Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00355368
Recruitment Status : Completed
First Posted : July 21, 2006
Results First Posted : December 15, 2011
Last Update Posted : December 15, 2011
Information provided by (Responsible Party):
Stephan Marsch, University Hospital, Basel, Switzerland

Study Type: Interventional
Study Design: Allocation: Randomized;   Intervention Model: Parallel Assignment;   Masking: Single (Participant);   Primary Purpose: Treatment
Condition: Intubation
Interventions: Drug: Succinylcholine
Drug: Rocuronium

  Participant Flow

Recruitment Details
Key information relevant to the recruitment process for the overall study, such as dates of the recruitment period and locations
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Pre-Assignment Details
Significant events and approaches for the overall study following participant enrollment, but prior to group assignment
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Reporting Groups
Succinylcholine 1mg/kg
Rocuronium 0.6mg/kg

Participant Flow:   Overall Study
    Succinylcholine   Rocuronium
STARTED   210   210 
COMPLETED   200   201 
Protocol Violation                8                7 
cardiac arrest prior to intubation                2                2 

  Baseline Characteristics

Population Description
Explanation of how the number of participants for analysis was determined. Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as imputation technique, as appropriate.
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Reporting Groups
Succinylcholine 1mg/kg
Rocuronium 0.6mg/kg
Total Total of all reporting groups

Baseline Measures
   Succinylcholine   Rocuronium   Total 
Overall Participants Analyzed 
[Units: Participants]
 210   210   420 
[Units: Participants]
<=18 years   0   0   0 
Between 18 and 65 years   123   108   231 
>=65 years   87   102   189 
[Units: Years]
Mean (Standard Deviation)
 60  (16)   63  (14)   61  (15) 
[Units: Participants]
Female   91   93   184 
Male   119   117   236 
Region of Enrollment 
[Units: Participants]
Switzerland   210   210   420 

  Outcome Measures

1.  Primary:   Number of Participants Exhibiting Desaturation >5%   [ Time Frame: at any time between the start of the intubation sequence and 2min after the completion of intubation ]

2.  Secondary:   Time to Completion of Intubation   [ Time Frame: time interval between the injection of the induction agent and the first appearance of endtidal CO2 ]

3.  Secondary:   Quality of Intubation Conditions Using a Validated Score: Viby-Mogensen et al. Good Clinical Research Practice (GCRP) in Pharmacodynamic Studies of Neuromuscular Blocking Agents. Acta Anaesthesiol Scand 1996;40:59-74.   [ Time Frame: during laryngoscopy and the first minute after completion of intubation ]

4.  Secondary:   Number of Participants With an Failed First Intubation Attempts   [ Time Frame: within the first 90 sec following the start of induction ]

5.  Secondary:   Haemodynamic Sequelae of Intubation   [ Time Frame: between start of induction sequence and 5 min after completion of intubation ]
Results not yet reported.   Anticipated Reporting Date:   No text entered.  

  Serious Adverse Events

  Other Adverse Events

  Limitations and Caveats

Limitations of the study, such as early termination leading to small numbers of participants analyzed and technical problems with measurement leading to unreliable or uninterpretable data
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  More Information

Certain Agreements:  
All Principal Investigators ARE employed by the organization sponsoring the study.

Results Point of Contact:  
Name/Title: Stephan Marsch
Organization: Medical Intensive care unit, University Hospital Basel
phone: + 41 61 265 2525

Publications automatically indexed to this study by Identifier (NCT Number):

Responsible Party: Stephan Marsch, University Hospital, Basel, Switzerland Identifier: NCT00355368     History of Changes
Other Study ID Numbers: EK 145/05
First Submitted: July 20, 2006
First Posted: July 21, 2006
Results First Submitted: August 8, 2011
Results First Posted: December 15, 2011
Last Update Posted: December 15, 2011