Effectiveness of DIM Supplements to Increase 2-OHE1/16 Ratio (EDIMI216OHE1)

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ClinicalTrials.gov Identifier: NCT02525159

Recruitment Status : Completed

First Posted : August 17, 2015

Last Update Posted : August 17, 2015

View this study on Beta.ClinicalTrials.gov

Sponsor:

Information provided by (Responsible Party):

Estela Ytelina Godínez Martínez, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes

No Study Results Posted on ClinicalTrials.gov for this Study

About Study Results Reporting on ClinicalTrials.gov

Recruitment Status :	Completed
Actual Primary Completion Date :	August 2009
Actual Study Completion Date :	February 2010

Publications:

Falk RT, Rossi SC, Fears TR, Sepkovic DW, Migella A, Adlercreutz H, Donaldson J, Bradlow HL, Ziegler RG. A new ELISA kit for measuring urinary 2-hydroxyestrone, 16alpha-hydroxyestrone, and their ratio: reproducibility, validity, and assay performance after freeze-thaw cycling and preservation by boric acid. Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):81-7.

Godinez Martinez EY, Santillan Ballesteros R, Lemus Bravo AE, Samano R, Tolentino Dolores M, Rodriguez Ventura AL, Juarez Gonzalez AR. [Determination of 2-hydroxyestrone /16alpha-hydroxyestrone ratio in urine of Mexican women as a risk indicator for breast cancer and its relationship with other risk factors]. Nutr Hosp. 2014 Oct 25;31(2):835-40. doi: 10.3305/nh.2015.31.2.8172. Spanish.

Reed GA, Peterson KS, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1953-60. doi: 10.1158/1055-9965.EPI-05-0121.

Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer. 2004;50(2):161-7. doi: 10.1207/s15327914nc5002_5.

Wong GY, Bradlow L, Sepkovic D, Mehl S, Mailman J, Osborne MP. Dose-ranging study of indole-3-carbinol for breast cancer prevention. J Cell Biochem Suppl. 1997;28-29:111-6. doi: 10.1002/(sici)1097-4644(1997)28/29+3.0.co;2-k.

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