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Atlas of Retinal Imaging in Alzheimer's Study (ARIAS)

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ClinicalTrials.gov Identifier: NCT03862222
Recruitment Status : Recruiting
First Posted : March 5, 2019
Last Update Posted : October 20, 2020
Sponsor:
Collaborators:
Stuart Sinoff, MD
Peter J Snyder, MD
BayCare Health System
Information provided by (Responsible Party):
Jessica Alber, University of Rhode Island

Tracking Information
First Submitted Date February 28, 2019
First Posted Date March 5, 2019
Last Update Posted Date October 20, 2020
Actual Study Start Date December 16, 2019
Estimated Primary Completion Date December 2021   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: February 28, 2019)
  • Structural retinal biomarkers assessed with OCT [ Time Frame: 5 years ]
    retinal nerve fiber layer (RNFL) thickness
  • Structural retinal biomarkers assessed with OCT [ Time Frame: 5 years ]
    RNFL volume
  • Metabolic retinal biomarkers assessed with OCT [ Time Frame: 5 years ]
    volume of retinal inclusion bodies containing beta amyloid
  • Metabolic retinal biomarkers assessed with OCT [ Time Frame: 5 years ]
    surface area of retinal inclusion bodies containing beta amyloid
  • Metabolic retinal biomarkers assessed with OCT [ Time Frame: 5 years ]
    macular pigment optical density (MPOD)
  • vascular retinal biomarkers assessed with OCT-A [ Time Frame: 5 years ]
    vessel caliber
  • vascular retinal biomarkers assessed with OCT-A [ Time Frame: 5 years ]
    vessel density
  • vascular retinal biomarkers assessed with OCT-A [ Time Frame: 5 years ]
    area of foveal avascular zone
  • vascular retinal biomarkers assessed with OCT-A [ Time Frame: 5 years ]
    fractal dimension
  • vascular retinal biomarkers assessed with OCT-A [ Time Frame: 5 years ]
    area of blood flow
  • vascular retinal biomarkers assessed with OCT-A [ Time Frame: 5 years ]
    area of blood non-flow
Original Primary Outcome Measures Same as current
Change History
Current Secondary Outcome Measures
 (submitted: February 28, 2019)
  • general cognition [ Time Frame: 5 years ]
    Montreal Cognitive Assessment (MoCA)
  • general cognition [ Time Frame: 5 years ]
    Repeatable Battery for the Assessment of Neuropsychological Status - Update (RBANS-U)
  • processing speed, attention [ Time Frame: 5 years ]
    Digit Symbol Substitution Task (DSST)
  • language [ Time Frame: 5 years ]
    Redden Lab Speech/Language Task
  • memory [ Time Frame: 5 years ]
    Free and Cued Selective Reminder Task (FCSRT)
  • physiological [ Time Frame: 5 years ]
    blood proteomics - 21 protein panel
  • physiological [ Time Frame: 5 years ]
    blood biomarkers (amyloid) measured with single molecule assay
  • physiological [ Time Frame: 5 years ]
    blood biomarkers (phosphorylated tau) measured with single molecule assay
  • physiological [ Time Frame: 5 years ]
    gait assessment (timed get up and go + timed get up and go dual task)
Original Secondary Outcome Measures Same as current
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Atlas of Retinal Imaging in Alzheimer's Study
Official Title Atlas of Retinal Imaging in Alzheimer's Study
Brief Summary The Atlas of Retinal Imaging in Alzheimer's (ARIAS) study is a 5-year study examining the natural history of retinal imaging biomarkers associated with disease risk, disease burden, and disease progression in Alzheimer's disease (AD). The objective of this project is to create a 'gold standard' reference database of structural anatomic and functional imaging of the retina, in order to enable the identification and development of both sensitive and reliable markers of AD risk and/or progression. Our ultimate goal is to develop a new screening protocol that identifies changes related to AD 10-20 years before AD is clinically visible.
Detailed Description

This will be a longitudinal, within-participants prospective natural history study. Participants will be recruited on the basis of serial referrals to the memory disorders centers at all three investigative sites, as well as by Institutional Review Board (IRB)-approved radio, social media and print advertisements. All participants will meet inclusion/exclusion criteria for one of the four (4) participant groups. All participants will be recruited into the study over a 24-month enrollment period. Once enrollment closes, participants will be followed for 3 years, with examinations at one of the four study locations at baseline, 12 months post-enrollment, 24 months post-enrollment, and 36 months post-enrollment. All exam and testing procedures are described below. All retinal imaging will be completed on an FDA-approved clinical OCT imaging system by trained study personnel (with quality assurance and participant safety managed by two Co-Principal Investigator (PI)'s and their staff). Pupillometry and contrast sensitivity vision testing will rely on FDA-approved and commercially widely available devices and standard clinical procedures. All techniques are well-known to both PI's, and these techniques have been in regular use by their clinical research and/or clinical care groups for the past 6+ years.

