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Comparing Blood Vessel Endothelial Function in HIV-Infected People and Matched HIV-Uninfected People

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Samir K Gupta, MD, MS, National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: June 11, 2009
Last updated: July 1, 2014
Last verified: July 2014
Results First Received: May 28, 2014  
Study Type: Observational
Study Design: Observational Model: Case Control;   Time Perspective: Prospective
Condition: HIV Infection

  Participant Flow

  Baseline Characteristics
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Population Description
Explanation of how the number of participants for analysis was determined. Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as imputation technique, as appropriate.
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Reporting Groups
HIV-Infected HIV-infected participants who are not currently receiving antiretroviral medications
HIV-Uninfected HIV-uninfected participants matched in age, sex, smoking status, and height to the HIV-infected participants
Total Total of all reporting groups

Baseline Measures
   HIV-Infected   HIV-Uninfected   Total 
Overall Participants Analyzed 
[Units: Participants]
 45   44   89 
[Units: Years]
Median (Inter-Quartile Range)
 (27 to 44) 
 (25 to 45) 
 (26 to 45) 
[Units: Participants]
Female   10   11   21 
Male   35   33   68 
Race (NIH/OMB) 
[Units: Participants]
American Indian or Alaska Native   0   0   0 
Asian   0   0   0 
Native Hawaiian or Other Pacific Islander   0   0   0 
Black or African American   28   14   42 
White   17   30   47 
More than one race   0   0   0 
Unknown or Not Reported   0   0   0 

  Outcome Measures

1.  Primary:   Endothelial Function (Brachial Artery Reactivity)   [ Time Frame: Single measurement ]

  Serious Adverse Events

  Other Adverse Events

  Limitations and Caveats
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Limitations of the study, such as early termination leading to small numbers of participants analyzed and technical problems with measurement leading to unreliable or uninterpretable data
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  More Information
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Certain Agreements:  
All Principal Investigators ARE employed by the organization sponsoring the study.

Results Point of Contact:  
Name/Title: Samir K. Gupta, MD, MS
Organization: Indiana University School of Medicine
phone: 317-274-7926

Responsible Party: Samir K Gupta, MD, MS, National Heart, Lung, and Blood Institute (NHLBI) Identifier: NCT00919724     History of Changes
Other Study ID Numbers: 661
R01HL095149 ( US NIH Grant/Contract Award Number )
Study First Received: June 11, 2009
Results First Received: May 28, 2014
Last Updated: July 1, 2014