Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers

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ClinicalTrials.gov Identifier: NCT00001693

Recruitment Status : Completed

First Posted : November 4, 1999

Last Update Posted : March 4, 2008

View this study on Beta.ClinicalTrials.gov

Sponsor:

Information provided by:

National Institutes of Health Clinical Center (CC)

No Study Results Posted on ClinicalTrials.gov for this Study

About Study Results Reporting on ClinicalTrials.gov

Recruitment Status :	Completed
Primary Completion Date :	No date given
Study Completion Date :	January 2002

Publications:

Marra G, Boland CR. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst. 1995 Aug 2;87(15):1114-25. doi: 10.1093/jnci/87.15.1114.

Reddy BS, Rao CV, Seibert K. Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. Cancer Res. 1996 Oct 15;56(20):4566-9.

Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 1995 Nov 3;83(3):493-501. doi: 10.1016/0092-8674(95)90127-2.

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