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Trial record 33 of 71 for:    "Asperger syndrome"

Neurocircuitry of Autism- fMRI and Transcranial Magnetic Stimulation Studies

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ClinicalTrials.gov Identifier: NCT01553240
Recruitment Status : Terminated (Principal Investigator (Dr. Sporn) left the sponsoring institution.)
First Posted : March 14, 2012
Results First Posted : January 13, 2017
Last Update Posted : January 13, 2017
Sponsor:
Information provided by (Responsible Party):
New York State Psychiatric Institute

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment;   Masking: None (Open Label);   Primary Purpose: Diagnostic
Conditions: Autism Spectrum Disorder
Asperger Disorder
Pervasive Developmental Disorder
Intervention: Device: TMS and functional MRI (Magstim)

  Participant Flow

Recruitment Details
Key information relevant to the recruitment process for the overall study, such as dates of the recruitment period and locations
P.I. has left the institution and NYSPI has no access to the data. Results will not be analyzed or presented.

Pre-Assignment Details
Significant events and approaches for the overall study following participant enrollment, but prior to group assignment
No text entered.

Reporting Groups
  Description
TMS and fMRI
  • functional MRI
  • single and paired pulse TMS (to identify the difference of motor excitability between patients and healthy controls)

TMS and functional MRI (Magstim): single and paired pulse low frequency TMS. 3T structural MRI scans, amplitude modulated continuous arterial spin labeling( CASL) perfusion imaging sequence optimized for 3T is employed for perfusion MR scans using GE FAIR sequence for parallel imaging.


Participant Flow:   Overall Study
    TMS and fMRI
STARTED   0 
COMPLETED   0 
NOT COMPLETED   0 



  Baseline Characteristics

Population Description
Explanation of how the number of participants for analysis was determined. Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as imputation technique, as appropriate.
P.I. has left the institution and NYSPI has no access to the data. Results will not be analyzed or presented.

Reporting Groups
  Description
TMS and fMRI
  • functional MRI
  • single and paired pulse TMS (to identify the difference of motor excitability between patients and healthy controls)

TMS and functional MRI (Magstim): single and paired pulse low frequency TMS. 3T structural MRI scans, amplitude modulated continuous arterial spin labeling( CASL) perfusion imaging sequence optimized for 3T is employed for perfusion MR scans using GE FAIR sequence for parallel imaging.


Baseline Measures
   TMS and fMRI 
Overall Participants Analyzed 
[Units: Participants]
 0 


  Outcome Measures

1.  Primary:   Repetitive Behavior Scale-revised   [ Time Frame: during screening ]

2.  Secondary:   Vineland Maladaptive Behavior Scale   [ Time Frame: during screening ]


  Serious Adverse Events


  Other Adverse Events


  Limitations and Caveats

Limitations of the study, such as early termination leading to small numbers of participants analyzed and technical problems with measurement leading to unreliable or uninterpretable data
No text entered.


  More Information

Certain Agreements:  
All Principal Investigators ARE employed by the organization sponsoring the study.


Results Point of Contact:  
Name/Title: Linda Sherman
Organization: New York State Psychiatric Institute
phone: (646) 774-7158
e-mail: lsherma@nyspi.columbia.edu


Publications of Results:
Roid, G.H. Stanford Binet Intelligence Scles, Fifth Edition ( Riverside Publishing, Itasca, IL, 2003)
APA. Diagnostic and Statistical Manual of Mental States Disorders. 4th ed. DSM-4-R( American Psychiatric Association, Washington, DC,2000)
Sparrow, S., Cicchetti, D. & Balla,D. The Vineland-2 Adaptive Behavior Scales( Survey Interview Form) ( American Guidance Service, Circle Pines, MN, 2005)
Constantino, J.N. The Social responsiveness Scale. ( Western psychological Services, Los Angeles, 2002)


Responsible Party: New York State Psychiatric Institute
ClinicalTrials.gov Identifier: NCT01553240     History of Changes
Other Study ID Numbers: 5438
First Submitted: July 19, 2011
First Posted: March 14, 2012
Results First Submitted: January 12, 2017
Results First Posted: January 13, 2017
Last Update Posted: January 13, 2017