Does Omeprazole Decrease Intestinal Calcium Absorption?

Recruitment Details

Key information relevant to the recruitment process for the overall study, such as dates of the recruitment period and locations
At least 5 years past onset of menopause; not taking proton pump inhibitors

Pre-Assignment Details

Significant events and approaches for the overall study following participant enrollment, but prior to group assignment
subjects completed a food diary

Reporting Groups

	Description
Experimental	Subjects will receive omeprazole 40 mg daily for 30 days

Participant Flow:   Overall Study

	Experimental
STARTED	23
COMPLETED	21
NOT COMPLETED	2
Protocol Violation	2

Population Description

Explanation of how the number of participants for analysis was determined. Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as imputation technique, as appropriate.
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Reporting Groups

	Description
Experimental	Subjects will receive omeprazole 40 mg daily for 30 days

Baseline Measures

	Experimental
Overall Participants Analyzed  [Units: Participants]	23
Age  [Units: Participants]
<=18 years	0
Between 18 and 65 years	23
>=65 years	0
Age  [Units: Years] Mean (Standard Deviation)	58  (7)
Gender  [Units: Participants]
Female	23
Male	0
Region of Enrollment  [Units: Participants]
United States	23

1.  Primary:

Change in Intestinal Calcium Absorption From Baseline to One Month   [ Time Frame: change in calcium absorption from baseline to 1 month ]

2.  Secondary:

Change in Bone Resorption From Baseline to 1 Month   [ Time Frame: change in bone resorption from baseline to 1 month ]

Limitations of the study, such as early termination leading to small numbers of participants analyzed and technical problems with measurement leading to unreliable or uninterpretable data
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