Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01196117
Recruitment Status : Completed
First Posted : September 8, 2010
Last Update Posted : April 10, 2014
Information provided by (Responsible Party):
B Tucker Woodson, Medical College of Wisconsin

Results Submitted - Not Posted on
Results information has been submitted to by the sponsor or investigator, but is not yet publicly available (or "posted") on The submitted information may not be available if it is pending Quality Control (QC) Review by the National Library of Medicine (NLM) or if issues identified during QC review are being addressed or corrected by the sponsor or investigator. NLM's limited QC review assesses for apparent errors, deficiencies, or inconsistencies. NLM staff do not verify the scientific validity or relevance of the submitted information.
  Recruitment Status : Completed
  Actual Primary Completion Date : December 2011
  Actual Study Completion Date : December 2011

Submission Cycle Results Submitted to Results Returned after Quality Control Review
1 January 15, 2016
February 11, 2016
2 February 19, 2016
March 21, 2016
3 May 6, 2016
June 13, 2016
Rapoport D, Rothenberg SA, Hollander CS, Goldring RM: Obstructive sleep apnea (OSA) and the neuroendocrine "stress" axis. Am Rev Respir Dis 1991; 143: A382 (abstract)
Raff H: Salivary cortisol: a useful measurement in the diagnosis of cushing's syndrome and the evaluation of the hypothalamic-pituitary-adrenal axis. The Endocrinologist 2000; 10: 9-17
Nater UM, Rohleder N, Gaab J, Berger S, Jud A, Wolf JM, Ehlert U: Reactivity of human salivary alpha-amylase in a psychosocial stress paradigm. J Psychophysiol 2002; 16(4): 245 (abstract)
Nater UM, La Marca R, Florin L, Koller MM, Ehlert U: The relationship between salivary alpha-amylase and plasma catecholamines. J Psychophysiol 2003; 17(3): 170 (abstract).
Graeber RC: Aircrew fatigue and circadian rhythmicity. In: Wiener E, Nagel DC, eds. Human Factors in Aviation. New York: Academic Press; 1987: 1-48
Lowenstein O, Feinberg R, Loewenfeld ID: Pupillary movements during acute and chronic fatigue. Investigative Ophthalmolog 1963; 2: 138-157
Merrit SL, Schnyders HC, Mercer P: Circadian aspects of papillary unrest reflecting daytime sleepiness. Sleep Research Online 1999; 2(Sup 1): 773
Merrit SL, Schnyders HC, Mercer P, Zhou X: The sensitivity of pupillography to circadian aspects of sleepiness. J Sleep Research 1998; 7(Sup 2): 176

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