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Phase 1a Study to Evaluate Immunogenicity of ASV®

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT03673020
Recruitment Status : Completed
First Posted : September 17, 2018
Last Update Posted : December 2, 2021
Information provided by (Responsible Party):
Agenus Inc.

Tracking Information
First Submitted Date  ICMJE September 11, 2018
First Posted Date  ICMJE September 17, 2018
Last Update Posted Date December 2, 2021
Actual Study Start Date  ICMJE May 16, 2019
Actual Primary Completion Date February 3, 2021   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: September 13, 2018)
Incidence of Treatment-Emergence Adverse Events (Safety and Tolerability) [ Time Frame: 1 Year ]
Assessed by monitoring the frequency, duration, and severity of drug-related AEs by completing physical examinations and clinical evaluations; evaluating changes in vital signs; and laboratory blood and urine sample evaluations.
Original Primary Outcome Measures  ICMJE Same as current
Change History
Current Secondary Outcome Measures  ICMJE Not Provided
Original Secondary Outcome Measures  ICMJE
 (submitted: September 13, 2018)
  • Vaccine-induced cellular Response [ Time Frame: 1 Year ]
    T-cell response to tumor-specific neo-epitopes contained in the vaccine (cytokine release assay)
  • Time of recurrence [ Time Frame: 1 Year ]
    Interval from the date of first dose of investigational, agent until the earliest date of cancer recurrence, as determined by investigator assessment of objective radiographic disease assessments, or death due to any cause if occurring sooner than recurrence.
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
Descriptive Information
Brief Title  ICMJE Phase 1a Study to Evaluate Immunogenicity of ASV®
Official Title  ICMJE Phase 1a First-in-Human Study of Safety and Tolerability of ASV® AGEN2017 With QS-21 Stimulon® Adjuvant as a Single Agent in Subjects With Solid Tumor at Risk of Relapse Undergoing Observation as SOC Following Complete Surgical Resection
Brief Summary This is an open-label Phase 1a First-in-Human Study to determine Safety and Tolerability of ASV® AGEN2017 with QS-21 Stimulon® Adjuvant as a Single Agent in Subjects With Tumors at Risk of Relapse Undergoing Observation as Standard of Care Following Complete Surgical Resection.
Detailed Description This is a Phase 1a study to evaluate neoantigen vaccine, AutoSynVax (ASV®) AGEN2017 in subjects with resected solid tumors, no evidence of disease (NED), and with an estimated life expectancy of ≥12 months from the time tissue has been submitted for vaccine manufacture. A minimum of 3 subjects will be enrolled to receive every two weeks subcutaneous injection of AGEN2017 + QS-21 adjuvant.
Study Type  ICMJE Interventional
Study Phase  ICMJE Phase 1
Study Design  ICMJE Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Condition  ICMJE Solid Tumor, Adult
Intervention  ICMJE Biological: ASV® AGEN2017 + QS-21 Stimulon® adjuvant
Neoantigen Vaccine
Study Arms  ICMJE Experimental: ASV® AGEN2017
ASV® AGEN2017 + QS-21 Stimulon® Adjuvant Vaccine
Intervention: Biological: ASV® AGEN2017 + QS-21 Stimulon® adjuvant
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: September 13, 2018)
Original Estimated Enrollment  ICMJE Same as current
Actual Study Completion Date  ICMJE February 3, 2021
Actual Primary Completion Date February 3, 2021   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  1. Signed, written informed consent.
  2. Age ≥18 years.
  3. Diagnosis of solid cancer that has been completely resected, NED, and eligible for observation only as SOC yet remain at risk of relapse per Investigator discretion. These include subjects diagnosed with malignant melanoma, non-small cell lung cancer, bladder cancer, colorectal cancer, breast cancer, renal cancer, head and neck cancer, cervical cancer, and soft tissue sarcoma.
  4. Life expectancy ≥12 months from the time of consent.
  5. Available fresh tissue from surgical excision. If fresh tissue is not available, formalin-fixed paraffin-embedded archival tissue may be used. The modality of the biopsy (e.g., endobronchial ultrasound, bronchoscopic, computed-tomography-guided needle biopsy) is not specified; however, core biopsy and fine needle aspiration are acceptable as long as the biopsy can be prepared as a cell block in paraffin-embedded tissue.
  6. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
  7. Adequate bone marrow function, as measured from studies of peripheral blood (absolute neutrophil count ≥1,500/mm3, absolute lymphocyte count ≥500/mm3, platelet count 50,000/mm3, hemoglobin >8.0 mg/dL).
  8. Adequate cardiac function (New York Heart Association class ≤II).
  9. Female subjects of childbearing potential must have a negative serum pregnancy test at the screening and pretreatment visits, and prior to first dose of study medication. Non-childbearing potential (other than by medical reasons) is defined as 1 of the following:

