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Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus

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ClinicalTrials.gov Identifier: NCT04363125
Recruitment Status : Completed
First Posted : April 27, 2020
Last Update Posted : April 28, 2020
Sponsor:
Collaborator:
Inonu University
Information provided by (Responsible Party):
Ufuk Uylas, Dr. Ersin Arslan Education and Training Hospital

Tracking Information
First Submitted Date April 23, 2020
First Posted Date April 27, 2020
Last Update Posted Date April 28, 2020
Actual Study Start Date January 1, 2019
Actual Primary Completion Date April 1, 2020   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: April 23, 2020)
Mortality [ Time Frame: three months ]
Mortality of sigmoid volvulus due to isolated hypoganglionosis
Original Primary Outcome Measures Same as current
Change History
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus
Official Title Systematic Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus
Brief Summary Isolated hypoganglionosis is rare and constitutes 3-5% of all congenital neurological bowel diseases. Since hypoganglionosis is associated with symptoms such as chronic constipation or pseudo-obstruction, it can be confused with Hirschprung's disease and it is important to make a differential diagnosis before treatment. Our aim in this study; In addition to sharing the rarely isolated hypoganglionosis and sigmoid volvulus in a 45-year-old male patient with mental retardation, the investigators present a systematic comprehensive review of hypoganglionosis.
Detailed Description

Isolated hypoganglionosis is rare and constitutes 3-5% of all congenital neurological bowel diseases. Since hypoganglionosis is associated with symptoms such as chronic constipation or pseudo-obstruction, it can be confused with Hirschprung's disease and it is important to make a differential diagnosis before treatment. Our aim in this study; In addition to sharing the rarely isolated hypoganglionosis and sigmoid volvulus in a 45-year-old male patient with mental retardation, the investigators present a systematic comprehensive review of hypoganglionosis. Pubmed and Scopus databases were scanned. No restrictions were used in the written language. Only isolated cases of hypoganglionosis were added to the study. In the cases; author, year of publication, country of publication, age, gender, surgical or non-surgical treatments, treatment results, and mortalities were examined.

When sigmoid volvulus is seen in children and adolescents, congenital neurological bowel diseases should be considered in the differential diagnosis. Hirschprung's disease must be ruled out by rectal biopsy. The histopathological investigation should be carried out for the diagnosis and determination of surgical margins in isolated hypoganglionosis.

Study Type Observational
Study Design Observational Model: Case-Only
Time Perspective: Other
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Non-Probability Sample
Study Population our case of isolated hypoganglionosis and published isolated hypoganglionosis studies patients.
Condition
  • Pathology
  • Sigmoid Volvulus
  • Hypoganglionosis
Intervention Diagnostic Test: Pathology result
Pathology result of rectal biopsy
Study Groups/Cohorts Not Provided
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Actual Enrollment
 (submitted: April 23, 2020)
310
Original Actual Enrollment Same as current
Actual Study Completion Date April 20, 2020
Actual Primary Completion Date April 1, 2020   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • isolated hypoganglionosis
  • our case of isolated hypoganglionosis

Exclusion Criteria:

  • hypoganglionosis with Hirschsprung's disease
Sex/Gender
Sexes Eligible for Study: All
Ages Child, Adult, Older Adult
Accepts Healthy Volunteers No
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Turkey
Removed Location Countries  
 
Administrative Information
NCT Number NCT04363125
Other Study ID Numbers 23042020
Has Data Monitoring Committee No
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement Not Provided
Responsible Party Ufuk Uylas, Dr. Ersin Arslan Education and Training Hospital
Study Sponsor Dr. Ersin Arslan Education and Training Hospital
Collaborators Inonu University
Investigators
Principal Investigator: ufuk uylas, Specialist Dr. Ersin Arslan Training and Resource Hospital
PRS Account Dr. Ersin Arslan Education and Training Hospital
Verification Date April 2020