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Accurate Diagnosis of Multiple Sclerosis Using Hybrid Positron Emission Tomography/Magnetic Resonance (PET/MR)

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ClinicalTrials.gov Identifier: NCT04521439
Recruitment Status : Not yet recruiting
First Posted : August 20, 2020
Last Update Posted : August 20, 2020
Sponsor:
Information provided by (Responsible Party):
Ruijin Hospital

Tracking Information
First Submitted Date  ICMJE August 14, 2020
First Posted Date  ICMJE August 20, 2020
Last Update Posted Date August 20, 2020
Estimated Study Start Date  ICMJE October 1, 2020
Estimated Primary Completion Date March 30, 2022   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: August 18, 2020)
  • Distribution Volume Ratio (DVR) [ Time Frame: Baseline ]
    Dynamic parameter of 18F-florbetapir distribution for quantitatively assessing the demyelination
  • Change from Baseline DVR at 6 months [ Time Frame: 6 months after baseline ]
    Change of 18F-florbetapir distribution in the demyelinated lesions after 6 months
  • Change from Baseline DVR at 1 year [ Time Frame: 1 year after baseline ]
    Change of 18F-florbetapir distribution in the demyelinated lesions after 1 year
  • Standardized Uptake Value Ratio (SUVR) [ Time Frame: Baseline ]
    Static parameter of 18F-florbetapir uptake for quantitatively assessing the demyelination
  • Change from Baseline SUVR at 6 months [ Time Frame: 6 months after baseline ]
    Change of 18F-florbetapir uptake in the demyelinated lesions after 6 months
  • Change from Baseline SUVR at 1 year [ Time Frame: 1 year after baseline ]
    Change of 18F-florbetapir uptake in the demyelinated lesions after 1 year
  • N-acetyl aspartate (NAA) quantification [ Time Frame: Baseline ]
    Neuronal activity marker based on magnetic resonance spectroscopy imaging (MRSI)
  • Change from Baseline NAA at 6 months [ Time Frame: 6 months after baseline ]
    Change of neuronal activity marker in the demyelinated lesions after 6 months
  • Change from Baseline NAA at 1 year [ Time Frame: 1 year after baseline ]
    Change of neuronal activity marker in the demyelinated lesions after 1 year
Original Primary Outcome Measures  ICMJE Same as current
Change History No Changes Posted
Current Secondary Outcome Measures  ICMJE Not Provided
Original Secondary Outcome Measures  ICMJE Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title  ICMJE Accurate Diagnosis of Multiple Sclerosis Using Hybrid Positron Emission Tomography/Magnetic Resonance (PET/MR)
Official Title  ICMJE Hybrid PET/MR Imaging to Assess Demyelination and Axonal Injury in Multiple Sclerosis
Brief Summary

Multiple sclerosis (MS) is an immune-mediated chronic inflammatory demyelinating disease of the central nervous system. Its main feature is progressive demyelination, which ultimately leads to axon damage and neuron loss. MR is the main imaging technique in the current diagnostic criteria of MS. The conventional MR sequence recommended in this diagnostic criteria has high sensitivity for detecting demyelination and axon damage, but has poor specificity, which makes disease modification therapy (DMT) blind, and it is also difficult to accurately determine the long-term prognosis.

PET is a non-invasive molecular imaging technology that can quantitatively monitor physiological or pathological processes in vivo. 18F-labeled thioflavin derivative probe (18F-florbetapir) can bind to myelin basic protein in the white matter, providing quantitative assessment of myelin content. Our preliminary studies have confirmed that the uptake of 18F-florbetapir in MS lesions is significantly related to the myelin content measured by histological staining. Therefore, 18F-florbetapir PET may be a very effective myelin imaging technology.

Advanced MR sequence such as magnetic resonance spectroscopy (MRS) can evaluate axonal damage by analyzing neuronal activity marker N-acetyl aspartate (NAA). The new whole-brain fast 3D MRS sequence breaks through the bottleneck of low signal-to-noise ratio and spatial resolution of the current MRS sequence, and provides a reliable method for obtaining neuronal activity markers in the three-dimensional space of MS sporadic lesions in the whole brain.

