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Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates (ZVITAMBO)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00198718
Recruitment Status : Active, not recruiting
First Posted : September 20, 2005
Last Update Posted : March 7, 2017
McGill University Health Center
University of Zimbabwe
Harare City Health Department, Harare, Zimbabwe
United States Agency for International Development (USAID)
Bill and Melinda Gates Foundation
Rockefeller Foundation
SARA and Linkages Projects, Academy for Educational Development, Washington DC.
Université de Montréal
Information provided by (Responsible Party):
Jean Humphrey, Johns Hopkins Bloomberg School of Public Health

No Study Results Posted on for this Study
  Recruitment Status : Active, not recruiting
  Primary Completion Date : May 2001
  Estimated Study Completion Date : May 2020
Publications of Results:

Other Publications:
Iliff PJ, Humphrey JH, Mahomva AI, Zvandasara P, Bonduelle M, Malaba LC, Nathoo KJ. Tolerance of large doses of vitamin A given to mothers and their babies shortly after delivery. Nutr Res 1999; 19 (10): 1437-1446.
Humphrey JH and Ichord RN: Safety of vitamin A supplementation of postpartum women and young children. Food and Nutrition Bulletin (2001) 22: 311-319.
Humphrey JH, Iliff PJ, Marinda E, Mutasa K, Moulton LH, Chidawanyika H, Ward BJ, Nathoo KJ, Malaba LC, Zijenah LS, Zvandasara P, Ntozini R, Mzengeza F, Mahomva A, Ruff A, Mbizvo M, Zunguza C, and the ZVITAMBO Study Group: Impact of single large doses of vitamin A given during the postpartum period to HIV-infected women and their neonates on breastfeeding-associated mother-to-child-transmission of HIV and infant mortality in Zimbabwe. J Infectious Diseases 2006, 193:860-871. Selected for an editorial: Fawzi, WW: The benefits and concerns related to vitamin A supplementation. J Infectious Diseases 2006;193:756-9.
Lunney KM,* Iliff P, Mutasa K, Ntozini R, Magder LS, Moulton LH, Humphrey JH. Associations between breast milk viral load, mastitis, exclusive breast-feeding, and postnatal transmission of HIV. Clin Infect Dis. 2010 Mar 1;50(5):762-9.Selected for an editorial: Kuhn L. Milk mysteries: Why are women who exclusively breast-feed less likely to transmit HIV during breast-feeding? Clin Inf Dis (2010) 50:770-772.
Koyanagi A,* Humphrey JH, Moulton LH, Ntozini R, Mutasa K, Iliff P, Ruff AJ, and the ZVITAMBO Study Group. Predictors of postpartum weight loss and predictive value of weight loss on maternal mortality in HIV-positive women of prolonged breastfeeding setting. AIDS Research and Human Retroviruses: DOI: 10.1089/AID.2010.0293