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Conditioned Pain Modulation in Chronic Neck Pain Patients

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ClinicalTrials.gov Identifier: NCT03362203
Recruitment Status : Not yet recruiting
First Posted : December 5, 2017
Last Update Posted : December 5, 2017
Sponsor:
Information provided by (Responsible Party):
guochen, Peking University People's Hospital

November 26, 2017
December 5, 2017
December 5, 2017
January 1, 2018
August 1, 2018   (Final data collection date for primary outcome measure)
Change of pressure pain threshold (PPT) [ Time Frame: The PPT will be measured before CPT, 30 seconds after the CPT begin, and immediately after CPT. ]
A cold pressor test (CPT) was used to induce pain and trigger the conditioned pain modulation (CPM) response. The conditioned stimulus was immersion of the leg in a bucket of ice water on the side ipsilateral to the most painful neck region. The neck PPT was recorded beginning 30 s after immersion of the leg with two PPT measures for each point. The PPT will be also measured again immediately after CPT.
Same as current
No Changes Posted
Numerical rating scale for pain (NRS) [ Time Frame: The patients used this scale to rate the pain intensity of the neck pain before the experiment. ]
The NRS evaluates levels of pain intensity using an 100-point scale (range 0-100), with 0 being classified as "no sensation", 30 "pain threshold", 100 "pain as bad as could be".
Same as current
Not Provided
Not Provided
 
Conditioned Pain Modulation in Chronic Neck Pain Patients
The Hypersensitivity and Changes of Conditioned Pain Modulation in Chronic Neck Pain Patients
The aim of this study was to evaluate changes in local and segmental hypersensitivity and endogenous pain inhibition in people with chronic nonspecific neck pain.
Quantitative sensory testing is widely used in human research to investigate the state of the peripheral and central nervous system contributions in pain processing. It is a valuable tool to help identify central sensitization and may be important in the treatment of chronic neck pain. This study is a cross-sectional study. Two groups including chronic neck pain group and healthy volunteers group will be arranged in this study. The healthy subjects will be matched for sex and age in relation to the neck pain group. The pressure pain threshold (PPT) will be measured at the neck muscle in both groups. The cold pressor test will be used in both groups to activate conditioned pain modulation.
Observational
Observational Model: Other
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample
  1. Chronic neck pain subjects People must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.Patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies. Those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded.
  2. Healthy volunteers These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.
Neck Pain
  • Other: Patients with chronic neck pain
    Patients,aged 21-80 years, must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
  • Other: Subjects without chronic neck pain
    Subjects,aged 21-80 years, must not have presented episodes of chronic neck pain for more than 7 days in the last 12 months.
  • Patients with chronic neck pain
    Patients,aged 21-80 years, must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
    Intervention: Other: Patients with chronic neck pain
  • Subjects without chronic neck pain
    Subjects,aged 21-80 years, must not have presented episodes of chronic neck pain for more than 7 days in the last 12 months.
    Intervention: Other: Subjects without chronic neck pain

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
30
Same as current
August 1, 2018
August 1, 2018   (Final data collection date for primary outcome measure)
  1. Chronic neck pain subjects

    Inclusion criteria:

    • Age 21-80 years old.
    • People must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.

    Exclusion Criteria:

    • Age under 21 or over 80.
    • Patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies, such as fractures, tumors or inflammatory diseases, such as ankylosing spondylitis, nerve root compromise confirmed by clinical neurological tests or severe cardiorespiratory diseases.
    • Those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded.
  2. Healthy volunteers

Inclusion criteria:

  • Age 21-80 years old.
  • These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.

Exclusion Criteria:

  • Age below 21 or over 80 years old.
  • These participants have presented episodes of low back pain for more than 7 days in the last 12 months.
Sexes Eligible for Study: All
21 Years to 80 Years   (Adult, Senior)
Yes
Contact: Weiwei Xia, Ph.D. 008613260001978 weiweixia2016@163.com
China
 
 
NCT03362203
Neckpainspine001
No
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Plan to Share IPD: No
guochen, Peking University People's Hospital
Peking University People's Hospital
Not Provided
Principal Investigator: Chen Guo, Master Peking University People's Hospital
Peking University People's Hospital
November 2017