Word-Retrieval Treatment for Aphasia: Semantic Feature Analysis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00125242
Recruitment Status : Completed
First Posted : July 29, 2005
Results First Posted : December 24, 2014
Last Update Posted : December 24, 2014
Information provided by (Responsible Party):
VA Office of Research and Development

Study Type: Interventional
Study Design: Allocation: Non-Randomized;   Intervention Model: Parallel Assignment;   Masking: None (Open Label);   Primary Purpose: Treatment
Conditions: Aphasia
Language Disorders
Speech Disorders
Intervention: Behavioral: Semantic Feature Analysis (SFA)Training

  Participant Flow

Recruitment Details
Key information relevant to the recruitment process for the overall study, such as dates of the recruitment period and locations
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Pre-Assignment Details
Significant events and approaches for the overall study following participant enrollment, but prior to group assignment
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Reporting Groups
Non Treatment Stimuli Development Participants Non-brain-injured participants who were enrolled for the purpose of stimuli development
SFA Treatment Participants Stroke survivors who received experimental therapy

Participant Flow:   Overall Study
    Non Treatment Stimuli Development Participants   SFA Treatment Participants
STARTED   94   16 
COMPLETED   87   14 
did not qualify                7                2 

  Baseline Characteristics

Population Description
Explanation of how the number of participants for analysis was determined. Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as imputation technique, as appropriate.
SFA Treatment Participants = Stroke survivors with chronic aphasia. Non Treatment Stimuli Development Participants = non-brain-damaged persons who were enrolled for purposes of stimuli development.

Reporting Groups
SFA Treatment Participants Semantic Feature Analysis (SFA) is a word-retrieval treatment for aphasia. SFA entails having the speech-language pathologist (SLP) guide the participant through generation of pertinent semantic features for pictured treatment items (e.g., category membership, physical description, location of item in context, personal associations, associated actions). For some participants, treatment items were grouped by typicality of category membership (e.g, robin-typical bird and penguin-atypical bird). Training of atypical items may stimulate a broader semantic activation of the category and thus, may promote greater generalization. Treatment was applied sequentially to sets of items in single-subject, multiple baseline designs. Thus, replication of treatment effects could be evaluated within and across participants. Treatment was administered by SLPs three times per week until prescribed accuracy levels were met during probes or a maximum number of treatment sessions was completed.
Non Treatment Stimuli Development Participants Participants for stimuli development provided normative data for stimuli development. e.g., Treatment items were grouped according to typicality of category membership (apple - typical fruit; coconut - atypical fruit). These participants provided the reponses that served as the basis for classifying/organizing stimuli. Because data from this group were used only for the purposes of stimuli development, no findings are reported for this group. See Cameron, R.M., Wambaugh, J.L., & Mauszycki, S. (2008). Effects of age, gender and education on semantic fluency for living and artifact categories. Aphasiology, 22(7/8), 790-801, doi: 10.1080/02687030701818018 for related findings.
Total Total of all reporting groups

Baseline Measures
   SFA Treatment Participants   Non Treatment Stimuli Development Participants   Total 
Overall Participants Analyzed 
[Units: Participants]
 16   94   110 
Age, Customized 
[Units: Participants]
21-80 Years   16   94   110 
[Units: Participants]
Female   4   47   51 
Male   12   47   59 

  Outcome Measures

1.  Primary:   Word Retrieval Accuracy   [ Time Frame: End of treatment and at 6 weeks post treatment ]

  Serious Adverse Events

  Other Adverse Events

  Limitations and Caveats

Limitations of the study, such as early termination leading to small numbers of participants analyzed and technical problems with measurement leading to unreliable or uninterpretable data
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  More Information

Certain Agreements:  
All Principal Investigators ARE employed by the organization sponsoring the study.

Results Point of Contact:  
Name/Title: Dr. Julie Wambaugh
Organization: VA Salt Lake City Health Care System
phone: 801-582-1565 ext 1363

Publications of Results:
Wambaugh JL, Mauszycki S, Wright S. Semantic feature analysis: Application to confrontation naming of actions in aphasia. Aphasiology. 2013 Oct 28; 28(1):DOI:10.1080/02687038.2013.845739.

Responsible Party: VA Office of Research and Development Identifier: NCT00125242     History of Changes
Other Study ID Numbers: C3826-R
First Submitted: July 27, 2005
First Posted: July 29, 2005
Results First Submitted: November 21, 2014
Results First Posted: December 24, 2014
Last Update Posted: December 24, 2014