. 2015 Jul-Aug;30(4):290-2. doi: 10.1097/HTR.0000000000000135.

Riberholt CG, Olesen ND, Thing M, Juhl CB, Mehlsen J, Petersen TH. Impaired Cerebral Autoregulation during Head Up Tilt in Patients with Severe Brain Injury. PLoS One. 2016 May 11;11(5):e0154831. doi: 10.1371/journal.pone.0154831. eCollection 2016.

Verheyden B, Ector H, Aubert AE, Reybrouck T. Tilt training increases the vasoconstrictor reserve in patients with neurally mediated syncope evoked by head-up tilt testing. Eur Heart J. 2008 Jun;29(12):1523-30. doi: 10.1093/eurheartj/ehn134. Epub 2008 Mar 27.

Lang EW, Lagopoulos J, Griffith J, Yip K, Mudaliar Y, Mehdorn HM, Dorsch NW. Noninvasive cerebrovascular autoregulation assessment in traumatic brain injury: validation and utility. J Neurotrauma. 2003 Jan;20(1):69-75.

Liu X, Czosnyka M, Donnelly J, Budohoski KP, Varsos GV, Nasr N, Brady KM, Reinhard M, Hutchinson PJ, Smielewski P. Comparison of frequency and time domain methods of assessment of cerebral autoregulation in traumatic brain injury. J Cereb Blood Flow Metab. 2015 Feb;35(2):248-56. doi: 10.1038/jcbfm.2014.192. Epub 2014 Nov 19.

Giacino JT, Kalmar K, Whyte J. The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility. Arch Phys Med Rehabil. 2004 Dec;85(12):2020-9.

Hankemeier A, Rollnik JD. The Early Functional Abilities (EFA) scale to assess neurological and neurosurgical early rehabilitation patients. BMC Neurol. 2015 Oct 19;15:207. doi: 10.1186/s12883-015-0469-z.

van Baalen B, Odding E, van Woensel MP, Roebroeck ME. Reliability and sensitivity to change of measurement instruments used in a traumatic brain injury population. Clin Rehabil. 2006 Aug;20(8):686-700.

Stubbs PW, Pallesen H, Pedersen AR, Nielsen JF. Using EFA and FIM rating scales could provide a more complete assessment of patients with acquired brain injury. Disabil Rehabil. 2014;36(26):2278-81. doi: 10.3109/09638288.2014.904935. Epub 2014 Mar 28.

Gronwall D, Wrightson P. Duration of post-traumatic amnesia after mild head injury. Journal of Clinical Neuropsychology. 1980;2(1):51-60.

Imholz BP, Wieling W, van Montfrans GA, Wesseling KH. Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res. 1998 Jun;38(3):605-16. Review.

Giller CA, Bowman G, Dyer H, Mootz L, Krippner W. Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery. 1993 May;32(5):737-41; discussion 741-2.

Beninato M, Gill-Body KM, Salles S, Stark PC, Black-Schaffer RM, Stein J. Determination of the minimal clinically important difference in the FIM instrument in patients with stroke. Arch Phys Med Rehabil. 2006 Jan;87(1):32-9.

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Riberholt CG, Lindschou J, Gluud C, Mehlsen J, Møller K. Early mobilisation by head-up tilt with stepping versus standard care after severe traumatic brain injury - Protocol for a randomised clinical feasibility trial. Trials. 2018 Nov 8;19(1):612. doi: 10.1186/s13063-018-3004-x.