During the screening visit a cheek swab will be obtained to determine apolipoprotein (APOE) genotype. Enrollment and group assignment will be established once the genotyping results are received (i.e., approximately 55 minutes following cheek swab, and by the end of each screening visit), at which point individuals who meet enrollment criteria will be scheduled for their baseline visit. PIs may choose to include disclosure of APOE genotyping results in their location-specific protocol, if they have the appropriate clinical resources and local IRB approval for disclosure procedures. Genotyping results will not be released to participants or their physicians except through the process of an IRB approved, site-specific protocol for disclosure.

At each study visit (i.e., baseline, 12 months, 24 months, and 36 months) participants will undergo an eye examination and screening for ophthalmic disease, a medical screening exam, vital signs, neuropsychological assessment, a blood sample for measurement of plasma biomarkers, and a full retinal imaging exam. All participants will be asked to provide consent to allow review of medical records, including relevant imaging (including both clinical reports and Digital Imaging and Communications in Medicine (DICOM) image files for computerized tomography (CT)/ magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET) neuroimaging) and cerebrospinal fluid (CSF) biomarker evidence of AD, if available. Additional clinical and experimental endpoints will include measures of gait, sleep quality, social and psychological health, and pupillometry. Assessment of sleep architecture (i.e., actigraphy measures) will be collected via wearable trackers over the course of a 2-week period following the baseline and 36-month study visits. A subset of participants, in each of the subject groups, will be asked to take an over-the-counter herbal supplement (Longvida curcumin; Verdure Sciences, Inc., www.longvida.com) for two days prior to their baseline exams.

Study Type Observational
Study Design Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration Not Provided
Biospecimen Retention:   Samples With DNA
Description:
blood draw for proteomic, biomarker, and future genome wide association study (GWAS)
Sampling Method Non-Probability Sample
Study Population Study population will be serial referrals from public outreach (community sample) and memory clinics, male or female, between the ages of 55-80. The cognitively normal - low risk (healthy control group) will be comprised of 25 individuals aged 55-65 and 25 individuals aged 65-80. Recruitment will take place at 3 active sites: Butler Hospital (Providence, RI), Morton Plant Hospital (Tampa, FLA) and St. Anthony's Hospital (St. Petersburg, FLA).
Condition
  • Alzheimer Disease
  • Mild Cognitive Impairment
  • Mild Dementia
  • Aging
  • Cognitive Change
Intervention
  • Other: Retinal Imaging
    Retinal imaging will be conducted on the Heidelberg SPECTRALIS (FDA 510k cleared) device, routinely used in clinical care in ophthalmology. Optical Coherence Tomography (OCT) and Angiography (OCT-A) sequences will be conducted, as well as a sequence examining macular pigment (MPOD).
  • Other: Pupillometry
    Participants will complete a task studying pupillary response to light
  • Other: Contrast Sensitivity
    Participants will complete a task evaluating contrast sensitivity
  • Diagnostic Test: Neuropsychological Evaluation
    Neuropsychological evaluation will be completed, including testing in domains of memory, executive function, visuospatial ability, language, processing speed. Results will be used for research purposes only.
  • Genetic: APOE genotyping
    APOE genotyping will be completed during screening to assign participants to the correct group. Results will not be shared with participants as part of the study.
  • Other: blood draw
    Blood will be drawn and banked for proteomic, biomarker, and GWAS analysis
  • Other: Gait Assessment
    Gait assessment will be conducted by trained researcher
    Other Name: Timed Up and Go, Timed Up and Go - Dual Task (TUG, TUG-DT)
  • Other: Actigraphy
    Actigraphy monitors will be worn by all participants for 2 weeks after each visit to examine physical activity, movement, and sleep patterns.
Study Groups/Cohorts
  • Cognitively normal - low risk
    Adults aged 55-80 without subjective memory complaints, family history of Alzheimer's disease, or genetic risk for Alzheimer's disease.
    Interventions:
    • Other: Retinal Imaging
    • Other: Pupillometry
    • Other: Contrast Sensitivity
    • Diagnostic Test: Neuropsychological Evaluation
    • Genetic: APOE genotyping
    • Other: blood draw
    • Other: Gait Assessment
    • Other: Actigraphy
  • Cognitively normal - high risk
    Adults aged 55-80 with subjective memory complaints, first degree family history of Alzheimer's disease, and at least one copy of the APOE E4 gene, a risk gene for Alzheimer's disease
    Interventions:
    • Other: Retinal Imaging
    • Other: Pupillometry
    • Other: Contrast Sensitivity
    • Diagnostic Test: Neuropsychological Evaluation
    • Genetic: APOE genotyping
    • Other: blood draw
    • Other: Gait Assessment
    • Other: Actigraphy
  • mild cognitive impairment
    Adults aged 55-80 who have a confirmed diagnosis of mild cognitive impairment.
    Interventions:
    • Other: Retinal Imaging
    • Other: Pupillometry
    • Other: Contrast Sensitivity
    • Diagnostic Test: Neuropsychological Evaluation
    • Genetic: APOE genotyping
    • Other: blood draw
    • Other: Gait Assessment
    • Other: Actigraphy
  • mild dementia
    Adults aged 55-80 with mild dementia due to probable Alzheimer's disease.
    Interventions:
    • Other: Retinal Imaging
    • Other: Pupillometry
    • Other: Contrast Sensitivity
    • Diagnostic Test: Neuropsychological Evaluation
    • Genetic: APOE genotyping
    • Other: blood draw
    • Other: Gait Assessment
    • Other: Actigraphy
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Recruiting
Estimated Enrollment
 (submitted: February 28, 2019)
330
Original Estimated Enrollment Same as current
Estimated Study Completion Date June 2025
Estimated Primary Completion Date December 2021   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria (ALL PARTICIPANTS):

