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Trial record 33 of 73 for:    "Asperger syndrome"

Neurocircuitry of Autism- fMRI and Transcranial Magnetic Stimulation Studies

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ClinicalTrials.gov Identifier: NCT01553240
Recruitment Status : Terminated (Principal Investigator (Dr. Sporn) left the sponsoring institution.)
First Posted : March 14, 2012
Results First Posted : January 13, 2017
Last Update Posted : January 13, 2017
Sponsor:
Information provided by (Responsible Party):
New York State Psychiatric Institute

Study Type Interventional
Study Design Intervention Model: Single Group Assignment;   Masking: None (Open Label);   Primary Purpose: Diagnostic
Conditions Autism Spectrum Disorder
Asperger Disorder
Pervasive Developmental Disorder
Intervention Device: TMS and functional MRI (Magstim)
Enrollment 8
Recruitment Details P.I. has left the institution and NYSPI has no access to the data. Results will not be analyzed or presented.
Pre-assignment Details  
Arm/Group Title TMS and fMRI
Hide Arm/Group Description
  • functional MRI
  • single and paired pulse TMS (to identify the difference of motor excitability between patients and healthy controls)

TMS and functional MRI (Magstim): single and paired pulse low frequency TMS. 3T structural MRI scans, amplitude modulated continuous arterial spin labeling( CASL) perfusion imaging sequence optimized for 3T is employed for perfusion MR scans using GE FAIR sequence for parallel imaging.

Period Title: Overall Study
Started 0
Completed 0
Not Completed 0
Arm/Group Title TMS and fMRI
Hide Arm/Group Description
  • functional MRI
  • single and paired pulse TMS (to identify the difference of motor excitability between patients and healthy controls)

TMS and functional MRI (Magstim): single and paired pulse low frequency TMS. 3T structural MRI scans, amplitude modulated continuous arterial spin labeling( CASL) perfusion imaging sequence optimized for 3T is employed for perfusion MR scans using GE FAIR sequence for parallel imaging.

Overall Number of Baseline Participants 0
Hide Baseline Analysis Population Description
P.I. has left the institution and NYSPI has no access to the data. Results will not be analyzed or presented.
Age, Categorical  
Number Analyzed 0 participants
<=18 years
Between 18 and 65 years
>=65 years
Gender  
Number Analyzed 0 participants
Female
Male
Region of Enrollment  
Unit of measure:  Participants
United States Number Analyzed 0 participants
1.Primary Outcome
Title Repetitive Behavior Scale-revised
Hide Description [Not Specified]
Time Frame during screening
Show Outcome Measure DataHide Outcome Measure Data
Hide Analysis Population Description
P.I. has left the institution and NYSPI has no access to the data. Results will not be analyzed or presented.
Arm/Group Title TMS and fMRI
Hide Arm/Group Description:
  • functional MRI
  • single and paired pulse TMS (to identify the difference of motor excitability between patients and healthy controls)

TMS and functional MRI (Magstim): single and paired pulse low frequency TMS. 3T structural MRI scans, amplitude modulated continuous arterial spin labeling( CASL) perfusion imaging sequence optimized for 3T is employed for perfusion MR scans using GE FAIR sequence for parallel imaging.

Overall Number of Participants Analyzed 0
No data displayed because Outcome Measure has zero total analyzed.
2.Secondary Outcome
Title Vineland Maladaptive Behavior Scale
Hide Description [Not Specified]
Time Frame during screening
Show Outcome Measure DataHide Outcome Measure Data
Hide Analysis Population Description
P.I. has left the institution and NYSPI has no access to the data. Results will not be analyzed or presented.
Arm/Group Title TMS and fMRI
Hide Arm/Group Description:
  • functional MRI
  • single and paired pulse TMS (to identify the difference of motor excitability between patients and healthy controls)

TMS and functional MRI (Magstim): single and paired pulse low frequency TMS. 3T structural MRI scans, amplitude modulated continuous arterial spin labeling( CASL) perfusion imaging sequence optimized for 3T is employed for perfusion MR scans using GE FAIR sequence for parallel imaging.

Overall Number of Participants Analyzed 0
No data displayed because Outcome Measure has zero total analyzed.
Time Frame [Not Specified]
Adverse Event Reporting Description P.I. has left the institution and NYSPI has no access to the data. Results will not be analyzed or presented.
 
Arm/Group Title TMS and fMRI
Hide Arm/Group Description
  • functional MRI
  • single and paired pulse TMS (to identify the difference of motor excitability between patients and healthy controls)

TMS and functional MRI (Magstim): single and paired pulse low frequency TMS. 3T structural MRI scans, amplitude modulated continuous arterial spin labeling( CASL) perfusion imaging sequence optimized for 3T is employed for perfusion MR scans using GE FAIR sequence for parallel imaging.

All-Cause Mortality
TMS and fMRI
Affected / at Risk (%)
Total   --/-- 
Show Serious Adverse Events Hide Serious Adverse Events
TMS and fMRI
Affected / at Risk (%)
Total   0/0 
Show Other (Not Including Serious) Adverse Events Hide Other (Not Including Serious) Adverse Events
Frequency Threshold for Reporting Other Adverse Events 0%
TMS and fMRI
Affected / at Risk (%)
Total   0/0 
Certain Agreements
All Principal Investigators ARE employed by the organization sponsoring the study.
Results Point of Contact
Name/Title: Linda Sherman
Organization: New York State Psychiatric Institute
Phone: (646) 774-7158
Publications of Results:
Roid, G.H. Stanford Binet Intelligence Scles, Fifth Edition ( Riverside Publishing, Itasca, IL, 2003)
APA. Diagnostic and Statistical Manual of Mental States Disorders. 4th ed. DSM-4-R( American Psychiatric Association, Washington, DC,2000)
Sparrow, S., Cicchetti, D. & Balla,D. The Vineland-2 Adaptive Behavior Scales( Survey Interview Form) ( American Guidance Service, Circle Pines, MN, 2005)
Constantino, J.N. The Social responsiveness Scale. ( Western psychological Services, Los Angeles, 2002)
Responsible Party: New York State Psychiatric Institute
ClinicalTrials.gov Identifier: NCT01553240     History of Changes
Other Study ID Numbers: 5438
First Submitted: July 19, 2011
First Posted: March 14, 2012
Results First Submitted: January 12, 2017
Results First Posted: January 13, 2017
Last Update Posted: January 13, 2017