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Identifying the Anti-Blood-Clotting Compounds in Garlic

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ClinicalTrials.gov Identifier: NCT00200785
Recruitment Status : Completed
First Posted : September 20, 2005
Results First Posted : January 11, 2010
Last Update Posted : January 11, 2010
Sponsor:
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)

Study Type Interventional
Study Design Allocation: Non-Randomized;   Intervention Model: Crossover Assignment;   Masking: None (Open Label);   Primary Purpose: Prevention
Conditions Arteriosclerosis
Intracranial Arteriosclerosis
Interventions Dietary Supplement: garlic powder added to ambient water
Dietary Supplement: garlic powder added to boiling water
Enrollment 9
Recruitment Details healthy participants were recruited in Utah county, Utah, in early 2006
Pre-assignment Details  
Arm/Group Title Garlic Powder: High Allicin Garlic Powder: No Allicin
Hide Arm/Group Description garlic powder in ambient water garlic powder in boiling water
Period Title: First Intervention
Started 9 6
Completed 9 6
Not Completed 0 0
Period Title: Washout Period of 1 Week
Started 9 6
Completed 9 6
Not Completed 0 0
Period Title: Second Intervention
Started 9 6
Completed 9 6
Not Completed 0 0
Arm/Group Title Garlic Powder: High Allicin Garlic Powder: No Allicin Total
Hide Arm/Group Description garlic powder in ambient water garlic powder in boiling water Total of all reporting groups
Overall Number of Baseline Participants 9 6 15
Hide Baseline Analysis Population Description
[Not Specified]
Age, Categorical  
Measure Type: Count of Participants
Unit of measure:  Participants
Number Analyzed 9 participants 6 participants 15 participants
<=18 years
0
   0.0%
0
   0.0%
0.0
Between 18 and 65 years
9
 100.0%
6
 100.0%
15.0
>=65 years
0
   0.0%
0
   0.0%
0.0
Age Continuous  
Mean (Standard Deviation)
Unit of measure:  Years
Number Analyzed 9 participants 6 participants 15 participants
32.2  (13.7) 36.5  (15.1) 32.2  (13.7)
Sex: Female, Male  
Measure Type: Count of Participants
Unit of measure:  Participants
Number Analyzed 9 participants 6 participants 15 participants
Female
4
  44.4%
3
  50.0%
7.0
Male
5
  55.6%
3
  50.0%
8.0
Region of Enrollment  
Measure Type: Number
Unit of measure:  Participants
United States Number Analyzed 9 participants 6 participants 15 participants
9 6 15
electrical impedance (ohms) at 0 weeks   [1] 
Mean (Standard Deviation)
Unit of measure:  Ohms
Number Analyzed 9 participants 6 participants 15 participants
12.7  (1.2) 15.0  (1.6) 13.9  (1.4)
[1]
Measure Description: collagen-induced platelet aggregation in whole blood (WB)
percent platelet aggregation at 0 weeks   [1] 
Mean (Standard Deviation)
Unit of measure:  Percent platelet aggregation
Number Analyzed 9 participants 6 participants 15 participants
76.0  (1.6) 71.8  (5.7) 73.9  (3.7)
[1]
Measure Description: collagen-induced aggregation in platelet-rich plasma (PRP)
1.Primary Outcome
Title Percent Platelet Aggregation
Hide Description percent platelet aggregation in collagen-induced platelet aggregation in platelet rich plasma (PRP)
Time Frame 4 weeks
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Garlic Powder: High Allicin Garlic Powder: No Allicin
Hide Arm/Group Description:
garlic powder in ambient water
garlic powder in boiling water
Overall Number of Participants Analyzed 9 6
Mean (Standard Deviation)
Unit of Measure: percent platelet aggregation
71.4  (4.3) 72.5  (5.5)
2.Secondary Outcome
Title Electrical Impedance in Ohms
Hide Description Electrical impedance (ohms) was measured using 0.5 mL of whole blood plus 0.5 mL saline in a Chronolog Whole Blood aggregometer. Ten mL of whole blood were collected and tested every week. There is no mathematical correlation between impedance (ohms) and percent aggregation.
Time Frame 4 weeks
Hide Outcome Measure Data
Hide Analysis Population Description
Nine persons participated in the "high allicin" test. Six of the same persons participated in the "no allicin" test.
Arm/Group Title Garlic Powder: High Allicin Garlic Powder: No Allicin
Hide Arm/Group Description:
garlic powder in ambient water
garlic powder in boiling water
Overall Number of Participants Analyzed 9 6
Mean (Standard Deviation)
Unit of Measure: ohms
13.8  (1.5) 15.0  (1.5)
Time Frame [Not Specified]
Adverse Event Reporting Description [Not Specified]
 
Arm/Group Title Garlic Powder: High Allicin Garlic Powder: No Allicin
Hide Arm/Group Description garlic powder in ambient water garlic powder in boiling water
All-Cause Mortality
Garlic Powder: High Allicin Garlic Powder: No Allicin
Affected / at Risk (%) Affected / at Risk (%)
Total   --/--   --/-- 
Hide Serious Adverse Events
Garlic Powder: High Allicin Garlic Powder: No Allicin
Affected / at Risk (%) Affected / at Risk (%)
Total   0/9 (0.00%)   0/6 (0.00%) 
Hide Other (Not Including Serious) Adverse Events
Frequency Threshold for Reporting Other Adverse Events 1%
Garlic Powder: High Allicin Garlic Powder: No Allicin
Affected / at Risk (%) Affected / at Risk (%)
Total   0/9 (0.00%)   0/6 (0.00%) 
Certain Agreements
Principal Investigators are NOT employed by the organization sponsoring the study.
There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.
Results Point of Contact
Layout table for Results Point of Contact information
Name/Title: Larry D. Lawson
Organization: Silliker, Inc./Plant Bioactives Research Institute, Inc.
Phone: 801-226-3041
EMail: larry.lawson@silliker.com
Layout table for additonal information
Responsible Party: Larry D. Lawson principal investigator, Silliker, Inc./Plant Bioactives Research Institute, Inc.
ClinicalTrials.gov Identifier: NCT00200785    
Other Study ID Numbers: R21AT001512-01 ( U.S. NIH Grant/Contract )
First Submitted: September 12, 2005
First Posted: September 20, 2005
Results First Submitted: April 23, 2009
Results First Posted: January 11, 2010
Last Update Posted: January 11, 2010