  • · Individuals between the ages of 55 and 80 years old (inclusive).

    • Permitted medications stable for at least 1 month prior to screening. In particular:
    • Participants may take stable doses of antidepressants lacking significant anticholinergic side effects (if they are not currently depressed and do not have a history of major depression within the past year).
    • Adequate visual and auditory acuity to allow neuropsychological testing, as determined by the eye exam and the neuropsychologist's judgment. Hearing augmentation by hearing aids is allowed.
    • Good general health or without any clinically significant abnormalities (see exclusion criteria) that would be expected to interfere with participation in the study.
    • Participants must be willing and able to provide written informed consent.
    • Participants must have a study partner (i.e., family member, close friend, or caregiver) who can attend study appointments with them and report on their level of daily functioning.
    • As this is entirely an observational study, without treatment intervention, we will allow concurrent enrollment in other clinical trials for mild cognitive impairment (MCI) or AD, including those that involved the use of investigational drugs. Relevant information about other studies in which participants are participating (e.g., study name, sponsor) will be collected and considered as a potential statistical covariate in the statistical analysis plan (SAP).

Additional Inclusion Criteria - Healthy Control Participants

  • Montreal Cognitive Assessment (MoCA) total score > 26 at screening
  • Clinical Dementia Rating (CDR) 0 at screening
  • An absence of substantial subjective memory complaints or worry
  • No first degree relative with either diagnosed AD or suspicion of AD
  • A screening genotype result showing non-carrier status for APOE ε4 allele

Additional Inclusion Criteria - High-Risk for Preclinical AD Participants

  • MoCA total score > 26 at screening
  • CDR 0 at screening
  • No clinical diagnosis of MCI or dementia of any type
  • Must have all of the following three risk factors for AD:
  • Subjective memory complaints as ascertained on a standardized questionnaire (i.e., ECOG).
  • A positive (suspected) first-degree family history for the disease.
  • A screening genotype result showing carrier status for at least one APOE ε4 gene allele Additional Inclusion Criteria - Patients with Mild Cognitive Impairment
  • MoCA total score > 19 at screening
  • CDR 0.5 at screening
  • A clinical diagnosis of MCI (amnestic type, but may include multiple domains) from qualified specialist or from a memory disorders clinic or center
  • Score of less than or equal to 85 (1.5 SD below age and education adjusted normative data) on the RBANS Delayed Memory Index (DMI)
  • Positive prior biomarker evidence of Alzheimer's disease (PET imaging or CSF study), if available

Additional Inclusion Criteria - Patients with Mild Alzheimer's Disease

  • MoCA total score > 15 and < 26 at screening
  • CDR 1 at screening
  • A clinical diagnosis of mild AD from qualified specialist or from a memory disorders clinic or center
  • Score of less than or equal to 85 (1.5 SD below age and education adjusted normative data) on the RBANS Delayed Memory Index (DMI)
  • Positive prior biomarker evidence of Alzheimer's disease (PET imaging or CSF study), if available
  • Informed consent provided from partner, caregiver or immediate family member, with verbal assent provided by individual patient.