Integrated PET/MR makes PET detector implant in the MR magnet, which realizes the simultaneous acquisition of PET and MR in one scan, ensuring the high consistency of the two modes. This makes it possible to simultaneously analyze PET and MRS quantitative parameters in multiple and different sizes of MS lesions, that is, to obtain two different pathological features of demyelination and neuronal damage. Separating these two pathological changes will help to more accurately and quantitatively evaluate the efficacy of DMT, program selection and prognostic judgment.

This project intends to recruit 30 MS patients between 18-65 years old, and 30 healthy volunteers with matched age and sex as normal controls. PET/MR imaging, serological examination and cerebrospinal fluid testing and scale evaluation will be performed. The aim of this project is to planned to establish a new imaging evaluation technology for accurate diagnosis and prognosis evaluation of MS.

Detailed Description Not Provided
Study Type  ICMJE Interventional
Study Phase  ICMJE Not Applicable
Study Design  ICMJE Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Condition  ICMJE Multiple Sclerosis
Intervention  ICMJE Diagnostic Test: 18F-florbetapir PET+MRSI
PET and MRS quantitative parameters in MS lesions are simultaneously analyzed using hybrid PET/MR for obtaining demyelination and neuronal damage information.
Study Arms  ICMJE
  • Experimental: MS Patients Group
    Intervention: Diagnostic Test: 18F-florbetapir PET+MRSI
  • Sham Comparator: Healthy Volunteers Group
    Intervention: Diagnostic Test: 18F-florbetapir PET+MRSI
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Not yet recruiting
Estimated Enrollment  ICMJE
 (submitted: August 18, 2020)
60
Original Estimated Enrollment  ICMJE Same as current
Estimated Study Completion Date  ICMJE September 30, 2022
Estimated Primary Completion Date March 30, 2022   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

MS Patients Group:

Inclusion Criteria:

  • between 18-65 years old;
  • diagnosed with mild or moderate disease (EDSS score ≤ 5 points); it meets the 2017 new version of McDonald diagnostic criteria for multiple sclerosis.
  • meet the diagnostic criteria of clinically isolated syndromes (CIS)

Exclusion Criteria:

  • No brain surgery/no brain trauma/no history of brain disease (stroke), no other independent neurological or psychiatric history;
  • No severe depression symptoms;
  • No alcoholism or drug dependence (addiction);
  • No other conditions that affect the smooth progress of the inspection: such as hearing impairment, comprehension impairment, poor compliance, etc.;
  • No rheumatic diseases and other acute or chronic inflammations (required for hematological markers).
  • No MR contrast agent allergy

Healthy Volunteers Group:

Inclusion Criteria:

  • between 18-65 years old;
  • able to understand the purpose of clinical research and test plan;
  • In the brain MR assessment, it is judged as "normal (corresponding to age)"

Exclusion Criteria:

  • Any major mental illness; history of schizophrenia or schizoaffective disorder
  • Any important neurological disease, such as cerebrovascular disease, inflammation or infectious disease, demyelinating disease, neurodegenerative disease, history of epilepsy or history of physical or craniocerebral trauma or brain surgery or intracranial hematoma with permanent brain history of injury;
  • Brain MR has pathological manifestations;
  • Any major diseases or unstable conditions (such as unstable angina, myocardial infarction or coronary revascularization within 12 months before enrollment, heart failure, chronic renal failure, chronic liver disease, severe lung disease, blood disease, poorly controlled diabetes, chronic infections);
  • Medical history of tumors (except skin or prostate cancer in situ) within 5 years before screening;
  • High risk of drug allergy (such as patients with allergic asthma) or history of severe allergic reactions to allergens;
  • History of alcohol or drug abuse/dependence;
  • MR contraindications (such as pacemaker or nerve stimulator or metal foreign body, high fever, etc.)
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years to 65 Years   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE Yes
Contacts  ICMJE
Listed Location Countries  ICMJE Not Provided
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT04521439
Other Study ID Numbers  ICMJE PET/MR-MS
Has Data Monitoring Committee Yes
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement  ICMJE Not Provided
Responsible Party Ruijin Hospital
Study Sponsor  ICMJE Ruijin Hospital
Collaborators  ICMJE Not Provided
Investigators  ICMJE Not Provided
PRS Account Ruijin Hospital
Verification Date August 2020

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP