Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00942786
Recruitment Status : Completed
First Posted : July 21, 2009
Results First Posted : June 29, 2015
Last Update Posted : June 29, 2015
Information provided by (Responsible Party):
Medical University of Graz

Study Type: Observational
Study Design: Observational Model: Cohort;   Time Perspective: Prospective
Condition: Surgery

  Participant Flow

Recruitment Details
Key information relevant to the recruitment process for the overall study, such as dates of the recruitment period and locations
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Pre-Assignment Details
Significant events and approaches for the overall study following participant enrollment, but prior to group assignment
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Reporting Groups
No Treatment Consecutive patients undergoing emergency surgery

Participant Flow:   Overall Study
    No Treatment
STARTED   297 
COMPLETED   297 [1] 
[1] date of last follow-up

  Baseline Characteristics

Population Description
Explanation of how the number of participants for analysis was determined. Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as imputation technique, as appropriate.
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Reporting Groups
One Arm consecutive patients presenting for emergent non-cardiac surgery

Baseline Measures
   One Arm 
Overall Participants Analyzed 
[Units: Participants]
[Units: Years]
Mean (Full Range)
 (51 to 103) 
[Units: Participants]
Female   180 
Male   117 

  Outcome Measures

1.  Primary:   Occurence of Adverse Cardiac Events   [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ]

2.  Other Pre-specified:   NT-ProBNP Preoperative   [ Time Frame: 0-24 hours before induction of anesthesia ]

3.  Other Pre-specified:   Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events   [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ]

  Serious Adverse Events

  Other Adverse Events

  Limitations and Caveats

Limitations of the study, such as early termination leading to small numbers of participants analyzed and technical problems with measurement leading to unreliable or uninterpretable data
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  More Information

Certain Agreements:  
All Principal Investigators ARE employed by the organization sponsoring the study.

Results Point of Contact:  
Name/Title: Elisabeth Mahla, MD
Organization: Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Austria
phone: ++43316385 ext 13027

Responsible Party: Medical University of Graz Identifier: NCT00942786     History of Changes
Other Study ID Numbers: 19-077 ex 07/08
First Submitted: July 18, 2009
First Posted: July 21, 2009
Results First Submitted: January 26, 2015
Results First Posted: June 29, 2015
Last Update Posted: June 29, 2015