Exclusion Criteria:

  • · Patients with histories of other ocular or neurologic disease that could affect the results, such as unusually high refractive errors ( > or < 5.0 diopters native spherical equivalent), age related macular degeneration, diabetic retinopathy, hypertensive retinopathy, retinal vascular disease, glaucoma, optic nerve disease, cystic macular edema, large cataracts or corneal disease that may preclude visualization of the retinal fundus, substantial ocular media opacity, and/or intraocular surgery within 90 days of any study visit will be excluded.

    • History of severe brain injury or other known neurologic disease or insult, which, as described by medical records, and/or as determined by the PI's clinical judgment, has resulted in lasting cognitive sequelae that would confound the assessment and staging of potential neurodegenerative disease.
    • Geriatric Depression Scale Short Form (GDS-S 15 Items) score > 6.
    • Poorly controlled major depression or another psychiatric disorder within the past year.
    • History of alcohol or substance abuse and/or dependence within the past 2 years (DSM-V criteria).
    • History of schizophrenia or a history of psychotic features, agitation or behavioral problems within the last 3 months, which could lead to difficulty complying with the protocol.
    • Participants who, in the investigator's opinion, will not comply with study procedures.
    • Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol including:
    • History of systemic cancer within the past 5 years (non-metastatic skin cancers are acceptable).
    • History of clinically significant liver disease, coagulopathy, or vitamin K deficiency within the past 2 years.
    • History of myocardial infarction within the past six (6) months or unstable or severe cardiovascular disease including angina or congestive heart failure (CHF) with symptoms at rest.
    • History of stroke(s) with lasting impairment to vision or the visual system, coagulopathy, uncontrolled hypertension (i.e., systolic BP > 170 or diastolic BP > 100) and uncontrolled or insulin requiring diabetes. Blood pressure will be recorded on the day of each examination.
    • Evidence of enlarged ventricles and/or normal pressure hydrocephalus on review of medical records or inspection of CT/MRI of the brain based on previous clinical diagnosis (MRI) as noted in their neurological history
    • History of Parkinson's disease, Parkinsonism due to multiple system atrophy (MSA), progressive supranuclear palsy (PSP), Shy Drager Syndrome (SDS) or other neuro-degenerative dementias
    • History of symptoms of narrow-angle glaucoma (warning signs include eye pain, restricted vision, blurred vision)
    • History of elevated intraocular pressure, or medical record evidence of intraocular pressure > 20 mm Hg
    • Regular (daily) use of narcotics or antipsychotic medications.
    • New use of anti-Parkinsonian medications (e.g., sinemet, amantaine, bromocriptine, pergolide and selegiline) within 2 months prior to screening.
    • New use of anti-convulsants (e.g., phenytoin, phenobarbital, carbamazepine) within 2 months prior to screening.
    • New use of centrally active beta-blockers, narcotics, methyldopa and clonidine within 4 weeks prior to screening.
    • New use of neuroleptics or narcotic analgesics within 4 weeks prior to screening.
    • New and chronic use of long-acting benzodiazepines or barbiturates within 4 weeks prior to screening.
    • Use of short-acting anxiolytics or sedative-hypnotics more frequently than 2 times per week within 4 weeks prior to screening (note: sedative agents should not be used within 72 hours of the baseline and follow-up visits).
    • Initiation or change in dose of an antidepressant lacking significant cholinergic side effects within the 4 weeks prior to screening (use of stable doses of antidepressants for at least 4 weeks prior to screening is acceptable)
    • An anticholinergic burden score of >3 on the Anticholinergic Cognitive Burden Scale (see appendix item 9.19).
    • Known hypersensitivity to anticholinergic medications, including tropicamide eye drops.
Sex/Gender
Sexes Eligible for Study: All
Ages 55 Years to 80 Years   (Adult, Older Adult)
Accepts Healthy Volunteers Yes
Contacts
Contact: Jessica Alber, PhD 4018742687 jalber@uri.edu
Contact: Catrina Montgomery 727-298-6077 Catrina.Montgomery@baycare.org
Listed Location Countries United States
Removed Location Countries  
 
Administrative Information
NCT Number NCT03862222
Other Study ID Numbers 900-403-2
Has Data Monitoring Committee Yes
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement
Plan to Share IPD: Undecided
Plan Description: Plan to make retinal atlas publicly available along with study data and retinal images.
Responsible Party Jessica Alber, University of Rhode Island
Study Sponsor University of Rhode Island
Collaborators
  • Stuart Sinoff, MD
  • Peter J Snyder, MD
  • BayCare Health System
Investigators
Principal Investigator: Stuart Sinoff, MD BayCare Health System
Principal Investigator: Peter J Snyder, PhD University of Rhode Island
PRS Account University of Rhode Island
Verification Date October 2020