    1. ≥45 years of age and amenorrheic for >1 year by self-report.
    2. Amenorrheic for >2 years without a hysterectomy and oophorectomy, and follicle-stimulating hormone value in the postmenopausal range upon screening evaluation.
    3. Status post-hysterectomy, -oophorectomy, or -tubal ligation. If of childbearing potential, female subjects must be willing to use adequate birth control during the study, starting with the screening visit through 120 days after the last dose of study therapy.

    Male subjects with a female partner(s) of childbearing potential must agree to use a condom throughout the trial, starting with the screening visit through 120 days after the last dose of study therapy. Male subjects with pregnant partners must agree to use a condom; no additional method of contraception is required for the pregnant partner.

    Note: Abstinence is acceptable for both female and male subjects if this is the subject's established and preferred contraception method.

  10. Subject is willing and able to comply with the requirements of the protocol.

Exclusion Criteria:

  1. Subjects must not have received anticancer medications or investigational drugs within the following intervals before first dose of study drug:

    1. ≤14 days for chemotherapy, targeted small molecule therapy, anticancer hormone therapy, or radiation therapy, with the following exceptions:

      • Bisphosphonates and denosumab are permitted.
      • Novel imaging agents that have Phase 1 safety data and have not demonstrated therapeutic activity are permitted.
      • Physiologic steroid replacement for adrenal insufficiency (e.g., <10 mg prednisone per day) is permitted.
      • Prophylactic use of inhaled or topical corticosteroid or short course of intravenous systemic corticosteroid (≤3 days) for radiographic procedures is permitted.
      • Use of physiologic corticosteroid replacement therapy must be approved by the medical monitor.
    2. ≤28 days for prior cancer immunotherapy.
    3. ≤28 days for prior monoclonal antibody used for anticancer therapy, with the exception of denosumab.
    4. ≤7 days for immunosuppressive treatment for any reason. Systemic corticosteroids are not allowed except as defined above.
    5. e. ≤28 days before first dose of study drug for all other investigational study drugs or devices.

    Note: Washout is applicable to the screening visit only, and not applicable prior to the first dose of study drug. Subjects are not to receive anti-cancer therapies from date of consent through the post treatment visit (end of treatment or final safety visit).

  2. Diagnosis of clinically significant immunodeficiency (as defined by the principal investigator), or actively receiving or potentially needing any form of immunosuppressive therapy within 7 days prior to the first dose of study drug until the end of the trial.
  3. History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator or medical monitor.
  4. Uncontrolled intercurrent illness, including but not limited to uncontrolled infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or social situations that would limit compliance with study requirements in the opinion of the treating investigator or medical monitor.
  5. History of intolerance or allergic reactions attributed to compounds of similar chemical or biologic composition to AGEN2017 or QS-21 adjuvant.
  6. Women who are pregnant or breastfeeding.
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE United States
Removed Location Countries  
Administrative Information
NCT Number  ICMJE NCT03673020
Other Study ID Numbers  ICMJE C-610-01
Has Data Monitoring Committee No
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement  ICMJE
Plan to Share IPD: No
Current Responsible Party Agenus Inc.
Original Responsible Party Same as current
Current Study Sponsor  ICMJE Agenus Inc.
Original Study Sponsor  ICMJE Same as current
Collaborators  ICMJE Not Provided
Investigators  ICMJE
Study Director: Medical Director Agenus Inc.
PRS Account Agenus Inc.
Verification Date December 2021

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP